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Progesterone or Progestin - A Mistaken Identity

by Gillson, M.D., Ph.D.

I'm writing to vent my spleen about the quality of some of the information

about progesterone being dispensed in the throwaway CME " journals " , so I hope

you will indulge me, as it is difficult to get negative comments published in

the magazines themselves. My first rant concerns an article entitled " Surviving

menopause without HRT " which appeared in The Canadian Journal of Diagnosis, pg

62, May 2004. The author, Dr. Christiane Kuntz notes that many of the adverse

outcomes seen in the Premarin/Provera arm of the WHIS were not seen in the

Premarin only arm. She finds this " fascinating " and goes on to ask " Could

progesterone be causing some of the perceived increase in risk? [risk

demonstrated in the combined HRT arm]. Dr. Kuntz, this would indeed be a

" fascinating " finding, since progesterone was not even studied in the WHIS !!!

People!! Please, please, please make the critical distinction between

progesterone and progestins in your mind and in your vocabulary! There is only

one progesterone, and the word progesterone is not a catch-all or substitute for

the words " progestin " or " progestagen " . Similarly with the molecules themselves.

Outside of contraceptive and oncologic uses, progestins are no substitute for

progesterone, and the sooner the medical profession gets this message, the

better. Casual interchange of these terms has helped us into the hormone pickle

in which we now find ourselves.

gracia-

if you read the study below- PROGESTERONE IS CITED IN THE STUDY. PROGESTINS

ARE the class of drugs FOR PROGESTERONE.

Please, do not tell me what the study was about BECAUSE UCLA WAS INVOLVED in

the study when I was in GRADUATE SCHOOL THERE. many of the researches who worked

with the study were from UCLA. Several of my professors in women's health were

involved in the study.

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