Soy Neurotoxicity, or CALORIC NEUROTOXICITY!!

[Guest guest]

I apologize in advance for perseverating on the issue of soy

neurotoxicity. I've now (finally) read the article a couple times, and I

just had a " duh " experience unexpectedly.

Given that we're all posting to the " CALORIC RESTRICTION " support

group, I feel dumb that I hadn't thought about calorie intake in the study!

(hence, the self-directed " Duh " ).

It stands to reason that those who ate more servings of tofu, were also

those who at more servings of food generally, and who took in more total

calories. I don't see any indication in the study (reading the " dietary

assessments " section very carefully) of measures of calorie intake being

reported. Furthermore, when they list covariates that they controlled the

effects of, they never mentioned caloric intake as a covariate.

My first concern, that the " tofu effect " was too small to worry about

was substantiated: there was a very small effect size uniquely associated

with greater tofu intake (.8 of one percent of the variability in dementia

(pg. 251)). Furthermore, and more importantly to us, CR science would

anticipate greater overall intake of food to be the cause of the effect seen

in the study. Actually, I would have expected a larger effect if greater

tofu intake was associated with greater caloric intake.

Please let me know if I missed something in the study that you picked

up on. More eyes and memories are certainly an improvement over mine alone.

R.