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I am postmenopausal, and stopped the Premprin I was on when the study reported

what

it had found. Now, my GYN says that I shouldn't start the estrogen again, in

any form.

Roni

Dusty <dusty@...> wrote:

I would advise against progesterone if you are a post menopausal

woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

There are some excellent books on hormones by Dr. Vliet. Before

you take the word of anyone on this list (mine included) avail yourself of

some of this reading material. There are also studies posted on MEDSCAPE

(you join, but no fee) and other medical sites.

Dusty

Re: Re: Anyone with weight gain have Liposuction?

iodine and progesterone.

seriously, iodine/iodide works miracles ( that's why we are warned not to

take it)

gracia

Hi Sam,

Since you mentioned it, about Fibrocystic Breast Disease: I noticed that my

boobs hurt like 2 weeks before my period, and this just started since taking

Armour, 6 months. Do you know what to do to stop that??

Thanks!!

Sam <k9gangopenaccess (DOT) <mailto:k9gang%40openaccess.org> org> wrote:

It's not just that I have lost 2 parts of my endocrine system and

started with a clean slate. There was damage done and severe iodine

deficiency - fibrocystic breast disease, osteoporosis, DNA and NIS

damage from the RAI and stuff like that. I was sort of ok just

without ovaries/uterus, but the bottom dropped out when my healthy

thyroid was ablated.

Yea, I wish it was just " starting with a clean slate " ...it would have

been way easier to climb out of that pit of doom I was lolling in for

so long. :-O

Sam :-D

> >

> > I don't think it's so much what you're dosing for, as it

is " how " .

> You

> > could dose hypothyroidism by using cocaine and probably feel

pretty

> > good... For a while. In your case you're using a product that

treats

> > the underlying disease, so it works. At least for you. So you

> aren't

> > JUST treating symptoms; you're addressing the real problem.

> >

> > Note I said it has it's limitations; I didn't say it wouldn't

work.

> >

> >

>

>

>

>

>

>

> ---------------------------------

> Be a better friend, newshound, and know-it-all with Mobile.

Try it now.

>

>

Link to comment
Share on other sites

,

I have the same problem along with being big in that area and my

ob/gyn suggested evening primrose with vitamin E and it works great

for me.-it even worked on the cramping,headaches and bloating..

-- In hypothyroidism , " Dusty " <dusty@...> wrote:

>

> I would advise against progesterone if you are a post menopausal

woman.

> Progsterone/Progestins are the reason the Women's Health Iniative on

> combined estrogens and progestins was cancelled, due to its

contributing to

> breast cancer increases. The estrogen alone study continued

because it did

> not increase the risk of breast cancer.

>

> There are some excellent books on hormones by Dr.

Vliet. Before

> you take the word of anyone on this list (mine included) avail

yourself of

> some of this reading material. There are also studies posted on

MEDSCAPE

> (you join, but no fee) and other medical sites.

>

> Dusty

>

>

>

> Re: Re: Anyone with weight gain have

Liposuction?

>

>

>

>

> iodine and progesterone.

> seriously, iodine/iodide works miracles ( that's why we are warned

not to

> take it)

> gracia

>

> Hi Sam,

> Since you mentioned it, about Fibrocystic Breast Disease: I noticed

that my

> boobs hurt like 2 weeks before my period, and this just started

since taking

> Armour, 6 months. Do you know what to do to stop that??

> Thanks!!

>

>

> Sam <k9gangopenaccess (DOT) <mailto:k9gang%40openaccess.org> org> wrote:

> It's not just that I have lost 2 parts of my endocrine system and

> started with a clean slate. There was damage done and severe iodine

> deficiency - fibrocystic breast disease, osteoporosis, DNA and NIS

> damage from the RAI and stuff like that. I was sort of ok just

> without ovaries/uterus, but the bottom dropped out when my healthy

> thyroid was ablated.

>

> Yea, I wish it was just " starting with a clean slate " ...it would

have

> been way easier to climb out of that pit of doom I was lolling in

for

> so long. :-O

>

> Sam :-D

>

>

> > >

> > > I don't think it's so much what you're dosing for, as it

> is " how " .

> > You

> > > could dose hypothyroidism by using cocaine and probably feel

> pretty

> > > good... For a while. In your case you're using a product that

> treats

> > > the underlying disease, so it works. At least for you. So you

> > aren't

> > > JUST treating symptoms; you're addressing the real problem.

> > >

> > > Note I said it has it's limitations; I didn't say it wouldn't

> work.

> > >

> > >

> >

> >

> >

> >

> >

> >

> > ---------------------------------

> > Be a better friend, newshound, and know-it-all with

Mobile.

> Try it now.

> >

> >

Link to comment
Share on other sites

Hi Joy,

Thank you for the email. How much of each do you take? How long did it take

before you noticed a difference?

:o)

Thanks!!

joy <jwalker8869@...> wrote:

,

I have the same problem along with being big in that area and my

ob/gyn suggested evening primrose with vitamin E and it works great

for me.-it even worked on the cramping,headaches and bloating..

-- In hypothyroidism , " Dusty " <dusty@...> wrote:

>

> I would advise against progesterone if you are a post menopausal

woman.

> Progsterone/Progestins are the reason the Women's Health Iniative on

> combined estrogens and progestins was cancelled, due to its

contributing to

> breast cancer increases. The estrogen alone study continued

because it did

> not increase the risk of breast cancer.

>

> There are some excellent books on hormones by Dr.

Vliet. Before

> you take the word of anyone on this list (mine included) avail

yourself of

> some of this reading material. There are also studies posted on

MEDSCAPE

> (you join, but no fee) and other medical sites.

>

> Dusty

>

>

>

> Re: Re: Anyone with weight gain have

Liposuction?

>

>

>

>

> iodine and progesterone.

> seriously, iodine/iodide works miracles ( that's why we are warned

not to

> take it)

> gracia

>

> Hi Sam,

> Since you mentioned it, about Fibrocystic Breast Disease: I noticed

that my

> boobs hurt like 2 weeks before my period, and this just started

since taking

> Armour, 6 months. Do you know what to do to stop that??

> Thanks!!

>

>

> Sam <k9gangopenaccess (DOT) <mailto:k9gang%40openaccess.org> org> wrote:

> It's not just that I have lost 2 parts of my endocrine system and

> started with a clean slate. There was damage done and severe iodine

> deficiency - fibrocystic breast disease, osteoporosis, DNA and NIS

> damage from the RAI and stuff like that. I was sort of ok just

> without ovaries/uterus, but the bottom dropped out when my healthy

> thyroid was ablated.

>

> Yea, I wish it was just " starting with a clean slate " ...it would

have

> been way easier to climb out of that pit of doom I was lolling in

for

> so long. :-O

>

> Sam :-D

>

>

> > >

> > > I don't think it's so much what you're dosing for, as it

> is " how " .

> > You

> > > could dose hypothyroidism by using cocaine and probably feel

> pretty

> > > good... For a while. In your case you're using a product that

> treats

> > > the underlying disease, so it works. At least for you. So you

> > aren't

> > > JUST treating symptoms; you're addressing the real problem.

> > >

> > > Note I said it has it's limitations; I didn't say it wouldn't

> work.

> > >

> > >

> >

> >

> >

> >

> >

> >

> > ---------------------------------

> > Be a better friend, newshound, and know-it-all with

Mobile.

> Try it now.

> >

> >

Link to comment
Share on other sites

Hi Dusty,

Thanks so much for the info!! I get scared with any hormones, to tell you the

truth!! I just wish that I could figure all of this out. I will definately

look into these references.

I am in my mid 30's, but still am afraid of HRT. I have heard the same things

about breast cancer.

:o)

Thank you again,

Dusty <dusty@...> wrote:

I would advise against progesterone if you are a post menopausal

woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

There are some excellent books on hormones by Dr. Vliet. Before

you take the word of anyone on this list (mine included) avail yourself of

some of this reading material. There are also studies posted on MEDSCAPE

(you join, but no fee) and other medical sites.

Dusty

Re: Re: Anyone with weight gain have Liposuction?

iodine and progesterone.

seriously, iodine/iodide works miracles ( that's why we are warned not to

take it)

gracia

Hi Sam,

Since you mentioned it, about Fibrocystic Breast Disease: I noticed that my

boobs hurt like 2 weeks before my period, and this just started since taking

Armour, 6 months. Do you know what to do to stop that??

Thanks!!

Sam <k9gangopenaccess (DOT) <mailto:k9gang%40openaccess.org> org> wrote:

It's not just that I have lost 2 parts of my endocrine system and

started with a clean slate. There was damage done and severe iodine

deficiency - fibrocystic breast disease, osteoporosis, DNA and NIS

damage from the RAI and stuff like that. I was sort of ok just

without ovaries/uterus, but the bottom dropped out when my healthy

thyroid was ablated.

Yea, I wish it was just " starting with a clean slate " ...it would have

been way easier to climb out of that pit of doom I was lolling in for

so long. :-O

Sam :-D

> >

> > I don't think it's so much what you're dosing for, as it

is " how " .

> You

> > could dose hypothyroidism by using cocaine and probably feel

pretty

> > good... For a while. In your case you're using a product that

treats

> > the underlying disease, so it works. At least for you. So you

> aren't

> > JUST treating symptoms; you're addressing the real problem.

> >

> > Note I said it has it's limitations; I didn't say it wouldn't

work.

> >

> >

>

>

>

>

>

>

> ---------------------------------

> Be a better friend, newshound, and know-it-all with Mobile.

Try it now.

>

>

Link to comment
Share on other sites

actually that is not entirely correct.

the study was terminated early because the Combined therapy of both estrogen

and progesterone was seen to increase the risk of breast cancer. we do NOT have

any info on whether progesterone ALONe causes breast cancer- because there has

NEVER been a study targeting it that.

nancie

here is the first source:

Does postmenopausal hormone treatment increase the risk of breast cancer?

Women who use postmenopausal hormone

treatment<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormonescfm#1>

have a higher risk for breast cancer compared with women who do not use hormone

treatment. In the past, hormone treatment used

estrogen<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm#1>

alone and the effects of this treatment have been studied more extensively.

These early studies saw breast cancer risk increase the longer the length of the

estrogen treatment. Breast cancer risk among women who used hormone treatment,

increased about 2% for each year of use compared to women who did not use

hormones. When hormone treatment is stopped, risk falls to previous levels over

a period of five years. Today, most women who receive postmenopausal hormone

treatment use estrogen combined with

progesterone<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm\

#1>. A number of recent studies indicate a higher risk of breast cancer is

associated with this form of hormone treatment. These studies found that

estrogen with progesterone treatment increased breast cancer risk by 6% to 8%

for each year of use. Confirming these results, a large clinical trial examining

estrogen with progesterone treatment in healthy women, the Women's Health

Initiative, was recently ended prematurely because of an association of

excessive breast cancer risk with this treatment. Trials of this type are the

'gold standard' for examining drug effects and this early termination result

raises strong concern about the use of estrogen with progesterone as a

beneficial treatment for healthy women after menopause.

source:

http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm<http://envir\

ocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm>

________________________________________________________________________________\

_________________________

Estrogen plus Progestin Effects on Breast Cancer and Mammograms

June 2003

a.. Frequently asked questions<http://www.whi.org/faq/faq_bc.php>

b.. Abstract of scientific paper in

JAMA<http://jama.ama-assn.org/cgi/content/abstract/289/24/3243>

Findings Summary

WHI study findings on the risk of breast cancer in women taking combined

estrogen plus progestin (E+P) were published in the July 2002 issue of the

Journal of the American Medical Association (JAMA). The E+P study continues to

be analyzed. Updated results (June 25 issue of JAMA) include data on additional

breast cancer cases, their characteristics, and mammogram results for women in

the study.

The 2002 report showed that more women taking E+P developed breast cancer than

those taking placebo (inactive) pills. This updated analysis shows that after an

average of 5.6 years, 245 of the 8,506 E+P women and 185 of the 8,102 women on

placebo developed breast cancer. Of the total cancers, 349 cases were invasive,

a type of breast cancer with a greater chance of spreading to other parts of the

body. The conclusions below are based on the invasive breast cancer group.

a.. The increased risk of breast cancer due to E+P was eight additional cases

of breast cancer for every 10,000 women over one year

b.. Overall, there was a 24% increase in the risk for breast cancer due to E+P

The breast cancers in the E+P group had similar characteristics (looked the same

under a microscope) to those in the placebo group. However, the tumors in the

E+P group tended to be larger and more advanced (had spread to the lymph nodes

or elsewhere in the body). A more advanced stage is usually associated with

poorer outcome. At this time, no direct statements can be made about the

prognosis of the breast cancer found in women taking E+P until more follow-up

information is collected.

After even one year, quite a few more women had abnormal mammograms in the E+P

group (9.4%) compared to the placebo group (5.4%); this pattern continued until

the study ended. An abnormal mammogram is a breast X-ray that results in a

recommendation for additional medical evaluation (most often, a shorter time

between mammograms, but sometimes, a breast biopsy or other tests). Although we

have known from other studies that E+P use increases the density of breast

tissue on mammograms, the increase in abnormal mammograms with E+P use seen in

this study is a new finding.

Further WHI studies are being done to learn what happens to breast cancer rates

and mammograms after E+P use is stopped.

source:

http://www.whi.org/findings/ht/eplusp_bc.php<http://www.whi.org/findings/ht/eplu\

sp_bc.php>

________________________________________________________________

Frequently Asked Questions about Estrogen plus Progestin and Breast Cancer

These questions and answers supplement the June 25, 2003 JAMA publication on E+P

and breast cancer.

1.. What were the main findings from the estrogen plus progestin and breast

cancer analyses?<http://www.whi.org/faq/faq_bc.php#1>

2.. What is the increased risk for women taking E+P for breast

cancer?<http://www.whi.org/faq/faq_bc.php#2>

3.. What were the main findings about E+P and

mammography?<http://www.whi.org/faq/faq_bc.php#3>

4.. What are the conclusions from these

findings?<http://www.whi.org/faq/faq_bc.php#4>

5.. What is breast cancer?<http://www.whi.org/faq/faq_bc.php#5>

6.. What is in situ breast cancer?<http://www.whi.org/faq/faq_bc.php#6>

7.. What is invasive breast cancer?<http://www.whi.org/faq/faq_bc.php#7>

8.. What is a mammogram?<http://www.whi.org/faq/faq_bc.php#8>

9.. What is an abnormal mammogram?<http://www.whi.org/faq/faq_bc.php#9>

10.. What happens to breast cancer risk and the frequency of abnormal

mammograms after E+P use is discontinued?<http://www.whi.org/faq/faq_bc.php#10>

11.. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI

study?<http://www.whi.org/faq/faq_bc.php#11>

12.. What type of hormone treatment did women in the E+P study

take?<http://www.whi.org/faq/faq_bc.php#12>

13.. Is there an increased risk of breast cancer and abnormal mammograms in

women taking estrogen alone (without progestin) or other E+P

formulas?<http://www.whi.org/faq/faq_bc.php#13>

14.. Should I discuss this information with my healthcare provider?

<http://www.whi.org/faq/faq_bc.php#14>

15.. If I have an abnormal mammogram now, and have taken (or I still take)

E+P, what should I do?<http://www.whi.org/faq/faq_bc.php#15>

16.. Was the effect of E+P on breast cancer different in women who had used

oral contraceptives in the past?<http://www.whi.org/faq/faq_bc.php#16>

17.. I am taking prescription hormones. What should I

do?<http://www.whi.org/faq/faq_bc.php#17>

1. What were the main findings from the estrogen plus progestin and breast

cancer analyses?

Answer: More women who took estrogen plus progestin (E+P) developed breast

cancer than women taking placebo (inactive pills). The cancer cases found in

women taking E+P had similar characteristics (looked the same under the

microscope), but the tumors were larger and had spread more throughout the body

than those in the placebo group.

2. What is the increased risk for women taking E+P for breast cancer?

Answer: A woman is more likely to develop breast cancer if she is taking E+P.

For every 10,000 women taking estrogen plus progestin, 41 women each year will

develop breast cancer as compared to 33 women per year who would develop breast

cancer while taking placebo. While this difference in risk is important, the

overall risk to an individual woman remains small.

The breast cancer cases which developed in women taking E+P were larger and more

advanced; about 25% had spread to lymph nodes or elsewhere in the body, compared

to 16% of women on placebo.

3. What were the main findings about E+P and mammography?

Answer: After just one year of taking E+P, a woman was much more likely to have

an abnormal mammogram compared to a woman taking placebo. In the E+P group, 9.4%

of women had an abnormal mammogram after one year, compared with 5.4% in the

placebo group. The increased rate of abnormal mammograms continued until the

study ended.

A woman's chance of having an abnormal mammogram resulting from E+P use was

about 1 in 25 for one year's use, and about 1 in 10 after 5½ years of use.

4. What are the conclusions from these findings?

Answer: Use of E+P increases the rate of more advanced breast cancer compared

with placebo and substantially increases the rate of abnormal mammograms. As a

result, abnormal mammograms in women receiving menopausal hormone therapy need

closer attention. The increased frequency of abnormal mammograms is a newly

found negative effect of even short-term E+P use. These findings should be

considered in the discussion of risks and benefits for women considering E+P use

for any amount of time.

5. What is breast cancer?

Answer: Breast cancer is a disease in which abnormal breast cells divide without

control and can spread to other parts of the body.

6. What is in situ breast cancer?

Answer: In situ is an early cancer where abnormal breast cells are confined to

the ducts or lobules in the breast. There are two forms, ductal carcinoma (DCIS)

and lobular carcinoma in situ (LCIS).

7. What is invasive breast cancer?

Answer: Invasive breast cancer involves abnormal breast cells which have spread

outside the breast duct or lobule where they began. This type of cancer accounts

for 80% of breast cancer cases. When the term " breast cancer " is used, it

generally means invasive breast cancer.

8. What is a mammogram?

Answer: A mammogram is an X-ray of the breast.

9. What is an abnormal mammogram?

Answer: An abnormal mammogram is a breast X-ray with characteristics leading the

radiologist to recommend some additional testing, either another mammogram

within 6 months, or occasionally other procedures. A recommendation to have a

repeat mammogram seldom results in a cancer diagnosis. Some characteristics

seen on a mammogram are suspicious enough to indicate that additional tests

(like a biopsy) are needed. These tests are more likely to result in a cancer

diagnosis.

An abnormal mammogram report is not the same as an incomplete mammogram report.

Quite often, a woman may be called back after a mammogram to have additional

X-rays taken, have an additional non-invasive procedure performed (such as an

ultrasound) or be asked to provide earlier mammograms for comparisons. These

evaluations are needed to better understand the current mammogram, and by

themselves do not signal an abnormal mammogram.

10. What happens to breast cancer risk and the frequency of abnormal mammograms

after E+P use is discontinued?

Answer: WHI researchers will be looking at these issues in future analyses, so

information is not yet available. Observational studies have suggested that

breast cancer risk will diminish over time.

To date, no studies have looked at what effect stopping E+P use has on abnormal

mammograms. There have been some studies about breast density change and

menopausal hormone therapy use. Increased mammogram density has been linked to

E+P use. In observational studies, mammogram density has been shown to decrease

when E+P use is stopped. It remains to be seen whether abnormal mammograms will

change when E+P use is stopped.

11. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI study?

Answer: There was a trend for somewhat higher risk in women in the E+P group who

reported prior menopausal hormone use. Whenever researchers examine factors like

this within a randomized trial, the analyses and interpretation become more

complex. Prior hormone use was not randomized and so other factors associated

with hormone use must be considered when analyzing this relationship. Though

there appears to be some relation between prior hormone use and breast cancer,

WHI researchers will be examining this in more detail to gain confidence in

their interpretation.

12. What type of hormone treatment did women in the E+P study take?

Answer: Women randomized (assigned by chance) to active hormones were taking one

tablet containing conjugated equine estrogens (0.625 mg) and medroxyprogesterone

acetate (2.5 mg) each day (PremproT). When WHI first began, this was the most

commonly prescribed menopausal hormonal therapy in the United States for women

with a uterus.

13. Is there an increased risk of breast cancer and abnormal mammograms in women

taking estrogen alone (without progestin) or other E+P formulas?

Answer: The current report addresses only the issue of E+P use in the form of

pills. Final results from the ongoing Estrogen-Alone (E-Alone) study are unknown

at this time. Importantly, the WHI investigators have been told that, as of May

31, 2002, no increase in breast cancer has been seen in the E-alone WHI trial.

Participants in the E-Alone study are asked to continue to take their study

pills and to come for their regular clinic visits. The National Heart, Lung, and

Blood Institute, which oversees WHI, continues to review the study for women

receiving E-Alone, and they will provide investigators and participants with any

new information about the study that might affect their participation

This information has been superceded by the 2004 Hormone Program

Update.<http://www.whi.org/updates/update_hrt2004.php>

14. Should I discuss this information with my healthcare provider?

Answer: Yes. Your healthcare provider may read the scientific paper in the June

25, 2003 issue of JAMA, or you may direct your provider to this web site. Your

provider may also want to speak with your local WHI Principal Investigator about

these results.

15. If I have an abnormal mammogram now, and have taken (or I still take) E+P,

what should I do?

Answer: Talk with your healthcare provider about your individual situation in

light of the WHI results.

Additional breast imaging tests may help in evaluating women with abnormal

mammograms, such as a nuclear medicine test (scintimammography) or Magnetic

Resonance Imaging (MRI); your mammography provider should have information about

these tests. However, no approach has been evaluated for women with abnormal

mammograms related to E+P use.

16. Was the effect of E+P on breast cancer different in women who had used oral

contraceptives in the past?

Answer: The analyses done so far do not suggest that use of oral contraceptives

had any important influence on the breast cancer findings. Less than half of the

women in this study had ever used oral contraceptives and the length of use was

often relatively short (less than 5 years). With the small number of breast

cancer cases that occurred in these women, these data do not provide a very

clear answer to this question.

17. I am taking prescription hormones. What should I do?

Answer: Talk with your healthcare provider about your individual risk profile

and the hormones you are currently taking in light of the WHI results.

source: http://www.whi.org/faq/faq_bc.php<http://www.whi.org/faq/faq_bc.php>

/Painful breasts

I would advise against progesterone if you are a post menopausal woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

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Correct in that synthetic sex hormones are bad bad bad news.

WIH study only looked at synthetic sex hormones, not at any of the

bio-identicals. So far the bio-identicals have proven to be safe as

long as they are not abused as in the wiley protocol which

recommended huge overdosages of progesterone and estradiol.

Sam

>

> I would advise against progesterone if you are a post menopausal

woman.

> Progsterone/Progestins are the reason the Women's Health Iniative on

> combined estrogens and progestins was cancelled, due to its

contributing to

> breast cancer increases. The estrogen alone study continued

because it did

> not increase the risk of breast cancer.

>

> There are some excellent books on hormones by Dr.

Vliet. Before

> you take the word of anyone on this list (mine included) avail

yourself of

> some of this reading material. There are also studies posted on

MEDSCAPE

> (you join, but no fee) and other medical sites.

>

> Dusty

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Share on other sites

I don't think you are being well served by a gyno who doesn't know what

estrogen does, and how it affects fibro. There are good books on hormones like

Hormone Solutions by Thierry Hertoghe MD.

Gracia

I am postmenopausal, and stopped the Premprin I was on when the study reported

what

it had found. Now, my GYN says that I shouldn't start the estrogen again, in

any form.

Roni

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this study used PROGESTINS which we know are dangerous,

not progesterone.

Gracia

actually that is not entirely correct.

the study was terminated early because the Combined therapy of both estrogen

and progesterone was seen to increase the risk of breast cancer. we do NOT have

any info on whether progesterone ALONe causes breast cancer- because there has

NEVER been a study targeting it that.

nancie

here is the first source:

Does postmenopausal hormone treatment increase the risk of breast cancer?

Women who use postmenopausal hormone

treatment<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormonescfm#1>

have a higher risk for breast cancer compared with women who do not use hormone

treatment. In the past, hormone treatment used

estrogen<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm#1>

alone and the effects of this treatment have been studied more extensively.

These early studies saw breast cancer risk increase the longer the length of the

estrogen treatment. Breast cancer risk among women who used hormone treatment,

increased about 2% for each year of use compared to women who did not use

hormones. When hormone treatment is stopped, risk falls to previous levels over

a period of five years. Today, most women who receive postmenopausal hormone

treatment use estrogen combined with

progesterone<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm\

#1>. A number of recent studies indicate a higher risk of breast cancer is

associated with this form of hormone treatment. These studies found that

estrogen with progesterone treatment increased breast cancer risk by 6% to 8%

for each year of use. Confirming these results, a large clinical trial examining

estrogen with progesterone treatment in healthy women, the Women's Health

Initiative, was recently ended prematurely because of an association of

excessive breast cancer risk with this treatment. Trials of this type are the

'gold standard' for examining drug effects and this early termination result

raises strong concern about the use of estrogen with progesterone as a

beneficial treatment for healthy women after menopause.

source:

http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm<http://envir\

ocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm>

__________________________________________________________

Estrogen plus Progestin Effects on Breast Cancer and Mammograms

June 2003

a.. Frequently asked questions<http://www.whi.org/faq/faq_bc.php>

b.. Abstract of scientific paper in

JAMA<http://jama.ama-assn.org/cgi/content/abstract/289/24/3243>

Findings Summary

WHI study findings on the risk of breast cancer in women taking combined

estrogen plus progestin (E+P) were published in the July 2002 issue of the

Journal of the American Medical Association (JAMA). The E+P study continues to

be analyzed. Updated results (June 25 issue of JAMA) include data on additional

breast cancer cases, their characteristics, and mammogram results for women in

the study.

The 2002 report showed that more women taking E+P developed breast cancer than

those taking placebo (inactive) pills. This updated analysis shows that after an

average of 5.6 years, 245 of the 8,506 E+P women and 185 of the 8,102 women on

placebo developed breast cancer. Of the total cancers, 349 cases were invasive,

a type of breast cancer with a greater chance of spreading to other parts of the

body. The conclusions below are based on the invasive breast cancer group.

a.. The increased risk of breast cancer due to E+P was eight additional cases

of breast cancer for every 10,000 women over one year

b.. Overall, there was a 24% increase in the risk for breast cancer due to E+P

The breast cancers in the E+P group had similar characteristics (looked the

same under a microscope) to those in the placebo group. However, the tumors in

the E+P group tended to be larger and more advanced (had spread to the lymph

nodes or elsewhere in the body). A more advanced stage is usually associated

with poorer outcome. At this time, no direct statements can be made about the

prognosis of the breast cancer found in women taking E+P until more follow-up

information is collected.

After even one year, quite a few more women had abnormal mammograms in the E+P

group (9.4%) compared to the placebo group (5.4%); this pattern continued until

the study ended. An abnormal mammogram is a breast X-ray that results in a

recommendation for additional medical evaluation (most often, a shorter time

between mammograms, but sometimes, a breast biopsy or other tests). Although we

have known from other studies that E+P use increases the density of breast

tissue on mammograms, the increase in abnormal mammograms with E+P use seen in

this study is a new finding.

Further WHI studies are being done to learn what happens to breast cancer

rates and mammograms after E+P use is stopped.

source:

http://www.whi.org/findings/ht/eplusp_bc.php<http://www.whi.org/findings/ht/eplu\

sp_bc.php>

__________________________________________________________

Frequently Asked Questions about Estrogen plus Progestin and Breast Cancer

These questions and answers supplement the June 25, 2003 JAMA publication on

E+P and breast cancer.

1.. What were the main findings from the estrogen plus progestin and breast

cancer analyses?<http://www.whi.org/faq/faq_bc.php#1>

2.. What is the increased risk for women taking E+P for breast

cancer?<http://www.whi.org/faq/faq_bc.php#2>

3.. What were the main findings about E+P and

mammography?<http://www.whi.org/faq/faq_bc.php#3>

4.. What are the conclusions from these

findings?<http://www.whi.org/faq/faq_bc.php#4>

5.. What is breast cancer?<http://www.whi.org/faq/faq_bc.php#5>

6.. What is in situ breast cancer?<http://www.whi.org/faq/faq_bc.php#6>

7.. What is invasive breast cancer?<http://www.whi.org/faq/faq_bc.php#7>

8.. What is a mammogram?<http://www.whi.org/faq/faq_bc.php#8>

9.. What is an abnormal mammogram?<http://www.whi.org/faq/faq_bc.php#9>

10.. What happens to breast cancer risk and the frequency of abnormal

mammograms after E+P use is discontinued?<http://www.whi.org/faq/faq_bc.php#10>

11.. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI

study?<http://www.whi.org/faq/faq_bc.php#11>

12.. What type of hormone treatment did women in the E+P study

take?<http://www.whi.org/faq/faq_bc.php#12>

13.. Is there an increased risk of breast cancer and abnormal mammograms in

women taking estrogen alone (without progestin) or other E+P

formulas?<http://www.whi.org/faq/faq_bc.php#13>

14.. Should I discuss this information with my healthcare provider?

<http://www.whi.org/faq/faq_bc.php#14>

15.. If I have an abnormal mammogram now, and have taken (or I still take)

E+P, what should I do?<http://www.whi.org/faq/faq_bc.php#15>

16.. Was the effect of E+P on breast cancer different in women who had used

oral contraceptives in the past?<http://www.whi.org/faq/faq_bc.php#16>

17.. I am taking prescription hormones. What should I

do?<http://www.whi.org/faq/faq_bc.php#17>

1. What were the main findings from the estrogen plus progestin and breast

cancer analyses?

Answer: More women who took estrogen plus progestin (E+P) developed breast

cancer than women taking placebo (inactive pills). The cancer cases found in

women taking E+P had similar characteristics (looked the same under the

microscope), but the tumors were larger and had spread more throughout the body

than those in the placebo group.

2. What is the increased risk for women taking E+P for breast cancer?

Answer: A woman is more likely to develop breast cancer if she is taking E+P.

For every 10,000 women taking estrogen plus progestin, 41 women each year will

develop breast cancer as compared to 33 women per year who would develop breast

cancer while taking placebo. While this difference in risk is important, the

overall risk to an individual woman remains small.

The breast cancer cases which developed in women taking E+P were larger and

more advanced; about 25% had spread to lymph nodes or elsewhere in the body,

compared to 16% of women on placebo.

3. What were the main findings about E+P and mammography?

Answer: After just one year of taking E+P, a woman was much more likely to

have an abnormal mammogram compared to a woman taking placebo. In the E+P group,

9.4% of women had an abnormal mammogram after one year, compared with 5.4% in

the placebo group. The increased rate of abnormal mammograms continued until the

study ended.

A woman's chance of having an abnormal mammogram resulting from E+P use was

about 1 in 25 for one year's use, and about 1 in 10 after 5½ years of use.

4. What are the conclusions from these findings?

Answer: Use of E+P increases the rate of more advanced breast cancer compared

with placebo and substantially increases the rate of abnormal mammograms. As a

result, abnormal mammograms in women receiving menopausal hormone therapy need

closer attention. The increased frequency of abnormal mammograms is a newly

found negative effect of even short-term E+P use. These findings should be

considered in the discussion of risks and benefits for women considering E+P use

for any amount of time.

5. What is breast cancer?

Answer: Breast cancer is a disease in which abnormal breast cells divide

without control and can spread to other parts of the body.

6. What is in situ breast cancer?

Answer: In situ is an early cancer where abnormal breast cells are confined to

the ducts or lobules in the breast. There are two forms, ductal carcinoma (DCIS)

and lobular carcinoma in situ (LCIS).

7. What is invasive breast cancer?

Answer: Invasive breast cancer involves abnormal breast cells which have

spread outside the breast duct or lobule where they began. This type of cancer

accounts for 80% of breast cancer cases. When the term " breast cancer " is used,

it generally means invasive breast cancer.

8. What is a mammogram?

Answer: A mammogram is an X-ray of the breast.

9. What is an abnormal mammogram?

Answer: An abnormal mammogram is a breast X-ray with characteristics leading

the radiologist to recommend some additional testing, either another mammogram

within 6 months, or occasionally other procedures. A recommendation to have a

repeat mammogram seldom results in a cancer diagnosis. Some characteristics seen

on a mammogram are suspicious enough to indicate that additional tests (like a

biopsy) are needed. These tests are more likely to result in a cancer diagnosis.

An abnormal mammogram report is not the same as an incomplete mammogram

report. Quite often, a woman may be called back after a mammogram to have

additional X-rays taken, have an additional non-invasive procedure performed

(such as an ultrasound) or be asked to provide earlier mammograms for

comparisons. These evaluations are needed to better understand the current

mammogram, and by themselves do not signal an abnormal mammogram.

10. What happens to breast cancer risk and the frequency of abnormal

mammograms after E+P use is discontinued?

Answer: WHI researchers will be looking at these issues in future analyses, so

information is not yet available. Observational studies have suggested that

breast cancer risk will diminish over time.

To date, no studies have looked at what effect stopping E+P use has on

abnormal mammograms. There have been some studies about breast density change

and menopausal hormone therapy use. Increased mammogram density has been linked

to E+P use. In observational studies, mammogram density has been shown to

decrease when E+P use is stopped. It remains to be seen whether abnormal

mammograms will change when E+P use is stopped.

11. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI study?

Answer: There was a trend for somewhat higher risk in women in the E+P group

who reported prior menopausal hormone use. Whenever researchers examine factors

like this within a randomized trial, the analyses and interpretation become more

complex. Prior hormone use was not randomized and so other factors associated

with hormone use must be considered when analyzing this relationship. Though

there appears to be some relation between prior hormone use and breast cancer,

WHI researchers will be examining this in more detail to gain confidence in

their interpretation.

12. What type of hormone treatment did women in the E+P study take?

Answer: Women randomized (assigned by chance) to active hormones were taking

one tablet containing conjugated equine estrogens (0.625 mg) and

medroxyprogesterone acetate (2.5 mg) each day (PremproT). When WHI first began,

this was the most commonly prescribed menopausal hormonal therapy in the United

States for women with a uterus.

13. Is there an increased risk of breast cancer and abnormal mammograms in

women taking estrogen alone (without progestin) or other E+P formulas?

Answer: The current report addresses only the issue of E+P use in the form of

pills. Final results from the ongoing Estrogen-Alone (E-Alone) study are unknown

at this time. Importantly, the WHI investigators have been told that, as of May

31, 2002, no increase in breast cancer has been seen in the E-alone WHI trial.

Participants in the E-Alone study are asked to continue to take their study

pills and to come for their regular clinic visits. The National Heart, Lung, and

Blood Institute, which oversees WHI, continues to review the study for women

receiving E-Alone, and they will provide investigators and participants with any

new information about the study that might affect their participation

This information has been superceded by the 2004 Hormone Program

Update.<http://www.whi.org/updates/update_hrt2004.php>

14. Should I discuss this information with my healthcare provider?

Answer: Yes. Your healthcare provider may read the scientific paper in the

June 25, 2003 issue of JAMA, or you may direct your provider to this web site.

Your provider may also want to speak with your local WHI Principal Investigator

about these results.

15. If I have an abnormal mammogram now, and have taken (or I still take) E+P,

what should I do?

Answer: Talk with your healthcare provider about your individual situation in

light of the WHI results.

Additional breast imaging tests may help in evaluating women with abnormal

mammograms, such as a nuclear medicine test (scintimammography) or Magnetic

Resonance Imaging (MRI); your mammography provider should have information about

these tests. However, no approach has been evaluated for women with abnormal

mammograms related to E+P use.

16. Was the effect of E+P on breast cancer different in women who had used

oral contraceptives in the past?

Answer: The analyses done so far do not suggest that use of oral

contraceptives had any important influence on the breast cancer findings. Less

than half of the women in this study had ever used oral contraceptives and the

length of use was often relatively short (less than 5 years). With the small

number of breast cancer cases that occurred in these women, these data do not

provide a very clear answer to this question.

17. I am taking prescription hormones. What should I do?

Answer: Talk with your healthcare provider about your individual risk profile

and the hormones you are currently taking in light of the WHI results.

source: http://www.whi.org/faq/faq_bc.php<http://www.whi.org/faq/faq_bc.php>

/Painful breasts

I would advise against progesterone if you are a post menopausal woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

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My daughter had that and she told me that she felt better when she didn't eat

bread. Dauphine999

and Irwin <familyirwin@...> wrote: Hi Joy,

Thank you for the email. How much of each do you take? How long did it take

before you noticed a difference?

:o)

Thanks!!

joy <jwalker8869@...> wrote:

,

I have the same problem along with being big in that area and my

ob/gyn suggested evening primrose with vitamin E and it works great

for me.-it even worked on the cramping,headaches and bloating..

-- In hypothyroidism , " Dusty " <dusty@...> wrote:

>

> I would advise against progesterone if you are a post menopausal

woman.

> Progsterone/Progestins are the reason the Women's Health Iniative on

> combined estrogens and progestins was cancelled, due to its

contributing to

> breast cancer increases. The estrogen alone study continued

because it did

> not increase the risk of breast cancer.

>

> There are some excellent books on hormones by Dr.

Vliet. Before

> you take the word of anyone on this list (mine included) avail

yourself of

> some of this reading material. There are also studies posted on

MEDSCAPE

> (you join, but no fee) and other medical sites.

>

> Dusty

>

>

>

> Re: Re: Anyone with weight gain have

Liposuction?

>

>

>

>

> iodine and progesterone.

> seriously, iodine/iodide works miracles ( that's why we are warned

not to

> take it)

> gracia

>

> Hi Sam,

> Since you mentioned it, about Fibrocystic Breast Disease: I noticed

that my

> boobs hurt like 2 weeks before my period, and this just started

since taking

> Armour, 6 months. Do you know what to do to stop that??

> Thanks!!

>

>

> Sam <k9gangopenaccess (DOT) <mailto:k9gang%40openaccess.org> org> wrote:

> It's not just that I have lost 2 parts of my endocrine system and

> started with a clean slate. There was damage done and severe iodine

> deficiency - fibrocystic breast disease, osteoporosis, DNA and NIS

> damage from the RAI and stuff like that. I was sort of ok just

> without ovaries/uterus, but the bottom dropped out when my healthy

> thyroid was ablated.

>

> Yea, I wish it was just " starting with a clean slate " ...it would

have

> been way easier to climb out of that pit of doom I was lolling in

for

> so long. :-O

>

> Sam :-D

>

>

> > >

> > > I don't think it's so much what you're dosing for, as it

> is " how " .

> > You

> > > could dose hypothyroidism by using cocaine and probably feel

> pretty

> > > good... For a while. In your case you're using a product that

> treats

> > > the underlying disease, so it works. At least for you. So you

> > aren't

> > > JUST treating symptoms; you're addressing the real problem.

> > >

> > > Note I said it has it's limitations; I didn't say it wouldn't

> work.

> > >

> > >

> >

> >

> >

> >

> >

> >

> > ---------------------------------

> > Be a better friend, newshound, and know-it-all with

Mobile.

> Try it now.

> >

> >

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Thanks Nancie,

I will look into this as well. I know I have read that progesterone cream

helps a lot with correcting underlying estrogen dominance, but I get fearful

with adding hormones (because I just don't know how to weed through all of the

stuff.)

Thanks again,

Nancie Barnett <deifspirit@...> wrote:

actually that is not entirely correct.

the study was terminated early because the Combined therapy of both estrogen and

progesterone was seen to increase the risk of breast cancer. we do NOT have any

info on whether progesterone ALONe causes breast cancer- because there has NEVER

been a study targeting it that.

nancie

here is the first source:

Does postmenopausal hormone treatment increase the risk of breast cancer?

Women who use postmenopausal hormone

treatment<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormonescfm#1>

have a higher risk for breast cancer compared with women who do not use hormone

treatment. In the past, hormone treatment used

estrogen<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm#1>

alone and the effects of this treatment have been studied more extensively.

These early studies saw breast cancer risk increase the longer the length of the

estrogen treatment. Breast cancer risk among women who used hormone treatment,

increased about 2% for each year of use compared to women who did not use

hormones. When hormone treatment is stopped, risk falls to previous levels over

a period of five years. Today, most women who receive postmenopausal hormone

treatment use estrogen combined with

progesterone<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm\

#1>. A number of recent studies indicate a higher risk of breast cancer is

associated with this form of hormone treatment. These studies found that

estrogen with progesterone treatment increased breast cancer risk by 6% to 8%

for each year of use. Confirming these results, a large clinical trial examining

estrogen with progesterone treatment in healthy women, the Women's Health

Initiative, was recently ended prematurely because of an association of

excessive breast cancer risk with this treatment. Trials of this type are the

'gold standard' for examining drug effects and this early termination result

raises strong concern about the use of estrogen with progesterone as a

beneficial treatment for healthy women after menopause.

source:

http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm<http://envir\

ocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm>

__________________________________________________________

Estrogen plus Progestin Effects on Breast Cancer and Mammograms

June 2003

a.. Frequently asked questions<http://www.whi.org/faq/faq_bc.php>

b.. Abstract of scientific paper in

JAMA<http://jama.ama-assn.org/cgi/content/abstract/289/24/3243>

Findings Summary

WHI study findings on the risk of breast cancer in women taking combined

estrogen plus progestin (E+P) were published in the July 2002 issue of the

Journal of the American Medical Association (JAMA). The E+P study continues to

be analyzed. Updated results (June 25 issue of JAMA) include data on additional

breast cancer cases, their characteristics, and mammogram results for women in

the study.

The 2002 report showed that more women taking E+P developed breast cancer than

those taking placebo (inactive) pills. This updated analysis shows that after an

average of 5.6 years, 245 of the 8,506 E+P women and 185 of the 8,102 women on

placebo developed breast cancer. Of the total cancers, 349 cases were invasive,

a type of breast cancer with a greater chance of spreading to other parts of the

body. The conclusions below are based on the invasive breast cancer group.

a.. The increased risk of breast cancer due to E+P was eight additional cases of

breast cancer for every 10,000 women over one year

b.. Overall, there was a 24% increase in the risk for breast cancer due to E+P

The breast cancers in the E+P group had similar characteristics (looked the same

under a microscope) to those in the placebo group. However, the tumors in the

E+P group tended to be larger and more advanced (had spread to the lymph nodes

or elsewhere in the body). A more advanced stage is usually associated with

poorer outcome. At this time, no direct statements can be made about the

prognosis of the breast cancer found in women taking E+P until more follow-up

information is collected.

After even one year, quite a few more women had abnormal mammograms in the E+P

group (9.4%) compared to the placebo group (5.4%); this pattern continued until

the study ended. An abnormal mammogram is a breast X-ray that results in a

recommendation for additional medical evaluation (most often, a shorter time

between mammograms, but sometimes, a breast biopsy or other tests). Although we

have known from other studies that E+P use increases the density of breast

tissue on mammograms, the increase in abnormal mammograms with E+P use seen in

this study is a new finding.

Further WHI studies are being done to learn what happens to breast cancer rates

and mammograms after E+P use is stopped.

source:

http://www.whi.org/findings/ht/eplusp_bc.php<http://www.whi.org/findings/ht/eplu\

sp_bc.php>

__________________________________________________________

Frequently Asked Questions about Estrogen plus Progestin and Breast Cancer

These questions and answers supplement the June 25, 2003 JAMA publication on E+P

and breast cancer.

1.. What were the main findings from the estrogen plus progestin and breast

cancer analyses?<http://www.whi.org/faq/faq_bc.php#1>

2.. What is the increased risk for women taking E+P for breast

cancer?<http://www.whi.org/faq/faq_bc.php#2>

3.. What were the main findings about E+P and

mammography?<http://www.whi.org/faq/faq_bc.php#3>

4.. What are the conclusions from these

findings?<http://www.whi.org/faq/faq_bc.php#4>

5.. What is breast cancer?<http://www.whi.org/faq/faq_bc.php#5>

6.. What is in situ breast cancer?<http://www.whi.org/faq/faq_bc.php#6>

7.. What is invasive breast cancer?<http://www.whi.org/faq/faq_bc.php#7>

8.. What is a mammogram?<http://www.whi.org/faq/faq_bc.php#8>

9.. What is an abnormal mammogram?<http://www.whi.org/faq/faq_bc.php#9>

10.. What happens to breast cancer risk and the frequency of abnormal mammograms

after E+P use is discontinued?<http://www.whi.org/faq/faq_bc.php#10>

11.. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI

study?<http://www.whi.org/faq/faq_bc.php#11>

12.. What type of hormone treatment did women in the E+P study

take?<http://www.whi.org/faq/faq_bc.php#12>

13.. Is there an increased risk of breast cancer and abnormal mammograms in

women taking estrogen alone (without progestin) or other E+P

formulas?<http://www.whi.org/faq/faq_bc.php#13>

14.. Should I discuss this information with my healthcare provider?

<http://www.whi.org/faq/faq_bc.php#14>

15.. If I have an abnormal mammogram now, and have taken (or I still take) E+P,

what should I do?<http://www.whi.org/faq/faq_bc.php#15>

16.. Was the effect of E+P on breast cancer different in women who had used oral

contraceptives in the past?<http://www.whi.org/faq/faq_bc.php#16>

17.. I am taking prescription hormones. What should I

do?<http://www.whi.org/faq/faq_bc.php#17>

1. What were the main findings from the estrogen plus progestin and breast

cancer analyses?

Answer: More women who took estrogen plus progestin (E+P) developed breast

cancer than women taking placebo (inactive pills). The cancer cases found in

women taking E+P had similar characteristics (looked the same under the

microscope), but the tumors were larger and had spread more throughout the body

than those in the placebo group.

2. What is the increased risk for women taking E+P for breast cancer?

Answer: A woman is more likely to develop breast cancer if she is taking E+P.

For every 10,000 women taking estrogen plus progestin, 41 women each year will

develop breast cancer as compared to 33 women per year who would develop breast

cancer while taking placebo. While this difference in risk is important, the

overall risk to an individual woman remains small.

The breast cancer cases which developed in women taking E+P were larger and more

advanced; about 25% had spread to lymph nodes or elsewhere in the body, compared

to 16% of women on placebo.

3. What were the main findings about E+P and mammography?

Answer: After just one year of taking E+P, a woman was much more likely to have

an abnormal mammogram compared to a woman taking placebo. In the E+P group, 9.4%

of women had an abnormal mammogram after one year, compared with 5.4% in the

placebo group. The increased rate of abnormal mammograms continued until the

study ended.

A woman's chance of having an abnormal mammogram resulting from E+P use was

about 1 in 25 for one year's use, and about 1 in 10 after 5½ years of use.

4. What are the conclusions from these findings?

Answer: Use of E+P increases the rate of more advanced breast cancer compared

with placebo and substantially increases the rate of abnormal mammograms. As a

result, abnormal mammograms in women receiving menopausal hormone therapy need

closer attention. The increased frequency of abnormal mammograms is a newly

found negative effect of even short-term E+P use. These findings should be

considered in the discussion of risks and benefits for women considering E+P use

for any amount of time.

5. What is breast cancer?

Answer: Breast cancer is a disease in which abnormal breast cells divide without

control and can spread to other parts of the body.

6. What is in situ breast cancer?

Answer: In situ is an early cancer where abnormal breast cells are confined to

the ducts or lobules in the breast. There are two forms, ductal carcinoma (DCIS)

and lobular carcinoma in situ (LCIS).

7. What is invasive breast cancer?

Answer: Invasive breast cancer involves abnormal breast cells which have spread

outside the breast duct or lobule where they began. This type of cancer accounts

for 80% of breast cancer cases. When the term " breast cancer " is used, it

generally means invasive breast cancer.

8. What is a mammogram?

Answer: A mammogram is an X-ray of the breast.

9. What is an abnormal mammogram?

Answer: An abnormal mammogram is a breast X-ray with characteristics leading the

radiologist to recommend some additional testing, either another mammogram

within 6 months, or occasionally other procedures. A recommendation to have a

repeat mammogram seldom results in a cancer diagnosis. Some characteristics seen

on a mammogram are suspicious enough to indicate that additional tests (like a

biopsy) are needed. These tests are more likely to result in a cancer diagnosis.

An abnormal mammogram report is not the same as an incomplete mammogram report.

Quite often, a woman may be called back after a mammogram to have additional

X-rays taken, have an additional non-invasive procedure performed (such as an

ultrasound) or be asked to provide earlier mammograms for comparisons. These

evaluations are needed to better understand the current mammogram, and by

themselves do not signal an abnormal mammogram.

10. What happens to breast cancer risk and the frequency of abnormal mammograms

after E+P use is discontinued?

Answer: WHI researchers will be looking at these issues in future analyses, so

information is not yet available. Observational studies have suggested that

breast cancer risk will diminish over time.

To date, no studies have looked at what effect stopping E+P use has on abnormal

mammograms. There have been some studies about breast density change and

menopausal hormone therapy use. Increased mammogram density has been linked to

E+P use. In observational studies, mammogram density has been shown to decrease

when E+P use is stopped. It remains to be seen whether abnormal mammograms will

change when E+P use is stopped.

11. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI study?

Answer: There was a trend for somewhat higher risk in women in the E+P group who

reported prior menopausal hormone use. Whenever researchers examine factors like

this within a randomized trial, the analyses and interpretation become more

complex. Prior hormone use was not randomized and so other factors associated

with hormone use must be considered when analyzing this relationship. Though

there appears to be some relation between prior hormone use and breast cancer,

WHI researchers will be examining this in more detail to gain confidence in

their interpretation.

12. What type of hormone treatment did women in the E+P study take?

Answer: Women randomized (assigned by chance) to active hormones were taking one

tablet containing conjugated equine estrogens (0.625 mg) and medroxyprogesterone

acetate (2.5 mg) each day (PremproT). When WHI first began, this was the most

commonly prescribed menopausal hormonal therapy in the United States for women

with a uterus.

13. Is there an increased risk of breast cancer and abnormal mammograms in women

taking estrogen alone (without progestin) or other E+P formulas?

Answer: The current report addresses only the issue of E+P use in the form of

pills. Final results from the ongoing Estrogen-Alone (E-Alone) study are unknown

at this time. Importantly, the WHI investigators have been told that, as of May

31, 2002, no increase in breast cancer has been seen in the E-alone WHI trial.

Participants in the E-Alone study are asked to continue to take their study

pills and to come for their regular clinic visits. The National Heart, Lung, and

Blood Institute, which oversees WHI, continues to review the study for women

receiving E-Alone, and they will provide investigators and participants with any

new information about the study that might affect their participation

This information has been superceded by the 2004 Hormone Program

Update.<http://www.whi.org/updates/update_hrt2004.php>

14. Should I discuss this information with my healthcare provider?

Answer: Yes. Your healthcare provider may read the scientific paper in the June

25, 2003 issue of JAMA, or you may direct your provider to this web site. Your

provider may also want to speak with your local WHI Principal Investigator about

these results.

15. If I have an abnormal mammogram now, and have taken (or I still take) E+P,

what should I do?

Answer: Talk with your healthcare provider about your individual situation in

light of the WHI results.

Additional breast imaging tests may help in evaluating women with abnormal

mammograms, such as a nuclear medicine test (scintimammography) or Magnetic

Resonance Imaging (MRI); your mammography provider should have information about

these tests. However, no approach has been evaluated for women with abnormal

mammograms related to E+P use.

16. Was the effect of E+P on breast cancer different in women who had used oral

contraceptives in the past?

Answer: The analyses done so far do not suggest that use of oral contraceptives

had any important influence on the breast cancer findings. Less than half of the

women in this study had ever used oral contraceptives and the length of use was

often relatively short (less than 5 years). With the small number of breast

cancer cases that occurred in these women, these data do not provide a very

clear answer to this question.

17. I am taking prescription hormones. What should I do?

Answer: Talk with your healthcare provider about your individual risk profile

and the hormones you are currently taking in light of the WHI results.

source: http://www.whi.org/faq/faq_bc.php<http://www.whi.org/faq/faq_bc.php>

/Painful breasts

I would advise against progesterone if you are a post menopausal woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

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michelle,

just caught your message while reading this post.. the brand I use is Nature's

Resource Evening Primrose with Vitamin E, 500 mg extract softgels. I take the

max amount..I usually shy away from pushing products but it worked so well for

me I just had to tell you.. I also stay clear of caffeine the two before and

during.. I'm suppose to stay clear 24/7 but when you are HypO you want your

caffeine.

take care..

joy

Re: Re: Anyone with weight gain have

Liposuction?

>

>

>

>

> iodine and progesterone.

> seriously, iodine/iodide works miracles ( that's why we are warned

not to

> take it)

> gracia

>

> Hi Sam,

> Since you mentioned it, about Fibrocystic Breast Disease: I noticed

that my

> boobs hurt like 2 weeks before my period, and this just started

since taking

> Armour, 6 months. Do you know what to do to stop that??

> Thanks!!

>

>

> Sam <k9gangopenaccess (DOT) <mailto:k9gang% 40openaccess. org> org> wrote:

> It's not just that I have lost 2 parts of my endocrine system and

> started with a clean slate. There was damage done and severe iodine

> deficiency - fibrocystic breast disease, osteoporosis, DNA and NIS

> damage from the RAI and stuff like that. I was sort of ok just

> without ovaries/uterus, but the bottom dropped out when my healthy

> thyroid was ablated.

>

> Yea, I wish it was just " starting with a clean slate " ...it would

have

> been way easier to climb out of that pit of doom I was lolling in

for

> so long. :-O

>

> Sam :-D

>

>

> > >

> > > I don't think it's so much what you're dosing for, as it

> is " how " .

> > You

> > > could dose hypothyroidism by using cocaine and probably feel

> pretty

> > > good... For a while. In your case you're using a product that

> treats

> > > the underlying disease, so it works. At least for you. So you

> > aren't

> > > JUST treating symptoms; you're addressing the real problem.

> > >

> > > Note I said it has it's limitations; I didn't say it wouldn't

> work.

> > >

> > >

> >

> >

> >

> >

> >

> >

> > ------------ --------- --------- ---

> > Be a better friend, newshound, and know-it-all with

Mobile.

> Try it now.

> >

> >

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If there is prementrual swelling of breast tissue, you might want to try 20 mgs

of furosemide

with a 99mgs potassium pill for the few days before your period. You'll need a

prescription. I

know there are natural water pills, but I don't know how effective they are,

honestly.

Roni

and Irwin <familyirwin@...> wrote:

Thanks Nancie,

I will look into this as well. I know I have read that progesterone cream helps

a lot with correcting underlying estrogen dominance, but I get fearful with

adding hormones (because I just don't know how to weed through all of the

stuff.)

Thanks again,

Nancie Barnett <deifspirit@...> wrote:

actually that is not entirely correct.

the study was terminated early because the Combined therapy of both estrogen and

progesterone was seen to increase the risk of breast cancer. we do NOT have any

info on whether progesterone ALONe causes breast cancer- because there has NEVER

been a study targeting it that.

nancie

here is the first source:

Does postmenopausal hormone treatment increase the risk of breast cancer?

Women who use postmenopausal hormone

treatment<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormonescfm#1>

have a higher risk for breast cancer compared with women who do not use hormone

treatment. In the past, hormone treatment used

estrogen<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm#1>

alone and the effects of this treatment have been studied more extensively.

These early studies saw breast cancer risk increase the longer the length of the

estrogen treatment. Breast cancer risk among women who used hormone treatment,

increased about 2% for each year of use compared to women who did not use

hormones. When hormone treatment is stopped, risk falls to previous levels over

a period of five years. Today, most women who receive postmenopausal hormone

treatment use estrogen combined with

progesterone<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm\

#1>. A number of recent studies indicate a higher risk of breast cancer is

associated with this form of hormone treatment. These studies found that

estrogen with progesterone treatment increased breast cancer risk by 6% to 8%

for each year of use. Confirming these results, a large clinical trial examining

estrogen with progesterone treatment in healthy women, the Women's Health

Initiative, was recently ended prematurely because of an association of

excessive breast cancer risk with this treatment. Trials of this type are the

'gold standard' for examining drug effects and this early termination result

raises strong concern about the use of estrogen with progesterone as a

beneficial treatment for healthy women after menopause.

source:

http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm<http://envir\

ocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm>

__________________________________________________________

Estrogen plus Progestin Effects on Breast Cancer and Mammograms

June 2003

a.. Frequently asked questions<http://www.whi.org/faq/faq_bc.php>

b.. Abstract of scientific paper in

JAMA<http://jama.ama-assn.org/cgi/content/abstract/289/24/3243>

Findings Summary

WHI study findings on the risk of breast cancer in women taking combined

estrogen plus progestin (E+P) were published in the July 2002 issue of the

Journal of the American Medical Association (JAMA). The E+P study continues to

be analyzed. Updated results (June 25 issue of JAMA) include data on additional

breast cancer cases, their characteristics, and mammogram results for women in

the study.

The 2002 report showed that more women taking E+P developed breast cancer than

those taking placebo (inactive) pills. This updated analysis shows that after an

average of 5.6 years, 245 of the 8,506 E+P women and 185 of the 8,102 women on

placebo developed breast cancer. Of the total cancers, 349 cases were invasive,

a type of breast cancer with a greater chance of spreading to other parts of the

body. The conclusions below are based on the invasive breast cancer group.

a.. The increased risk of breast cancer due to E+P was eight additional cases of

breast cancer for every 10,000 women over one year

b.. Overall, there was a 24% increase in the risk for breast cancer due to E+P

The breast cancers in the E+P group had similar characteristics (looked the same

under a microscope) to those in the placebo group. However, the tumors in the

E+P group tended to be larger and more advanced (had spread to the lymph nodes

or elsewhere in the body). A more advanced stage is usually associated with

poorer outcome. At this time, no direct statements can be made about the

prognosis of the breast cancer found in women taking E+P until more follow-up

information is collected.

After even one year, quite a few more women had abnormal mammograms in the E+P

group (9.4%) compared to the placebo group (5.4%); this pattern continued until

the study ended. An abnormal mammogram is a breast X-ray that results in a

recommendation for additional medical evaluation (most often, a shorter time

between mammograms, but sometimes, a breast biopsy or other tests). Although we

have known from other studies that E+P use increases the density of breast

tissue on mammograms, the increase in abnormal mammograms with E+P use seen in

this study is a new finding.

Further WHI studies are being done to learn what happens to breast cancer rates

and mammograms after E+P use is stopped.

source:

http://www.whi.org/findings/ht/eplusp_bc.php<http://www.whi.org/findings/ht/eplu\

sp_bc.php>

__________________________________________________________

Frequently Asked Questions about Estrogen plus Progestin and Breast Cancer

These questions and answers supplement the June 25, 2003 JAMA publication on E+P

and breast cancer.

1.. What were the main findings from the estrogen plus progestin and breast

cancer analyses?<http://www.whi.org/faq/faq_bc.php#1>

2.. What is the increased risk for women taking E+P for breast

cancer?<http://www.whi.org/faq/faq_bc.php#2>

3.. What were the main findings about E+P and

mammography?<http://www.whi.org/faq/faq_bc.php#3>

4.. What are the conclusions from these

findings?<http://www.whi.org/faq/faq_bc.php#4>

5.. What is breast cancer?<http://www.whi.org/faq/faq_bc.php#5>

6.. What is in situ breast cancer?<http://www.whi.org/faq/faq_bc.php#6>

7.. What is invasive breast cancer?<http://www.whi.org/faq/faq_bc.php#7>

8.. What is a mammogram?<http://www.whi.org/faq/faq_bc.php#8>

9.. What is an abnormal mammogram?<http://www.whi.org/faq/faq_bc.php#9>

10.. What happens to breast cancer risk and the frequency of abnormal mammograms

after E+P use is discontinued?<http://www.whi.org/faq/faq_bc.php#10>

11.. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI

study?<http://www.whi.org/faq/faq_bc.php#11>

12.. What type of hormone treatment did women in the E+P study

take?<http://www.whi.org/faq/faq_bc.php#12>

13.. Is there an increased risk of breast cancer and abnormal mammograms in

women taking estrogen alone (without progestin) or other E+P

formulas?<http://www.whi.org/faq/faq_bc.php#13>

14.. Should I discuss this information with my healthcare provider?

<http://www.whi.org/faq/faq_bc.php#14>

15.. If I have an abnormal mammogram now, and have taken (or I still take) E+P,

what should I do?<http://www.whi.org/faq/faq_bc.php#15>

16.. Was the effect of E+P on breast cancer different in women who had used oral

contraceptives in the past?<http://www.whi.org/faq/faq_bc.php#16>

17.. I am taking prescription hormones. What should I

do?<http://www.whi.org/faq/faq_bc.php#17>

1. What were the main findings from the estrogen plus progestin and breast

cancer analyses?

Answer: More women who took estrogen plus progestin (E+P) developed breast

cancer than women taking placebo (inactive pills). The cancer cases found in

women taking E+P had similar characteristics (looked the same under the

microscope), but the tumors were larger and had spread more throughout the body

than those in the placebo group.

2. What is the increased risk for women taking E+P for breast cancer?

Answer: A woman is more likely to develop breast cancer if she is taking E+P.

For every 10,000 women taking estrogen plus progestin, 41 women each year will

develop breast cancer as compared to 33 women per year who would develop breast

cancer while taking placebo. While this difference in risk is important, the

overall risk to an individual woman remains small.

The breast cancer cases which developed in women taking E+P were larger and more

advanced; about 25% had spread to lymph nodes or elsewhere in the body, compared

to 16% of women on placebo.

3. What were the main findings about E+P and mammography?

Answer: After just one year of taking E+P, a woman was much more likely to have

an abnormal mammogram compared to a woman taking placebo. In the E+P group, 9.4%

of women had an abnormal mammogram after one year, compared with 5.4% in the

placebo group. The increased rate of abnormal mammograms continued until the

study ended.

A woman's chance of having an abnormal mammogram resulting from E+P use was

about 1 in 25 for one year's use, and about 1 in 10 after 5½ years of use.

4. What are the conclusions from these findings?

Answer: Use of E+P increases the rate of more advanced breast cancer compared

with placebo and substantially increases the rate of abnormal mammograms. As a

result, abnormal mammograms in women receiving menopausal hormone therapy need

closer attention. The increased frequency of abnormal mammograms is a newly

found negative effect of even short-term E+P use. These findings should be

considered in the discussion of risks and benefits for women considering E+P use

for any amount of time.

5. What is breast cancer?

Answer: Breast cancer is a disease in which abnormal breast cells divide without

control and can spread to other parts of the body.

6. What is in situ breast cancer?

Answer: In situ is an early cancer where abnormal breast cells are confined to

the ducts or lobules in the breast. There are two forms, ductal carcinoma (DCIS)

and lobular carcinoma in situ (LCIS).

7. What is invasive breast cancer?

Answer: Invasive breast cancer involves abnormal breast cells which have spread

outside the breast duct or lobule where they began. This type of cancer accounts

for 80% of breast cancer cases. When the term " breast cancer " is used, it

generally means invasive breast cancer.

8. What is a mammogram?

Answer: A mammogram is an X-ray of the breast.

9. What is an abnormal mammogram?

Answer: An abnormal mammogram is a breast X-ray with characteristics leading the

radiologist to recommend some additional testing, either another mammogram

within 6 months, or occasionally other procedures. A recommendation to have a

repeat mammogram seldom results in a cancer diagnosis. Some characteristics seen

on a mammogram are suspicious enough to indicate that additional tests (like a

biopsy) are needed. These tests are more likely to result in a cancer diagnosis.

An abnormal mammogram report is not the same as an incomplete mammogram report.

Quite often, a woman may be called back after a mammogram to have additional

X-rays taken, have an additional non-invasive procedure performed (such as an

ultrasound) or be asked to provide earlier mammograms for comparisons. These

evaluations are needed to better understand the current mammogram, and by

themselves do not signal an abnormal mammogram.

10. What happens to breast cancer risk and the frequency of abnormal mammograms

after E+P use is discontinued?

Answer: WHI researchers will be looking at these issues in future analyses, so

information is not yet available. Observational studies have suggested that

breast cancer risk will diminish over time.

To date, no studies have looked at what effect stopping E+P use has on abnormal

mammograms. There have been some studies about breast density change and

menopausal hormone therapy use. Increased mammogram density has been linked to

E+P use. In observational studies, mammogram density has been shown to decrease

when E+P use is stopped. It remains to be seen whether abnormal mammograms will

change when E+P use is stopped.

11. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI study?

Answer: There was a trend for somewhat higher risk in women in the E+P group who

reported prior menopausal hormone use. Whenever researchers examine factors like

this within a randomized trial, the analyses and interpretation become more

complex. Prior hormone use was not randomized and so other factors associated

with hormone use must be considered when analyzing this relationship. Though

there appears to be some relation between prior hormone use and breast cancer,

WHI researchers will be examining this in more detail to gain confidence in

their interpretation.

12. What type of hormone treatment did women in the E+P study take?

Answer: Women randomized (assigned by chance) to active hormones were taking one

tablet containing conjugated equine estrogens (0.625 mg) and medroxyprogesterone

acetate (2.5 mg) each day (PremproT). When WHI first began, this was the most

commonly prescribed menopausal hormonal therapy in the United States for women

with a uterus.

13. Is there an increased risk of breast cancer and abnormal mammograms in women

taking estrogen alone (without progestin) or other E+P formulas?

Answer: The current report addresses only the issue of E+P use in the form of

pills. Final results from the ongoing Estrogen-Alone (E-Alone) study are unknown

at this time. Importantly, the WHI investigators have been told that, as of May

31, 2002, no increase in breast cancer has been seen in the E-alone WHI trial.

Participants in the E-Alone study are asked to continue to take their study

pills and to come for their regular clinic visits. The National Heart, Lung, and

Blood Institute, which oversees WHI, continues to review the study for women

receiving E-Alone, and they will provide investigators and participants with any

new information about the study that might affect their participation

This information has been superceded by the 2004 Hormone Program

Update.<http://www.whi.org/updates/update_hrt2004.php>

14. Should I discuss this information with my healthcare provider?

Answer: Yes. Your healthcare provider may read the scientific paper in the June

25, 2003 issue of JAMA, or you may direct your provider to this web site. Your

provider may also want to speak with your local WHI Principal Investigator about

these results.

15. If I have an abnormal mammogram now, and have taken (or I still take) E+P,

what should I do?

Answer: Talk with your healthcare provider about your individual situation in

light of the WHI results.

Additional breast imaging tests may help in evaluating women with abnormal

mammograms, such as a nuclear medicine test (scintimammography) or Magnetic

Resonance Imaging (MRI); your mammography provider should have information about

these tests. However, no approach has been evaluated for women with abnormal

mammograms related to E+P use.

16. Was the effect of E+P on breast cancer different in women who had used oral

contraceptives in the past?

Answer: The analyses done so far do not suggest that use of oral contraceptives

had any important influence on the breast cancer findings. Less than half of the

women in this study had ever used oral contraceptives and the length of use was

often relatively short (less than 5 years). With the small number of breast

cancer cases that occurred in these women, these data do not provide a very

clear answer to this question.

17. I am taking prescription hormones. What should I do?

Answer: Talk with your healthcare provider about your individual risk profile

and the hormones you are currently taking in light of the WHI results.

source: http://www.whi.org/faq/faq_bc.php<http://www.whi.org/faq/faq_bc.php>

/Painful breasts

I would advise against progesterone if you are a post menopausal woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

Recent Activity

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Gracia -

This is a dangerous statement. We do NOT know whether or not progesterone

is dangerous - as it has never been studied. There is absolutely no proof

of your claim.

Re: /Painful breasts

this study used PROGESTINS which we know are dangerous,

not progesterone.

Gracia

actually that is not entirely correct.

the study was terminated early because the Combined therapy of both estrogen

and progesterone was seen to increase the risk of breast cancer. we do NOT

have any info on whether progesterone ALONe causes breast cancer- because

there has NEVER been a study targeting it that.

nancie

here is the first source:

Does postmenopausal hormone treatment increase the risk of breast cancer?

Women who use postmenopausal hormone treatment<http://envirocancer

<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormonescfm#1>

..cornell.edu/Factsheet/general/fs40.hormonescfm#1> have a higher risk for

breast cancer compared with women who do not use hormone treatment. In the

past, hormone treatment used estrogen<http://envirocancer

<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm#1>

..cornell.edu/Factsheet/general/fs40.hormones.cfm#1> alone and the effects of

this treatment have been studied more extensively. These early studies saw

breast cancer risk increase the longer the length of the estrogen treatment.

Breast cancer risk among women who used hormone treatment, increased about

2% for each year of use compared to women who did not use hormones. When

hormone treatment is stopped, risk falls to previous levels over a period of

five years. Today, most women who receive postmenopausal hormone treatment

use estrogen combined with progesterone<http://envirocancer

<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm#1>

..cornell.edu/Factsheet/general/fs40.hormones.cfm#1>. A number of recent

studies indicate a higher risk of breast cancer is associated with this form

of hormone treatment. These studies found that estrogen with progesterone

treatment increased breast cancer risk by 6% to 8% for each year of use.

Confirming these results, a large clinical trial examining estrogen with

progesterone treatment in healthy women, the Women's Health Initiative, was

recently ended prematurely because of an association of excessive breast

cancer risk with this treatment. Trials of this type are the 'gold standard'

for examining drug effects and this early termination result raises strong

concern about the use of estrogen with progesterone as a beneficial

treatment for healthy women after menopause.

source: http://envirocancer

<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm>

..cornell.edu/Factsheet/general/fs40.hormones.cfm<http://envirocancer

<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm>

..cornell.edu/Factsheet/general/fs40.hormones.cfm>

__________________________________________________________

Estrogen plus Progestin Effects on Breast Cancer and Mammograms

June 2003

a.. Frequently asked questions<http://www.whi.

<http://www.whi.org/faq/faq_bc.php> org/faq/faq_bc.php>

b.. Abstract of scientific paper in JAMA<http://jama.

<http://jama.ama-assn.org/cgi/content/abstract/289/24/3243>

ama-assn.org/cgi/content/abstract/289/24/3243>

Findings Summary

WHI study findings on the risk of breast cancer in women taking combined

estrogen plus progestin (E+P) were published in the July 2002 issue of the

Journal of the American Medical Association (JAMA). The E+P study continues

to be analyzed. Updated results (June 25 issue of JAMA) include data on

additional breast cancer cases, their characteristics, and mammogram results

for women in the study.

The 2002 report showed that more women taking E+P developed breast cancer

than those taking placebo (inactive) pills. This updated analysis shows that

after an average of 5.6 years, 245 of the 8,506 E+P women and 185 of the

8,102 women on placebo developed breast cancer. Of the total cancers, 349

cases were invasive, a type of breast cancer with a greater chance of

spreading to other parts of the body. The conclusions below are based on the

invasive breast cancer group.

a.. The increased risk of breast cancer due to E+P was eight additional

cases of breast cancer for every 10,000 women over one year

b.. Overall, there was a 24% increase in the risk for breast cancer due to

E+P

The breast cancers in the E+P group had similar characteristics (looked the

same under a microscope) to those in the placebo group. However, the tumors

in the E+P group tended to be larger and more advanced (had spread to the

lymph nodes or elsewhere in the body). A more advanced stage is usually

associated with poorer outcome. At this time, no direct statements can be

made about the prognosis of the breast cancer found in women taking E+P

until more follow-up information is collected.

After even one year, quite a few more women had abnormal mammograms in the

E+P group (9.4%) compared to the placebo group (5.4%); this pattern

continued until the study ended. An abnormal mammogram is a breast X-ray

that results in a recommendation for additional medical evaluation (most

often, a shorter time between mammograms, but sometimes, a breast biopsy or

other tests). Although we have known from other studies that E+P use

increases the density of breast tissue on mammograms, the increase in

abnormal mammograms with E+P use seen in this study is a new finding.

Further WHI studies are being done to learn what happens to breast cancer

rates and mammograms after E+P use is stopped.

source: http://www.whi. <http://www.whi.org/findings/ht/eplusp_bc.php>

org/findings/ht/eplusp_bc.php<http://www.whi.

<http://www.whi.org/findings/ht/eplusp_bc.php>

org/findings/ht/eplusp_bc.php>

__________________________________________________________

Frequently Asked Questions about Estrogen plus Progestin and Breast Cancer

These questions and answers supplement the June 25, 2003 JAMA publication on

E+P and breast cancer.

1.. What were the main findings from the estrogen plus progestin and breast

cancer analyses?<http://www.whi. <http://www.whi.org/faq/faq_bc.php#1>

org/faq/faq_bc.php#1>

2.. What is the increased risk for women taking E+P for breast

cancer?<http://www.whi. <http://www.whi.org/faq/faq_bc.php#2>

org/faq/faq_bc.php#2>

3.. What were the main findings about E+P and mammography?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#3> org/faq/faq_bc.php#3>

4.. What are the conclusions from these findings?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#4> org/faq/faq_bc.php#4>

5.. What is breast cancer?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#5> org/faq/faq_bc.php#5>

6.. What is in situ breast cancer?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#6> org/faq/faq_bc.php#6>

7.. What is invasive breast cancer?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#7> org/faq/faq_bc.php#7>

8.. What is a mammogram?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#8> org/faq/faq_bc.php#8>

9.. What is an abnormal mammogram?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#9> org/faq/faq_bc.php#9>

10.. What happens to breast cancer risk and the frequency of abnormal

mammograms after E+P use is discontinued?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#10> org/faq/faq_bc.php#10>

11.. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI study?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#11> org/faq/faq_bc.php#11>

12.. What type of hormone treatment did women in the E+P study

take?<http://www.whi. <http://www.whi.org/faq/faq_bc.php#12>

org/faq/faq_bc.php#12>

13.. Is there an increased risk of breast cancer and abnormal mammograms in

women taking estrogen alone (without progestin) or other E+P

formulas?<http://www.whi. <http://www.whi.org/faq/faq_bc.php#13>

org/faq/faq_bc.php#13>

14.. Should I discuss this information with my healthcare provider?

<http://www.whi. <http://www.whi.org/faq/faq_bc.php#14>

org/faq/faq_bc.php#14>

15.. If I have an abnormal mammogram now, and have taken (or I still take)

E+P, what should I do?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#15> org/faq/faq_bc.php#15>

16.. Was the effect of E+P on breast cancer different in women who had used

oral contraceptives in the past?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#16> org/faq/faq_bc.php#16>

17.. I am taking prescription hormones. What should I do?<http://www.whi.

<http://www.whi.org/faq/faq_bc.php#17> org/faq/faq_bc.php#17>

1. What were the main findings from the estrogen plus progestin and breast

cancer analyses?

Answer: More women who took estrogen plus progestin (E+P) developed breast

cancer than women taking placebo (inactive pills). The cancer cases found in

women taking E+P had similar characteristics (looked the same under the

microscope), but the tumors were larger and had spread more throughout the

body than those in the placebo group.

2. What is the increased risk for women taking E+P for breast cancer?

Answer: A woman is more likely to develop breast cancer if she is taking

E+P. For every 10,000 women taking estrogen plus progestin, 41 women each

year will develop breast cancer as compared to 33 women per year who would

develop breast cancer while taking placebo. While this difference in risk is

important, the overall risk to an individual woman remains small.

The breast cancer cases which developed in women taking E+P were larger and

more advanced; about 25% had spread to lymph nodes or elsewhere in the body,

compared to 16% of women on placebo.

3. What were the main findings about E+P and mammography?

Answer: After just one year of taking E+P, a woman was much more likely to

have an abnormal mammogram compared to a woman taking placebo. In the E+P

group, 9.4% of women had an abnormal mammogram after one year, compared with

5.4% in the placebo group. The increased rate of abnormal mammograms

continued until the study ended.

A woman's chance of having an abnormal mammogram resulting from E+P use was

about 1 in 25 for one year's use, and about 1 in 10 after 5½ years of use.

4. What are the conclusions from these findings?

Answer: Use of E+P increases the rate of more advanced breast cancer

compared with placebo and substantially increases the rate of abnormal

mammograms. As a result, abnormal mammograms in women receiving menopausal

hormone therapy need closer attention. The increased frequency of abnormal

mammograms is a newly found negative effect of even short-term E+P use.

These findings should be considered in the discussion of risks and benefits

for women considering E+P use for any amount of time.

5. What is breast cancer?

Answer: Breast cancer is a disease in which abnormal breast cells divide

without control and can spread to other parts of the body.

6. What is in situ breast cancer?

Answer: In situ is an early cancer where abnormal breast cells are confined

to the ducts or lobules in the breast. There are two forms, ductal carcinoma

(DCIS) and lobular carcinoma in situ (LCIS).

7. What is invasive breast cancer?

Answer: Invasive breast cancer involves abnormal breast cells which have

spread outside the breast duct or lobule where they began. This type of

cancer accounts for 80% of breast cancer cases. When the term " breast

cancer " is used, it generally means invasive breast cancer.

8. What is a mammogram?

Answer: A mammogram is an X-ray of the breast.

9. What is an abnormal mammogram?

Answer: An abnormal mammogram is a breast X-ray with characteristics leading

the radiologist to recommend some additional testing, either another

mammogram within 6 months, or occasionally other procedures. A

recommendation to have a repeat mammogram seldom results in a cancer

diagnosis. Some characteristics seen on a mammogram are suspicious enough to

indicate that additional tests (like a biopsy) are needed. These tests are

more likely to result in a cancer diagnosis.

An abnormal mammogram report is not the same as an incomplete mammogram

report. Quite often, a woman may be called back after a mammogram to have

additional X-rays taken, have an additional non-invasive procedure performed

(such as an ultrasound) or be asked to provide earlier mammograms for

comparisons. These evaluations are needed to better understand the current

mammogram, and by themselves do not signal an abnormal mammogram.

10. What happens to breast cancer risk and the frequency of abnormal

mammograms after E+P use is discontinued?

Answer: WHI researchers will be looking at these issues in future analyses,

so information is not yet available. Observational studies have suggested

that breast cancer risk will diminish over time.

To date, no studies have looked at what effect stopping E+P use has on

abnormal mammograms. There have been some studies about breast density

change and menopausal hormone therapy use. Increased mammogram density has

been linked to E+P use. In observational studies, mammogram density has been

shown to decrease when E+P use is stopped. It remains to be seen whether

abnormal mammograms will change when E+P use is stopped.

11. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI study?

Answer: There was a trend for somewhat higher risk in women in the E+P group

who reported prior menopausal hormone use. Whenever researchers examine

factors like this within a randomized trial, the analyses and interpretation

become more complex. Prior hormone use was not randomized and so other

factors associated with hormone use must be considered when analyzing this

relationship. Though there appears to be some relation between prior hormone

use and breast cancer, WHI researchers will be examining this in more detail

to gain confidence in their interpretation.

12. What type of hormone treatment did women in the E+P study take?

Answer: Women randomized (assigned by chance) to active hormones were taking

one tablet containing conjugated equine estrogens (0.625 mg) and

medroxyprogesterone acetate (2.5 mg) each day (PremproT). When WHI first

began, this was the most commonly prescribed menopausal hormonal therapy in

the United States for women with a uterus.

13. Is there an increased risk of breast cancer and abnormal mammograms in

women taking estrogen alone (without progestin) or other E+P formulas?

Answer: The current report addresses only the issue of E+P use in the form

of pills. Final results from the ongoing Estrogen-Alone (E-Alone) study are

unknown at this time. Importantly, the WHI investigators have been told

that, as of May 31, 2002, no increase in breast cancer has been seen in the

E-alone WHI trial.

Participants in the E-Alone study are asked to continue to take their study

pills and to come for their regular clinic visits. The National Heart, Lung,

and Blood Institute, which oversees WHI, continues to review the study for

women receiving E-Alone, and they will provide investigators and

participants with any new information about the study that might affect

their participation

This information has been superceded by the 2004 Hormone Program

Update.<http://www.whi. <http://www.whi.org/updates/update_hrt2004.php>

org/updates/update_hrt2004.php>

14. Should I discuss this information with my healthcare provider?

Answer: Yes. Your healthcare provider may read the scientific paper in the

June 25, 2003 issue of JAMA, or you may direct your provider to this web

site. Your provider may also want to speak with your local WHI Principal

Investigator about these results.

15. If I have an abnormal mammogram now, and have taken (or I still take)

E+P, what should I do?

Answer: Talk with your healthcare provider about your individual situation

in light of the WHI results.

Additional breast imaging tests may help in evaluating women with abnormal

mammograms, such as a nuclear medicine test (scintimammography) or Magnetic

Resonance Imaging (MRI); your mammography provider should have information

about these tests. However, no approach has been evaluated for women with

abnormal mammograms related to E+P use.

16. Was the effect of E+P on breast cancer different in women who had used

oral contraceptives in the past?

Answer: The analyses done so far do not suggest that use of oral

contraceptives had any important influence on the breast cancer findings.

Less than half of the women in this study had ever used oral contraceptives

and the length of use was often relatively short (less than 5 years). With

the small number of breast cancer cases that occurred in these women, these

data do not provide a very clear answer to this question.

17. I am taking prescription hormones. What should I do?

Answer: Talk with your healthcare provider about your individual risk

profile and the hormones you are currently taking in light of the WHI

results.

source: http://www.whi. <http://www.whi.org/faq/faq_bc.php>

org/faq/faq_bc.php<http://www.whi. <http://www.whi.org/faq/faq_bc.php>

org/faq/faq_bc.php>

/Painful breasts

I would advise against progesterone if you are a post menopausal woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

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gracia-

if you read the study below- PROGESTERONE IS CITED IN THE STUDY. PROGESTINS ARE

AL LAYMAN'S TERM FOR PROGESTERONE.

Please, do not tell me what the study was about BECAUSE UCLA WAS INVOLVED in

the study when I was in GRADUATE SCHOOL THERE. many of the researches who worked

with the study were from UCLA. Several of my professors in women's health were

involved in the study.

/Painful breasts

I would advise against progesterone if you are a post menopausal woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

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Incorrect Sam. There is no such proof because the studies haven't been done

on bio's alone. How silly and irresponsible of you to make such a claim

when no one actually knows how many women have come down with hormonally

caused cancers while using only bio's.

Dusty

Re: /Painful breasts

Correct in that synthetic sex hormones are bad bad bad news.

WIH study only looked at synthetic sex hormones, not at any of the

bio-identicals. So far the bio-identicals have proven to be safe as

long as they are not abused as in the wiley protocol which

recommended huge overdosages of progesterone and estradiol.

Sam

>

> I would advise against progesterone if you are a post menopausal

woman.

> Progsterone/Progestins are the reason the Women's Health Iniative on

> combined estrogens and progestins was cancelled, due to its

contributing to

> breast cancer increases. The estrogen alone study continued

because it did

> not increase the risk of breast cancer.

>

> There are some excellent books on hormones by Dr.

Vliet. Before

> you take the word of anyone on this list (mine included) avail

yourself of

> some of this reading material. There are also studies posted on

MEDSCAPE

> (you join, but no fee) and other medical sites.

>

> Dusty

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plus PROGESTERONES ARE NOT DANGEROUS IF YOU USE THEM CORRECTLY, GRACIA.

OBIVIOUSLY IF YOU OVERDOSE ON ANY NATURAL SUBSTANCE IT CAN BE DANGEROUS. THE

SMART IDEA IS NOT TO.

PROGESTERONE is the CHEMICAL name for PROGESTIN [ which is a class of drug ]. I

do not expect you to really know that since you are a medical provider.....

/Painful breasts

I would advise against progesterone if you are a post menopausal woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

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So far, the bioidenticals are proving to be SAFE according to the

doctors that have been prescribing them and the people that are

taking them. ASK THEM yourself.

My 11+ grains of Armour and my BHRT are currently being presribed by

real live medical care professionals, so what is your problem!

>

> Incorrect Sam. There is no such proof because the studies haven't

been done

> on bio's alone. How silly and irresponsible of you to make such a

claim

> when no one actually knows how many women have come down with

hormonally

> caused cancers while using only bio's.

>

> Dusty

>

> Re: /Painful breasts

>

>

>

> Correct in that synthetic sex hormones are bad bad bad news.

> WIH study only looked at synthetic sex hormones, not at any of the

> bio-identicals. So far the bio-identicals have proven to be safe as

> long as they are not abused as in the wiley protocol which

> recommended huge overdosages of progesterone and estradiol.

>

> Sam

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Gracia,

Cortef is cortisone

Progestin is progesterone

It's simple.

Whatever the name they give to it the drug is the same.

Roni

Nancie Barnett <deifspirit@...> wrote:

gracia-

if you read the study below- PROGESTERONE IS CITED IN THE STUDY. PROGESTINS ARE

AL LAYMAN'S TERM FOR PROGESTERONE.

Please, do not tell me what the study was about BECAUSE UCLA WAS INVOLVED in the

study when I was in GRADUATE SCHOOL THERE. many of the researches who worked

with the study were from UCLA. Several of my professors in women's health were

involved in the study.

/Painful breasts

I would advise against progesterone if you are a post menopausal woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

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Thanks Joy! I will check this out.

:0)

Joy <jwalker8869@...> wrote:

michelle,

just caught your message while reading this post.. the brand I use is Nature's

Resource Evening Primrose with Vitamin E, 500 mg extract softgels. I take the

max amount..I usually shy away from pushing products but it worked so well for

me I just had to tell you.. I also stay clear of caffeine the two before and

during.. I'm suppose to stay clear 24/7 but when you are HypO you want your

caffeine.

take care..

joy

Re: Re: Anyone with weight gain have

Liposuction?

>

>

>

>

> iodine and progesterone.

> seriously, iodine/iodide works miracles ( that's why we are warned

not to

> take it)

> gracia

>

> Hi Sam,

> Since you mentioned it, about Fibrocystic Breast Disease: I noticed

that my

> boobs hurt like 2 weeks before my period, and this just started

since taking

> Armour, 6 months. Do you know what to do to stop that??

> Thanks!!

>

>

> Sam <k9gangopenaccess (DOT) <mailto:k9gang% 40openaccess. org> org> wrote:

> It's not just that I have lost 2 parts of my endocrine system and

> started with a clean slate. There was damage done and severe iodine

> deficiency - fibrocystic breast disease, osteoporosis, DNA and NIS

> damage from the RAI and stuff like that. I was sort of ok just

> without ovaries/uterus, but the bottom dropped out when my healthy

> thyroid was ablated.

>

> Yea, I wish it was just " starting with a clean slate " ...it would

have

> been way easier to climb out of that pit of doom I was lolling in

for

> so long. :-O

>

> Sam :-D

>

>

> > >

> > > I don't think it's so much what you're dosing for, as it

> is " how " .

> > You

> > > could dose hypothyroidism by using cocaine and probably feel

> pretty

> > > good... For a while. In your case you're using a product that

> treats

> > > the underlying disease, so it works. At least for you. So you

> > aren't

> > > JUST treating symptoms; you're addressing the real problem.

> > >

> > > Note I said it has it's limitations; I didn't say it wouldn't

> work.

> > >

> > >

> >

> >

> >

> >

> >

> >

> > ------------ --------- --------- ---

> > Be a better friend, newshound, and know-it-all with

Mobile.

> Try it now.

> >

> >

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Thanks Roni,

You said something very interesting...I wonder if I am gaining weight because

of water retention. Would that indicate kidney issues??

Thanks!!

Roni Molin <matchermaam@...> wrote:

If there is prementrual swelling of breast tissue, you might want to

try 20 mgs of furosemide

with a 99mgs potassium pill for the few days before your period. You'll need a

prescription. I

know there are natural water pills, but I don't know how effective they are,

honestly.

Roni

and Irwin <familyirwin@...> wrote:

Thanks Nancie,

I will look into this as well. I know I have read that progesterone cream helps

a lot with correcting underlying estrogen dominance, but I get fearful with

adding hormones (because I just don't know how to weed through all of the

stuff.)

Thanks again,

Nancie Barnett <deifspirit@...> wrote:

actually that is not entirely correct.

the study was terminated early because the Combined therapy of both estrogen and

progesterone was seen to increase the risk of breast cancer. we do NOT have any

info on whether progesterone ALONe causes breast cancer- because there has NEVER

been a study targeting it that.

nancie

here is the first source:

Does postmenopausal hormone treatment increase the risk of breast cancer?

Women who use postmenopausal hormone

treatment<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormonescfm#1>

have a higher risk for breast cancer compared with women who do not use hormone

treatment. In the past, hormone treatment used

estrogen<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm#1>

alone and the effects of this treatment have been studied more extensively.

These early studies saw breast cancer risk increase the longer the length of the

estrogen treatment. Breast cancer risk among women who used hormone treatment,

increased about 2% for each year of use compared to women who did not use

hormones. When hormone treatment is stopped, risk falls to previous levels over

a period of five years. Today, most women who receive postmenopausal hormone

treatment use estrogen combined with

progesterone<http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm\

#1>. A number of recent studies indicate a higher risk of breast cancer is

associated with this form of hormone treatment. These studies found that

estrogen with progesterone treatment increased breast cancer risk by 6% to 8%

for each year of use. Confirming these results, a large clinical trial examining

estrogen with progesterone treatment in healthy women, the Women's Health

Initiative, was recently ended prematurely because of an association of

excessive breast cancer risk with this treatment. Trials of this type are the

'gold standard' for examining drug effects and this early termination result

raises strong concern about the use of estrogen with progesterone as a

beneficial treatment for healthy women after menopause.

source:

http://envirocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm<http://envir\

ocancer.cornell.edu/Factsheet/general/fs40.hormones.cfm>

__________________________________________________________

Estrogen plus Progestin Effects on Breast Cancer and Mammograms

June 2003

a.. Frequently asked questions<http://www.whi.org/faq/faq_bc.php>

b.. Abstract of scientific paper in

JAMA<http://jama.ama-assn.org/cgi/content/abstract/289/24/3243>

Findings Summary

WHI study findings on the risk of breast cancer in women taking combined

estrogen plus progestin (E+P) were published in the July 2002 issue of the

Journal of the American Medical Association (JAMA). The E+P study continues to

be analyzed. Updated results (June 25 issue of JAMA) include data on additional

breast cancer cases, their characteristics, and mammogram results for women in

the study.

The 2002 report showed that more women taking E+P developed breast cancer than

those taking placebo (inactive) pills. This updated analysis shows that after an

average of 5.6 years, 245 of the 8,506 E+P women and 185 of the 8,102 women on

placebo developed breast cancer. Of the total cancers, 349 cases were invasive,

a type of breast cancer with a greater chance of spreading to other parts of the

body. The conclusions below are based on the invasive breast cancer group.

a.. The increased risk of breast cancer due to E+P was eight additional cases of

breast cancer for every 10,000 women over one year

b.. Overall, there was a 24% increase in the risk for breast cancer due to E+P

The breast cancers in the E+P group had similar characteristics (looked the same

under a microscope) to those in the placebo group. However, the tumors in the

E+P group tended to be larger and more advanced (had spread to the lymph nodes

or elsewhere in the body). A more advanced stage is usually associated with

poorer outcome. At this time, no direct statements can be made about the

prognosis of the breast cancer found in women taking E+P until more follow-up

information is collected.

After even one year, quite a few more women had abnormal mammograms in the E+P

group (9.4%) compared to the placebo group (5.4%); this pattern continued until

the study ended. An abnormal mammogram is a breast X-ray that results in a

recommendation for additional medical evaluation (most often, a shorter time

between mammograms, but sometimes, a breast biopsy or other tests). Although we

have known from other studies that E+P use increases the density of breast

tissue on mammograms, the increase in abnormal mammograms with E+P use seen in

this study is a new finding.

Further WHI studies are being done to learn what happens to breast cancer rates

and mammograms after E+P use is stopped.

source:

http://www.whi.org/findings/ht/eplusp_bc.php<http://www.whi.org/findings/ht/eplu\

sp_bc.php>

__________________________________________________________

Frequently Asked Questions about Estrogen plus Progestin and Breast Cancer

These questions and answers supplement the June 25, 2003 JAMA publication on E+P

and breast cancer.

1.. What were the main findings from the estrogen plus progestin and breast

cancer analyses?<http://www.whi.org/faq/faq_bc.php#1>

2.. What is the increased risk for women taking E+P for breast

cancer?<http://www.whi.org/faq/faq_bc.php#2>

3.. What were the main findings about E+P and

mammography?<http://www.whi.org/faq/faq_bc.php#3>

4.. What are the conclusions from these

findings?<http://www.whi.org/faq/faq_bc.php#4>

5.. What is breast cancer?<http://www.whi.org/faq/faq_bc.php#5>

6.. What is in situ breast cancer?<http://www.whi.org/faq/faq_bc.php#6>

7.. What is invasive breast cancer?<http://www.whi.org/faq/faq_bc.php#7>

8.. What is a mammogram?<http://www.whi.org/faq/faq_bc.php#8>

9.. What is an abnormal mammogram?<http://www.whi.org/faq/faq_bc.php#9>

10.. What happens to breast cancer risk and the frequency of abnormal mammograms

after E+P use is discontinued?<http://www.whi.org/faq/faq_bc.php#10>

11.. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI

study?<http://www.whi.org/faq/faq_bc.php#11>

12.. What type of hormone treatment did women in the E+P study

take?<http://www.whi.org/faq/faq_bc.php#12>

13.. Is there an increased risk of breast cancer and abnormal mammograms in

women taking estrogen alone (without progestin) or other E+P

formulas?<http://www.whi.org/faq/faq_bc.php#13>

14.. Should I discuss this information with my healthcare provider?

<http://www.whi.org/faq/faq_bc.php#14>

15.. If I have an abnormal mammogram now, and have taken (or I still take) E+P,

what should I do?<http://www.whi.org/faq/faq_bc.php#15>

16.. Was the effect of E+P on breast cancer different in women who had used oral

contraceptives in the past?<http://www.whi.org/faq/faq_bc.php#16>

17.. I am taking prescription hormones. What should I

do?<http://www.whi.org/faq/faq_bc.php#17>

1. What were the main findings from the estrogen plus progestin and breast

cancer analyses?

Answer: More women who took estrogen plus progestin (E+P) developed breast

cancer than women taking placebo (inactive pills). The cancer cases found in

women taking E+P had similar characteristics (looked the same under the

microscope), but the tumors were larger and had spread more throughout the body

than those in the placebo group.

2. What is the increased risk for women taking E+P for breast cancer?

Answer: A woman is more likely to develop breast cancer if she is taking E+P.

For every 10,000 women taking estrogen plus progestin, 41 women each year will

develop breast cancer as compared to 33 women per year who would develop breast

cancer while taking placebo. While this difference in risk is important, the

overall risk to an individual woman remains small.

The breast cancer cases which developed in women taking E+P were larger and more

advanced; about 25% had spread to lymph nodes or elsewhere in the body, compared

to 16% of women on placebo.

3. What were the main findings about E+P and mammography?

Answer: After just one year of taking E+P, a woman was much more likely to have

an abnormal mammogram compared to a woman taking placebo. In the E+P group, 9.4%

of women had an abnormal mammogram after one year, compared with 5.4% in the

placebo group. The increased rate of abnormal mammograms continued until the

study ended.

A woman's chance of having an abnormal mammogram resulting from E+P use was

about 1 in 25 for one year's use, and about 1 in 10 after 5½ years of use.

4. What are the conclusions from these findings?

Answer: Use of E+P increases the rate of more advanced breast cancer compared

with placebo and substantially increases the rate of abnormal mammograms. As a

result, abnormal mammograms in women receiving menopausal hormone therapy need

closer attention. The increased frequency of abnormal mammograms is a newly

found negative effect of even short-term E+P use. These findings should be

considered in the discussion of risks and benefits for women considering E+P use

for any amount of time.

5. What is breast cancer?

Answer: Breast cancer is a disease in which abnormal breast cells divide without

control and can spread to other parts of the body.

6. What is in situ breast cancer?

Answer: In situ is an early cancer where abnormal breast cells are confined to

the ducts or lobules in the breast. There are two forms, ductal carcinoma (DCIS)

and lobular carcinoma in situ (LCIS).

7. What is invasive breast cancer?

Answer: Invasive breast cancer involves abnormal breast cells which have spread

outside the breast duct or lobule where they began. This type of cancer accounts

for 80% of breast cancer cases. When the term " breast cancer " is used, it

generally means invasive breast cancer.

8. What is a mammogram?

Answer: A mammogram is an X-ray of the breast.

9. What is an abnormal mammogram?

Answer: An abnormal mammogram is a breast X-ray with characteristics leading the

radiologist to recommend some additional testing, either another mammogram

within 6 months, or occasionally other procedures. A recommendation to have a

repeat mammogram seldom results in a cancer diagnosis. Some characteristics seen

on a mammogram are suspicious enough to indicate that additional tests (like a

biopsy) are needed. These tests are more likely to result in a cancer diagnosis.

An abnormal mammogram report is not the same as an incomplete mammogram report.

Quite often, a woman may be called back after a mammogram to have additional

X-rays taken, have an additional non-invasive procedure performed (such as an

ultrasound) or be asked to provide earlier mammograms for comparisons. These

evaluations are needed to better understand the current mammogram, and by

themselves do not signal an abnormal mammogram.

10. What happens to breast cancer risk and the frequency of abnormal mammograms

after E+P use is discontinued?

Answer: WHI researchers will be looking at these issues in future analyses, so

information is not yet available. Observational studies have suggested that

breast cancer risk will diminish over time.

To date, no studies have looked at what effect stopping E+P use has on abnormal

mammograms. There have been some studies about breast density change and

menopausal hormone therapy use. Increased mammogram density has been linked to

E+P use. In observational studies, mammogram density has been shown to decrease

when E+P use is stopped. It remains to be seen whether abnormal mammograms will

change when E+P use is stopped.

11. Was the effect of E+P on breast cancer different in women who had taken

menopausal hormone therapy before entering the WHI study?

Answer: There was a trend for somewhat higher risk in women in the E+P group who

reported prior menopausal hormone use. Whenever researchers examine factors like

this within a randomized trial, the analyses and interpretation become more

complex. Prior hormone use was not randomized and so other factors associated

with hormone use must be considered when analyzing this relationship. Though

there appears to be some relation between prior hormone use and breast cancer,

WHI researchers will be examining this in more detail to gain confidence in

their interpretation.

12. What type of hormone treatment did women in the E+P study take?

Answer: Women randomized (assigned by chance) to active hormones were taking one

tablet containing conjugated equine estrogens (0.625 mg) and medroxyprogesterone

acetate (2.5 mg) each day (PremproT). When WHI first began, this was the most

commonly prescribed menopausal hormonal therapy in the United States for women

with a uterus.

13. Is there an increased risk of breast cancer and abnormal mammograms in women

taking estrogen alone (without progestin) or other E+P formulas?

Answer: The current report addresses only the issue of E+P use in the form of

pills. Final results from the ongoing Estrogen-Alone (E-Alone) study are unknown

at this time. Importantly, the WHI investigators have been told that, as of May

31, 2002, no increase in breast cancer has been seen in the E-alone WHI trial.

Participants in the E-Alone study are asked to continue to take their study

pills and to come for their regular clinic visits. The National Heart, Lung, and

Blood Institute, which oversees WHI, continues to review the study for women

receiving E-Alone, and they will provide investigators and participants with any

new information about the study that might affect their participation

This information has been superceded by the 2004 Hormone Program

Update.<http://www.whi.org/updates/update_hrt2004.php>

14. Should I discuss this information with my healthcare provider?

Answer: Yes. Your healthcare provider may read the scientific paper in the June

25, 2003 issue of JAMA, or you may direct your provider to this web site. Your

provider may also want to speak with your local WHI Principal Investigator about

these results.

15. If I have an abnormal mammogram now, and have taken (or I still take) E+P,

what should I do?

Answer: Talk with your healthcare provider about your individual situation in

light of the WHI results.

Additional breast imaging tests may help in evaluating women with abnormal

mammograms, such as a nuclear medicine test (scintimammography) or Magnetic

Resonance Imaging (MRI); your mammography provider should have information about

these tests. However, no approach has been evaluated for women with abnormal

mammograms related to E+P use.

16. Was the effect of E+P on breast cancer different in women who had used oral

contraceptives in the past?

Answer: The analyses done so far do not suggest that use of oral contraceptives

had any important influence on the breast cancer findings. Less than half of the

women in this study had ever used oral contraceptives and the length of use was

often relatively short (less than 5 years). With the small number of breast

cancer cases that occurred in these women, these data do not provide a very

clear answer to this question.

17. I am taking prescription hormones. What should I do?

Answer: Talk with your healthcare provider about your individual risk profile

and the hormones you are currently taking in light of the WHI results.

source: http://www.whi.org/faq/faq_bc.php<http://www.whi.org/faq/faq_bc.php>

/Painful breasts

I would advise against progesterone if you are a post menopausal woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

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progestins are frankenstein hormones, chemically altered to be patented.

progesterone cannot be patented last time I looked.

progesterone is safe and bioidentical, progestin is not.

I am not a medical provider, I am a health care consumer.

Gracia

plus PROGESTERONES ARE NOT DANGEROUS IF YOU USE THEM CORRECTLY, GRACIA.

OBIVIOUSLY IF YOU OVERDOSE ON ANY NATURAL SUBSTANCE IT CAN BE DANGEROUS. THE

SMART IDEA IS NOT TO.

PROGESTERONE is the CHEMICAL name for PROGESTIN [ which is a class of drug ].

I do not expect you to really know that since you are a medical provider.....

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progestin's are the name of THE CLASS of hormones of which premarin, provera and

depo-provera are included. PROGESTERONE is the name of the hormone that is our

bodies and also the chemical structure of the hormone.

when we studied progesterone in the study we used the class of drugs called

progestin's because they are molecularly and CHEMICALLY identical to

progesterone. AND they are the most widely used hormone replacements. the

authors of the study wanted to see what these drugs would do since they ARE

prescribed over 90% of the time. the study DID NOT address bio-identicals. I

agree that they should do a study that included bio-identicals, so we can see if

they are any risks associated with them. BUT right NOW we are in the dark as far

as the long term risks with using bio-identicals in breast cancer and ovarian

cancer and especially if one uses more then the recommended doses.

nancie

----- Original Message -----

progestins are frankenstein hormones, chemically altered to be patented.

progesterone cannot be patented last time I looked.

progesterone is safe and bioidentical, progestin is not.

I am not a medical provider, I am a health care consumer.

Gracia

.

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grapefruit juice, cucumbers and watermelon juice are also good diuretics and

asparagus also will do the trick.

nancie

/Painful breasts

I would advise against progesterone if you are a post menopausal woman.

Progsterone/Progestins are the reason the Women's Health Iniative on

combined estrogens and progestins was cancelled, due to its contributing to

breast cancer increases. The estrogen alone study continued because it did

not increase the risk of breast cancer.

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you think there should be a study to see if the hormones which are natural to

our own bodies are dangerous? I wonder who would fund that one?

http://www.womensinternational.com

Gracia

progestin's are the name of THE CLASS of hormones of which premarin, provera

and depo-provera are included. PROGESTERONE is the name of the hormone that is

our bodies and also the chemical structure of the hormone.

when we studied progesterone in the study we used the class of drugs called

progestin's because they are molecularly and CHEMICALLY identical to

progesterone. AND they are the most widely used hormone replacements. the

authors of the study wanted to see what these drugs would do since they ARE

prescribed over 90% of the time. the study DID NOT address bio-identicals. I

agree that they should do a study that included bio-identicals, so we can see if

they are any risks associated with them. BUT right NOW we are in the dark as far

as the long term risks with using bio-identicals in breast cancer and ovarian

cancer and especially if one uses more then the recommended doses.

nancie

----- Original Message -----

progestins are frankenstein hormones, chemically altered to be patented.

progesterone cannot be patented last time I looked.

progesterone is safe and bioidentical, progestin is not.

I am not a medical provider, I am a health care consumer.

Gracia

.

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I have tried that link 6 times and it won't go through

nancie

Re: /Painful breasts

you think there should be a study to see if the hormones which are natural to

our own bodies are dangerous? I wonder who would fund that one?

http://www.womensinternational.com<http://www.womensinternational.com/>

Gracia

progestin's are the name of THE CLASS of hormones of which premarin, provera

and depo-provera are included. PROGESTERONE is the name of the hormone that is

our bodies and also the chemical structure of the hormone.

when we studied progesterone in the study we used the class of drugs called

progestin's because they are molecularly and CHEMICALLY identical to

progesterone. AND they are the most widely used hormone replacements. the

authors of the study wanted to see what these drugs would do since they ARE

prescribed over 90% of the time. the study DID NOT address bio-identicals. I

agree that they should do a study that included bio-identicals, so we can see if

they are any risks associated with them. BUT right NOW we are in the dark as far

as the long term risks with using bio-identicals in breast cancer and ovarian

cancer and especially if one uses more then the recommended doses.

nancie

----- Original Message -----

progestins are frankenstein hormones, chemically altered to be patented.

progesterone cannot be patented last time I looked.

progesterone is safe and bioidentical, progestin is not.

I am not a medical provider, I am a health care consumer.

Gracia

.

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