Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT) > health indices

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Hi All, The /below/PDF-available paper describes the effectiveness of Diet,

Exercise, and Weight Loss Intervention Trial (DEW-IT) on improving health

indices. It looked good.

I posted the whole paper to the main crsociety list, if you are interested

in details.

Just before the paper, I put their triglycerides results. It was not

significantly changed, and in the discussion they say this contrasts with

changes expected for high carbohydrate diets. I was a bit surprised it rose

at all, since my levels are at all-time lows, while on a pretty hefty

carbohydrate diet. I guess that CRON outperforms DEW.

Cheers, Al.

" In the lifestyle group, change in total cholesterol, net of control,

was -25 mg/dL (95% CI: -44 to -10, P =0.003), change in LDL-C was -18 mg/dL

(95% CI: -36 to 0, P =0.056), and change in HDL-C was -4.5 mg/dL (95%

CI: -11.6 to -0.8, P =0.026) (Table 2). There was no significant net change

in triglyceride levels (7 mg/dL [95% CI: -10 to 24, P =0.43]), TC/HD ratio

(-0.23 [95% CI: -0.75 to 0.28, P =0.36]), or fasting glucose (-4 mg/dL [95%

CI: -15 to 7, P =0.47]). "

Hypertension 2002 Nov;40(5):612-8

Results of the Diet, Exercise, and Weight Loss Intervention Trial (DEW-IT).

ER 3rd, Erlinger TP, Young DR, Jehn M, ton J, D, Wasan

SK, Appel LJ.

National guidelines for the prevention and treatment of hypertension

recommend

sodium reduction, weight loss, the Dietary Approach to Stop Hypertension

(DASH)

diet, and regular aerobic exercise. However, no trial has assessed the

efficacy

of simultaneously implementing all of these recommendations. The objective

of

this study was to determine the effects on blood pressure and other

cardiovascular disease risk factors of a comprehensive lifestyle

intervention.

We conducted a randomized controlled trial of 44 hypertensive, overweight

adults

on a single blood pressure medication. Participants were randomized to a

lifestyle or control group. For 9 weeks, the lifestyle group was fed a

hypocaloric version of the DASH diet that provided 100 mmol/d of sodium.

This

group also participated in a supervised, moderate-intensity exercise program

3

times per week. The control group received no intervention. Outcomes were

ambulatory blood pressure, serum lipids, weight, and fitness. At the end of

the

intervention, mean weight loss in the lifestyle group, net of control, was

4.9

kilograms. In the lifestyle group mean net reductions in 24-hour ambulatory

systolic and diastolic blood pressures were 9.5 mm Hg (P<0.001) and 5.3 mm

Hg

(P<0.002), respectively. Corresponding changes in daytime systolic and

diastolic

blood pressures were 12.1 mm Hg (P<0.001) and 6.6 mm Hg (P<0.001). The

lifestyle

group experienced mean reductions in total cholesterol (-25 mg/dL, P<0.001),

low-density lipoprotein cholesterol (-18 mg/dL, P=0.005), high-density

lipoprotein cholesterol (-5 mg/dL, P<0.001), net of control. In conclusion,

among hypertensive overweight adults already on antihypertensive medication,

a

comprehensive lifestyle intervention can substantially lower blood pressure

and

improve blood pressure control.

PMID: 12411452 [PubMed - in process]

Alan Pater, Ph.D.; Faculty of Medicine; Memorial University; St. 's, NL

A1B 3V6 Canada; Tel. No.: (709) 777-6488; Fax No.: (709) 777-7010; email:

apater@...