Pubmed study: Fasting better than CR (?)

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Intermittent fasting dissociates beneficial effects of dietary

restriction on glucose metabolism and neuronal resistance to injury

from calorie intake.

Anson RM, Guo Z, de Cabo R, Iyun T, Rios M, Hagepanos A, Ingram DK,

Lane MA, Mattson MP.

Laboratory of Neurosciences, Gerontology Research Center, National

Institute on Aging, 5600 Shock Drive, Baltimore, MD 21224, USA.

Dietary restriction has been shown to have several health benefits

including increased insulin sensitivity, stress resistance, reduced

morbidity, and increased life span. The mechanism remains unknown, but

the need for a long-term reduction in caloric intake to achieve these

benefits has been assumed. We report that when C57BL6 mice are

maintained on an intermittent fasting (alternate-day fasting)

dietary-restriction regimen their overall food intake is not decreased

and their body weight is maintained. ~~~Nevertheless, intermittent

fasting resulted in beneficial effects that met or exceeded those of

caloric restriction including reduced serum glucose and insulin levels

and increased resistance of neurons in the brain to excitotoxic

stress. Intermittent fasting therefore has beneficial effects on

glucose regulation and neuronal resistance to injury in these mice

that are independent of caloric intake.~~~

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