Re: Aging Research Article & Low Insulin IGF-1 Extends Life?

[Guest guest]

Hello Dean ~

Given the article/interview on Kenyon [ " I Want to Live

Forever " ] that you posted (I read the full piece using the link you

provided)...have you made any alterations/revisions in either your

diet or supplementation? If yes, would you care to expound? If no,

can you explain what you did not find credible in her answers?

Thanks!

~ Andy

[Guest guest]

Andy Wrote:

Given the article/interview on Kenyon ["I Want to LiveForever"] that you posted (I read the full piece using the link youprovided)...have you made any alterations/revisions in either yourdiet or supplementation? If yes, would you care to expound? If no,can you explain what you did not find credible in her answers?

Hi Andy & ALL:

I suppose this is a long-term research issue for me meaning many days to months or more before I might track down good data about Insulin response & "load" compared to GI/GL. Walford notes such POSSIBLE valid ageing theories in his B120 book. Check Index for insulin/IGF-1.

Fortunately, there is a lot of diabetes research out there that might provide some clues or answers as far as fasting and foods go affecting Insulin & its "load".

I do think Kenyon is onto a key(s) to unlock some unresolved aging gene questions by focusing on these receptors to Insulin/IGF-1. There is a lot of related research out there supporting such ideas.

Like anything regarding this type of learning is how can we apply this to ourselves now? I think the answer could be fasting techniques & certain food combinations or avoidance of those which cause too much "Insulin load".

I am definitely considering reducing my meal frequency, fasting "x" amount of time, & eliminating foods or combinations, when possible, that might boost Insulin response & loads. I know GI/GL can be important clues, even correlated, to how Insulin can or usually responds, but there's evidence this is NOT always the case. There might even be rather dramatic differences between the two.

The key point of the Kenyon article, now quoting: "So hormones control ageing. They speed it up."

Since her "keyed-on" focus is Insulin/IGF-1 receptors, it SEEMS to follow the less stimulation one does to Insulin/IGF-1 the better off we might be reducing all the downstream cascading hormone effects. A one data point (very weak) "support" of this idea is one of the CR primates that is longest living is diabetic too. Of course, CR itself stimulates less these receptors, so there may be ways to enhance this "lowered response" by food selection and/or combinations & meal frequency that is very beneficial & enhances the anti-aging effects too.

I'm certainly interested in anyone's further commentary or thoughts on such issues.

..

[Guest guest]

--- In , " jwwright " <jwwright@e...>

wrote:

The glycation or glycolysation seems to me correct as to aging, but I

think also it's a necessary thing for our system. Regardless of diet

we need glucose and our body will make it to provide the fuel. Cells

use glucose and fatty acids to produce energy and the req't to work

puts more stress on the system. Using more glucose ages manual

laborers faster. So if we exercise not to extreme, and not use excess

glucose we should live longer. That seems congruent with CR.

But I also think the human body is a great deal more complex than a

worm, with many more corrective mechanisms in place.

*****Yes, that is certainly true: the human body IS more complex than

a worm's. However, in the " big " picture, the differences in

complexity may in fact be irrelevant. What seems to work for a worm

has, over the course of numerous experiments, " translated " into

larger species as well, and according to Walford:

" We are dealing with the question of 'translatability.' What is the

probability that a phenomenon observed in animals can be translated

to humans? Well, it depends on the phenomenon. Fertilization,

growth, development, and aging are basically much the same across

large species differences. There may be an occasional uniqueness in

the mechanims of aging. Salmon and octopuses, for example, age

almost overnight as the result of a programmed hormonal outpuring.

And a few animals, lobsters for example, don't show any features of

aging; they simply outgrow their ecological niche. But these are

easily recognized exceptions. Nobody doubts that most animals -- for

example, mice, rats, horses, chimpanzees, and humans -- age by

similar mechanisms. Any general process that retards aging in one

such species ought to do so in another. The CRON-dietary regime is

such a process. The fact that it induces the same physiologic

changes in all mammalian species so far tested further reinforces the

likelihood of life extension for humans. "

~ andy