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LDN every night? Here's why.

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The debate on whether to take LDN continuosly or with breaks, really

centers on your philosophy. When taking it continuosly, one believes

in a " receptor blockade " approach. When taking it intermittently,

one believes in periodically giving rest to the endorphin receptors.

The principle can be better appreciated by most, when applied to

alcohol, opiates etc. Regular dosing (receptor blockade), dulls the

response and builds tolerance after some time. You need to take

higher doses to get the same response.

Dr.Bihari possibly proposes the continuos dose regimen, because the

half-life of LDN is quite short, 4 hrs for naltrexone. In effect it

is an intermmitent dose, since most of the drug is excreted in 5-6

half lives, i.e. 4x6=24 hrs, therefore by the next dose 24 hrs

later, the receptors would be empty. i.e. even Dr.Bihari's regime is

intermittent !.

Dr.Lawrence's alternative point of view could be that one also needs

to consider the important, metabolite of naltrexone (6-beta-

naltrexol) with a half life of 13 hrs. i.e.in 6 half lives (6x 13

hrs= 3 days approx), the patient will have attained steady state

levels. In other words, after 3 doses, LDN is present in your body

the whole time. One would like to block the endorphin receptors for

a few days more, and then empty the receptors to refresh them (i.e.

after 10 days of LDN). Therefore when you wish to refresh the

receptors, you need to take a 3 day break (6 half lives) to rid the

body of LDN and refresh the receptors.

I believe the intermittent approach is theoretically superior, but

who am I to know :-)

Yash

P.S. I have never contacted Drs.Bihari/Lawrence,so the above is

really my speculation as to what may be their reasoning.

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