Re: How translatable is this response? Do we dare find out? - a personal opinion

[Guest guest]

Good luck Cub Lea. I wish you well.

Tom from Edmonton

----- Original Message -----

From: Cub Lea

low dose naltrexone

Sent: Saturday, May 01, 2004 4:47 PM

Subject: [low dose naltrexone] How translatable is this response? Do we dare find out? - a personal opinion

Practically from the moment I heard about LDN, I had a suspicion that I'd stumbled onto something much bigger than it appeared. I'm now utterly convinced of it.I believe what we have here is the advent of a new form of treatment for neurotransmitter imbalance. The question now is how far it can go, and how long it can be maintained, and what's required to maintain benefits.This week I'm going to wheedle some propranolol from my GP and try experimenting with low-dose beta blockers as a possible treatment for anxiety disorder. I strongly suspect that if I can follow the same trail left by naltrexone, I could find this to be far more effective and side-effect-free than new-generation tetracyclic antidepressants.My theory is this: LDN's effect is not isolated, and that neurotransmitter uptake blockers of other types can be "tweaked" to achieve similar benefits. Adrenaline/epinephrine blockers at low dosages could, when their use is understood, be incredibly effective antidepressants. NOR-adrenaline blockers at low dosages could be very useful for anxiety and obsessive/compulsive disorders. GABA blockers could have the same benefits for autism/Asperger's/ADHD/etc. Acetylcholine blockers could slow or prevent the onset of problems such as age-related memory loss, Parkinsonism, and many other problems. And of course the big prize - serotonin blockers - could cause a ruckus in the pharmaceutical industry like we haven't seen for a long time. Can you imagine the uproar if a 1/75th-normal dose of an "orphan" serotonin blocker turned out to be effective for half the people currently on Paxil, Effexor, Wellbutrin, etc.?Anyone with info, links etc. on these effects, I'd love to hear more.(Speaking of uproar, I kind of wonder when the nasty backlash against Bihari is going to hit. Seems to me that when the public profile of LDN hits a critical mass, we're going to see some pretty heavy criticism and a lot of pressure not to use this kind of treatment. I've already gotten whiffs of this backlash from friends who suggest - not without ridicule, either - that I wouldn't have any need to THINK of LDN if I only devoted myself to the Lord's work (sigh) or put in a heavy workout a few times a week.)Once again, for those who may have been on drugs, I am not a doctor, I just bill like one.-Cub Lea-P.S.: Not all of us are bozos on this bus. (HONK)

[Guest guest]

It is worth mentioning that the NIH is funding a trial of copaxone

with albuterol.

Yash

> Good luck Cub Lea. I wish you well.

>

> Tom from Edmonton

> ----- Original Message -----

> From: Cub Lea

> low dose naltrexone

> Sent: Saturday, May 01, 2004 4:47 PM

> Subject: [low dose naltrexone] How translatable is this response?

Do we dare find out? - a personal opinion

>

>

> Practically from the moment I heard about LDN, I had a suspicion

that I'd stumbled onto something much bigger than it appeared. I'm

now utterly convinced of it.

>

> I believe what we have here is the advent of a new form of

treatment for neurotransmitter imbalance. The question now is how

far it can go, and how long it can be maintained, and what's

required to maintain benefits.

>

> This week I'm going to wheedle some propranolol from my GP and

try experimenting with low-dose beta blockers as a possible

treatment for anxiety disorder. I strongly suspect that if I can

follow the same trail left by naltrexone, I could find this to be

far more effective and side-effect-free than new-generation

tetracyclic antidepressants.

>

> My theory is this: LDN's effect is not isolated, and that

neurotransmitter uptake blockers of other types can be " tweaked " to

achieve similar benefits. Adrenaline/epinephrine blockers at low

dosages could, when their use is understood, be incredibly effective

antidepressants. NOR-adrenaline blockers at low dosages could be

very useful for anxiety and obsessive/compulsive disorders. GABA

blockers could have the same benefits for

autism/Asperger's/ADHD/etc. Acetylcholine blockers could slow or

prevent the onset of problems such as age-related memory loss,

Parkinsonism, and many other problems. And of course the big prize -

serotonin blockers - could cause a ruckus in the pharmaceutical

industry like we haven't seen for a long time. Can you imagine the

uproar if a 1/75th-normal dose of an " orphan " serotonin blocker

turned out to be effective for half the people currently on Paxil,

Effexor, Wellbutrin, etc.?

>

> Anyone with info, links etc. on these effects, I'd love to hear

more.

>

> (Speaking of uproar, I kind of wonder when the nasty backlash

against Bihari is going to hit. Seems to me that when the public

profile of LDN hits a critical mass, we're going to see some pretty

heavy criticism and a lot of pressure not to use this kind of

treatment. I've already gotten whiffs of this backlash from friends

who suggest - not without ridicule, either - that I wouldn't have

any need to THINK of LDN if I only devoted myself to the Lord's work

(sigh) or put in a heavy workout a few times a week.)

>

> Once again, for those who may have been on drugs, I am not a

doctor, I just bill like one.

>

> -Cub Lea-

>

> P.S.: Not all of us are bozos on this bus. (HONK)

>

>

>

[Guest guest]

Thanks, Tom. Don't know how much I do find out would be applicable to more than

a few in this forum though. I expect the big benefits in MS might come from

low-dose anticholinergics if this effect does translate, and that's not

something for which I seem to have a need at present...that could change in the

next decade since my family does tend toward Parkinsonism.

I haven't managed to hit on any useful keyword combinations leading to

information on other possible applications of low-dose neurotransmitter reuptake

inhibitors. If anyone does, please share 'em, publicly or privately...many

thanks!

-Cub-

At 01:48 PM 5/2/04, you wrote:

>Good luck Cub Lea. I wish you well.

>

>Tom from Edmonton

>----- Original Message -----

>From: <mailto:cub@...>Cub Lea

><mailto:low dose naltrexone >low dose naltrexone

>Sent: Saturday, May 01, 2004 4:47 PM

>Subject: [low dose naltrexone] How translatable is this response? Do we dare find

out? - a personal opinion

>

>Practically from the moment I heard about LDN, I had a suspicion that I'd

stumbled onto something much bigger than it appeared. I'm now utterly convinced

of it.

>

>I believe what we have here is the advent of a new form of treatment for

neurotransmitter imbalance. The question now is how far it can go, and how long

it can be maintained, and what's required to maintain benefits.