3mg stronger than 4.5mg

[Guest guest]

I don't what is what. I do know that it is working for me. I started at 3mg, and after a month

went up to 4.5mg. Timewise, right around 10pm seems to be the best for myself. I didn't

notice any significent difference when going up in dosage, just had to get used to the

higher dose before I slept better, and I've never really gotten over the stiffness. Had it

before starting ldn and still have it. Stretching seems to get most of the kinks out. And

if I sit for any length of time, then it's stretch a little bit again and move on. I can do this!

http://www.low dose naltrexone.org/ldn_and_ms.htm

The statements below were taken directly from the above link.

Presumably, these people have "normal" levels of endorphins.

When it was licensed, Dr. Bihari, then involved in running programs for treating addiction, tried it in more than 50 heroin addicts who had stopped heroin use. None of the patients would stay on the drug because of side effects experienced at 50 mg such as insomnia, depression, irritability and loss of feelings of pleasure, all due to the effect of the drug at this dose in blocking endorphins.

Now according to this, people with ms and probably other immune-related diseases

have low endorphin levels.

The apparent mechanism of action of LDN in this disease parallels that in AIDS and other immune-related diseases. A small dose of the drug taken nightly at bedtime triples the endorphin levels in the body all of the next day restoring levels to normal. Since endorphin levels are low in people with MS, immune function is poorly orchestrated with significant impairment of the normal immune supervisory function of CD4 cells.

http://www.low dose naltrexone.org/index.htm#How_does_LDN_work_

Paragraphs below from the above link.

The brief blockade of opioid receptors between 2 a.m. and 4 a.m. that is caused by taking LDN at bedtime each night is believed to produce a prolonged up-regulation of vital elements of the immune system by causing an increase in endorphin and enkephalin production. Normal volunteers who have taken LDN in this fashion have been found to have much higher levels of beta-endorphins circulating in their blood in the following days. Animal research by I. Zagon, Ph.D., and his colleagues has shown a marked increase in metenkephalin levels as well. [Note: Additional information for Dr. Zagon can be found at the end of this page.]

In general, in people with diseases that are partially or largely triggered by a deficiency of endorphins (including cancer and autoimmune diseases), or are accelerated by a deficiency of endorphins (such as HIV/AIDS), restoration of the body's normal production of endorphins is the major therapeutic action of LDN.

This was taken directly from the low dose naltrexone web sites.

Have a Great Day.

Jim