Accuracy of Gene Testing to determine CD

[Guest guest]

I am curious about the gene tests. Some sources say it is Imposible to have

celiac without the DQ2 & 8 ....but some people have mentioned that it is not

impossible to develop it.

Does any one have a credible source for the argument that CD can occur

without the DQ2 & 8?

This is from University of Chicago -CD Center

" There is a blood test available to determine whether or not an at-risk

individual carries the genes responsible for the development of celiac

disease. These genes are located on the HLA-class II complex and are called

DQ2 and DQ8. Each case of celiac disease has been found to show these

so-called " haplotypes " ; therefore, a negative gene test indicates that

celiac disease cannot develop in that individual.

There are two main reasons for using the genetic test when evaluating an

individual for celiac disease. The first case is to " rule out " celiac

disease, which is a medical term that indicates an individual does not

possess a necessary risk factor for the development of celiac disease,

genetic predisposition. Without this factor, it is impossible that the

individual with a negative gene test will develop celiac disease in the

future. "

http://www.uchospitals.edu/pdf/uch_007936.pdf

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[Guest guest]

Dr. Scot Lewey, a celiac and strong promoter of celiac disease awareness told me he has neither the DQ2 or DQ8. We have met others in the same boat on our book tours and through our website - positive blood tests, positive endoscopy with biopsy, yet negative gene tests. New research points to the possibility that non-HLA genes may also be involved. (DQ2 and DQ8 are HLA) The gene tests were thought to be almost 100% but are now estimated to be more like 90%. They should be used as a screen, not a 100% pass/fail.

You can find more information on the various tests and how they work here http://www.glutenfreeworks.com

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