Late Life CR is Effective

[Guest guest]

Hello Mike and CR ALL:

> On 19 Sep 2003, Warren wrote:

> The cheerful knowledge below (that CR can work even for

> older people in their latter years) is really important

> to a lot of us.

Here is some of the laboratory proof, that mid-life to

late-life CR works:

.... Lifespan (LS) for one group of rats CR restricted from

30 days of age and then switched to Ad Lib (AL) at 12 months;

and lifespan (LS) of another group of rats fed Ad Lib (AL)

until 12 months of age and then switched to CR. This is what

is called a " cross-over " experiment. The rats are

genetically identical and of the same species, so that

animal-to-animal variability is minimized.

They had similar mean and maximum lifespans (LSs) ... !!

Note: Mean LS measures health; Max LS measures anti-aging.

And it didn't matter whether is was late-life CR or early-life CR !!

Group Mean LS (weeks) Maximum LS** (weeks)

---------------- -------------- -------------------

Ad libitum 133.1 +/- 4.1 169.4 +/- 1.9

Restricted 163.4 +/- 3.9 200.1 +/- 3.1

Ad lib/Restricted 150.0 +/- 4.6 178.6 +/- 1.5

Restricted/ad lib 149.2 +/- 3.6 182.6 +/- 2.1

Using mathematical extrapolation with curve fitting methods:

A (Ad Lib) ...... 180 weeks

R (Restricted).... 220 weeks

AL/R ............ 190 weeks

R/AL ............ 190 weeks

LS** = Mean survival for the longest lived 10% of each population.

Source: J Gerontol. 1986 Jan;41(1):13-9. Effect of Age of

Initiation of Feed Restriction on Growth, Body Composition,

and Longevity of Rats. Beauchene RE, Bales CW, Bragg CS,

Hawkins ST, Mason RL. PMID 3941250

Link: http://timtyler.org/pmid/?n=3941250

-- Warren

================================== ====================

> -----Original Message-----

> From: Mike Harkreader [mailto:titanmeister@...]

> Sent: Friday, September 19, 2003 9:10 AM

>

> Subject: [ ] Neat article

>

>

> Study: Even mid-life diet change can extend life

> Friday, September 19, 2003 Posted: 8:41 AM EDT (1241 GMT)

>

>

>

>

> WASHINGTON (AP) -- It has long been known that laboratory animals

> live longer on a low-calorie diet. Now a study suggests that even if

> sensible eating is delayed until middle age, health can be improved

> and life extended.

> ...