Do endorphin levels vary in MS

[Guest guest]

I have previously posted a study by Gironi et.al. that MS patients

have low endorphin levels. In response to that article, Mr.Sullivan

asks if beta endorphins vary in a circadian manner. He points out

that beta -endorphins are known to vary during the day in many other

conditions and implies that this may also be true for MS.

The implication for us is that this fits in perfectly with the idea

that LDN needs to be taken at a particular time.

Yash

Does MS-related plasma beta-endorphin vary in circadian manner? 19

November 2003

J. Sullivan,

Dear Editor

As it is well known, endorphin levels change in different

circumstances, for example, in injury, illness, or as a result of

circadian influences, among others.[1-7] It would be helpful to know

which was the primary stimulus for endorphin level changes in MS

patients. Perhaps a further experiment can show that it is or is not

circadian.

References

(1) Covelli V, Massari F, Fallacara C, Munno I, Jirillo E, Savastano

S, Tommaselli AP, Lombardi G. Interleukin-1 beta and beta-endorphin

circadian rhythms are inversely related in normal and stress-altered

sleep. Int J Neurosci. 1992 Apr;63(3-4):299-305.

(2) Iranmanesh A, Lizarralde G, ML, Veldhuis JD. Circadian,

ultradian, and episodic release of beta-endorphin in men, and its

temporal coupling with cortisol.J Clin Endocrinol Metab. 1989 Jun;68

(6):1019-26.

(3) Sekiya K, Nawata H, Kato K, Motomatsu T, Ibayashi H. Diurnal

rhythms of proopiomelanocortin-derived N-terminal peptide, beta-

lipotropin, beta-endorphin and adrenocorticotropin in normal

subjects and in patients with 's disease and Cushing's

disease. Endocrinol Jpn. 1986 Oct;33(5):713-9.

(4) Melmed S. Series Introduction: The immuno-neuroendocrine

interface. J Clin Invest, December 2001, Volume 108, Number 11, 1563-

1566

(5) Barreca T, Siani C, Franceschini R, Francaviglia N, Messina V,

Perria C, Rolandi E. Diurnal beta-endorphin changes in human

cerebrospinal fluid. Life Sci. 1986 Jun 16;38(24):2263-7.

(6) Shanks MF, Clement- V, Linsell CJ, Mullen PE, Rees LH,

Besser GM. A study of 24-hour profiles of plasma met-enkephalin in

man. Brain Res. 1981 May 18;212(2):403-9.

(7) Gil-Ad I, Dickerman Z, Amdursky S, Laron Z. Diurnal rhythm of

plasma beta endorphin, cortisol and growth hormone in schizophrenics

as compared to control subjects. Psychopharmacology (Berl). 1986;88

(4):496-9.

[Guest guest]

Hi All .. I remember thinking about this a great deal and then I read

on the LDN site ...

If I have to work on a night shift, for example from midnight to

8a.m., at what time should I take my LDN?

Continue to take LDN as recommended above; i.e., between 9pm and 3am.

This relates to the fact that the endorphins for each day are always

produced in the pre-dawn hours, regardless of the hours when one is

awake or sleeping

That to me says that individual circadian rhythms don't matter with

LDN.

All The Best

> I have previously posted a study by Gironi et.al. that MS patients

> have low endorphin levels. In response to that article, Mr.Sullivan

> asks if beta endorphins vary in a circadian manner. He points out

> that beta -endorphins are known to vary during the day in many

other

> conditions and implies that this may also be true for MS.

>

> The implication for us is that this fits in perfectly with the idea

> that LDN needs to be taken at a particular time.

>

> Yash

>

> Does MS-related plasma beta-endorphin vary in circadian manner? 19

> November 2003

>

> J. Sullivan,

>

>

>

> Dear Editor

>

> As it is well known, endorphin levels change in different

> circumstances, for example, in injury, illness, or as a result of

> circadian influences, among others.[1-7] It would be helpful to

know

> which was the primary stimulus for endorphin level changes in MS

> patients. Perhaps a further experiment can show that it is or is

not

> circadian.

>

> References

>

> (1) Covelli V, Massari F, Fallacara C, Munno I, Jirillo E,

Savastano

> S, Tommaselli AP, Lombardi G. Interleukin-1 beta and beta-endorphin

> circadian rhythms are inversely related in normal and stress-

altered

> sleep. Int J Neurosci. 1992 Apr;63(3-4):299-305.

>

> (2) Iranmanesh A, Lizarralde G, ML, Veldhuis JD. Circadian,

> ultradian, and episodic release of beta-endorphin in men, and its

> temporal coupling with cortisol.J Clin Endocrinol Metab. 1989 Jun;68

> (6):1019-26.

>

> (3) Sekiya K, Nawata H, Kato K, Motomatsu T, Ibayashi H. Diurnal

> rhythms of proopiomelanocortin-derived N-terminal peptide, beta-

> lipotropin, beta-endorphin and adrenocorticotropin in normal

> subjects and in patients with 's disease and Cushing's

> disease. Endocrinol Jpn. 1986 Oct;33(5):713-9.

>

> (4) Melmed S. Series Introduction: The immuno-neuroendocrine

> interface. J Clin Invest, December 2001, Volume 108, Number 11,

1563-

> 1566

>

> (5) Barreca T, Siani C, Franceschini R, Francaviglia N, Messina V,

> Perria C, Rolandi E. Diurnal beta-endorphin changes in human

> cerebrospinal fluid. Life Sci. 1986 Jun 16;38(24):2263-7.

>

> (6) Shanks MF, Clement- V, Linsell CJ, Mullen PE, Rees LH,

> Besser GM. A study of 24-hour profiles of plasma met-enkephalin in

> man. Brain Res. 1981 May 18;212(2):403-9.

>

> (7) Gil-Ad I, Dickerman Z, Amdursky S, Laron Z. Diurnal rhythm of

> plasma beta endorphin, cortisol and growth hormone in

schizophrenics

> as compared to control subjects. Psychopharmacology (Berl). 1986;88

> (4):496-9.