Guest guest Posted March 12, 2004 Report Share Posted March 12, 2004 I switched Pharmacies as well. I now use a compounding Pharmacy (Hobbs. near my home in Merritt Island, Fla.) and haven't noticed any changes since I switched from Irmat's. They are using the same filler (lactose) as Irmat's did. I just got tired of paying Irmat for an over night fee, and not getting it sometimes up till 5 days late! Ask your pharmacist what filler they are using, maybe that has something to do with the stiffness your'e experiencing. Just a thought! Good Luck to you. Carol Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 13, 2004 Report Share Posted March 13, 2004 I noticed more stiffness too when I switched to SKips. Since I didn't have much stiffness when I started with another pharmacy, I am treating this like I am starting over and experiencing the same side effects many others have. (does that make sense). I am going to give it some time. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 25, 2007 Report Share Posted January 25, 2007 Dr. Bihari's info says between 2100-0300 regardless of when you sleep. http://www.low dose naltrexone.org/further_q_and_a.htm Question 4 clearly states 2100-0300: If I have to work on a night shift, for example from midnight to 8a.m., at what time should I take my LDN? Continue to take LDN as recommended above; i.e., between 9pm and 3am. This relates to the fact that the endorphins for each day are always produced in the pre-dawn hours, regardless of the hours when one is awake or sleeping That was actually MY very first question because I Wake UP at 2300, I go to sleep before 1900. I've been taking my LDN within an hour or 2 of waking up for my day, MyStory The 'recommended time' is between 9pm and 3am, regardless of sleep. Most who try any other timeframe seem to not get the same results as 2100-0300 [low dose naltrexone] SKips Pharmacy I just spoke with Skip at Skips Pharmacy and he told me that there is a lot of confusion about when to take the LDN. He said that it's important to take it at Bedtime because of what it does to your endorphine levels. He said that if you're going to sleep at 3:00am you should take it then. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 28, 2007 Report Share Posted January 28, 2007 I think what skip meant is that people are confused about when to take it because of past discussions on the board. Dr Bihari dr Gluck etc have been very clear about when to take it. skip has been very clear. I was clear. and when i asked the people who were blasting this they were taking it in the morning to stop. now people call all the time and they said someone on the internet said to take in the morning and they wre following that persons directions. but thats where that comes from art cyndi [low dose naltrexone] Re: SKips Pharmacy >> I just spoke with Skip at Skips Pharmacy and he told me that there is a > lot of confusion about when to take the LDN. He said that it's > important to take it at Bedtime because of what it does to your > endorphine levels. He said that if you're going to sleep at 3:00am you > should take it then.>Actually, I don't think there's any confusion regarding when to take LDN. The main website, http://www.low dose naltrexone.org/, is very clear about the times:What dosage and frequency should my physician prescribe?The usual adult dosage is 4.5mg taken once daily at night. Because of the rhythms of the body's production of master hormones, LDN is best taken between 9pm and 3am. Most patients take it at bedtime.People who have multiple sclerosis that has led to muscle spasms are advised to use only 3mg daily and to maintain that dosage.Rarely, the naltrexone may need to be purchased as a solution — in distilled water — with 1mg per ml dispensed with a 5ml medicine dropper. If LDN is used in a liquid form, it is important to keep it refrigerated.The therapeutic dosage range for LDN is from 1.75mg to 4.5mg every night. Dosages below this range are likely to have no effect at all, and dosages above this range are likely to block endorphins for too long a period of time and interfere with its effectiveness.> IMPORTANT: Make sure to specify that you do NOT want LDN in a slow-release form (see above). Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 28, 2007 Report Share Posted January 28, 2007 In the protocol for Crohn's, 5 people were moved to the morning because they could not tolerate the nighttime problems. There was no differential effect of those 5, that is, they improved as much as the night timers. Their sleep improved and they were able to stay at 4.5. This is not to say that the evening time is not preferred, it is. There are many reasons in theory that it makes sense to stay with an evening dose if you can manage it. For those smaller number of patients who cannot sleep no matter what, the morning represents an alternative rather than no LDN at all. Still, it is important to keep in mind that for most patients, the sleep problems abate within two weeks, and so, patients are better served to try and hang in there. But there are some who cannot tolerate it. In our protocol for MS, we will move people to morning if they cannot tolerate, trying to keep them at 4.5. Best, Pincus [low dose naltrexone] Re: SKips Pharmacy > > I just spoke with Skip at Skips Pharmacy and he told me that there is a > lot of confusion about when to take the LDN. He said that it's > important to take it at Bedtime because of what it does to your > endorphine levels. He said that if you're going to sleep at 3:00am you > should take it then. > Actually, I don't think there's any confusion regarding when to take LDN. The main website, http://www.low dose naltrexone.org/, <http://www.low dose naltrexone.org/,> is very clear about the times: What dosage and frequency should my physician prescribe? The usual adult dosage is 4.5mg taken once daily at night. Because of the rhythms of the body's production of master hormones, LDN is best taken between 9pm and 3am. Most patients take it at bedtime. People who have multiple sclerosis that has led to muscle spasms are advised to use only 3mg daily and to maintain that dosage. Rarely, the naltrexone may need to be purchased as a solution — in distilled water — with 1mg per ml dispensed with a 5ml medicine dropper. If LDN is used in a liquid form, it is important to keep it refrigerated. The therapeutic dosage range for LDN is from 1.75mg to 4.5mg every night. Dosages below this range are likely to have no effect at all, and dosages above this range are likely to block endorphins for too long a period of time and interfere with its effectiveness. > IMPORTANT: Make sure to specify that you do NOT want LDN in a slow- release form (see above). Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 28, 2007 Report Share Posted January 28, 2007 I think that Dr Smit also eluded to the fact that LDN mioght actually be working differently with Crohns patient. Dr Pincus if you want her entire lecture email me and i'll send it to you. Maybe if people take it in the morning they can be a part of a subgroup of your study. For the most part sleep disturbances seem to be the biggest side effect and as long as people start low and go up slow it hasn't been much of an issue. cyndi [low dose naltrexone] Re: SKips Pharmacy >> I just spoke with Skip at Skips Pharmacy and he told me that thereis a > lot of confusion about when to take the LDN. He said that it's > important to take it at Bedtime because of what it does to your > endorphine levels. He said that if you're going to sleep at 3:00amyou > should take it then.>Actually, I don't think there's any confusion regarding when to takeLDN. The main website, http://www.low dose naltrexone.org/,<http://www.low dose naltrexone.org/,> is very clear about the times:What dosage and frequency should my physician prescribe?The usual adult dosage is 4.5mg taken once daily at night. Becauseof the rhythms of the body's production of master hormones, LDN is besttaken between 9pm and 3am. Most patients take it at bedtime.People who have multiple sclerosis that has led to muscle spasms areadvised to use only 3mg daily and to maintain that dosage.Rarely, the naltrexone may need to be purchased as a solution — in distilled water — with 1mg per ml dispensed with a 5ml medicine dropper. If LDN is used in a liquid form, it is important to keep itrefrigerated.The therapeutic dosage range for LDN is from 1.75mg to 4.5mg every night. Dosages below this range are likely to have no effect at all,and dosages above this range are likely to block endorphins for too long a period of time and interfere with its effectiveness.> IMPORTANT: Make sure to specify that you do NOT want LDN in aslow-release form (see above). Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 28, 2007 Report Share Posted January 28, 2007 what link? Skip's is http://www.skipspharmacy.COM the main LDN site is .ORG http://www.low dose naltrexone.ORG and/or http://www.ldninfo.org I do have a shortcut link at http://www.larrygc.com/ldn but it takes you to the above site the .com with low dose naltrexone is a stolen site and has NOTHING to do with Low Dose Naltrexone AT ALL, it's a stolen name site for advertising everything BUT LDN [low dose naltrexone] Re: SKips Pharmacylow dose naltrexone > > >> > I just spoke with Skip at Skips Pharmacy and he told me that > there > is a > > lot of confusion about when to take the LDN. He said that > it's > > important to take it at Bedtime because of what it does to > your > > endorphine levels. He said that if you're going to sleep at > 3:00am > you > > should take it then.> >> > Actually, I don't think there's any confusion regarding when to > take > LDN. The main website, http://www.low dose naltrexone.org/, is > very > clear about the times:> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 28, 2007 Report Share Posted January 28, 2007 > > Just FYI-that link has to have .com for the ending not '.org' I just tried it. thanks kate from NY > [low dose naltrexone] Re: SKips Pharmacy > low dose naltrexone > Excuse me for disagreeing with you, Kate, but the website is http://www.low dose naltrexone.org/. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 29, 2007 Report Share Posted January 29, 2007 larry is 100% correct cyndi Re: [low dose naltrexone] Re: SKips Pharmacy > >what link? > >Skip's is http://www.skipspharmacy.COM > >the main LDN site is .ORG http://www.low dose naltrexone.ORG and/or http://www.ldninfo.org > >I do have a shortcut link at http://www.larrygc.com/ldn but it takes you to the above site > >the .com with low dose naltrexone is a stolen site and has NOTHING to do with Low Dose Naltrexone AT ALL, it's a stolen name site for advertising everything BUT LDN > > > > > > [low dose naltrexone] Re: SKips Pharmacy > low dose naltrexone > > > > > > > > > I just spoke with Skip at Skips Pharmacy and he told me that > > there > > is a > > > lot of confusion about when to take the LDN. He said that > > it's > > > important to take it at Bedtime because of what it does to > > your > > > endorphine levels. He said that if you're going to sleep at > > 3:00am > > you > > > should take it then. > > > > > > > Actually, I don't think there's any confusion regarding when to > > take > > LDN. The main website, http://www.low dose naltrexone.org/, is > > very > > clear about the times: > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 29, 2007 Report Share Posted January 29, 2007 thanks brenda. we discussed this in length with Dr Gluck about times and past studies that have failed when given in the morning. the crohns patients are different. I so want Dr Pincus's study to suceed. and I don't want any ms patients Z(or any others) to progress cyndi [low dose naltrexone] Re: SKips Pharmacy > > >> >> In the protocol for Crohn's, 5 people were moved to the morning >> because they could not tolerate the nighttime problems. There was no >> differential effect of those 5, that is, they improved as much as >the night >> timers. Their sleep improved and they were able to stay at 4.5. >This is >> not to say that the evening time is not preferred, it is. There are >many >> reasons in theory that it makes sense to stay with an evening dose >if you >> can manage it. For those smaller number of patients who cannot >sleep no >> matter what, the morning represents an alternative rather than no >LDN at >> all. Still, it is important to keep in mind that for most patients, >the >> sleep problems abate within two weeks, and so, patients are better >served to >> try and hang in there. But there are some who cannot tolerate it. >In our >> protocol for MS, we will move people to morning if they cannot >tolerate, >> trying to keep them at 4.5. Best, Pincus >> >============== > >LDN works differently for crohn's. People with crohn's were actually >able to come off the drug and not regress. A person with MS cannot do >that and Dr. Bihari found that the best time for MS'ers to take LDN so >that disease progression could have the best chance of being halted >was between the hours of 9pm and 3am. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 29, 2007 Report Share Posted January 29, 2007 Don't know what you were expecting to find but low dose naltrexone.com is a rip off site - absolute waste of time and just trying to sucker people looking for low dose naltrexone.org which is where all the real info is. katelloydkidz@... wrote: > *Just FYI-that link has to have .com for the ending not '.org' I just > tried it. thanks kate from NY > *----- Original Message ----- > > Actually, I don't think there's any confusion regarding when to > > take > > LDN. The main website, http://www.low dose naltrexone.org/, is > > very > > clear about the times: Quote Link to comment Share on other sites More sharing options...
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