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Re: Rapid Anti-Aging Benefits of CR

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Hi Warren:

Perhaps it is helpful to distinguish two meanings of the

word 'reversal'.

Reversal can mean: someone with a biological age of 60 goes on CR

and two years later has a biological age of 50. But thereafter

continues to get older (biological age) even while continuing CR.

The drop in age from 60 to 50 could be called 'reversal'.

Reversal can also mean: someone with a biological age of 60 goes on

some form of health procedure and sees their age drop steadily to 25

and stay there.

I believe the Spindler use of the term is the first above. I believe

the telomerase use of the term may, IF IF IF it proves out in the

long term, be the second in terms of cell senescence.

The CR experiments in animals seem conclusive for the first. The

experiments with human and other CELLS (much different from an entire

organism) seem conclusive of the second. In my opinion. For what it

is worth.

Rodney.

> Hello CR ALL:

>

> Anti-aging benefits of CR quoted from Dr. Spindler:

>

> " CR can reverse the majority of the deleterious age-related changes

> in gene expression that we found. "

>

> My comment: The gene reprogramming benefits of CR affect the

MAJORITY

> of genes (not just a few). The benefit occurs very quickly in

weeks.

> It happens with short-term CR. It happens in the very elderly.

>

> -- Warren

> ------------------------------------ -------------------------------

--------

>

> http://www.lef.org/magazine/mag2001/dec2001_cover_spindler_01.html

>

> LEF: So if you see an anti-aging benefit in these mice, it's a true

> anti-aging

> benefit, not just a correction of some life-shortening genetic

defect. Now,

> let's attack this from a slightly different angle. Since the

animals were

> already extremely old when you imposed short-term calorie

restriction on

> them,

> and since their gene expression profiles appeared more like those

of young

> animals after the short-term calorie restriction, it seems

inescapable that

> calorie restriction is not only able to slow age-related changes,

but that

> it

> is able to reverse age-related changes as well. And it is able to

do so

> over a

> remarkably short period of time.

>

> S.S.: I think that may be our most significant contribution here.

>

> L.E.: Has anyone else ever suggested that calorie restriction could

reverse

> aging, not just slow it? Or is your finding truly unique?

>

> S.S.: As far as I know, there had been no suggestion in the

literature

> before

> our study that calorie restriction could reverse age-related

changes in gene

> expression. I think the assumption has been that it prevents

deleterious

> age-

> related changes in gene expression. It had been our assumption as

well, and

> we've published a number of papers on gene expression where we just

assumed

> that calorie restriction was preventing deleterious changes. What

these

> studies

> showed for the first time was that in fact that assumption was

incorrect.

> Calorie restriction can reverse the majority of the deleterious age-

related

> changes in gene expression that we found.

>

> ====================================== =============================

>

> Here is the PubMed citation for the PNAS article by

Spindler:

>

> http://www.pnas.org/cgi/content/abstract/98/19/10630

>

> PNAS, 11 Sep 2001, vol 98, no 19, pp 10630-10635, Genomic profiling

of

> short-

> and long-term caloric restriction effects in the liver of aging

mice.

> X. Cao, ph M. Dhahbi, L. Mote, and R.

Spindler*

> Dept of Biochemistry, Univ Calif, Riverside, CA 92521

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