Re: CR and Frailty

[Guest guest]

Thanks, Thin Man, for the article. Thanks to Suz for the link.

The book, Biomarkers,by Roseberg, , and and published in 1991,

was based on some work at Tufts University.

In it they delineate a program for building strength and fitness that was

used with 60 and 70 year old men, and women aged 87 to 96. All were

successful in developing dramatic increases in strength, including some

increase in muscle size.

The Okinawans are quite capable phyically to what are considered to be

advanced ages. They maintain an active lifestyle. There is not retirement,

per se.

Other societies, don't remember specifics, don't consider old age to begin

'til the mid eighties. Then there seems to be some loss of strength. But,

remember, these people (perhaps unlike some of the Okinawans) are not even

on an " on " program let alone " cron. "

By the time I had to quit taking Lipitor, I was definitely losing strength

and muscle mass. Since I use weights (moderate), it's easy to tell if

you're getting weaker instead of stronger. But, within about four months

of dropping the Lipitor, I have found it is once again quite easy to

increase strength and gain a pound or two of lean body mass, If I wish.

Actually, I don't mind being stronger, but muscle mass just burns more

calories. With 148 pounds lbm at 5 feet 8 inches, I have enough muscle

now. I also carry about 25% fat, but that's down from nearly 45% at one

point.

My take is that most cronies understand the need for moderate aerobic and

resistance exercise. This article is excellent reinforcement for that

understanding. Thank you,

Ed

----- Original Message -----

From: " thin_man02 " <thin_man02@...>

< >

Sent: Tuesday, November 19, 2002 7:00 AM

Subject: [ ] CR and Frailty

> An interesting article by Kolata in the New York Times today: " Is

Frailty

> Inevitable? Some Experts Say No, " Nov. 19, 2002--http://www.nytimes.com/

> 2002/11/19/health/aging/19FRAI.html?pagewanted=print & position=top (you

> may need to register). It links the development of frailty to

inflammation

> processes.

>

> " But if frailty is an independent disease, the researchers asked, what

> underlies it? They looked for biochemical abnormalities in the blood, and,

in a

> paper published on Nov. 11 in The Archives of Internal Medicine, they

> reported that frailty was associated with increased levels of three

proteins that

> are linked to chronic inflammation, a sort of low-grade response to an

> infection or irritation of body tissues. "

>

> The three proteins are C-reactive protein, a measure of inflammation, and

> fibrinogen and Factor VIII, which are blood-clotting proteins that are

activated

> by inflammation.

>

> Cr has anti-inflammatory effects. It attenuates age-related increases in

key

> molecules involved in inflammation (e.g., NF-kappaB, IL-1beta, IL-6, TNF-

> alpha, cyclooxygenase-2, and inducible NO synthase). Thus, there is some

> evidence that CRONies have a reasonable chance of limiting frailty as they

> age.

>

> See:

>

> Chung HY, et al. " Molecular inflammation hypothesis of aging based on the

> anti-aging mechanism of calorie restriction. " Microsc Res Tech 2002 Nov

> 15;59(4):264-72

>

> (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db=

> PubMed & list_uids=12424787 & dopt=Abstract)

>

>

>

>

>