Re: Two Articles -- Low Carb Diet; Lifetime CR Dog Study

[Guest guest]

Low carbohydrate diet benefit analysis --

Free http://www.jci.org/cgi/reprint/104/8/1087.pdf

Lifetime CR Study in Dogs

20$ http://www.nutrition.org/cgi/reprint/133/9/2887

bye

>

> Upcoming J Nutr articles in the Sept issue ...

>

> J. S. Volek, M. J. Sharman, A. L. Gomez, T. P. Scheett, and W. J.

Kraemer

>

> An Isoenergetic Very Low-Carbohydrate Diet Is Associated With

Improved Serum

> High-Density Lipoprotein Cholesterol (HDL-C), Total Cholesterol to

HDL-C

> Ratio, Triacylglycerols, and Postprandial Lipemic Responses

Compared to a

> Low-Fat Diet in Normal Weight, Normolipidemic Women

>

> and

>

> T. Larson, D. F. Lawler, E. L. Spitznagel, and R. D. Kealy

>

> Improved Glucose Tolerance with Lifetime Diet Restriction Favorably

Affects

> Disease and Survival in Dogs

>

> in the Sept issue of J Nutr not yet released sound promising.

>

> Cheers, al.

>

> Alan Pater, Ph.D.; Faculty of Medicine; Memorial University; St.

's, NL

> A1B 3V6 Canada; Tel. No.: (709) 777-6488; Fax No.: (709) 777-7010;

email:

> apater@m...

[Guest guest]

Abstract of CR Dog Study:

Nutrition and Aging

Improved Glucose Tolerance with Lifetime Diet Restriction Favorably

Affects Disease and Survival in Dogs

T. Larson1, Dennis F. Lawler, L. Spitznagel, Jr* and

D. Kealy

Nestlé Purina PetCare Research, St. Louis, MO 63164 and * Department

of Mathematics, Washington University, St. Louis, MO 63130

1To whom correspondence should be addressed. E-mail:

.Larson@....

Labrador retrievers (42 of original 48) were used to assess the

effects of lifetime diet restriction on glucose tolerance at ages 9–

12 y. Restricted-fed (RF) dogs were fed 75% of the same diet consumed

by control-fed (CF) pair-mates. An intravenous glucose tolerance test

was done annually (maximal stimulation, nonsteady-state). Diet

treatment, age, and interactions were fixed effects. Statistical

procedures used included mixed-model, repeated-measures ANOVA; least-

squares means; Tukey's multiple comparison; paired t tests; and

Spearman rank correlations. Glucose k-value and half-life, and

insulin sensitivity (total, and 9, 10, 11 y, and per lean mass) were

higher (P < 0.05) in RF than in CF dogs. Late-phase insulin release

[area under the curve (AUC) 30–120 min] was less (P < 0.05) in RF

than in CR dogs. Early-phase insulin release (AUC 0–5 min), y 12

insulin sensitivity and insulinogenic index did not differ between RF

and CF dogs. Insulin peak, and total AUC increased (P < 0.05) with

age, whereas the glucose k-value and glucose half-life were not

affected by age. Insulin sensitivity was negatively, and insulin AUC

30–120 min, peak and glucose were positively correlated with body

weight, body condition score, fat mass, percentage of fat and

abdominal fat/total tissue. Higher insulinogenic indices tended (P =

0.053) to be associated with greater median survival and dogs with

higher insulin sensitivity were at lower (P < 0.05) risk of dying or

receiving chronic disease treatment. Time to first osteoarthritis

treatment or death was greater with lower basal glucose and higher

insulin sensitivity (P < 0.05), but diet restriction explained most

of this relationship's variation. Glucose disposal efficiency and

insulin response were associated with increased quality and length of

life in diet-restricted dogs.

> >

> > Upcoming J Nutr articles in the Sept issue ...

> >

> > J. S. Volek, M. J. Sharman, A. L. Gomez, T. P. Scheett, and W. J.

> Kraemer

> >

> > An Isoenergetic Very Low-Carbohydrate Diet Is Associated With

> Improved Serum

> > High-Density Lipoprotein Cholesterol (HDL-C), Total Cholesterol

to

> HDL-C

> > Ratio, Triacylglycerols, and Postprandial Lipemic Responses

> Compared to a

> > Low-Fat Diet in Normal Weight, Normolipidemic Women

> >

> > and

> >

> > T. Larson, D. F. Lawler, E. L. Spitznagel, and R. D. Kealy

> >

> > Improved Glucose Tolerance with Lifetime Diet Restriction

Favorably

> Affects

> > Disease and Survival in Dogs

> >

> > in the Sept issue of J Nutr not yet released sound promising.

> >

> > Cheers, al.

> >

> > Alan Pater, Ph.D.; Faculty of Medicine; Memorial University; St.

> 's, NL

> > A1B 3V6 Canada; Tel. No.: (709) 777-6488; Fax No.: (709) 777-

7010;

> email:

> > apater@m...

[Guest guest]

Hey Mike -- Thanks for discovering these two PDF sources.

I just posted two messages on topics discussed in each of them!

-- Warren

=======================

> On 19 Nov 2003, leopardmike [leopardmike@...] wrote:

>

> Low carbohydrate diet benefit analysis --

> Free http://www.jci.org/cgi/reprint/104/8/1087.pdf

>

> Lifetime CR Study in Dogs

> 20$ http://www.nutrition.org/cgi/reprint/133/9/2887

>

> bye