CR, Soy & BDNF

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Re: /message/7361

" old542000 " <apater@m...> wrote:

> Hi All,

>

> Saul appears to describe evidence based on animal models for the

> testing using unknown concentrations of phytochemicals relative to

> human consumption and in animals that may not be appropriate to

model

> human conditions.

>

> See the bottom, since I believe that mortality is the bottom line.

>

> Cheers, Al.

>

> Am J Epidemiol. 2002 Nov 1;156(9):824-31.

>

> Soy and fish oil intake and mortality in a Japanese community.

>

> The relation between intake of fish and soy products and subsequent

> all-cause and cause-specific mortality was examined in a cohort of

> 13,355 male and 15,724 female residents of Takayama, Gifu, Japan.

>

> A diet that included soy and fish intake was assessed in 1992

> by using a validated semiquantitative food frequency

> questionnaire. ....

>

> For men, the highest compared with the lowest quintile of total soy

> product intake was marginally significantly inversely associated

with

> total mortality after adjustment for total energy and nondietary

> covariates (hazard ratio = 0.83, 95% confidence interval: 0.69,

1.01;

> p for trend = 0.07). After adjustment for nondietary covariates, a

> decreased hazard ratio for the highest compared with the lowest

> quintile of total soy product intake was also observed for women

> (hazard ratio = 0.83, 95% confidence interval: 0.68, 1.02; p for

> trend = 0.04). Additional adjustment for dietary factors

> significantly associated with total mortality did not attenuate

these

> associations. For women but not for men, n-3 fatty acids from fish

> were significantly inversely associated with total mortality.

>

> Results showed that soy intake may have moderate but beneficial

> effects on total mortality.

IAN: This study Al cites is important re his observation that the

bottom line tends to be overall lifespan. But again we're looking

at another correlation. It's probably going to be some time till

we've got a clear picture. However, given that CR appears to

benefit the brain in part by raising BDNF and that soy may lower

BDNF in the male brain, my following a CRON diet tends to increase

the case against eating soy. Consider that CR might increase the

odds of neuro-impairment IF it was not offset by a BDNF increase.

In otherwords, a CR-induced BDNF increase may be intended to save

the brain from energy restriction that might otherwise be a threat.

IF soy counteracts that protective reaction in males, what happens?

Obviously none of us knows, and I'd just as well not find out.

http://IanGoddard.net/cr.htm