Guest guest Posted November 19, 2002 Report Share Posted November 19, 2002 An interesting article by Kolata in the New York Times today: " Is Frailty Inevitable? Some Experts Say No, " Nov. 19, 2002--http://www.nytimes.com/ 2002/11/19/health/aging/19FRAI.html?pagewanted=print & position=top (you may need to register). It links the development of frailty to inflammation processes. " But if frailty is an independent disease, the researchers asked, what underlies it? They looked for biochemical abnormalities in the blood, and, in a paper published on Nov. 11 in The Archives of Internal Medicine, they reported that frailty was associated with increased levels of three proteins that are linked to chronic inflammation, a sort of low-grade response to an infection or irritation of body tissues. " The three proteins are C-reactive protein, a measure of inflammation, and fibrinogen and Factor VIII, which are blood-clotting proteins that are activated by inflammation. Cr has anti-inflammatory effects. It attenuates age-related increases in key molecules involved in inflammation (e.g., NF-kappaB, IL-1beta, IL-6, TNF- alpha, cyclooxygenase-2, and inducible NO synthase). Thus, there is some evidence that CRONies have a reasonable chance of limiting frailty as they age. See: Chung HY, et al. " Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. " Microsc Res Tech 2002 Nov 15;59(4):264-72 (http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve & db= PubMed & list_uids=12424787 & dopt=Abstract) Quote Link to comment Share on other sites More sharing options...
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