Guest guest Posted February 15, 2002 Report Share Posted February 15, 2002 So far, June, this is all I am finding: http://www.centerwatch.com/patient/studies/stu31303.html Sounds like it could be it this one, but the description is unsatisfyingly vague. If I find anything else, I'll let you know. Do you have any other information like the name of the research center or drug company - anything? Is it a new drug they are trying (I'm assuming a DMARD), mainly the type of delivery system, or both? Not to worry, a should be posting again soon. [ ] new study > Hi ,I have been searching,with no luck,to find out about a NDS that my niece in Ohio has been asked to take part in. The med is for people who have taken meds such as Mtx,plaquenil and gold,that have stopped working for them. It is a small device,a little smaller than a computer mouse and they stick it to your chest or abdomen to deliver the medication. If you should happen to find out anything I would appreciate it. > > BTW is a away? > > Hugs > June Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 20, 2002 Report Share Posted February 20, 2002 This may be it, I am not sure: J. , Ph.D.An Extended Phase I/II Study of a Novel Non-Depleting Fully Human Anti-CD4 Monoclonal Antibody (HuMax CD4) in Rheumatoid Arthritis Patients Treated with Methotrexate Circulating T cells contribute significantly in the pathogenesis of rheumatoid arthritis (RA). In RA, one of the most prominent infiltrating T cells in the synovium is the CD4+ T cell. CD4+ T cells become activated when presented with an antigen by Class II Major Histocompatibility Complex (MHC) molecules. Activated T cells ultimately produce an inflammatory immune response resulting in joint destruction. A CD4 monoclonal antibody may present a novel therapeutic agent to suppress inflammation in RA. Objective: To assess the safety and tolerability of a fully humanized monoclonal antibody (IgG1-k, HuMax-CD4) and to study CD4 receptor occupancy, CD4+ T cell counts, and plasma levels of HuMax-CD4) in patients with active rheumatoid arthritis treated with methotrexate. Methods: 10 subjects with active RA received a single subcutaneous infusion of HuMax-CD4 (4.0mg/kg) in combination with concurrent stable treatment of methotrexate (> 12.5mg/week) with a 28 day follow-up. CD4 receptor occupancy with competing and non-competing anti-CD4 antibodies was obtained by double flourescence staining. Results: Near maximal saturation of CD4 receptors was observed between day 1 and 7 and peaked on day 2 with values ranging from 79% to 92% in all patients. No significant changes were observed in the actual number of CD4+ cells. Plasma levels of HuMax peaked on day 2, ranging from 2.3 to 3.3 mg/ml. Reductions in clinical assessment of swollen and tender joints and the physician global assessment of disease activity were observed with medians of 54%, 38%, and 54% respectively. A 20% ACR20 response was obtained. Mild adverse events unrelated to treatment were reported. Conclusions: A single infusion of HuMax CD4 at 4.0mg/kg was well tolerated. Circulating CD4+T cells are not depleted in RA patients with concomitant treatment with methotrexate a wrote: > So far, June, this is all I am finding: > > http://www.centerwatch.com/patient/studies/stu31303.html > > Sounds like it could be it this one, but the description is > unsatisfyingly vague. If I find anything else, I'll let you know. Do you > have any other information like the name of the research center or drug > company - anything? > > Is it a new drug they are trying (I'm assuming a DMARD), mainly the type > of delivery system, or both? > > Not to worry, a should be posting again soon. > > > > > [ ] new study > > > > Hi ,I have been searching,with no luck,to find out about a NDS > that my niece in Ohio has been asked to take part in. The med is for > people who have taken meds such as Mtx,plaquenil and gold,that have > stopped working for them. It is a small device,a little smaller than a > computer mouse and they stick it to your chest or abdomen to deliver the > medication. If you should happen to find out anything I would appreciate > it. > > > > BTW is a away? > > > > Hugs > > June > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 18, 2004 Report Share Posted January 18, 2004 The Multiple Sclerosis Association of America web site has information on an MS study coming up: " INOSINE Research Study being done by Clyde Markowitz, MD at the Hospital of The University of Pennsylvania. Purpose of the study: The Inosine study is a research study to find out if Inosine given as an oral capsule is safe and has an effect on disease activity in patients diagnosed with Multiple Sclerosis. Inosine is taken in a pill form. The study will be a double-blind, placebo-controlled study. Study Size: We are looking for up to 30 patients with relapsing-remitting multiple sclerosis (MS). Study Length: The Inosine study will last approximately 6-8 months What is Inosine: Inosine is a dietary supplement that can be purchased in health food stores, it is a natural substance in our body Low levels of uric acid may be a factor that contributes to the progression of MS Inosine is absorbed in the gastrointestinal tract, and turned into uric acid Elevated levels of uric acid in MS may be beneficial in stopping the progression " full text and further information is found here: http://www.msaa.com click on Fast Find Menu, then Exciting & New, and MS-related stories Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 18, 2004 Report Share Posted January 18, 2004 , I've been giving this to my wife for about a month now. If you punch up the following web page you'll get the clinical trial. http://www.clinicaltrials.gov/ct/show/NCT00067327?order=1 I believe the idea came about because there are few if any people with gout that also have MS. I have been trying to convince her to take 5-6 500 mg tablets at once instead of spreading them. So far we haven't noticed anything positive. With the naltrexone however, she said she had a slight feeling in one of her feet. If you get into a clinical trial, I think that they want you to discontinue other treatments. As trials come along, and if I can get my hands on the item being tested, I use. I figure that I have all the bases covered. The bad thing with PPMS is that is usually one of the first exclusion criteria. If you ever find out about the inosine protocol let me know. I have read that athletes take 3000 mg before working out. Gerry ----- Original Message ----- From: low dose naltrexone Sent: Saturday, January 17, 2004 11:07 PM Subject: [low dose naltrexone] new study The Multiple Sclerosis Association of America web site has information on an MS study coming up:"INOSINE Research Study being done by Clyde Markowitz, MD at the Hospital of The University of Pennsylvania.Purpose of the study:The Inosine study is a research study to find out if Inosine given as an oral capsule is safe and has an effect on disease activity in patients diagnosed with Multiple Sclerosis. Inosine is taken in a pill form. The study will be a double-blind, placebo-controlled study.Study Size:We are looking for up to 30 patients with relapsing-remitting multiple sclerosis (MS).Study Length:The Inosine study will last approximately 6-8 monthsWhat is Inosine: Inosine is a dietary supplement that can be purchased in health food stores, it is a natural substance in our body Low levels of uric acid may be a factor that contributes to the progression of MS Inosine is absorbed in the gastrointestinal tract, and turned into uric acid Elevated levels of uric acid in MS may be beneficial in stopping the progression "full text and further information is found here:http://www.msaa.comclick on Fast Find Menu, then Exciting & New, and MS-related stories Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 19, 2004 Report Share Posted January 19, 2004 Hi Gerry, I'll kepp an eye on it! Quote Link to comment Share on other sites More sharing options...
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