Re: What is an active lesion?

[Guest guest]

Hi ... This is my understanding of MRI lesions ... I can't remember

the source, just have this in my files from a while back ...

All the Best

Early Active lesions: These lesions are heavily infiltrated by T

cells and macrophages. Myelin sheaths are in the process of

disintegration and macrophages contain degradation products.

Late active lesions : In these lesions myelin is already destroyed

and removed from axons. Macrophages contain degradation products.

Inactive lesions with active border : The inactive center of radially

expanding lesions still show pronounced inflammation and macrophage

infiltration. The macrophages reveal empty vacuoles and show no

immunoreactivity for myelin proteins.

Inactive lesions : These lesions show no evidence for ongoing myelin

destruction at their borders. Although some of these lesions too

contain T cells and macrophages, their number was much lower compared

to active ones.

Remyelinated shadow plaques: These lesions are characterized by

myelin pallor, due to abnormally thin myelin sheaths. Similar to

inactive lesions, residual inflammation is present.

enaltrexone , " foono14 " <lorigrady214@c...> wrote:

> Could anyone tell me the difference between active and inactive

> lesions. My latest MRI showed new lesions, but not active. This is

> supposed to be good..

>

> Any ingo is appreciated.

[Guest guest]

I would think an active lesion would be one that is growing. If it's not

growing it wouldn't be very active.

Noland

----- Original Message -----

From: " foono14 " <lorigrady214@...>

<low dose naltrexone >

Sent: Friday, February 20, 2004 12:03 PM

Subject: [low dose naltrexone] What is an active lesion?

> Could anyone tell me the difference between active and inactive

> lesions. My latest MRI showed new lesions, but not active. This is

> supposed to be good..

>

> Any ingo is appreciated.

>

>

>

>

>

>