Re: CR and nicotinamide

[Guest guest]

Take a look on

http://www.futurepundit.com/archives/001231.html

--- In , " Suzanne Cart " <massuz@c...>

wrote:

>I wonder if you would mind sharing your source for your comment

that " large doses of niacinamide taken regularly might either reduce

lifespan in general or at least it might block the lifespan-

extending effects of calorie restriction. "

[Guest guest]

Hi "leopardmike" and welcome to the group. Please tell us about yourself and how you happened upon our group.

I don't know if anybody here is taking large doses of nicotinamide (not niacin), but I would doubt it. This is a pretty sensible group actually. But for the sake of opening up discussion, I wonder if you would mind sharing your source for your comment that "large doses of niacinamide taken regularly might either reduce lifespan in general or at least it might block the lifespan-extending effects of calorie restriction."

Here's a blurb regarding niacin/nicotinamide/niacinamide just to get us all started out on the same foot:

For metabolic purposes, niacin is interchangeable with its amide, niacinamide, also known as nicotinamide. Important in the biochemistry of humans and other organisms, both substances are components of the coenzymes nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which function in a number of oxidation and reduction reactions catalyzed by enzymes. A niacin deficiency in humans often leads to a chronic illness called pellagra, characterized by gastrointestinal problems, lesions of the skin, and dementia. In dogs, a similar condition is known as black tongue disease. Both illnesses can generally be avoided by regularly including sources of niacin in the diet, including legumes, lean meats, and whole-grain or enriched breads and cereals. Some protein-rich food items that are poor sources of niacin, such as eggs and milk, can also help reduce the risk of niacin deficiency because they contain tryptophan, an amino acid that can be converted into niacin through bacterial action in the body. (See http://micro.magnet.fsu.edu/vitamins/pages/niacin.html)

Suz

----- Original Message -----

From: leopardmike

Sent: Monday, August 11, 2003 7:21 PM

Subject: [ ] CR and nicotinamide

Hi!Somebody use large dose of nicotinamide (not niacin) on CRAN ?If yes, think about that:<< large doses of niacinamide taken regularly might either reduce lifespan in general or at least it might block the lfespan-extending effects of calorie restriction >>

[Guest guest]

Should I stop taking a multivitamin which contains niacin? I take 1

multi on most days simply as insurance currently.

-

> Take a look on

> http://www.futurepundit.com/archives/001231.html

s of calorie restriction. "

[Guest guest]

Niacin and nicotinamide it's not same, both have naming B3 but

only nicotinamide can reduce lifespan.

For me, I stop taking a multivitamin which contains nicotinamide for

a multivitamin which contains niacin.

> Should I stop taking a multivitamin which contains niacin? I take 1

> multi on most days simply as insurance currently.

>

[Guest guest]

Mine contains niacinamide, which I assume is what you were referring too?

-Zulu

> Niacin and nicotinamide it's not same, both have naming B3 but

> only nicotinamide can reduce lifespan.

>

> For me, I stop taking a multivitamin which contains nicotinamide for

> a multivitamin which contains niacin.

[Guest guest]

Yes

nicotinamide is another name for niacinamide and nicotinic acid is

another name for niacin

Niacin is the form of vitamin B3 that causes the flushing effect of

hot red skin

I find one multivitamine with niacin, Bayer make it

> Mine contains niacinamide, which I assume is what you were

referring too?

>

[Guest guest]

Hi,

Here's a possible explanation for the confusion (and an additional

warning or two)

nicotinamide is B3.

nicotinic acid is actually B7! (also known as niacin I assume?)

A source of confusion is that it's common to refer to niacin as B3...

I read this in a dutch book named 'You can live longer!'(but than in

Dutch;), by G.Defares (a dutch physician, physiologist,

biologist, mathematician and gerontologist...hmmm apparently he did

a lot of studying

Oh yeah, and did I mention him being dutch?...

He also writes that the thesis by J.B.Deyer (at the vrije

universiteit of Amsterdam) named 'Vitamins and Memory'(1993)

concludes that 'The avarage memory enhancing effects of niacine and

B6 (pyridoxine) is approximately 12%.'

Wich brings up the point of skipping the multivitaminsupplement:

A moral of Deyers thesis: One doesn't need to get really ill or sick

to have some deficiency of some kind of nutrient.

This moral can be found in alot of research concerning the

(drastically!) positive effect of suppletion of vitamins and

minerals on intelligence (memory, IQ, etc.) of people of all ages.

(see for instance research by D.Benton (Wales) or S.J. Schoenthaler

(California)) But of course you all knew this already.

So a deficiency can stay unnoticed while it cripples you! Not sick

doesn't mean optimal. So think twice before you decide to skip your

multivitamin!

Also today I came across a B-complex (by Davitamon) wich lable

contains the following info:

- a vitamin table saying it contains niacin

- an ingredients list saying it contains nicotinamide

So this is a case where the word niacin was used to term niacinamide!

Hence when the lable of your vitaminsupplement mentions niacin, but

not nicotinic acid, it can actually contain niacinamide! Skrew me!

Well it's a B-complex story if you ask me...(not funny.. I know)

Ciao,

.

[Guest guest]

Or is B7 actually biotin?... Skrew me! (yes again)

--- In , " alexmatul " <alrmatul@h...>

wrote:

> Hi,

>

> Here's a possible explanation for the confusion (and an additional

> warning or two)

> nicotinamide is B3.

> nicotinic acid is actually B7! (also known as niacin I assume?)

> A source of confusion is that it's common to refer to niacin as

B3...

>

> I read this in a dutch book named 'You can live longer!'(but than

in

> Dutch;), by G.Defares (a dutch physician, physiologist,

> biologist, mathematician and gerontologist...hmmm apparently he

did

> a lot of studying

> Oh yeah, and did I mention him being dutch?...

>

>

> He also writes that the thesis by J.B.Deyer (at the vrije

> universiteit of Amsterdam) named 'Vitamins and Memory'(1993)

> concludes that 'The avarage memory enhancing effects of niacine

and

> B6 (pyridoxine) is approximately 12%.'

>

> Wich brings up the point of skipping the multivitaminsupplement:

>

> A moral of Deyers thesis: One doesn't need to get really ill or

sick

> to have some deficiency of some kind of nutrient.

> This moral can be found in alot of research concerning the

> (drastically!) positive effect of suppletion of vitamins and

> minerals on intelligence (memory, IQ, etc.) of people of all ages.

> (see for instance research by D.Benton (Wales) or S.J.

Schoenthaler

> (California)) But of course you all knew this already.

> So a deficiency can stay unnoticed while it cripples you! Not sick

> doesn't mean optimal. So think twice before you decide to skip

your

> multivitamin!

>

> Also today I came across a B-complex (by Davitamon) wich lable

> contains the following info:

> - a vitamin table saying it contains niacin

> - an ingredients list saying it contains nicotinamide

> So this is a case where the word niacin was used to term

niacinamide!

> Hence when the lable of your vitaminsupplement mentions niacin,

but

> not nicotinic acid, it can actually contain niacinamide! Skrew

me!

>

> Well it's a B-complex story if you ask me...(not funny.. I know)

> Ciao,

> .