Spindler Proves CR Works in Old Animals

[Guest guest]

Hello CR ALL:

Q1) Is CR effective in older animals? The answer is yes,

and it is provable using gene chip microarrays.

Q2) How effective is CR in older animals? The answer is

that CR appears to be effective in older animals in

all the same ways that CR is effective in animals

that are young.

Q3) Why is this good news? The answer is that an older

person who initiates a CR program stands to gain

the same type of CR benefits that a young person

would gain from CR.

Q4) How soon do the effects of CR occur in an older animal?

CR effects occur almost immediately (within weeks),

and they are significant and measurable.

Dr Spindler is a scientist who has been studying

Calorie Restriction in middle-age and old-age animals

using gene chips. These gene chips are RNA-DNA micro-array

measurement devices that allow reading the level of gene

expression in animal tissues, to see if when CR is begun

in an older animal, whether the gene expression

(the proteins the genes encode for) reverts back to that

of a YOUNGER animal.

This reversion of genetic expression to that of a younger

animal is a characteristic signature of CR that was

discovered by Dr. Spindler, and became the first biological

proof that CR actually causes " age reversal " , or " anti-aging "

in the scientific sense that CR causes the genes to change

their expression to a more youthful state.

The anti-aging discovery about CR made front page headlines

approx 2 years ago, when it was announced that CR initiates

age reversal in middle-age and old-age animals. Now a new

paper has been released on Dr. Spindler's research at a

conference on aging, where further benefits of CR in older

animals are discussed. A quote from the abstract

http://www.gen.cam.ac.uk/iabg10/abs/Spindler.htm

reads this way:

''Caloric restriction is the most robust environmental method known

for decelerating aging and the development of age-related diseases.

CR is also widely thought to be less effective in older animals.

Using survival and high-density microarray studies, we demonstrate

that CR acts rapidly and reversibly to establish a pattern of

gene expression temporally associated with enhanced life span

and reduced tumor incidence in mice. CR was fully effective at

extending life span and reducing tumor incidence when begun in

old animals. The results indicate that therapies mimicking the

gene expression effects of CR may be rapidly effective, even

in old animals.''

The word temporary means that the CR effects remain, so long as

the animal remains in a CR state.

This is outstanding news for the middle-aged and senior citizens

within our ranks. Here is wisdom: Cut calories, improve nutrition,

live better, live longer, and be happy!

-- Warren

PS: Thank you Tim Tyler, who called attention to the abstract above.