On Aging Reversal Issue

[Guest guest]

Hi Francesca, Warren and Rodney:

I readed the entire paper of Dr. Spindler at PNAS

that the Warren cited below in 1999.

What Spindler claims is quite surprising:

CR imposes imediate changes in gene expression

(measured by DNA microarray experiments). The gene

expression when CR is imposed, changes to the same

patterns seen in youth. CR changes the activity of

11.000 genes and not only delays aging,

but partially *reverses* it. But only *partially*.

What cames into mind of people affictioned in

science, like I am, is that CR may be turning on genes

that can potentially reverse aging.

The microarray (DNA chip put inside the cell)

shows that these genes are off when the cell is producing

energy. But are turned on when the cell produces less

energy.

In other words, the production of energy

is something that do little " biochemical hurts "

inside the cell and the genes that can potentially

recover from these hurts are off when cell is

producing energy, that is, hurting itself.

When the hurt stops, the miraculous nanorobots of

nature (proteins) that are produced by the mRNA

trascribed by the genes turned on by CR, begin

their work correcting these damages in a very

efficient and perfect way.

The reconstruction is not perfect:

Some information is lost, of course.

This is one point: The view of aging as

something like " information loss " process.

This view can be considered

consistent with studies on

Hutchinson-Gifford syndrome (cromossomal abnormalities

lead to lifespan of 16 years in children). Such

syndrome involves lots of information lost.

Information loss aging, is rather especulative,

but is nonethless plausible, and deserves attention.

That may be for example,

the reason fasting and EOD feeding can increase

lifespan. Not because aging is only retarded, but

perhaps because it is even being reversed in such

experiments and that is the " exposure to the calories

by tissues " that counts, not only calories, calories...

The second point is that reversing aging is

aways impossible without modifications on the

cell's energy production structure :

The energy necessary for the *complete* reversion

of cells aging is *aways* grater than the

energy that the damaged mithocondria can provide.

You ask: How can we solve this problem?

Possible answer: By nanothecnology. Put extra

nanorobots inside the cell. Not only nanorobots that

repair structural damage in the cell (what is already

done by miraculous reparative proteins)

but nanorobots that correct

what is making energy production less eficient.

What is going wrong for this process happen.

The possibility to do this *today* is science

fiction, because we just don't know what exactly

is going wrong. To acess this we would need an analisis

and simulation tool unacessible:

Large Scale Computer Data Analisis and Simulation

of an ENTIRE cell.

The power of computers today (believe me) is yet a

bottleneck for real time simulations of the cell, of

this kind.

But there's hope!!

Just stay alive in the next 30-50 and you will

see things that no one could imagine

when was get born.

-- The inspired student Gandhi.

http://www.rense.com/general1

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