MSM and arthritis

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Below this article is a statement from one who is using MSM for arthritis.

LIGNISUL MSM (Methylsulfonylmethane) A DOUBLE BLIND STUDY OF ITS USE IN

DEGENERATIVE ARTHRITIS

(A Preliminary Correspondence)

By M. Lawrence, M.D., Ph.D.

Assistant Clinical Professor

U.C.L.A. School of Medicine

Los Angeles, California

Methyl-Sulfonyl-Methane (M.S.M.) is an organic sulfur compound which is a

metabolite of dimethyl-sulfoxide (D.M.S.O.). It is a white, odorless,

slightly bitter tasting, crystalline substance, which contains 34 percent

elemental sulfur. It is easily soluble in water. Its chemical formula is

(CH3)2SO2. It has been suggested by Lovelock and his associate's (1) that

M.S.M. and its related compounds D.M.S.O. and D.M.S. (dimethyl sulfide)

provide 85 percent of the sulfur found in all living organisms.

The cycle of these naturally occurring sulfur compounds begins in the ocean

where microscopic plankton release sulfur compounds called dimethyl

sulfonium salts. These salts are transformed in the ocean into the very

volatile compound D.M.S. which escapes from the water as a gas which rises

into the upper atmosphere. Exposed to ozone and high energy ultraviolet

light the D.M.S. is converted to D.M.S.O. and M.S.M. Both the D.M.S.O. and

M.S.M. are very soluble in water and they return to the surface of the earth

in rainwater. Plants then take up the two compounds into their root systems

concentrating them up to one hundred fold. M.S.M. (sulfur) is incorporated

into the plant structure. Through the process of plant metabolism the

M.S.M., along with the other sulfur compounds it has spawned, are ultimately

mineralized and transported back to the ocean and the sulfur cycle begins

again.

M.S.M. is found naturally in the human body. It occurs in the blood and in

other organs and has been detected in normal human urine (2). The level of

M.S.M. in the circulatory system of an adult human male is about 0.2 parts

per million (3). Normal human adults excrete from four to eleven milligrams

M.S.M. per day in their urine. Experiments using radiolabled sulfur (S35) in

M.S.M. have shown that after ingestion the sulfur in M.S.M. helps form the

essential amino acids methionine and cysteine (4).

M.S.M. is rated as one of the least toxic substances in biology, similar in

toxicity to water (5). The lethal dose (LD50) of M.S.M. for mice is over 20

grams per kilogram of body weight. Hundreds of patients have been treated at

the Oregon Health Sciences University (6) with oral M.S.M. at levels above

two grams daily for many years without serious toxicity.

Since sulfur is found to be needed for the formation of connective tissue,

M.S.M. has been studied for its use in treating arthritis of various types

(7). Sulfur concentration in arthritic cartilage has been shown to be about

one-third the level compared to normal cartilage (8). In addition, the amino

acid cystine has been noted to be diminished in arthritic patients.

Personal communication with Stanley , M.D., Gerlinger Professor,

Department of Surgery, Oregon Health Sciences University, Portland, Oregon,

substantiated his personal experiences using M.S.M. in the treatment of

patients with degenerative (osteoarthritis) arthritis.

Study Design

M.S.M. was provided in a crystalline form (LIGINSULMSMT) which we

encapsulated in a clear gelatin capsule providing 750 mgms of LIGINSULMSMT)

per capsule. The placebo substance, which was also placed in clear gelatin

capsules, consisted of sugar (sucrose) to which a small amount of quinine

sulfate was added to create a slightly bitter taste. This was done in case

the capsule was opened and tasted, since M.S.M. also has a slightly bitter

taste.

A total of sixteen patients were studied over a period of four months.

Initially twelve patients were admitted to the study and subsequently (two

months later) an additional four patients were added to the study group. The

initial twelve patients were divided as follows. Eight were given the

M.S.M., while four received the placebo. Later, the additional four patients

were divided into two on M.S.M. and two on placebo. Totally, therefore, we

had ten patients on M.S.M. and six patients on placebo.

Criteria for Selection

Patients ranged from age 55 to age 78. All patients had x-ray evidence of

degenerative joint disease (degenerative arthritis). All patients had pain

in the involved area ranging from four weeks to six months. Most of the

patients had tried non-steroidal anti-inflammatory drugs or aspirin type

compounds. None had taken steroids either orally or by injection. All

non-steroidal anti-inflammatory drugs or other anti-arthritic medications or

alternative health remedies were stopped a least three days prior to their

entering the study.

Patients were randomly chosen by lot and assigned to either the active

(M.S.M.) group or the placebo group. The treating physician did not have

knowledge as to which patient received which agent until after the

completion of the study. Records were kept by an independent evaluator until

the study was terminated. Both the patients and the physicians were blinded.

Of the eight patients on Liginsul M.S.M., two had osteoarthritis in their

hands, three had lumbar degenerative joint disease, two had degenerative

arthritis in their knees, and one had arthritis in the shoulder.

Of the six patients who received the placebo, two had degenerative arthritis

in the knees, two had lumbar degenerative joint disease, one had

degenerative arthritis in the hip, and one had osteoarthritis in the neck.

Dosage

Patients were instructed to take two capsules on an empty stomach in the

A.M. after arising and one capsule before lunch. This constituted a 2250

milligram dose of Liginsul M.S.M. daily and zero dose of M.S.M. on the

placebo.

Measurement

Each patient was administered a visual analog scale (V.A.S.) which consisted

of a 10-cm line anchored at one end by a label of " no pain " and at the other

end a label of " pain as bad as could possibly be. " The scoring is

accomplished by having the patient mark the line indicating pain intensity,

and the line is then measured to the mark on a 1-100 scale (9).

Results

The V.A.S. was completed by each patient at the four week and at the six

week visit. Records were measured by an independent evaluator.

At the four week visit, the patients on the Liginsul M.S.M. showed a 60

percent improvement on average, while at the six week V.A.S. evaluation the

patients showed and 82 percent improvement in pain on average.

Those on the placebo showed an improvement of 20 percent on average at four

weeks and an 18 percent improvement on average at six weeks.

ABSTRACT

This preliminary simple study was performed to initially evaluate 16

patients suffering from degenerative arthritis as to the effect of using

Liginsul M.S.M. to control their pain. Eight patients, randomly chosen, were

treated with 2250 mgms of M.S.M. per day. Six patients received placebo

capsules. Results indicate a better than 80 percent control of pain within

six weeks of beginning the study, while only two patients showed a minimal

improvement (less than 20 percent) on the placebo. Although this was only a

simple preliminary study, it appears that a more intensive investigation of

M.S.M. is warranted. A larger group of arthritic patients an additional

measurement evaluation (such as range of motion, etc.) should be utilized in

such a future study. Liginsul M.S.M. may offer a significant new nutritional

substance for the control of arthritic pain as a safe, non-toxic method.

REFERENCES

Lovelock, J.E. et al. Nature, Vol. 237, p452, 1972

, K.I.H. et al. Arch Biochem Biophys, Vol. 113, p251, 1966

, S.W. and Herschler, R., Ann NY Acad Sci, Vol. 411, pxii 1983

Richmond, V.L., J Nutrition, Vol. 116 NO. 6, June, 1986

Deichman, W.B. & Gerarde, H.W. " Toxicology of Drugs & Chemicals, 4th

Edition, Arcadia Press, 1969

, S.W., Oregon Health Sciences University, Portland, Oregon, Personal

communication

, S.W., Oregon Health Sciences University, Portland, Oregon, personal

communication

Rizzo, R. et al. Jour Exp Zool, 1995 September, 1,273(1):82-6

Carlson

" MSM is a dietary supplement, (Methylsulfonylmethane) that I have taken for

arthritis. I imagine there are other uses for it, also. It seemed to help

the pain when the weather got cold, at least for me. I have heard that KT

is good for arthritis, also, though it may take awhile to notice.

Judy "

carmen g wrote:

>Pardon my ignorance but wha

Smart is believing only half of what you hear,

brilliant is knowing which half to believe.

Atlantic1@...