Re: protein glycosylation-blocking agents

[Guest guest]

Hello S Rudek,

" aware of work with protein-glycosilation-blocking drugs or

supplements? 

Carnosine fits the bill for this. Non toxic even in high doses and can even

reverse some of the damage. Aminoguanidine also blocks AGE's at an earlier

stage, but there are some questions about its safety.

Chromium pic supposedly reduces insulin spike as does green tea before a

carb meal.

Metformin reduces sugar/insulin roller coaster and is well tolerated.

I hope this is helpful. Google and Pubmed have tons of stuff about carnosine

and the rest.

MM

_________________________________________________________________

Protect your PC - get McAfee.com VirusScan Online

http://clinic.mcafee.com/clinic/ibuy/campaign.asp?cid=3963

[Guest guest]

> Hello S Rudek,

>

> " aware of work with protein-glycosilation-blocking drugs or

> supplements? 

> Carnosine fits the bill for this. Non toxic even in high doses and

can even

> reverse some of the damage. Aminoguanidine also blocks AGE's at an

earlier

> stage, but there are some questions about its safety.

> Chromium pic supposedly reduces insulin spike as does green tea

before a

> carb meal.

> Metformin reduces sugar/insulin roller coaster and is well

tolerated.

>

> I hope this is helpful. Google and Pubmed have tons of stuff about

carnosine

> and the rest.

> MM

-----------

Thank you SO much! Apparently the reason the US F.D.A. hasn't

approved any aldose-reductase inhibitors for preventing neuropathy in

diabetics is that all candidates have been insufficiently specific

and have also inhibited aldehyde-reductase on the other side of

the " sorbitol trap " . The article I read said only that buildup of

aldehyde is toxic. Anyway, if I understand correctly, it is elevated

levels of sorbitol which are suspected of causing most diabetic

damage (and, *I* suspect, many or possibly most of the degenerative

diseases of old age in non-diabetics).

Do you know if the prescription aldose-reductase inhibitors which I

had heard were available outside the US are still available or how

they compare to carnitine et. al.?

Any idea how risky the aldehyde buildup actually is? I presume it

can be monitored in lab tests . . . ?

This is a CRITICAL issue for me. Although my body is still intact

after 33 years of diabetic B.S., neuropathy and lower limb atrophy/

healing problems are becoming rapidly worse. I'm prepared to risk

a " possible " aldehyde problem vs. a CERTAIN glycosilation problem

which even CRON is not likely to stop/reverse (though I'm sure it can

help).

I've heard of some studies using oil of evening primrose (linolenic

acid?) to alleviate neuropathy pain. I don't know if this involves

the same mechanism or not; I also don't know how effective it would

really be, in any case, since it isn't the pain that I'm most

concerned about.

If you uncover any additional information I'd vastly appreciate it.

I'll try to research your suggestions.