re ted friedman, md research part 2 for chuck

[Guest guest]

RESEARCH PAPERS

A. RESEARCH PAPERS (PEER-REVIEWED)

1.. Friedman, T. C., Orlowski, M. and Wilk, S. (1984) Prolyl Endopeptidase:

Inhibition in vivo by N- benzyloxycarbonyl-prolyl-prolinal. J. Neurochem. 42:

237-241.

2.. Friedman, T. C., Orlowski, M. and Wilk, S. (1984) Peptide-Degrading

Enzymatic Activities in GH3 Cells and Rat Anterior Pituitary Homogenates.

Endocrinology 114: 1407-1412

3.. Friedman, T. C., Kline, T. B. and Wilk, S. (1985) 5-Oxoprolinal:

Transition State Aldehyde Inhibition of Pyroglutamyl Peptide Hydrolase.

Biochemistry 24: 3907-3913.

4.. Wilk, S., Friedman, T. C. and Kline, T. B. (1985) Pyroglutamyl

omethyl Ketone: Potent Inhibitor of Mammalian Pyroglutamyl Peptide

Hydrolase. Biochem. Biophys. Res. Commun. 130: 662-668.

5.. Friedman, T. C. and Wilk, S. (1985) The Effects of Inhibitors of Prolyl

Endopeptidase and Pyroglutamyl Peptide Hydrolaseon TRH Degradation in Rat

Serum. Biochem. Biophys. Res. Commun. 132: 787-794.

6.. Friedman, T. C., Davies, T. F. and Wilk, S. (1986) Evidence for Regulation

of a TRH Degradation Pathway in GH3 Cells. Endocrinology 118: 562- 566.

7.. Friedman, T. C., and Wilk, S. (1986) Delineation of a Particulate

Thyrotropin-Releasing Hormone- Degrading Enzyme in Rat Brain by the Use of

Specific Inhibitors of Prolyl Endopeptidase and Pyroglutamyl Peptide Hydrolase.

J. Neurochem. 46: 1231-1239.

8.. Friedman, T. C. and Fulop, G. (1988) Disulfiram Use at Hospital-Based and

Free-Standing Alcoholism Treatment Centers. J.Subst. Abuse Treatment 5:139-143.

9.. Friedman, T.C., , P.M., Fleisher, T.A., Feuillan, P., , R. I.,

Cassorla, F. and Chrousos, G.P. (1991) Frequent Occurence of Asplenism and

Gallstones in Patients with Autoimmune Polyglandular Disease Type I. Am. J.

Med. 91:625-631.

10.. Estivariz, F.E., Friedman, T.C., Chikuma, T. and Loh, Y.P. (1992)

Processing of Adrenocorticotropin by Two Proteases in Bovine Intermediate Lobe

Secretory Vesicle Membranes: A Distinct, Acidic, Tetrabasic-Residue Specific,

Calcium-Activated Serine Protease, and a PC2- like Enzyme. J. Biol. Chem.

267:7456-7463.

11.. Doppman, J.L., Gill, J.R. Jr., , D.L., Chang, R., Gupta, R.,

Friedman, T.C., Choyke, P.L., Feurstein, I.M., Dwyer, A.J., Jicha, D.L.,

Walther, M.M., Norton, J.A. and Linehan, W.M. (1992) Distinction Between

Hyperaldosteronism Due to Bilateral Hyperplasia and Unilateral Aldosteronoma:

Reliability of CT. Radiology 184:677-682.

12.. Oerter, K.E., Friedman, T.C., Andersson H.C. and Cassorla, F.G. (1992) A

Familial Syndrome of Endocrine and . 44:487-491.

13.. Mixson, A.J., Friedman, T.C., Katz, D.A., Feuerstein, I.M.,

Taubenberger, J.K., Colandrea J.M., Oldfield, E.H andWeintraub, B.D. (1993)

Thyrotropin- Secreting Pituitary Carcinoma. J. Clin.Endocrinol. Metab.

76:529-533.

14.. Azaryan, A.V., Wong, M., Friedman, T.C.,Cawley, N.X., Estivariz, F.E.,

Chen, H.-C., and Loh, Y.P. (1993) PurificationandCharacterization of a Novel

Yeast Aspartic Protease Encoded by the YAP3Gene:Similarity tothe Mammalian

Proopiomelanocortin Converting Enzyme.J. Biol.Chem. 260:7194-7205.

15.. Crofford, L.J., Sano, H., Karalis, K., Friedman, T.C., Epps, H.R.,

Remmers, E.F., Mathem, P., Chrousos, G.P., and Wilder,R.L. (1993)

Corticotropin-Releasing Hormone in Synovial Fluids and Tissuesof Patients with

Rheumatoid Arthritis and Osteoarthritis. J. Immunol. 151:1587-1596.

16.. Mastorakos, G., Webster, E.L., Friedman,T.C., and Chrousos, G.P. (1993)

Immunoreactive Corticotropin Releasing Hormone(CRH) and its Binding Sites in the

Rat Ovary. J. Clin. Invest. 92:961-968.

17.. Bouzas, E.A., Mastorakos, G., Friedman, T.C., , M.H., Chrousos,

G.P., and Kaiser-Kupfer, M.I. (1993) Posterior Subscapsular Cataracts in

Endogenous Cushing Syndrome: An Uncommon Manifestation. Invest. Ophthalmol. Vis.

Sci. 34:3497-3500.

18.. Friedman, T.C., Chen, H.C., and Loh, Y.P. (1993) Generation of (1-37) and

(1-38) Forms of Adrenocorticotropin By Mono- and Di-Peptidyl Serine

Carboxypeptidase Activities in Bovine Pituitary Secretory Vesicles.

Endocrinology 133:2951-2961.

19.. Auchus, R.J., Mastorakos, G., Friedman, T.C., and Chrousos, G.P. (1994)

Corticotropin-Releasing Hormone Production by a Small Cell Lung Carcinoma in a

Patient with ACTH-Dependent Cushing Syndrome. J. Endocrinol. Invest. 17:447-452.

20.. Friedman, T.C., -Borreguero, D., Hardwick, D., Akuete, C.N.,

Stambuk, M.K., Dorn, L.D., Starkman, M.N., Loh, Y.P., and Chrousos, G.P. (1994)

Diurnal Rhythm of Plasma Delta Sleep-Inducing Peptide in Humans: Evidence for

Positive Correlation with Body Temperature and Negative Correlation with Rapid

Eye Movement and Slow Wave Sleep. J. Clin. Endocrinol. Metab. 78:1085-1089.

21.. Mastorakos, G., Scopa, C.D., Vryonidou, A., Friedman, T.C., Kattis, D.,

Phenekos, C., Merino, M.J., and Chrousos, G.P. (1994) Presence of Immunoreactive

Corticotropin Releasing Hormone (CRH) in Normal and Polycystic Human Ovaries.

J.Clin. Endocrinol. Metab. 79:1191-1197.

22.. Friedman, T.C., Loh, Y.P and Birch, N.P.(1994) In Vitro Processing of

Pro-opiomelanocortin by Purified RecombinantPC1(SPC3). Endocrinology

135:854-862.

23.. Friedman, T.C., -Borreguero, D., Hardwick, D., Akuete, C.N.,

Doppman, J.L., Dorn, L.D., Yanovski, J.A., and Chrousos, G.P. (1994) Decreased

Delta Sleep and Plasma Delta Sleep-Inducing Peptide Concentrations in Patients

with Cushing Syndrome Neuroendocrinol. 60:626-634.

24.. Scopa, C.D., Mastorakos, G., Friedman, T.C., Melanchrinou, M., Merino,

M.J., and Chrousos, G.P. (1994) Presence of Immunoreactive Corticotropin

Releasing Hormone in Thyroid Lesions. Am. J. Pathol. 145:1159-1167.

25.. Pu, L-P., , W.P., Mill, J.F., Friedman, T.C., and Loh, Y.P. (1995)

Expression of the Prohormone Convertase PC2 mRNA in Xenopus Laevis CNS:

Co-localization with Pro-Thyrotropin-Releasing Hormone. J. Comp. Neuro.

354:71-86.

26.. Friedman, T.C., Gordon, V.M., Leppla, S.H., Klimpel, K.R., Birch, N.P.

and Loh, Y.P. (1995) In Vitro Processing of Protective Antigen by Recombinant

PC1(SPC3) and Bovine Intermediate Lobe Secretory Vesicle Membranes. Arch.

Biochem. Biophys. 316:5-13.

27.. Friedman, T.C., Yanovski, J.A., Jayasvasti, V., Yanovski, S.Z., Koenig,

R.J., and Wilk, S. (1995) Pyroglutamyl peptidase II ( " Thyroliberinase " ) Activity

in Human Serum: Influence of Weight and Thyroid Status. J. Clin. Endocrinol.

Metab. 80:1086-1089.

28.. Friedman, T.C., Loh, Y.P., Cawley, N.X.,Birch, N.P., Huang, S.S.,

, I.M.D., and Nillni, E.A. (1995) ProcessingofPro-TRH by Bovine

Intermediate Lobe Secretory Vesicle Membrane PC1 andPC2Enzymes. Endocrinology

136:4462-4472.

29.. Mastorakos, G., Bouzas, E.A., Silver, P.B., Friedman, T.C., Chan, C-C.,

Caspi, R.R., and Chrousos, G.P. (1995) Immune Corticotropin-Releasing Hormone is

Present in the Eyes of and Promotes Experimental Autoimmune Uveoretinitis in

Rodents. Endocrinology 136:4650-4658.

30.. Vgontzas, A.N., Friedman, T.C., Chrousos, G.P., Bixler, E.O., Vela-Bueno,

A., and Kales, A. (1995) Delta Sleep-Inducing Peptide in Normals and in Sleep

Apnea and Narcolepsy. Peptides 16:1153-1156.

31.. Dorn, L.D., Burgess, E.S., Dubbert, B., Simpson, S.-E., Friedman, T.,

Kling, M., Gold, P.W., and Chrousos, G.P. (1995) Psychopathology in Patients

with Cushing Syndrome: Melancholic or " Atypical " Features. Clin. Endocrinol.

43:433-442.

32.. Nillni, E.A., Friedman, T.C., Todd, R.B., Birch, N.P. Loh, Y.P., and

, I.M.D. (1995) ProTRH Processing by PC1. J. Neurochem. 65:2462-2472.

33.. Friedman, T.C. and Yanovski, J.A. (1995)Morning Plasma Free Cortisol:

Inability to Distinguish Patients with MildCushingSyndrome from Patients with

Pseudo-Cushing States. J. Endocrinol.Invest.18:696-701.

34.. Friedman, T.C., Cool, D.R., Jayasvasti, V., Louie, D., and Loh. Y.P.

(1996) Processing of Pro-opiomelanocortin in GH3 Cells: Inhibition by Prohormone

Convertase 2 (PC2) Antisense mRNA. Mol. Cell. Endocrinol. 116:89-96.

35.. Mastorakos, G., Scopa, C.D., Kao, L.C., Vryonidou, A., Friedman, T.C.,

Kattis, D., Phenekos, C., Rabin, D., and Chrousos, G.P. (1996) Presence of

Immunoreactive Corticotropin Releasing Hormone Human Endometrium. J. Clin.

Endocrinol. Metab. 81:1046-1050.

36.. Kalogeras, K.T., Nieman, L.K., Friedman,T.C., Doppman, J.L., Cutler, Jr.,

G.B., Chrousos, G.P., Wilder, R.L., Gold,P.W., and Yanovski, J.A. (1996)

Inferior Petrosal Sinus Sampling in HealthyHuman Subjects Reveals a Unilateral

Corticotropin-releasing Hormone-inducedArginine Vasopressin Release Associated

with Ipsilaterally Lateralized Adrenocorticotropin Secretion. J. Clin. Invest.

97:2045-2050.

37.. Friedman, T.C., Yanovski, J.A., Nieman, L.K., Doppman, J.L., Cutler, Jr.,

G.B., Oldfield, E.H., Gold, P.M., Chrousos, G.P., and Kalogeras, K.T. (1996)

Inferior Petrosal Sinus Arginine Vasopressin Concentrations in Normal Volunteers

and Patients with Cushing's Disease. J. Clin. Endocrinol. Metab. 81:3068-3072.

38.. Yanovski, J.A., Yanovski, S.Z., Friedman, T.C., Loh, Y.P., Jayasvasti,

V., Cutler, Jr., G.B., and Chrousos, G.P. (1996) Etiology of the Differences in

Corticotropin-Releasing Hormone-Induced ACTH Secretion of Black and White Women.

J. Clin. Endocrinol. Metab. 81:3307-3311.

39.. Friedman, T.C., Mastorakos, G., Bouzas, E.A., Newman, T.D., Mullen, N.M.,

Horton, E.G., Costello, R., Papadopoulos, N.M., and Chrousos, G.P. (1996)

Carbohydrate and Lipid Metabolism in Endogenous Hypercortisolism: Shared

Features with Metabolic Syndrome X and NIDDM. Endocrine J. 43:645-655.

40.. Dorn, L.D., Burgess, E.S., Friedman, T.,Gold, P.W., and Chrousos, G.P.

(1997) The Longitudinal Course of Psychopathology in Cushing's Syndrome after

Correction of Hypercortisolism. J. Clin. Endocrinol. Metab. 82:912-919.

41.. Taymans, S.E., DeVries, A.C., DeVries, M.B., , R.J., Friedman,

T.C., Castro, M., Detera-Wadleigh, S., , C.S., and Chrousos, G.P. (1997)

The Prairie Vole (Microtus Ochrogaster) as a Model of Glucocorticoid Resistance.

Gen. Comp. Endocrinol. 106:48-61.

42.. Yanovski, J.A., Friedman, T.C., Nieman, L.K., Chrousos, G.P., Cutler,

Jr., G.B., Doppman, J.L., and Kalogeras, K.T. (1997) Inferior Petrosal Sinus

Arginine Vasopressin in Patients with Cushing Syndrome. Clin. Endocrinol.

47:199-206.

43.. Ting, P., Cushenberry, P.A., Friedman, T.C., and Loh, Y.P. (1997)

Enhanced Brain Opioid Receptor Activity Precedes Blood-Brain Barrier Disruption.

Acta Neurochir. (Suppl.) 70:250-253.

44.. Li, Q.-L., Yano, H., Ren, S.G., Li, X., Friedman, T.C., Melmed, S. (1997)

Leukemia Inhibitory Factor (LIF) Modulates Pro-opiomelanocortin (POMC) Gene

Regulation in Stably-Transfected AtT-20 Cells Over-Expressing LIF. Endocrine

7:325-330.

45.. Shimon, I., Yan, X., Magoffin, D.A., Friedman, T.C., and Melmed, S.

(1998) Intact Leptin Receptor is Selectively Expressed in Human Fetal Pituitary

and Pituitary Adenomas and Signals Human Fetal Pituitary Growth Hormone

Secretion. J. Clin. Endocrinol. Metab. 83: 4059-4064.

46.. Yanovski, J.A., , K.D., Kino, T., Friedman, T.C., Chrousos, G.P.,

Tsigos, C. and Falloon, J. (1999) Endocrine and Metabolic Evaluation of Human

Immunodeficiency Virus-Infected Patients with Evidence of Protease

Inhibitor-Associated Lipodystrophy. J. Clin. Endocrinol. Metab. 84:1925-1931.

47.. Li, Q.-L., Jansen, E., and Friedman, T.C. (1999) Regulation of Prohormone

Convertase 1 (PC1) By gp130-Related Cytokines. Molecular and Cellular

Endocrinology 158:143-152.

48.. Nie, Y., Nakashima, M., Brubaker, P.L., Li, Q.-L., Perfetti, R., Jansen,

E., Zambre, Y., Pipeleers, D., and Friedman, T.C. (2000) Regulation of

Pancreatic PC1 and PC2 Associated with Increased GLP-1 in Diabetic Rats. J.

Clin. Invest. 105:955-965.

49.. Nawab, S.S., , C.S., Dale, J.K., Greenberg, B.D., Friedman, T.C.,

Chrousos, G.P., Straus, S.E., and Rosenthal, N.E. (2000) Self-reported

sensitivity to chemical exposures in five clinical populations and healthy

controls. Psychiatry Res. 95:67-74.

50.. Li, Q.-L., Jansen, E., Brent, G.A., Naqvi, S., Wilber, J.F., and

Friedman, T.C. (2000) Interactions Between the Prohormone Convertase 2 (PC2)

Promoter and the Thyroid Hormone Receptor. Endocrinology. 141:3256-3266.

51.. -Borreguero, D., Wehr, T.A., Larrosa, O., Granizo, J.J., Hardwick,

D., Chrousos, G.P., and Friedman, T.C. (2000) Glucocorticoid Replacement is

Permissive for REM sleep and Sleep Consolidation in Patients with Adrenal

Insufficiency. J. Clin. Endocrinol. Metab. 85:4201-4206.

52.. Li, Q.-L., Jansen, E., Brent, G.A., and Friedman, T.C. (2001) Regulation

of Prohormone Convertase 1 (PC1) by Thyroid Hormone. Am J. Physiol.

280:E160-E170.

53.. Nakashima, M., Nie, Y., Li, Q.-L, and Friedman, T.C. (2001) Induction of

Splenic Prohormone Convertases PC1 and PC2 in Diabetic Rats. Reg. Peptides

102:135-45.

54.. Li, Q.-L., Naqvi, S., Shen, X., Liu, Y.-J., Lindberg, I., and Friedman,

T.C. (2003) Prohormone Convertase 2 (PC2) Enzymatic Activity and its Regulation

in Endocrine Cells. Reg. Peptides. 110:197-205.

55.. Liu, Y.J., Nakagawa, Y., Wang, Y., Li, R.S., Li. X.J. Ohzeki, T., and

Friedman, T.C. (2003) Leptin Activates Intracellular Corticosterone Production

in the Liver of ob/ob Mice. Diabetes. 52:1409-1416.

56..

57.. Wang, C., Swerdloff, R., Kipnes, M., Matsumoto, A. M., Dobs, A.S.,

Cunningham, G., Katznelson, L., Weber, T.J., Friedman, T.C., Snyder, P., Levine,

H.L. (2004) New Testosterone Buccal System (Striant ) Delivers Physiologic

Testosterone Levels: Pharmacokinetics Study in Hypogonadal Men. J. Clin.

Endocrinol. Metab.

58.. Shen, X., Li, Q.-L., Brent, G.A., and Friedman, T.C. (2003) Thyroid

Hormone Regulation of Prohormone Convertase 1 (PC1): Characterization of

Negative Thyroid Hormone Response Elements and Studies in Rat Brain.

Endocrinology.

59.. Nillni, E.A., Münzberg, H., Friedman, T.C. and Bjørbæk, C. (2003)

Regulation of Hypothalamic Prohormone Convertase (PC1 and PC2) Expression by

Leptin. Endocrinology.

60.. Nie, Y., Jansen, E., Li, Q.-L., and Friedman, T.C. (2003) Regulation of

PC1 and PC2 by Morphine and Naltrexone: Implications for the Homeostatic

Response to Opiate Addiction. Nature Medicine.

61.. Hardiman, A., Friedman, T.C., Grunwald, Jr., W. C., Furuta, M., Steiner,

D.F., and Cool, D.R. (2003) Analysis of Posterior Pituitary Prohormone

Processing in PC2-Null Mice Using SELDI-TOF Mass Spectrometry. J. Neurochem.

62.. Choi, J.-J. H., Cornford, M., Sun, J., Wang, L. and Friedman, T.C. (2003)

A Mysterious Suprasellar Mass. Pituitary.

63.. Shen, X., Li, Q.-L., Brent, G.A., and Friedman, T.C. (2003) Regulation of

Regional Expression in Rat Brain Prohormone Convertase 2 (PC2) by Thyroid

Hormone/Characterization of Negative Thyroid Hormone Response Elements in the

PC2 Promoter. Am. J. Physiol.

CHAPTERS

1.. Azaryan, A.V., Friedman, T.C., Cawley,N.X. and Loh, Y.P. (1995)

Characteristics of YAP3, A New Prohormone Processing Aspartic Protease from S.

Cerevisiae. in Aspartic Proteinases: Structure, Function, Biology, and

Biomedical Implications (Takahashi, K., ed.) Plenum Press, New York, pp.

569-572.

2.. Loh, Y.P., Cawley, N.X., Friedman, T.C. and Pu, L-P. (1995) Yeast and

Mammalian Paired Basic Residue-Specific Aspartic Proteases in Prohormone

Conversion in Aspartic Proteinases: Structure, Function, Biology, and Biomedical

Implications (Takahashi, K., ed.) Plenum Press, New York, pp. 519-527.

3.. Friedman, T.C. and Braunstein, G.D. (1997) Adrenal Gland in Cecil

Essentials of Medicine, 4th edition (Andreoli, T.E., , J.C., Carpenter,

C.C.J., and Plum, F., eds.) W.B. Saunders, Philadelphia, pp. 497-508.

4.. Herman-Bonert, V., Friedman, T.C. and Braunstein, G.D. (1997) The Thyroid

Gland in Cecil Essentials of Medicine, 4th edition (Andreoli, T.E., ,

J.C., Carpenter, C.C.J., and Plum, F., eds.) W.B. Saunders, Philadelphia, pp.

487-496.

5.. Friedman, T.C. and Braunstein, G.D. (1999) Adrenal Gland in Cecil

Essentials of Medicine, 5th edition (Andreoli, T.E., , J.C., Carpenter,

C.C.J., and Plum, F., eds.) W.B. Saunders, Philadelphia, (in press).

6.. Herman-Bonert, V., Friedman, T.C. and Braunstein, G.D. (1999) The Thyroid

Gland in Cecil Essentials of Medicine, 5th edition (Andreoli, T.E., ,

J.C., Carpenter, C.C.J., and Plum, F., eds.) W.B. Saunders, Philadelphia, (in

press).

7.. Friedman, T.C. (2001) Pseudo-Cushing Syndrome in Contemporary

Endocrinology: Adrenal Disorders (Margioris A.N. and Chrousos, G.P., eds.)

Humana Press, Totowa, NJ, pp. 203-218.

8.. Friedman, T. (2001) Pseudo-Cushing's in Pituitary Patient Resources Guide,

3rd edition (Ezzat, S. and Knutzen, R. eds.) Pituitary Network Association,

Thousand Oaks, CA, pp. 53-60.

9.. Friedman, T.C. (2004) The Adrenal Gland in Cecil Essentials of Medicine,

6th edition (Carpenter, C.C.J., Griggs, R.C. and Loscalzo, J., eds.) W.B.

Saunders, Philadelphia, 603-614.

10.. Herman-Bonert, V. and Friedman, T.C. (2004) The Thyroid Gland in Cecil

Essentials of Medicine, 6th edition (Carpenter, C.C.J., Griggs, R.C. and

Loscalzo, J., eds.) W.B. Saunders, Philadelphia, 593-602.

11.. Friedman, T.C. and Cool, D.R. (2004) Prohormones in The Encyclopedia of

Endocrinology and Endocrine Diseases, i, L. (ed.) Academic Press, San

Diego, in press.

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<http://goodhormonehealth.com/meet_dr/Friedman_cv.html#CURRICULUM_VITAE>

LETTERS TO THE EDITOR

1.. Friedman, T.C., and Chrousos, G.P. (1993) Transsphenoidal Resection in

Cushing's Disease: Definition of Success (letter). Clin. Endocrinol. 39:701.

2.. Friedman, T.C., and Papanicolaou, D. (1998) High Urinary Free Cortisol

Excretion in a Patient with Psychogenic Polydipsia (letter). J. Clin.

Endocrinol. Metab. 83:3378.

3.. Friedman, T.C., Adesanya, A. and Poland, R.E. (1999) Low-Dose

Hydrocortisone Treatment Of Chronic Fatigue Syndrome: A Randomized Controlled

Trial (letter). JAMA 281:1888.

4.. Friedman, T.C., Echeverry, D. and Poland, R.E. (2001) Orthostatic

Hypotension and Chronic Fatigue Syndrome: A Randomized Controlled Trial

(letter). JAMA 285:1442-1443.

5.. Padero, C., Friedman, T. Salehian, B. (2001) Comment on the Editorial " The

role of Androgens in Women " (letter). J. Clin. Endocrinol. Metab. 86: 5091-2.

REVIEWS

REVIEWS-PEER-REVIEWED:

1.. Crofford, L.J., Sano, H., Karalis, K., Webster, E.A., Friedman, T.C.,

Chrousos, G.P., Wilder, R.L. (1995) Local Expression of Corticotropin-Releasing

Hormone in Inflammatory Arthritis. Ann. N.Y. Acad. Sci. 771:459-471.

2.. Padero, C., Bhasin, S. Friedman, T.C. (2002) Androgen Supplementation in

Older Women: Too Much Hype, Not Enough Data J. Am. Geriatr. Soc. 50:1131-1140.

3.. Friedman, T.C., Norris, K.C. (2002) The role of vitamin D hormone in mild

to moderate chronic kidney disease. Trends Endocrinol Metab. 13:189-194.

REVIEWS-NON-PEER REVIEWED:

4.. Friedman, T.C., Pseudo Cushing's (1999) Network 8:16-18.

5.. Friedman, T.C. and Kimball, C. (2003) Endocrine Causes of Chronic Fatigue:

A review of Symptoms, Treatments. The CFIDS Chronicle, 16:5-7.

ABSTRACTS

1.. Gal, J., Basile, A. and Friedman, T.C. (1979) In Vitro Reductive

Metabolism of N-nitrosodibenzylamine. Pharmacologist 21: 191.

2.. Gal, J., Harper, T., Friedman, T.C. and , J.A. (1980)

Stereoselective Reduction of Chiral Ketones to Chiral Alcohols by Rabbit Liver

Cytosol. Pharmacologist 22: 242.

3.. Friedman, T. C., Orlowski, M. and Wilk, S. (1983) Inhibition of Prolyl

Endopeptidase by Benzyloxycarbonyl-prolyl-prolinal In Vivo. Fed. Proc. 42: 357.

4.. Friedman, T.C., Davies, T. F. and Wilk, S. (1985) Inhibitor Stimulated

Increase in Pyroglutamyl Peptide Hydrolase in GH3 Cells. Fifth Int. Washington

Spring Symposium. Neural and Endocrine Peptides and Receptors. Abst. #189.

5.. Wilk, S. and Friedman, T. C. (1985) Active-site Directed Inhibitors of

TRH-Degrading Enzymes. Fifth Int. Washington Spring Symposium. Neural and

Endocrine Peptides and Receptors. Abst. #142

6.. Wilk, S., Friedman, T. C. and Wilk, E. (1986) Purification and

Properties of Rabbit Brain " Thyroliberinase " , a Membrane-Bound

Thyrotropin-Releasing Hormone Degrading Enzyme. Fed. Proc. 45: 796.

7.. Mixson, A., Friedman, T., Doppman, J., Oldfield, E. and Weintraub, B.

(1990) Thyrotropin-Secreting Pituitary Carcinoma. Clinical Research 38:383A.

8.. Friedman, T. C. (1990) Concentrations of Delta Sleep-Inducing Peptide in

Inferior Petrosal Sinus and Simultaneous Peripheral Venous Samples in Patients

with Cushing's Syndrome. Endocrine Soc. 72:38.

9.. Friedman, T.C., , P. and Fleisher, T. (1991) High Prevalence of

Asplenism and Gallstones in Patients with Autoimmune Polyglandular Disease Type

I. Endocrine Soc. 73:98.

10.. Friedman, T.C., Kalogeras, K.T., Loh, Y.P., Doppman, J.L., Yanovski,

J.A., Hardwick, D., Gold, P.W. and Chrousos, G.P. (1991) Concentrations of

Arginine Vasopressin and Corticotropin-Releasing Hormone in Simultaneous

Bilateral Inferior Petrosal Sinus and PeripheralVenous Samples in Patients with

Cushing's Disease. First Summer NeuropeptideConference.

11.. Friedman, T.C., , P., Fleisher, T., Feuillan, P., , R. I.,

Cassorla, F. and Chrousos, G.P. (1991) Occurence of Asplenism and Gallstones in

Patients with Autoimmune Polyglandular Disease Type I. NIH Research Festival.

12.. Friedman, T.C., Kalogeras, K.T., Loh, Y.P., Doppman, J.L., Yanovski,

J.A., Hardwick, D., Gold, P.W. and Chrousos, G.P. (1991) Concentrations of

Arginine Vasopressin and Corticotropin-Releasing Hormone in Simultaneous

Bilateral Inferior Petrosal Sinus and PeripheralVenous Samples in Patients with

Cushing's Disease. NIH Research Festival.

13.. Friedman, T.C., Estivariz, F.E. and Loh,Y.P. (1991) Processing of

Adrenocorticotropin by Two Proteases in BovineIntermediate Lobe Secretory

Vesicle Membranes: An Acidic, Tetrabasic-ResidueSpecific,Calcium-Stimulated

Serine Protease and a Kex2/PC2-like Protease.31th AnnualMeeting of the American

Society for Cell Biology. Abst. #1749.

14.. Friedman, T.C., Hardwick, D., -Borreguero, D. and Loh, Y.P.

(1992) Abnormal Thermoregulation in Patients with Cushing's Syndrome. Endocrine

Soc. 74:855.

15.. Loh, Y.P., Friedman, T.C. and Estivariz,F.E. (1992) Identification and

Partial Purification of Two Adrenocorticotropin-Processing Enzymes in Bovine

Intermediate Lobe Secretory Vesicle Membranes. Endocrine Soc. 74:933.

16.. Loh, Y.P., Friedman, T.C., and Estivariz, F.E.. (1992) Characterization

of Endoprotease and Carboxypeptidase ACTH-Processing Activities in Bovine

Intermediate Lobe Secretory Vesicle Membranes. Second Summer Neuropeptide

Conference.

17.. Friedman, T.C., Estivariz, F.E. and Loh,Y.P. (1992) Characterization of

Endoprotease and Carboxypeptidase ACTH-Processing Activities in Bovine

Intermediate Lobe Secretory Vesicle Membranes. Ninth International Congress of

Endocrinology.

18.. Friedman, T.C., Hardwick, D., -Borreguero, D. and Loh, Y.P.

(1992) Abnormal Thermoregulation in Patients with Cushing's Syndrome.

International Symposium on Endocrinology Under 35. Abst.#11.

19.. Friedman, T.C., Estivariz, F.E. and Loh,Y.P. (1992) Characterization of

Endoprotease and Carboxypeptidase ACTH-Processing Activities in Bovine

Intermediate Lobe Secretory Vesicle Membranes. NIH Research Festival.

20.. Mastorakos, G., Kokia, E., Webster, E.L., Friedman, T.C., Adashi, E.Y.,

and Chrousos, G.P. (1992) Ovarian Corticotropin-Releasing Hormone and its

Potential Role. NIH Research Festival.

21.. Friedman, T.C., Chen, H.C., and Loh, Y.P. (1992) A Unique Serine

Carboxyl-Terminal Adrenocorticotropin-Cleaving Enzyme in Bovine Intermediate

Lobe Secretory Vesicle Membranes. 32nd Annual Meeting of the American Society

for Cell Biology. Abst.#1122

22.. Friedman, T.C., -Borreguero, D., Hardwick, D., Akuete, C.,

Stambuk, M., Green, E., and Starkman, M.N. (1993) Circadian Rhythm of Plasma

Delta Sleep-Inducing Peptide in Humans: Evidence for Correlation with Body

Temperature But Not Sleep Stage. Endocrine Soc. 75:855.

23.. Nillni, E.A., Friedman, T.C., Todd, R.B., Birch, N.P., and Loh, Y.P.

(1993) Enzymatic Conversion of ProTRH by Secretory Vesicle Membranes and

Partially Purified PC1 Enzyme. Endocrine Soc. 75:1696.

24.. Azaryan, A.V., Wong, M., Friedman, T.C.,Cawley, N.X., Estivariz, F.E.,

Chen, H.-C. and Loh, Y.P. (1993) Characteristicsof YAP3, a New Prohormone

Processing Aspartic Protease from S. Cerevisae.5th Aspartic Protease Conference.

25.. Friedman, T.C., Kalogeras, K.T., Loh, Y.P and Birch, N.P.. (1993) In

Vitro Processing of POMC by Purified Recombinant PC1. 23rd Annual Meeting

Society for Neuroscience. Abstract #441.6.

26.. Friedman, T.C., Loh, Y.P and Birch, N.P.(1993) In Vitro Processing of

POMC by Purified Recombinant PC1. NIH ResearchFestival.

27.. Newman, T., Friedman, T.C., Mastorakos, G., Bouzas, E.A., Mullen, N.M.,

Horton, E. and Chrousos, G.P. (1994) Carbohydrate Metabolism, Bone Density and

Ophthalmologic Findings in Endogenous Hypercortisolism. American Society for

Clinical Investigation Abstract #A-EN-0053.

28.. Friedman, T.C. and Yanovski, J.A. (1994)Plasma Free Cortisol in

Patients with Cushing Syndrome, Pseudo-Cushing Statesand Normal Volunteers.

Endocrine Soc. 76:355.

29.. Yanovski, J., Yanovski, S,. Friedman, T., Harrington, L. and Chrousos,

G. (1994) Differences in the Hypothalmic-Pituitary-Adrenal (HPA) Axis of Blacks

and Whites. Endocrine Soc. 76:39.

30.. Mastorakos, G., Scopa, C.D., Vryonidou, A., Friedman, T.C., Phenekos,

C., and Chrousos, G.P. (1994) Presence of Immunoreactive Corticotropin Releasing

Hormone (CRH) in Normal and Polycystic Human Ovaries. Endocrine Soc. 76:1667.

31.. Friedman, T.C., Gordon, V.M., Leppla, S.H., Klimpel, K.R., Birch, N.P.

and Loh, Y.P. (1994) In Vitro Processing of Anthrax Toxin Protective Antigen by

Recombinant PC1(SPC3) and Bovine Intermediate Lobe Secretory Vesicle Membranes.

The Gordon Research Conference on Hormonal and Neural Peptide Biosynthesis.

32.. Friedman, T.C., Yanovski, J.A., , J., Alvarez, J.F., and

Kalogeras, K.T. (1994) Arginine Vasopressin Concentrations in the Inferior

Petrosal Sinuses of Normal Volunteers and Patients with Cushing Disease. First

World Congress on Stress, Abstract #69.

33.. -Borreguero, D., Friedman, T., Neuhaus, I., Munson, P., Chrousos,

G.P., and Kling, M. (1994) Pattern of Secretion of ACTH Pulses During REM Sleep

in Healthy Adults. Preliminary Results. First World Congress on Stress, Abstract

#74.

34.. Taymans, S.E., DeVries, A.C., Friedman, T.C., Jayasvasti, V., ,

C.S., and Chrousos, G.P. (1994) HPA Axis Hormones in Monogamous Vs. Polygamous

Voles. First World Congress on Stress, Abstract #256.

35.. Yao, P.D., Yanovski, J.A., Friedman, T.C., de la Paz, M., Bargas, L.R.,

Foroughi, A., Doppman, J.L., Kalogeras, K.T.(1994) The Role of Posterior

Pituitary Hormones in the Regulation of the Hypothalamic-Pituitary-Adrenal Axis

in the Inferior Petrosal Sinuses of Normal Human Subjects. First World Congress

on Stress, Abstract #284.

36.. Friedman, T.C., Cool, D.R., Jayasvasti, V., Louie, D., and Loh. Y.P.

(1995) Processing of POMC in GH3 Cells: Insights from Antisense Experiments.

Cedars-Sinai Research Institute-3rd Annual Retreat, Abstract #14.

37.. Friedman, T.C., Cool, D.R., Jayavasti, V., Louie, D., and Loh. Y.P.

(1995) Processing of POMC in GH3 Cells: Insights from Antisense Experiments.

Endocrine Soc. 77:OR13-2.

38.. Mastorakos, G., Bouzas, E.A., Silver, P.B., Sartani, G., Friedman,

T.C., Chan, C-C., Caspi, R.C., and Chrousos, G.P.(1995) Immune Corticotropin

Releasing Hormone (CRH) is Present in the Eyesof and Promotes Experimental

Autoimmune Uveoretinitis (EAU) in Rodents. Endocrine Soc. 77:OR15-2.

39.. Mastorakos, G., Skopa, C.D., Kao, L.C., Vryonidou, A., Friedman, T.C.,

Kattis, D., Phenekos, C., Rabin, D., and Chrousos, G.P. (1995) Presence of

Immunoreactive Corticotropin Releasing Hormone (CRH) in Human Endometrium.

Endocrine Soc. 77:P1-105.

40.. Dorn, L.D., Friedman, T.C., Gold, P.W., and Chrousos, G.P. (1995) The

Post Cure Longitudinal Course of Psychopathology in Cushing Syndrome. Endocrine

Soc. 77:P2-167.

41.. Yanovski, J.A., Friedman, T.C., Nieman, L.K., Doppman, J.L., Cutler,

Jr., G.B., Chrousos, G.P., and Kalogeras, K.T. (1996) Arginine Vasopressin in

the Inferior Petrosal Sinuses of Patients with Cushing Disease, Ectopic ACTH

Syndrome and Adrenal Adenomas. Tenth InternationalCongress of Endocrinology

P3-591.

42.. Nie, Y. and Friedman, T.C. (1998) Regulation of PC1 and PC2 by Morphine

and Naltrexone: Implication in the Homeostatic Response to Opiate Addiction.

Endocrine Soc. 80:P1-75.

43.. Li, Q.-L., Jude, M., and Friedman, T.C. (1998) Regulation of the

Prohormone Convertase 1 (PC1) by JAK/STAT related cytokines. Endocrine Soc.

80:OR51-6.

44.. Friedman, T.C., Readhead, C.W., and Govan, III, H.L. (1998) Prohormone

Convertase 4 (PC4) Isoforms in Testicular Cell Lines. Endocrine Soc. 80:P2-67.

45.. Yanovski, J.A.,, K.D., Friedman, T.C., , E., Chrousos, G.P.,

and Falloon, J. (1998) HPA-Axis Function in HIV+ Patients with Indinavir-Induced

Lipodystrophy. Endocrine Soc. 80:P2-453.

46.. Shimon, I., Yan, X., Ren, S.G., Magoffin, D.A., Friedman, T.C., and

Melmed, S. (1998) Long Leptin Receptor Isoformis Selectively Expressed in Human

Fetal Pituitary and Pituitary AdenomasandSignals Fetal Pituitary Growth Hormone

Secretion. Endocrine Soc. 80:P2-211.

47.. -Borreguero, D., Friedman, T.C., Chrousos, G.P., and Wehr, T.A.

(1998) Withdrawal of glucocorticoids increases REM-sleep latency in patients

with adrenal insufficiency. J. Sleep Res. 7: Supplement 2.

48.. Nie, Y., Nakashima, M., Perfetti, R., Jansen, E., Plagova, M.,

Pipeleers, D., and Friedman, T.C. (1999) Regulation of Pancreatic PC1 in

Diabetic Rats. Endocrine Soc. 81:P2-231.

49.. Li, Q.-L., Brent, G., Wilber, J.F., Jansen, E., and Friedman, T.C.

(1999) Interactions Between the Prohormone Convertase 2 (PC2) Promoter and the

Thyroid Hormone Receptor. Endocrine Soc. 81:P2-662.

50.. Nie, Y., Nakashima, M., Perfetti, R., Jansen, E., Plagova, M.,

Pipeleers, D., and Friedman, T.C. (2000) Regulation of Pancreatic PC1 and PC2

Associated with Increased GLP-1 in Diabetic Rats. Endocrine Soc. 82:350.

51.. Friedman, T.C., Nakashima, M., Li, Q.-L., Nie, Y., Perfetti, R. and

Friedman, T.C. (2000) Regulation of Pancreatic PC1 and PC2 Associated with

Increased GLP-1 in Diabetic Rats. Endocrine Soc. 82:350.

52.. Ahmat, A.T., Brent, G.A., and Friedman, T.C., (2001) Treatment of

Amiodarone-induced Hypothyroidism by Triiodothyronine. Endocrine Soc. 82:MTP350.

53.. Brubaker, P.L., Nakashima, M., Li, Q.-L., Nie, Y., Perfetti, R. and

Friedman, T.C., (2000) Increased Pancreatic PC1 and PC2 are Associated with

Increased GLP-1 in Diabetic Rats. Canadian Diabetes Assoc.

54.. Friedman, T.C., Nie, Y., Nakashima, M., Li, Q.-L., Chen, F., and

Brubaker, P. (2001) Regulation of Pancreatic PC1 and PC2 Associated with

Increased GLP-1 in Diabetic Rats and Pancreatic Cell Lines. J. Invest. Med.

49:61S.

55.. Echeverry, D.M. and Friedman, T.C. (2001) Glucocorticoid-Remedial

Aldosteronism: Nuances and Clues to the Diagnosis. Endocrine Soc. 83:M58-2.

56.. Liu, Y.J., Nakagawa, Y. , Wang, Y., Toya, K. , Friedman, T.C., Li, R.S.

and Ohzeki, T. (2001) Reduction of 11 -Hydroxysteroid Dehydrogenase Type 1

Messenger Ribonucleic Acid Expression in Livers of ob/ob Mice. Endocrine Soc.

83:P1-299.

57.. Friedman, T.C., Li, Q.-L., Shen, X., Lindberg, I. (2001) Prohormone

Convertase 2 (PC2) Enzymatic Activity and its Regulation in Endocrine Cells.

Endocrine Soc. 83:P3-361.

58.. Liu, Y.J., Lutfy, K., Steiner, D.F., Friedman, T.C., (2002)

Nocioception, Tolerance and Dependence in PC2 Knockout Mice. Endocrine Soc.

84:P1-191.

59.. Shen , X., Li, Q.-L., Jansen, E., Brent, GA., Friedman, T.C. (2002)

Interactions Between the Prohormone Convertase 1 (PC1) Promoter and Thyroid

Hormone. Endocrine Soc. 84:P2-518.

60.. Wang, C., Kipnes, M., Matsumoto, A., Dobbs, A.S., Cunningham, G.,

Katznelson, L., Weber, T.J., Friedman, T.C., Snyder, P. (2002) Novel

Testosterone Bioadhesive Buccal Tablet - Pharmacokinetics and Safety Evaluation.

Endocrine Soc. 84:P2-645.

bi.. *^ Lutfy, K., Liu, Y.J., Steiner, D.F., Furutu, M., Friedman, T.C.,

(2002) Nocioception, Tolerance and Dependence in PC2 Knockout Mice. 33rd

International Narcotics Research Conference. S13.

bj.. Friedman, T.C., Davoudi, S., Daigle, K., Barron, D.S., Lee, M.L.,

Poland, R.E. (2003) Renin-Aldosterone Axis and Orthostatic Hypotension in

Patients with CFS. 6th International Conference on Chronic Fatigue Syndrome,

Fibromyalgia and Related Illnesses. Physiology Abstracts.

bk.. Friedman, T.C., Zuckerbraun, E., Storer, T., Berman, J., Magliano, L.,

Woodhouse, L., Bhasin, S. (2003) Muscle strength, physical and sexual function

in women with hypopituitarism. 8th International Pituitary Congress. P71.

bl.. Liu, Y., Nakagawa, Y., Wang, Y., Li, R., Ohzeki, T., Friedman, T.C.

(2003) The Interaction of Leptin with 11?-Hydroxysteroid Dehydrogenase Type 1 in

Hepatocytes May Mediate the Obesity Phenotype of Ob/Ob Mice. Endocrine Soc. 85:

P1-444.

bm.. Friedman, T.C., Zuckerbraun, E., Ghanaat, F., Daigle, K., Barron, D.S.,

Poland, R.E. (2003) High Prevalence of Renin-Aldosterone Axis Abnormalities in

Patients with Chronic Fatigue Syndrome (CFS). Endocrine Soc. 85:P1-533.

bn.. , V.C., Goldstein, J., Stuart, R., Munzberg, H., Friedman, T.C.,

Liu, Y., Bjorbaek, C., Nillni, E.A. (2003) Regulation of the Hypothalamic

Prohormone Convertases 1 and 2 Expression by Fasting and Leptin Endocrine Soc.

85:P3-113.

bo.. Choi, H.H., Friedman, T.C. (2003) Mysterious Suprasellar Mass Causing

Hypopituitarism. Endocrine Soc. 85:P3-648.

*Oral presentation

^Travel award