Rapid Anti-Aging Benefits of CR

[Guest guest]

Hello CR ALL:

Anti-aging benefits of CR quoted from Dr. Spindler:

" CR can reverse the majority of the deleterious age-related changes

in gene expression that we found. "

My comment: The gene reprogramming benefits of CR affect the MAJORITY

of genes (not just a few). The benefit occurs very quickly in weeks.

It happens with short-term CR. It happens in the very elderly.

-- Warren

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http://www.lef.org/magazine/mag2001/dec2001_cover_spindler_01.html

LEF: So if you see an anti-aging benefit in these mice, it's a true

anti-aging

benefit, not just a correction of some life-shortening genetic defect. Now,

let's attack this from a slightly different angle. Since the animals were

already extremely old when you imposed short-term calorie restriction on

them,

and since their gene expression profiles appeared more like those of young

animals after the short-term calorie restriction, it seems inescapable that

calorie restriction is not only able to slow age-related changes, but that

it

is able to reverse age-related changes as well. And it is able to do so

over a

remarkably short period of time.

S.S.: I think that may be our most significant contribution here.

L.E.: Has anyone else ever suggested that calorie restriction could reverse

aging, not just slow it? Or is your finding truly unique?

S.S.: As far as I know, there had been no suggestion in the literature

before

our study that calorie restriction could reverse age-related changes in gene

expression. I think the assumption has been that it prevents deleterious

age-

related changes in gene expression. It had been our assumption as well, and

we've published a number of papers on gene expression where we just assumed

that calorie restriction was preventing deleterious changes. What these

studies

showed for the first time was that in fact that assumption was incorrect.

Calorie restriction can reverse the majority of the deleterious age-related

changes in gene expression that we found.

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Here is the PubMed citation for the PNAS article by Spindler:

http://www.pnas.org/cgi/content/abstract/98/19/10630

PNAS, 11 Sep 2001, vol 98, no 19, pp 10630-10635, Genomic profiling of

short-

and long-term caloric restriction effects in the liver of aging mice.

X. Cao, ph M. Dhahbi, L. Mote, and R. Spindler*

Dept of Biochemistry, Univ Calif, Riverside, CA 92521