Coffee, caffeine and homocysteine

[Guest guest]

Hi All, The PDF is available at apater@... for the below saying coffee

especially caffeinated lowers homocysteine. Decaf does also, I wonder?

Cheers, Al.

.........randomized crossover.... lasting 2 wk. ....: The mean fasting plasma

homocysteine concentration after the placebo treatment was 9.6 +/- 3.1 micro

mol/L. The caffeine and coffee treatments increased fasting homocysteine by

0.4 micro mol/L (95% CI: 0.1, 0.7; P = 0.04), or 5%, and by 0.9 micro mol/L

(95% CI: 0.6, 1.2; P = 0.0001), or 11%, respectively, compared with placebo.

The increase in homocysteine concentrations 4 h after consumption of 0.45 L

coffee relative to consumption of 3 placebo capsules was 19% (P = 0.0001).

Caffeine treatment had a much weaker acute effect on homocysteine (4%; P =

0.09). Effects of caffeine were stronger in women than in men, but the

effects of coffee did not differ significantly between men and women.

CONCLUSIONS: Caffeine is partly responsible for the homocysteine-raising

effect of coffee. Coffee, but not caffeine, affects homocysteine metabolism

within hours after intake,......

Randomized Controlled Trial

PMID: 12450889 [PubMed - indexed for MEDLINE]