Re: About Inosine

[Guest guest]

I have 2 jars of Inosine left. Used it for some time, but it did not

have a spectacular effect on me.

Chey

> Inosine

> What it does

> Where found

> Helpful for

> Are you deficient?

> Amount to take

> Side Effects & Interactions

> References

> What does it do?

> Inosine is a nucleoside, one of the basic compounds comprising

cells. It is a

> precursor to adenosine, an important energy molecule, and plays

many

> supportive roles in the body.

> Based upon anecdotal reports by Russian and Eastern European

athletes,

> inosine has been investigated for exercise-boosting (ergogenic)

effects. However,

> controlled studies have concluded that inosine does not improve

athletic

> performance and may even impair it.1 2

> Inosine is a precursor to uric acid, a compound that occurs

naturally in the

> body. Uric acid is believed to block the effect of a toxic free-

radical

> compound (peroxynitrite) that may play a role in the development

of multiple

> sclerosis (MS).3 In an attempt to raise uric acid levels, ten

patients with MS were

> treated with inosine in amounts up to 3 grams per day for 46

weeks. Three of

> the ten treated patients showed some evidence of improved function

and the

> others remained stable.4 Controlled studies are needed to confirm

these preliminary

> results.

> Where is it found?

> Inosine is found in brewer’s yeast and organ meats. It is also

available as a

> supplement.

> Inosine has been used in connection with the following conditions

(refer to

> the individual health concern for complete information):

> RatingHealth Concerns

> Multiple Sclerosis

> Reliable and relatively consistent scientific data showing a

substantial

> health benefit.

> Contradictory, insufficient, or preliminary studies suggesting a

health

> benefit or minimal health benefit.

> An herb is primarily supported by traditional use, or the herb or

supplement

> has little scientific support and/or minimal health benefit.

>

> Who is likely to be deficient?

> Inosine is not an essential nutrient, so deficiencies do not occur.

> How much is usually taken?

> Although a common amount of inosine taken by athletes is

5,000†" 6,000 mg per

> day, little scientific evidence supports the use of this

supplement in any

> amount.

> Are there any side effects or interactions?

> No side effects have been reported with the use of inosine for two

to five

> days in the limited research available. However, unused inosine is

converted by

> the body to uric acid, which may be hazardous to people at risk

for gout.

> At the time of writing, there were no well-known drug interactions

with

> inosine.

> References

> 1. Starling RD, Trappe TA, Short KR, et al. Effect of inosine

supplementation

> on aerobic and anaerobic cycling performance. Med Sci Sports Ex

1996;28:1193†"

> 8.

> 2. MH, Kreider RB, Hunter DW, et al. Effect of inosine

> supplementation on 3-mile treadmill run performance and VO2 peak.

Med Sci Sports Exerc

> 1990;22:517†" 22.

> 3. Koprowski H, Spitsin SV, Hooper DC. Prospects for the treatment

of

> multiple sclerosis by raising serum levels of uric acid, a

scavenger of

> peroxynitrite. Ann Neurol 2001;49:139.

> 4. Koprowski H, Spitsin SV, Hooper DC. Prospects for the treatment

of

> multiple sclerosis by raising serum levels of uric acid, a

scavenger of

> peroxynitrite. Ann Neurol 2001;49:139.