Catabolism of aging: is it an inflammatory process?

[Guest guest]

Hi All, Is this paper counter CR? The " reduced dietary energy intake (the

anorexia of aging) " caught my eye. The ovoid copy is available.

Cheers, Al.

Curr Opin Clin Nutr Metab Care 2003 May;6(3):295-9

Catabolism of aging: is it an inflammatory process?

Roubenoff R.

PURPOSE OF REVIEW

Research in the field of sarcopenia is evolving rapidly, and the process is

now recognized as an important cause of frailty and morbidity in the

elderly. This review focuses on recent developments in the field, especially

regarding the role of catabolic stimuli in causing sarcopenia.

RECENT FINDINGS

There is now an impressive body of literature implicating increased

interleukin-6 levels in successfully aging adults. New data indicate that

high interleukin-6 levels carry a poor prognosis, although it is not clear

if the cytokine has primarily a causal or counter-regulatory function.

Interleukin-6 and other cytokines could function through direct catabolic

effects, or by causing reduced dietary energy intake (the anorexia of

aging), or by inducing insulin resistance or lowering growth

hormone-insulin-like growth factor-I concentrations. Furthermore, apoptosis

has now been linked to sarcopenia, suggesting that an inflammatory signal

could trigger loss of muscle cells in the elderly even in the absence of

overt inflammatory disease.

SUMMARY

Aging causes loss of many of the anabolic signals to muscle that are present

in young adulthood. Recent research suggests that there is also an increase

in catabolic signals with age.

PMID: 12690262 [PubMed - in process]

Alan Pater, Ph.D.; Faculty of Medicine; Memorial University; St. 's, NL

A1B 3V6 Canada; Tel. No.: (709) 777-6488; Fax No.: (709) 777-7010; email:

apater@...

[Guest guest]

Alan,

It seems to me that relating the anorexia and sarcopenia of old age with a

cron plan including moderate exercise is suggesting that starvation with no

exercise is comparable to calorie restriction and at least good nutrition

(since there is no concensus on what optimal nutrition is)with moderate

exercise. Apples and oranges are much closer than that.

----- Original Message -----

From: " Alan Pater " <apater@...>

" 'CR List' " <crsociety@...>

Cc: " CR Support Group (E-mail) " <CRSupportgroup >

Sent: Sunday, April 13, 2003 3:13 PM

Subject: [ ] Catabolism of aging: is it an inflammatory

process?

> Hi All, Is this paper counter CR? The " reduced dietary energy intake (the

> anorexia of aging) " caught my eye. The ovoid copy is available.

>

> Cheers, Al.

>

> Curr Opin Clin Nutr Metab Care 2003 May;6(3):295-9

> Catabolism of aging: is it an inflammatory process?

> Roubenoff R.

>

> PURPOSE OF REVIEW

> Research in the field of sarcopenia is evolving rapidly, and the process

is

> now recognized as an important cause of frailty and morbidity in the

> elderly. This review focuses on recent developments in the field,

especially

> regarding the role of catabolic stimuli in causing sarcopenia.

>

> RECENT FINDINGS

> There is now an impressive body of literature implicating increased

> interleukin-6 levels in successfully aging adults. New data indicate that

> high interleukin-6 levels carry a poor prognosis, although it is not clear

> if the cytokine has primarily a causal or counter-regulatory function.

> Interleukin-6 and other cytokines could function through direct catabolic

> effects, or by causing reduced dietary energy intake (the anorexia of

> aging), or by inducing insulin resistance or lowering growth

> hormone-insulin-like growth factor-I concentrations. Furthermore,

apoptosis

> has now been linked to sarcopenia, suggesting that an inflammatory signal

> could trigger loss of muscle cells in the elderly even in the absence of

> overt inflammatory disease.

>

> SUMMARY

> Aging causes loss of many of the anabolic signals to muscle that are

present

> in young adulthood. Recent research suggests that there is also an

increase

> in catabolic signals with age.

>

> PMID: 12690262 [PubMed - in process]

>

> Alan Pater, Ph.D.; Faculty of Medicine; Memorial University; St. 's,

NL

> A1B 3V6 Canada; Tel. No.: (709) 777-6488; Fax No.: (709) 777-7010; email:

> apater@...

>

>

>

>