Opioid for reducing the masses (fat that is)?

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Hi All, Opioid for reducing the masses (fat that is)? It was one way to

reduce weight and remarkably spared lean mass while reducing specifically

fat mass.

The PDF is available at: apater@...

Am J Physiol Regul Integr Comp Physiol 2003 Jun;284(6):R1399-R1408

Peptides that Regulate Food Intake: Antagonism of opioid receptors reduces body

fat in obese rats by decreasing food intake and stimulating lipid utilization.

Statnick MA, Tinsley FC, Eastwood BJ, Suter TM, Mitch CH, Heiman ML.

Agonists to opioid receptors induce a positive energy balance, whereas

antagonists at these receptors reduce food intake and body weight in rodent

models of obesity. An analog of 3,4-dimethyl-4-(3-hydroxyphenyl)piperidine,

LY255582, is a potent non-morphinan antagonist for & mgr;-, kappa-, and

delta-receptors (K(i) of 0.4, 2.0, and 5.2 nM, respectively). In the present

study, we examined the effects of oral LY255582 treatment on caloric intake,

calorie expenditure, and body composition in dietary-induced obese rats. Acute

oral treatment of LY255582 produced a dose-dependent decrease in energy intake

and respiratory quotient (RQ), which correlated with the occupancy of central

opioid receptors. Animals receiving chronic oral treatment with LY255582 for 14

days maintained a negative energy balance that was sustained by increased lipid

use. Analysis of body composition revealed a reduction in fat mass accretion,

with no change in lean body mass, in animals treated with LY255582. Therefore,

chronic treatment with LY255582 reduces adipose tissue mass by reducing energy

intake and stimulating lipid use.

PMID: 12736177 [PubMed - as supplied by publisher]