(No subject)

January 6, 2004

Antioxidants in the Treatment of Multiple Sclerosis

The term, antioxidants, is a general term applied to a group of nutrient compounds (certain vitamins or minerals) which either act independently, or serve to support the function and activity of the antioxidant enzymes (see below).

Their purpose is to protect the body from the damaging effects of what are known as free radicals.

Free radicals are small, highly reactive chemical groups, each of which has one or more unpaired electrons within the molecule. It is the presence of these unpaired electrons, which makes them so reactive and ready to combine with, or otherwise influence, other chemical structures or processes.

In this way, they are capable of damaging, or otherwise disrupting, certain cell structures or biochemical processes within the body.

The antioxidants thus provide protection from these various damaging effects.

The most common free radical is, in fact, oxygen, which exists, in its most damaging form, as ozone. It is the action of sunlight on the products of petrol combustion, which produces low-level ozone, a critical pollutant in our towns and cities.

Free radicals are also produced as a result of natural metabolic processes and increase greatly during periods of intense exercise or activity. There is also an increase in the production of free radicals resulting from situations of abnormal body temperature rise, for example, during a period of infection.

Free radicals are also produced from combustion, as occurs in the burning of fossil fuels, including oil, petrol and coal. This is the main cause of pollution in towns and industrial areas. The free radicals produced include oxides of nitrogen and sulphur.

It is also why smoking is so harmful. Burning tobacco produces an absolute torrent of free radicals which are inhaled directly into the lungs, causing not only direct harm to the lung itself, but also more widespread damage to the heart and blood vessels. These organs rapidly receive the free radicals by absorbing them from the blood in which they are transmitted.

Ionising radiation, due to such as sunlight, is also a powerful inducer of free radicals. This is the reason why sunlight is a significant cause of premature skin aging in those having outdoor occupations or who persist in excessive sunbathing or use of artificial sunbeds.

Certain chemicals too may act as free radical inducers. A wide range of hydrocarbons and other chemical compounds, used in industry, plastics production, and medicine are effective in acting as free radical inducers.

Free radicals, in excess, are active in causing oxidative cell damage. Smoking thus promotes damage to the lungs, the heart and blood vessels, producing cancer, chronic bronchitis, emphysema, atherosclerosis (clogging of the arteries) and hypertension (high blood pressure).

Oxidation, due to the presence of free radicals, also causes the destructive conversion of the beneficial poly-unsaturated fatty acids (PUFAs), producing potentially harmful saturated fats, which contribute to the pre-existing damage in the arteries.

This damaging process thus reduces the presence of PUFAs, which would otherwise be available for use within the cell structure, for conversion to PGs, or the production of such as myelin, in the brain and spinal cord.

The Antioxidant Enzymes: These are protective enzymes, which divert the free radicals away from the tissues that would otherwise be harmed by them.

These enzymes permit and promote a series of chemical processes which allow the free radicals to be inactivated harmlessly out of the way.

There is however, a limit to the body's capability in this process, and that limit is exceeded by such unnatural processes as smoking tobacco! To a much lesser extent, excessive exercise in an untrained individual can also be harmful in a similar way.

Superoxide dismutase (SOD): the first of three important antioxidant enzymes.

This enzyme exists in two different forms: the first, and most important, is found throughout the body and utilises, as part of its structure, two minerals, zinc and copper. Within this context therefore, both zinc and copper may be considered as antioxidant minerals. Details of the necessary doses of these minerals are presented in the information sheet, "Zinc Deficiency and the Zinc Taste Test", available on request.

The second form of SOD is found only in the region of a cell structure known as mitochondria. The mitochondria are responsible for the conversion of the chemical energy (from various food sources) to usable energy within the cell.

Mitochondrial SOD incorporates two essential minerals: zinc and manganese.

The recommended daily requirement for manganese is at least 1.5 mg/ day. In conditions where excessive fatigue and tiredness is a feature therefore, a suitable therapeutic dose would be 5 mg/ day.

Glutathione peroxidase: This equally important enzyme permits the use of glutathione (a protein component of living cells) as an `oxygen carrier' allowing free radicals to be harmlessly inactivated.

This enzyme incorporates a vital, and often deficient, trace element, selenium. The recommended dose is 200 microgrammes (mcg)/ day.

Because the geological rock strata of Britain is low in selenium the average natural dietary intake is only 35 mcg/ day. In South Wales, which is a very low selenium area, the average intake is even lower, at only 25 mcg/ day.

It has been suggested that the relatively high incidence of a range of cancers in Britain may be related to this low selenium intake. It has been found that the highest cancer rates exist in regions of lowest selenium availability. Conversely, it has equally been demonstrated that regions of the world, such as Texas, where natural selenium levels are high, have a very low cancer rate (other factors being taken into consideration).It has thus been proved, by extensive research, that a supplemental dose of selenium 200 mcg/ day, will reduce the risk of developing cancer by 50%.

It is believed that this defensive function is due to the protection of the cell membranes and DNA by the antioxidant enzyme, glutathione peroxidase.

Catalase: This acts by converting hydrogen peroxide, produced by the normal processes of body metabolism, into its components, oxygen and water.

In conditions where there is a disturbance of either fatty acid and/or PG metabolism due to gross inflammation of specific tissues, the balance can at least be part restored by providing an adequate supply of all the antioxidant vitamins and minerals. These include zinc, copper, manganese and selenium, as discussed above, together with the essential antioxidant vitamins, C, E and A.

Vitamin C: This appears to be the most essential of the three. A suitable dose would be up to three grammes each day. Generally however, the optimum economic and therapeutic balance seems to be at a dose of just one gramme (1000 mg) per day.

Vitamin E: The optimum therapeutic dose of vitamin E is 400 international units per day.

The power and therapeutic benefit of this dose was demonstrated by a major study at Addenbrook Hospital, Cambridge in 1996. It was found that in a group of patients who had suffered one previous heart attack, the risk of a second heart attack was reduced by 79% by taking vitamin E 400 int. units/ day.

Vitamin E is therefore of specific benefit in protecting the heart and circulation. It is also effective in promoting the regeneration of blood vessels, thus restoring the circulation to regions deprived by thrombosis or atherosclerosis. Major studies have demonstrated its benefit in improving memory and cognitive ability in the elderly.

Vitamin A: The safest means of obtaining vitamin A is by taking a natural source of beta carotene 15 mg/ day. This is readily converted to vitamin A in the body, as it is required.

Vitamin A is also contained in fish liver oils, together with vitamin D. The content of vitamin A in cod liver oil is 5000 units per gramme of oil.

Thus, in young women who are, or are likely to become, pregnant (where an excess of vitamin A might cause foetal abnormalities), the limit of cod liver oil should be a maximum of two grammes per day. The safe limit of vitamin A in pregnancy is considered to be 10,000 units/ day. This risk may be eliminated by taking flax-seed oil, as an alternative to fish oil. Flax-seed oil contains the same N3 fatty acids as fish oil, but no vitamin A.

The antioxidant nutrients are therefore necessary and beneficial in both health and disease. They may be used as a preventative against heart disease, auto-immune disease, atopic problems and cancer.

Registered Office:- Dietary Research Limited, 10 Heol Gerrig, Treboeth, Swansea, SA5 9BP Telephone: 01792-417514: Company Registered Number 2615367

January 6, 2004

Treatment Summary: Zenwa Dietary treatment Method

Multiple sclerosis

To clarify the treatment regime the various stages of the programme, as described in the advice booklet, are summarised below:

1) Start the anti-oxidants (see chapter V) selenium 200 mcg/ day, vitamin C 1000 mg/ day, and natural vitamin E 400 - 500 int. units/ day. These supplements should be started immediately and continued indefinitely.

2) For maximum benefit natural beta carotene, 15 mg/ day, may also be added. Beta carotene is converted into active vitamin A in the body. This is however, moderately expensive and, because there is plenty of vitamin A in the cod liver oil that is also advised, may be excluded in the treatment of moderate or minor conditions.

3) To promote healing, improve energy and vitality, and reduce depression, vitamin B complex (non yeast-derived) may be added at this, or a later stage (see chapter IV). B50 complex is a sufficient dose.

4) Read, and follow the advice offered, in chapter III and IIIA.

5) Start the zinc supplements (chapter IV, or see info on the Zinc Taste Test) as necessary, according to the taste test response. Add copper 1 mg with doses of zinc below 50 mg and copper, 2.5 mg/ day, when the dose of zinc has reached, or exceeded, 50 mg/ day.

6) When the dose of zinc has reached a stable level (as indicated by the zinc taste test) introduce the fatty acid supplements as described in chapter IV, or see data sheet on EFAs.

7) Add any additional supplements as may be considered necessary (see chapter IV). These may include such as anthocyanidins (see information sheet); vitamin D (25 to 50 mcg/ day = 1000 to 2000 int. units) vanadium, as vanadyl sulphate, or additional doses of folic acid, vitamin B6 or B12.

Any queries, questions or doubts regarding this method may be resolved by writing to, or calling, Dr M R Lawrence, at Dietary Research Limited, 10 Heol Gerrig, Treboeth, Swansea, West Glam SA5 9BP. Tel: 01792-417514.

January 6, 2004

I asked this via e-mail and never got an answer. Best wishes on your new attempt. I really hope that your successful.

Dan

----- Original Message -----

From: son

I AM CANADIAN;Cabbie54@...

Cc: low dose naltrexone

Sent: 1/6/2004 12:00:19 PM

Subject: RE: [low dose naltrexone] RE: (no subject)

I wanted to let you know that I wrote to the MSAA asking that they consider doing research on LDN for use for people with MS. Apparently there are no studies done on this treatment and I feel allot of people would benefit from it if there was. Typically it takes a study and a write up on a drug for it to get recognized as a treatment for a specific disease. I know that there is a study for LDN being used for Chrones disease but wouldn’t It be great if there were more studies?

The MSAA funds allot of research so I felt they were a good place to start and ask them to jump at researching LDN.

Lets hope they listen.

son

Owner/ operator

Friends with MS.com

or join our email newsgroup:

FriendsWithMS/

-----Original Message-----From: I AM CANADIAN [mailto:lvlail_lvle@...] Sent: Tuesday, January 06, 2004 10:20 AMCabbie54@...Cc: low dose naltrexone Subject: [low dose naltrexone] RE: (no subject)

Look Cabbie I have communicated directly with Dr. Lawrence as well okay. TYhere are other people who take several things along with LDN because their respective doctors believe attacking on all fronts gives them a better chance. It is not our place to tell people they cannot take those drugs together. They are safe together and many come just wondering if they CAN take them together because not many know anything about LDN.

You can read my email to Jodygirl again and see that I say some doctors feel they work in opposition to one another… just as Dr. Lawrence says here and has said to me… (maybe you don’t remember me posting my personal emails from Dr. Lawrence to this group and the other LDN group but I did). And I don’t appreciate you putting this in my face as though I haven’t read the same things before! I’m sure you know how long I have been here and have read every single post since I have arrived!

It is up to each of us to make our own educated decisions. And for none of us to treat people badly if they choose to not follow what Dr. Lawrence says but what they feel or their personal doctors and they think.

LDN has not yet been studied and so until it is we can’t say for certain that interactions with Rebif, Avonex, Chemo based treatments, or Betaseron etc… are negative with LDN. Don’t get me wrong here I believe what Dr. Lawrence has to say but I am not going to make decisions for others I will tell them that it is alright to take other medications with it IF THEY CHOOSE TO!

Let me also add as you put this in my face others put in my face that LDN is quackery… I don’t know you personally I don’t know them personally… I formed my own decision with everything I have seen and so should each and every other person considering any treatment. Not have their doctor make up their minds for them and follow blindly not have a group make up their minds for them either! Get all the facts and make their own!

Got it? Good. Now thank you for thinking you are educating me further than I have been but you are not.

From: Cabbie54@... [mailto:Cabbie54@...] Sent: Tuesday, January 06, 2004 12:41 PMlvlail_lvle@...Subject: (no subject)

This is what Dr. Lawrence said about the immune suppressants and ldn together...

Dear Carol,

I will be more affirmative than Dr Bihari and tell you that it is a complete waste of time taking LDN if you continue to take Rebif, or any other immune suppressants. The two treatments are simply working in opposition. It is a little like adding ice to a heated kettle that you are trying to boil. It will get you no-where!

If you intend making a serious attempt to adopt this treatment (the LDN) you must stop all the immune suppressant drugs first.

I am not surprised that you suffered headaches and depression with this combined therapy. Your body must have been in such a state of conflict I imagine almost anything could have happened. It is sure that you were getting no benefit from either therapy!

We must also consider the possible effects on your blood pressure. What was your blood pressure before and after the Cozaar. Was your blood pressure checked when you had the headache? What was the pressure then? Do you have your own sphygmomanometer to check it yourself?

There is no hard and fast rule to determine the time that you should be off the interferon. Two weeks is sufficient to get the drugs out of your system but your immune system may still be in a state of suppression. It is similar, but worse, with steroids. After steroids, it may take months to recover from the adrenal and immune suppression resulting from these dangerous and, as far as MS is concerned, useless drugs.

Starting LDN after using immune suppressants is going to be an unpredictable process under any circumstances. All that I do in such a situation is simply monitor the patients response to the LDN, each day if necessary, and offer the most appropriate advice in answer to the response prevelent at that time. It can be a slow, arduous, traumatic, and time-consuming process. Having started on the wrong foot (the interferon) you must be prepared to fight your way back to a more productive and beneficial method of therapy.

The headaches may actually be a sign of a beneficial response, when there is an increase in cerebral blood circulation. Until your body adjusts to this new internal environment you should take nothing more than paracetamol (acetaminophen), or low-dose ibuprofen, at a minimal dose. Similar headaches are seen to occur in response to vitamin E, zinc, EFAs, or even HBO. These are all clearly beneficial in MS.

Your diet I would consider a little questionable. As a routine I would not advise bread, eggs, or coffee (or is it de-caff?).

The list of supplements I recommend are listed in the attachments. Zinc and the EFAs are the most important. I have remained stable for the last 15 years on this regime with minimal rate of progression and no relapses. Since starting the LDN I have now slowly begun to improve, although after having MS for 26 years I still have a long way to go.

Having used, and prescribed LDN, for almost two years it has become obvious that the method is far more complicated than I had initially envisaged. With time, a little thought, and sometimes more than a little moral support, most people find the method greatly beneficial. The drop-out rate is presently only about 2%, which is a lot better than beta interferon!

With kind regards,

Bob Lawrence

January 6, 2004

I know a few

people on LDN who are seeing progress and staying on their injectables. They have a decrease in symptoms from

the LDN yet are still doing their avonex or beta.

son

Owner/

operator

Friends with MS.com

or

join our email newsgroup:

FriendsWithMS/

-----Original Message-----

From: I AM CANADIAN

[mailto:lvlail_lvle@...]

Sent: Tuesday, January 06, 2004 10:20 AM

Cabbie54@...

Cc:

low dose naltrexone

Subject: [low dose naltrexone] RE:

(no subject)

Look Cabbie I

have communicated directly with Dr. Lawrence as well okay. TYhere are other

people who take several things along with LDN because their respective doctors

believe attacking on all fronts gives them a better chance. It is not our place

to tell people they cannot take those drugs together. They are safe together

and many come just wondering if they CAN

take them together because not many know anything about LDN.

You can read my

email to Jodygirl again and see that I say some doctors feel they work in

opposition to one another… just as Dr. Lawrence says here and has said to

me… (maybe you don’t remember me posting my personal emails from

Dr. Lawrence to this group and the other LDN group but I did). And I

don’t appreciate you putting this in my face as though I haven’t

read the same things before! I’m sure you know how long I have been here

and have read every single post since I have arrived!

It is up to

each of us to make our own educated decisions. And for none of us to treat

people badly if they choose to not follow what Dr. Lawrence says but what they

feel or their personal doctors and they think.

LDN has not yet

been studied and so until it is we can’t say for certain that

interactions with Rebif, Avonex, Chemo based treatments, or Betaseron

etc… are negative with LDN. Don’t get me wrong here I believe what

Dr. Lawrence has to say but I am not going to make decisions for others I will

tell them that it is alright to take other medications with it IF THEY CHOOSE TO!

Let me also add

as you put this in my face others put in my face that LDN is quackery… I

don’t know you personally I don’t know them personally… I

formed my own decision with everything I have seen and so should each and every

other person considering any treatment. Not have their doctor make up their

minds for them and follow blindly not have a group

make up their minds for them either! Get all the facts and make their own!

Got it? Good.

Now thank you for thinking you are educating me further than I have been but

you are not.

From:

Cabbie54@... [mailto:Cabbie54@...]

Sent: Tuesday, January 06, 2004

12:41 PM

lvlail_lvle@...

Subject: (no subject)

This is what Dr. Lawrence said about the immune

suppressants and ldn together...

Dear Carol,

I will be more affirmative than Dr Bihari and tell you

that it is a complete waste of time taking LDN if you continue to take Rebif,

or any other immune suppressants. The two treatments are simply working

in opposition. It is a little like adding ice to a heated kettle that you

are trying to boil. It will get you no-where!

If you intend making a serious attempt to adopt this

treatment (the LDN) you must stop all the immune suppressant drugs first.

I am not surprised that you suffered headaches and

depression with this combined therapy. Your body must have been in such a

state of conflict I imagine almost anything could have happened. It is

sure that you were getting no benefit from either therapy!

We must also consider the possible effects on your

blood pressure. What was your blood pressure before and after the Cozaar.

Was your blood pressure checked when you had the headache? What was the

pressure then? Do you have your own sphygmomanometer to check it

yourself?

There is no hard and fast rule to determine the time

that you should be off the interferon. Two weeks is sufficient to get the

drugs out of your system but your immune system may still be in a state of

suppression. It is similar, but worse, with steroids. After

steroids, it may take months to recover from the adrenal and immune suppression

resulting from these dangerous and, as far as MS is concerned, useless drugs.

Starting LDN after using immune suppressants is going

to be an unpredictable process under any circumstances. All that I do in

such a situation is simply monitor the patients response to the LDN, each

day if necessary, and offer the most appropriate advice in answer to the

response prevelent at that time. It can be a slow, arduous,

traumatic, and time-consuming process. Having started on the wrong

foot (the interferon) you must be prepared to fight your way back to a more

productive and beneficial method of therapy.

The headaches may actually be a sign of a

beneficial response, when there is an increase in cerebral blood

circulation. Until your body adjusts to this new internal environment you

should take nothing more than paracetamol (acetaminophen), or low-dose

ibuprofen, at a minimal dose. Similar headaches are seen to occur in

response to vitamin E, zinc, EFAs, or even HBO. These are all clearly beneficial

in MS.

Your diet I would consider a little

questionable. As a routine I would not advise bread, eggs, or coffee (or

is it de-caff?).

The list of supplements I recommend are listed in the

attachments. Zinc and the EFAs are the most important. I have

remained stable for the last 15 years on this regime with minimal rate of

progression and no relapses. Since starting the LDN I have now slowly

begun to improve, although after having MS for 26 years I still have a long way

to go.

Having used, and prescribed LDN, for almost two years

it has become obvious that the method is far more complicated than I had

initially envisaged. With time, a little thought, and sometimes more

than a little moral support, most people find the method greatly beneficial.

The drop-out rate is presently only about 2%, which is a lot better than beta

interferon!

With kind regards,

Bob Lawrence

Groups Links

·

To visit your group on the

web, go to:

low dose naltrexone/

·

To unsubscribe from this

group, send an email to:

low dose naltrexone-unsubscribe

·

January 6, 2004

I wanted to let you know that I wrote to

the MSAA asking that they consider doing research on LDN for use for people

with MS. Apparently there are

no studies done on this treatment and I feel allot of people would benefit from

it if there was. Typically it

takes a study and a write up on a drug for it to get recognized as a treatment

for a specific disease. I

know that there is a study for LDN being used for Chrones disease but wouldn’t

It be great if there were more studies?

The MSAA funds

allot of research so I felt they were a good place to start and ask them to

jump at researching LDN.

Lets hope they

listen.

son

Owner/

operator

Friends with MS.com

or

join our email newsgroup:

FriendsWithMS/

-----Original Message-----

From: I AM CANADIAN

[mailto:lvlail_lvle@...]

Sent: Tuesday, January 06, 2004 10:20 AM

Cabbie54@...

Cc:

low dose naltrexone

Subject: [low dose naltrexone] RE:

(no subject)

Look Cabbie I

have communicated directly with Dr. Lawrence as well okay. TYhere are other

people who take several things along with LDN because their respective doctors

believe attacking on all fronts gives them a better chance. It is not our place

to tell people they cannot take those drugs together. They are safe together

and many come just wondering if they CAN

take them together because not many know anything about LDN.

You can read my

email to Jodygirl again and see that I say some doctors feel they work in

opposition to one another… just as Dr. Lawrence says here and has said to

me… (maybe you don’t remember me posting my personal emails from

Dr. Lawrence to this group and the other LDN group but I did). And I

don’t appreciate you putting this in my face as though I haven’t

read the same things before! I’m sure you know how long I have been here

and have read every single post since I have arrived!

It is up to

each of us to make our own educated decisions. And for none of us to treat

people badly if they choose to not follow what Dr. Lawrence says but what they

feel or their personal doctors and they think.

LDN has not yet

been studied and so until it is we can’t say for certain that

interactions with Rebif, Avonex, Chemo based treatments, or Betaseron

etc… are negative with LDN. Don’t get me wrong here I believe what

Dr. Lawrence has to say but I am not going to make decisions for others I will

tell them that it is alright to take other medications with it IF THEY CHOOSE TO!

Let me also add

as you put this in my face others put in my face that LDN is quackery… I

don’t know you personally I don’t know them personally… I

formed my own decision with everything I have seen and so should each and every

other person considering any treatment. Not have their doctor make up their

minds for them and follow blindly not have a group

make up their minds for them either! Get all the facts and make their own!

Got it? Good.

Now thank you for thinking you are educating me further than I have been but

you are not.

From:

Cabbie54@... [mailto:Cabbie54@...]

Sent: Tuesday, January 06, 2004

12:41 PM

lvlail_lvle@...

Subject: (no subject)

This is what Dr. Lawrence said about the immune

suppressants and ldn together...

Dear Carol,

I will be more affirmative than Dr Bihari and tell you

that it is a complete waste of time taking LDN if you continue to take Rebif,

or any other immune suppressants. The two treatments are simply working

in opposition. It is a little like adding ice to a heated kettle that you

are trying to boil. It will get you no-where!

If you intend making a serious attempt to adopt this

treatment (the LDN) you must stop all the immune suppressant drugs first.

I am not surprised that you suffered headaches and

depression with this combined therapy. Your body must have been in such a

state of conflict I imagine almost anything could have happened. It is

sure that you were getting no benefit from either therapy!

We must also consider the possible effects on your

blood pressure. What was your blood pressure before and after the Cozaar.

Was your blood pressure checked when you had the headache? What was the

pressure then? Do you have your own sphygmomanometer to check it

yourself?

There is no hard and fast rule to determine the time

that you should be off the interferon. Two weeks is sufficient to get the

drugs out of your system but your immune system may still be in a state of

suppression. It is similar, but worse, with steroids. After

steroids, it may take months to recover from the adrenal and immune suppression

resulting from these dangerous and, as far as MS is concerned, useless drugs.

Starting LDN after using immune suppressants is going

to be an unpredictable process under any circumstances. All that I do in

such a situation is simply monitor the patients response to the LDN, each

day if necessary, and offer the most appropriate advice in answer to the

response prevelent at that time. It can be a slow, arduous,

traumatic, and time-consuming process. Having started on the wrong

foot (the interferon) you must be prepared to fight your way back to a more

productive and beneficial method of therapy.

The headaches may actually be a sign of a

beneficial response, when there is an increase in cerebral blood

circulation. Until your body adjusts to this new internal environment you

should take nothing more than paracetamol (acetaminophen), or low-dose

ibuprofen, at a minimal dose. Similar headaches are seen to occur in

response to vitamin E, zinc, EFAs, or even HBO. These are all clearly beneficial

in MS.

Your diet I would consider a little

questionable. As a routine I would not advise bread, eggs, or coffee (or

is it de-caff?).

The list of supplements I recommend are listed in the

attachments. Zinc and the EFAs are the most important. I have

remained stable for the last 15 years on this regime with minimal rate of

progression and no relapses. Since starting the LDN I have now slowly

begun to improve, although after having MS for 26 years I still have a long way

to go.

Having used, and prescribed LDN, for almost two years

it has become obvious that the method is far more complicated than I had

initially envisaged. With time, a little thought, and sometimes more

than a little moral support, most people find the method greatly beneficial.

The drop-out rate is presently only about 2%, which is a lot better than beta

interferon!

With kind regards,

Bob Lawrence

Groups Links

·

To visit your group on the

web, go to:

low dose naltrexone/

·

To unsubscribe from this

group, send an email to:

low dose naltrexone-unsubscribe

·

January 29, 2004

I just sent this to these Politicians that want to be elected or reelected as President. Anybody want to bet I only get e-mail generated replies? This is my own unscientific poll of who deserves to be our next President.

Poll results sent upon request.

Ken Moulton

Will anybody respond to this National Health and Safety issue that makes families sick and causes many to become homeless and lose their live savings, or will I only get e-mail generated replies?

Health, Heirlooms and Dreams?

For those of us across America that have become Victims of dangerous Toxic Mold, we know the price we have paid. For most of us, the primary loss has been the destruction of our Family's health. Our respiratory systems, immune systems and overall health have been destroyed.

For some of us, we have seen our Family members, Parents, Children and Grandchildren, have uncontrolled bouts of vomiting and diarrhea. We have had to watch as Family members get eye infections, memory loss and have hair loss from the Toxic Mold. You cry yourself to sleep every night.

Almost every documented case of Toxic Mold across America was preventable. Sadly, most in society that could help stop the Toxic Mold, State and Federal officials, insurance companies, builders, banks, realtors and government inspectors, refuse to act. They hold Legislative Hearings on our proposed Legislation and then refuse to listen to our cries for help.

They refuse to acknowledge that Toxic Mold is the byproduct of water and/or extreme moisture. This water/moisture is usually an effect of a busted water or frozen pipe, inferior and/or illegal construction and incompetent home inspections.

The busted or frozen water pipes are usually covered by homeowners insurance. Sadly for many homeowners, insurance companies make piece meal fixes instead of correcting the entire problem. They consider profits more important than consumer protection.

In the inspection issue, Federal and State licensed banks have routinely used local government building inspectors to inspect new construction and/or home improvement loans they have given to developers and builders. This practice creates an immediate conflict of interest because the local government inspector is being paid, usually a lower salary from the community, to inspect for code and safety enforcement.

Across America there are thousands of documented cases where government inspectors having knowingly passed illegal and unsafe construction for banks, realtors, developers and builders. This means that citizens, and their Family's, lose any guarantee of safety.

Most communities and States across America say they are not liable for the acts of their employees. Sadly, in most cases, the communities and States know of the illegal and corrupt acts of their employees and go to great lengths to protect them. They all forget that their only job is protecting the citizens, not the criminals they employ and pay with our taxes.

In almost all of these cases, the local or state government derives profits from taxes they levy on the illegal and unsafe construction. These taxes might be levied on your home, the office building you work in, the nursing home a parent is in, the hospital you go to when you are sick or injured or the school your children attend or the Church you worship at.

The illegal and unsafe construction might also be at the Nuclear Power Plant in your community. Maybe the illegal and substandard construction was overlooked in the highway, bridge or tunnel you use on your way to work.

I recently learned of a case in ST. sburg Florida that goes to the heart of the issue. It seems that a family bought an older home that they later learned was built on a low water lot. Water leaked into the home and Toxic Mold grew.

When they discovered this they found that to correct the issue would cost more than the home was worth. They sold the home, telling of the Toxic Mold, to a realtor that buys ugly and depressed homes. They lost over two-thirds of what they had paid for the home. The land alone was worth what they sold everything for.

This company than sold the home to another realtor/developer. This new company than painted over the Toxic Mold and installed new kitchen cabinets. I'm told by the original owner that as they left they found mushrooms growing in the home from the moisture.

The new company had paid 20 thousand dollars more than what the first developer paid the original owner. They than sold the home, Toxic Mold and all, to a family. The new family was never informed of the Toxic Mold by the new company. They new company charged a profit of over 40 thousand dollars over what they had paid.

The new family started having health and breathing problems. They have just learned of the Toxic Mold and want their money back. Sadly, Florida, like almost all states, has no lemon laws to protect homebuyers in this type of situation. It becomes a "buyer beware" situation.

For most of us, when we first get married, buying a home is a lifelong dream. We save every penny we can and scrimp on extra "luxury" items like medicine, clothes, food and cars.

Buying a home is the biggest financial investment we will ever make during our lifetime. The home purchase is also an investment in our children's future. We may borrow on the homes equity to send our children onto college or pay for some life saving surgery.

Sadly, there is no protection for our investment. While we can buy insurance to protect us from fires, floods or theft, we are powerless against the biggest threat of all. This threat is corrupt builders and realtors and corrupt private, local and state government building inspectors.

You might think that if there are laws to protect you when you buy a faulty car, appliance or consumer service, you are protected here too. You see you are defenseless against government and white collar corruption.

In Massachusetts I have been trying to get Legislation passed, since 1996, that will put an end to many of these deceptive and illegal acts that have led to Toxic Mold. Sadly, for Massachusetts citizens, the Massachusetts Legislature, Governor's and Attorney General's have decided to protect the illegal acts and wrong doers rather than the citizens.

Ken Moulton

P O Box 874

Hyannisport, MA 02647

February 7, 2004

HI CAT

HERE'S A LIST I KEPT . I'VE HAD IT SINCE OCTOBER , IT HELPED ME AND

I HOPE IT DOES THE SAME FOR YOU.

Doctors who have prescribed LDN. Some of these will do it over the phonecharging a consultation fee.Dr. Bernard Bihari New York, NY 212-929-4196Dr. Wisconsin 608-785-0038 Dr. Sidney, NY 607-561-2000Dr. Carole Saratoga Springs, NY 518-587-3438Dr. Stafford Colorado Springs, C O 719-636-5234Dr. Bruce Sharpnack Hickory, PA 724-356-2273Dr. Jeff Esper Erie, PA 814-877-4600 Sullivan Mechanicsburg, PA 717-697-5050Dr. Patti Townely Dwight, IL 815-584-3343Dr. Myers Skokie, IL & n bsp; 847-677-2980Dr. Alan Buchman Chicago, IL 312-695-5620Dr. Bernard s Vernon Hills, Illinois 847-367-0843Dr. Stanley Knep (Neuro) Clifton, NJ 973-471-3680Dr. Wisconsin 608-785-0038Dr. ph Wezensky, MD, GPDr. Rick Jensen, NDKokopelli Health & Wellness Grand Junction, CO 970-263-4660www.tahoma-clinic.com On-line c linichttp://www.acam.org/dr_search/ Dr. searchwww.lef.org search of innovative DR. Pharmacies that fill LDN perscriptions correctly:=================================================The Prescription Center Wisconsin 800-203-9066 Skips's Pharmacy Florida 800-553-7429Fallston Pharmacy Beatty Fallston, land., 410-879-9000fallstonpharmacy@...,(From Dr. Bihari's website)Irmat Pharmacy ; New York, NY 212-685-0500Village Apothecary New York, NY 212-807-7566Key Pharmacy South Kent, WA 800-878-1322The Medicine Shoppe, Canandaigua, NY 800-396-9970's Pharmacy, Toronto, Canada 800-361-6624

February 7, 2004

Doctors who have prescribed LDN. Some of these will do it over the phonecharging a consultation fee.Dr. Bernard Bihari New York, NY 212-929-4196Dr. Wisconsin 608-785-0038 Dr. Sidney, NY 607-561-2000Dr. Carole Saratoga Springs, NY 518-587-3438Dr. Stafford Colorado Springs, C O 719-636-5234Dr. Bruce Sharpnack Hickory, PA 724-356-2273Dr. Jeff Esper Erie, PA 814-877-4600 Sullivan Mechanicsburg, PA 717-697-5050Dr. Patti Townely Dwight, IL 815-584-3343Dr. Myers Skokie, IL & n bsp; 847-677-2980Dr. Alan Buchman Chicago, IL 312-695-5620Dr. Bernard s Vernon Hills, Illinois 847-367-0843Dr. Stanley Knep (Neuro) Clifton, NJ 973-471-3680Dr. Wisconsin 608-785-0038Dr. ph Wezensky, MD, GPDr. Rick Jensen, NDKokopelli Health & Wellness Grand Junction, CO 970-263-4660www.tahoma-clinic.com On-line c linichttp://www.acam.org/dr_search/ Dr. searchwww.lef.org search of innovative DR. Pharmacies that fill LDN perscriptions correctly:=================================================The Prescription Center Wisconsin 800-203-9066 Skips's Pharmacy Florida 800-553-7429Fallston Pharmacy Beatty Fallston, land., 410-879-9000fallstonpharmacy@...,(From Dr. Bihari's website)Irmat Pharmacy ; New York, NY 212-685-0500Village Apothecary New York, NY 212-807-7566Key Pharmacy South Kent, WA 800-878-1322The Medicine Shoppe, Canandaigua, NY 800-396-9970's Pharmacy, Toronto, Canada 800-361-6624

February 10, 2004

Doctors who have prescribed LDN. Some of these will do it over the phonecharging a consultation fee.Dr. Bernard Bihari New York, NY 212-929-4196Dr. Wisconsin 608-785-0038 Dr. Sidney, NY 607-561-2000Dr. Carole Saratoga Springs, NY 518-587-3438Dr. Stafford Colorado Springs, C O 719-636-5234Dr. Bruce Sharpnack Hickory, PA 724-356-2273Dr. Jeff Esper Erie, PA 814-877-4600 Sullivan Mechanicsburg, PA 717-697-5050Dr. Patti Townely Dwight, IL 815-584-3343Dr. Myers Skokie, IL & n bsp; 847-677-2980Dr. Alan Buchman Chicago, IL 312-695-5620Dr. Bernard s Vernon Hills, Illinois 847-367-0843Dr. Stanley Knep (Neuro) Clifton, NJ 973-471-3680Dr. Wisconsin 608-785-0038Dr. ph Wezensky, MD, GPDr. Rick Jensen, NDKokopelli Health & Wellness Grand Junction, CO 970-263-4660www.tahoma-clinic.com On-line c linichttp://www.acam.org/dr_search/ Dr. searchwww.lef.org search of innovative DR. Pharmacies that fill LDN perscriptions correctly:=================================================The Prescription Center Wisconsin 800-203-9066 Skips's Pharmacy Florida 800-553-7429Fallston Pharmacy Beatty Fallston, land., 410-879-9000fallstonpharmacy@...,(From Dr. Bihari's website)Irmat Pharmacy ; New York, NY 212-685-0500Village Apothecary New York, NY 212-807-7566Key Pharmacy South Kent, WA 800-878-1322The Medicine Shoppe, Canandaigua, NY 800-396-9970's Pharmacy, Toronto, Canada 800-361-6624

April 7, 2004

b,

It is my understanding that one must be off of the pain meds for two weeks prior to starting LDN, so the LDN that is taken occassionally may not be able to do any good. As if the MS is not bad enough, your husband has certainly got more than his share of ailments. I hope the best for him and you!

Marcie (PPMS)

In a message dated 4/7/2004 8:02:11 AM Central Standard Time, toredol580@... writes:

Subj:[low dose naltrexone] (no subject)

Date:4/7/2004 8:02:11 AM Central Standard Time

From: toredol580@...

Reply-to: low dose naltrexone

low dose naltrexone

Hello everyone. My name is , and I have occasionally, though rarely, responded to various posts. Now, I've come to ask for your input.

My husband suffers from Secondary Progressive MS, and was diagnosed in the mid-90's, though I suspect he had it many years prior to the diagnosis.

He also is a Vietnam-era vet who suffers from service-related spinal cord injury, post-traumatic stress disorder, diabetes and COPD.

For months last year, I struggled to find someone within the VA Hospital system who was willing to prescribe LDN. Ultimately, I went outside the "institution" by snatching one page of his medical records from them that confirmed his DX so we could get him started on the med I hoped would put a halt to this traveling destruction.

All this was done with his permission, but he was unable to even figure it out how to do it himself.

He has been on the drug now since November and, in the beginning, experienced incredible results. However, the spinal cord injury has reared its ugly head in the past couple of months. Because of that, he's having to use the Oxycodone that was prescribed early last fall, which means the LDN is only a once-in-awhile option for us now.

It seems like for every four days he takes the Oxy, he's able to go without it only two days. We've tried using the LDN on those days, but the way it looks, it's not doing much good this way.

I'm just wondering if anyone else has any comparable experience, whether with pain because of an injury, or pain due to the MS itself.

I feel desperate, yet it's hard to read my husband's feelings on this. Depression seems to be running rampant within him and I try to avoid getting him too agitated by bringing up his obviously failing health.

Any input will help; I'm grasping here. Thanks, b

April 7, 2004

I have a learned opinion about LDN and narcotics. If anyone would like to see it, let me know. I don't want to clutter this board any more than necessary.

Larry J. Frieders,RPh |The Compounder575 W. Illinois Ave ~ Aurora, IL 60506 630-859-0333 FAX 630-859-0114 Sample newsletter http://www.theCompounder.com/NL-Sample.html

Any health related information on our web pages or in our newsletters is for educational purposes only. None of the information we provide is to be construed as medical advice. Before applying any therapy or use of herbs, you may want to seek advice from your health care professional. Our information should not be a substitute for physician evaluation or treatment by a health care professional and is not intended to provide or confirm a diagnosis.

----- Original Message -----

From: marciemjm@...

low dose naltrexone

Sent: Wednesday, April 07, 2004 9:23 AM

Subject: Re: [low dose naltrexone] (no subject)

b, It is my understanding that one must be off of the pain meds for two weeks prior to starting LDN, so the LDN that is taken occassionally may not be able to do any good. As if the MS is not bad enough, your husband has certainly got more than his share of ailments. I hope the best for him and you! Marcie (PPMS) In a message dated 4/7/2004 8:02:11 AM Central Standard Time, toredol580@... writes:

Subj:[low dose naltrexone] (no subject) Date:4/7/2004 8:02:11 AM Central Standard Time From: toredol580@... Reply-to: low dose naltrexone low dose naltrexone Hello everyone. My name is , and I have occasionally, though rarely, responded to various posts. Now, I've come to ask for your input. My husband suffers from Secondary Progressive MS, and was diagnosed in the mid-90's, though I suspect he had it many years prior to the diagnosis. He also is a Vietnam-era vet who suffers from service-related spinal cord injury, post-traumatic stress disorder, diabetes and COPD. For months last year, I struggled to find someone within the VA Hospital system who was willing to prescribe LDN. Ultimately, I went outside the "institution" by snatching one page of his medical records from them that confirmed his DX so we could get him started on the med I hoped would put a halt to this traveling destruction. All this was done with his permission, but he was unable to even figure it out how to do it himself. He has been on the drug now since November and, in the beginning, experienced incredible results. However, the spinal cord injury has reared its ugly head in the past couple of months. Because of that, he's having to use the Oxycodone that was prescribed early last fall, which means the LDN is only a once-in-awhile option for us now. It seems like for every four days he takes the Oxy, he's able to go without it only two days. We've tried using the LDN on those days, but the way it looks, it's not doing much good this way. I'm just wondering if anyone else has any comparable experience, whether with pain because of an injury, or pain due to the MS itself. I feel desperate, yet it's hard to read my husband's feelings on this. Depression seems to be running rampant within him and I try to avoid getting him too agitated by bringing up his obviously failing health. Any input will help; I'm grasping here. Thanks, b

April 7, 2004

I'd sure like to see it. I'm concerned about the effectiveness of pain killers if I were to be involved in an accident...

----- Original Message -----

From: Larry J. Frieders

low dose naltrexone

Sent: Wednesday, April 07, 2004 9:07 AM

Subject: Re: [low dose naltrexone] (no subject)

I have a learned opinion about LDN and narcotics. If anyone would like to see it, let me know. I don't want to clutter this board any more than necessary.

Larry J. Frieders,RPh |The Compounder575 W. Illinois Ave ~ Aurora, IL 60506 630-859-0333 FAX 630-859-0114 Sample newsletter http://www.theCompounder.com/NL-Sample.html

Any health related information on our web pages or in our newsletters is for educational purposes only. None of the information we provide is to be construed as medical advice. Before applying any therapy or use of herbs, you may want to seek advice from your health care professional. Our information should not be a substitute for physician evaluation or treatment by a health care professional and is not intended to provide or confirm a diagnosis.

----- Original Message -----

From: marciemjm@...

low dose naltrexone

Sent: Wednesday, April 07, 2004 9:23 AM

Subject: Re: [low dose naltrexone] (no subject)

b, It is my understanding that one must be off of the pain meds for two weeks prior to starting LDN, so the LDN that is taken occassionally may not be able to do any good. As if the MS is not bad enough, your husband has certainly got more than his share of ailments. I hope the best for him and you! Marcie (PPMS) In a message dated 4/7/2004 8:02:11 AM Central Standard Time, toredol580@... writes:

Subj:[low dose naltrexone] (no subject) Date:4/7/2004 8:02:11 AM Central Standard Time From: toredol580@... Reply-to: low dose naltrexone low dose naltrexone Hello everyone. My name is , and I have occasionally, though rarely, responded to various posts. Now, I've come to ask for your input. My husband suffers from Secondary Progressive MS, and was diagnosed in the mid-90's, though I suspect he had it many years prior to the diagnosis. He also is a Vietnam-era vet who suffers from service-related spinal cord injury, post-traumatic stress disorder, diabetes and COPD. For months last year, I struggled to find someone within the VA Hospital system who was willing to prescribe LDN. Ultimately, I went outside the "institution" by snatching one page of his medical records from them that confirmed his DX so we could get him started on the med I hoped would put a halt to this traveling destruction. All this was done with his permission, but he was unable to even figure it out how to do it himself. He has been on the drug now since November and, in the beginning, experienced incredible results. However, the spinal cord injury has reared its ugly head in the past couple of months. Because of that, he's having to use the Oxycodone that was prescribed early last fall, which means the LDN is only a once-in-awhile option for us now. It seems like for every four days he takes the Oxy, he's able to go without it only two days. We've tried using the LDN on those days, but the way it looks, it's not doing much good this way. I'm just wondering if anyone else has any comparable experience, whether with pain because of an injury, or pain due to the MS itself. I feel desperate, yet it's hard to read my husband's feelings on this. Depression seems to be running rampant within him and I try to avoid getting him too agitated by bringing up his obviously failing health. Any input will help; I'm grasping here. Thanks, b

April 7, 2004

LARRY - I'D LIKE TO KNOW YOUR OPINION OF LDN AND NARCOTICS -

AND DO YOU HAVE ANY EXPERIENCE WITH LDN AND FENTANOL OR

VERSID. I HAVE CATARACT SURGERY ON 4/22 AND WILL GET

ANESTHESIA OF COURSE.

THANKS.

BESTAUNT

April 7, 2004

Naltrexone is a pure opioid (narcotic) antagonist. Itattenuates (partially blocks) or completely blocks the effectsof opioids. When administered with morphine for a long period,for example, it can block the physical dependence on morphine.It has no opioid agonist activity - it does NOT have anyadditive effect. It is chemically similar to some of theopioids but it doesn't have the effects of an opioid.

Naltrexone 50mg will block the effect of IV heroin for 24 hours.Doubling the dose extends the blocking to 48 hours and triplingit extends the blocking time to 72 hours.

Naltrexone binds to opioid receptor sites and prevents theopioid from acting by blocking the receptors. Once blocked,however, the addition of more opioid can overcome the effect ofthe naltrexone by bumping the naltrexone OFF the receptors.Whichever agent is dominant in the blood will offset the actionof the other. So, increasing the amounts of narcotic used willagain give both the pain relief - and the HIGH. However, largeincreases in opioid doses causes many people to suffer fromexcess histamine release and those symptoms are usuallyunacceptable - and uncontrolled.

Naltrexone is almost 100% absorbed from the stomach (veryquickly). The levels in the blood peak within 1 hour and thenbegin to fall. It can take 4 to 13 hours for half of anabsorbed dose to be lost in the urine. The drug is excreted bythe kidneys so good kidney health is important. People who haveimpaired renal function may experience the effect of naltrexonelonger.

The above is extracted form the published literature aboutnaltrexone and is in direct response to doses of 50mg and more.The LDN dose is rarely above 5mg per day - one-tenth the dosesin the literature. While it is POSSIBLE that LDN can interferewith the effects of some opioids I think the effect is reallylow. First, the dose is very small. Second, a single dose istaken at bedtime - past the time when most people are usingnarcotic pain relievers.

Let's look at an example. Assume that a 50mg tablet ofnaltrexone will block the effects of a pain reliever - any oneof them and at any appropriate strength. A 3.5mg LDN is 7% ofthe 50mg dose. That suggests that it possesses about 7% of theblocking action of the regular tablet. Some of the activemetabolite of naltrexone is out of the active body in about 4hours. If a person would need an added dose of narcotic(opioid) after about 4 hours there would realistically noimpact from the naltrexone remaining in the body.

Naltrexone competitively binds to the same receptors to whichopioids bind. Adding a narcotic to a body that already has theLDN on board may result in a slight reduction in opioid effect -it may not be as effective at relieving pain - but by a factor of7% or less. I suggest it isn't likely that a person can detecta 7% difference in effect.

Furthermore, if 50mg of naltrexone will block the effects ofopioids for 24 hours, a 3mg LDN would have the blocking effectof 6% of 24 hours (1.44 hours) - this is based on the reportedeffect of using 50mg for 24 hours, 100mg for 48 hours and 150mgfor 72 hours of blocking. If using more extends the effectiveblocking time then using less should shorten it. A 4.5mgdose would, then, have an effective blocking time of 2.16 hours.

That suggests that taking a 3mg dose at 9PM will essentiallyhave no direct blocking activity after about an hour and a half- say 10:30. The 4.5mg dose may be in effect until a littleafter 11pm.

Even if the effects of the opioid are minimally blocked, thenaltrexone wouldn't cause any specific ill effects. Unlike someother treatments, combining naltrexone with opioids or alcoholwill not make the person sick. It supposedly just block thereceptors - thereby reducing the effectiveness of the opioid.

I conclude that patients need to be AWARE of the potential forblocking narcotic activity, but that they should NOT worry aboutit - unless they are regularly using opioids (for medical orrecreational purposes). People who use an opioid intermittentlywould probably not experience any negative effects from takingLDN - regardless of the dose.

Larry J. Frieders,RPh |The Compounder575 W. Illinois Ave ~ Aurora, IL 60506 630-859-0333 FAX 630-859-0114 Sample newsletter http://www.theCompounder.com/NL-Sample.html

Any health related information on our web pages or in our newsletters is for educational purposes only. None of the information we provide is to be construed as medical advice. Before applying any therapy or use of herbs, you may want to seek advice from your health care professional. Our information should not be a substitute for physician evaluation or treatment by a health care professional and is not intended to provide or confirm a diagnosis.

----- Original Message -----

From: BESTAUNT@...

low dose naltrexone

Sent: Wednesday, April 07, 2004 12:51 PM

Subject: Re: [low dose naltrexone] (no subject)

LARRY - I'D LIKE TO KNOW YOUR OPINION OF LDN AND NARCOTICS - AND DO YOU HAVE ANY EXPERIENCE WITH LDN AND FENTANOL OR VERSID. I HAVE CATARACT SURGERY ON 4/22 AND WILL GET ANESTHESIA OF COURSE.THANKS.BESTAUNT

April 7, 2004