Guest guest Posted October 1, 2008 Report Share Posted October 1, 2008 I heard there is someone that said the opitmal range is 0.3-2.5. but not sure if it is true or not. Many are treated for TSH level is as low as 1? I just read a paper that states 3 ranges of low TSH levels classified into three degrees, it said that as follows (extract from it). " 1. 0.1-0.4mU/L,---subclinical hyperthyroidism 2.0.05-0.1mU/L( for some authors, 0.02-0.1 or 0.2mU/L).--The different diagnosis is similar to the previous one. Some others consider that is overt hyperthyroidism. Such TSH levels are the goal of T4 treatment in patients with differentiated thyroid cancer. 3.less than 0.02mU/L--endogenous hyperthyroidism and possibly in severe panhypituitarism. And for 0.45-2.5 mU/L with a median of 1.0-1.5mU/L is the normal range. " What is your thought? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 2, 2008 Report Share Posted October 2, 2008 Have a look at the following Fragrance. There is a great deal of controversy regarding TSH. Here in the UK, one of the reasons why many of us cannot get a diagnosis (and will never get a diagnosis unless things change) is that the British Thyroid Association with the Association of Clinical Biochemists drew up new TFT guidelines in 2006 and decided that the TSH range should be between 0.5 and 10. One wonders why? _________________________________ If the serum TSH reference range would be based upon a cohort of truly normal individuals with no personal or family history of thyroid dysfunction, no visible or palpable goiter, not taking any medication, who are seronegative for thyroid peroxidase antibodies, and whose blood samples are drawn fasting in the morning hours (06–10 h), the TSH reference range would become 0.4–2.5 mU/L (Demers & co, Baloch & co.) Demers LM, Spencer CA. Laboratory medicine practice guidelines: laboratory support for the diagnosis and monitoring of thyroid disease. Clin Endocrinol (Oxf). 2003;58:138–40 Hollowell JG, Staehling NW, Flanders WD, Gunter EW, Spencer CA, Braverman LE. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002; 87:489–99 Baloch Z, Carayon P, Conte-Devolx B, Demers LM, Feldt-Rasmussen U, Henry JF, LiVosli VA, Niccoli-Sire P, R, Ruj J, Smyth PP, Spencer CA, Stockigt JR, Guidelines Committee, National Academy of Clinical Biochemistry 2003 Laboratory medicine practice guidelines. Thyroid. 2003 Jan;13(1):3-126 When data for subjects with positive TPOAb or a family history of autoimmune thyroid disease are excluded, the normal reference interval becomes much tighter, i.e. 0.4–2.0 mU/liter. This tighter reference range may certainly be more applicable to African-Americans, who have a lower mean TSH Hollowell JG, Staehling NW, Flanders WD, Gunter EW, Spencer CA, Braverman LE. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002; 87:489–99 Demers LM, Spencer CA. Laboratory medicine practice guidelines: laboratory support for the diagnosis and monitoring of thyroid disease. Clin Endocrinol (Oxf). 2003;58:138–40 Publications with data to support a more narrow reference range for serum TSH that would be obtained when persons with diffuse hypoechogenicity of the thyroid on ultrasound, a condition that precedes thyroid peroxidase antibody positivity in autoimmune thyroid disease, would be excluded Pedersen OM, Aardal NP, Larssen TB, Varhaug JE, Myking O, Vik-Mo H. The value of ultrasonography in predicting autoimmune thyroid disease. Thyroid. 2000;10:251–9 For the American Association of Clinical Endocrinologists the revised reference TSH range is 0.3–3.0 mU/L American Association of Clinical Endocrinologists. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract. 2002;8:457–69 Ethnic differences: the mean TSH level in African-Americans is 1.18 mU/liter, in contrast to a mean of 1.40 mU/liter in Caucasians, due to the greater frequency of autoimmune thyroid disease in whites (12.3%) than in blacks (4.3%), which may have unjustifiedly skewed the upper end of the TSH curve (NHANES data). For African-Americans, the TSH reference range should therefore be lower than in whites Hollowell JG, Staehling NW, Flanders WD, Gunter EW, Spencer CA, Braverman LE. Serum TSH, T4, and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). J Clin Endocrinol Metab. 2002;87:489–9 A study, which suggests that the serum TSH cut-off point between hypo- and euthyroidism is 2, not 4 or 5.5 Michalopoulou G, Alevizaki M, Piperingos G, Mitsibounas D, Mantzos E, Adampoulos P, Koutras DA. High serum cholesterol levels in persons with 'high-normal' TSH levels: Should one extend the definition of subclinical hypothyroidism? Eur J Endocrinol. 1998 Feb;138(2):141-5(Treating TPO antibody-positive hypercholesterolemic patients with TSH levels between 2-4 mU/L with low dose levothyroxine normalizes TSH levels and improves the lipid profile) In 2003, the National Academy of Clinical Biochemistry (NACB) has reduced the upper limit of the reference range from 5.5 to 4.1 mU/L, but stating also that "greater than 95% of healthy, euthyroid subjects have a serum TSH concentration between 0.4 - 2.5 mU/L". ".. patients with a serum TSH >2.5 mU/L, when confirmed by repeat TSH measurement made after 3 to 4 weeks, may be in the early stages of thyroid failure, especially if thyroid peroxidise antibodies are detected” Baloch Z, Carayon P, Conte-Devolx B, Demers LM, Feldt-Rasmussen U, Henry JF, LiVosli VA, Niccoli-Sire P, R, Ruj J, Smyth PP, Spencer CA, Stockigt JR, Guidelines Committee, National Academy of Clinical Biochemistry 2003 Laboratory medicine practice guidelines. Thyroid. 2003 Jan;13(1):3 Supporters of the recommendations of the consensus panel (Endocrine Society, American Association of Clinical Endocrinologists, American Thyroid Association) promote a target TSH range of 1.0–1.5 mU/liter in patients already receiving T4 therapy Baloch Z, Carayon P, Conte-Devolx B, Demers LM, Feldt-Rasmussen U, Henry JF, LiVosli VA, Niccoli-Sire P, R, Ruj J, Smyth PP, Spencer CA, Stockigt JR, Guidelines Committee, National Academy of Clinical Biochemistry 2003 Laboratory medicine practice guidelines. Thyroid. 2003 Jan;13(1):3-126 I heard there is someone that said the opitmal range is 0.3-2.5. butnot sure if it is true or not. Many are treated for TSH level is as low as 1?What is your thought? No virus found in this incoming message.Checked by AVG - http://www.avg.com Version: 8.0.173 / Virus Database: 270.7.5/1702 - Release Date: 01/10/2008 09:05 Quote Link to comment Share on other sites More sharing options...
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