Re: Going for 3 days of IV Solumedrol tomorrow - have to stop LDN for how long?

[Guest guest]

<Anyhow, my question is... I have to stop LDN until the treatment is

over and I have done the 1 week Prednisone taper off. How much time

must then pass before I can begin LDN again?>

With the caveat that no one really knows, you answer your own

question. I personally would wait between 1-2, preferably 2 weeks

after the pred treatment. The reason is that some steroids can bind

to the opioid receptors on the brain. (see reference below). My

speculation is that if steroids bind to opiate receptors, they may

actually increase endorphin levels similar to LDN.

Yash

Authors

Gutierrez M. Menendez L. Brieva R. Hidalgo A. Baamonde A.

Institution

Departamento de Medicina, Facultad de Medicina, Oviedo, Spain.

Title

Different types of steroids inhibit [3H]diprenorphine binding in

mouse brain membranes.

Source

General Pharmacology. 31(5):747-51, 1998 Nov.

Abstract

1. The binding of 60 drugs, mainly steroids, to opioid receptors was

studied in crude membrane fractions from mouse brains. 2.

Competition assays with the different drugs (5 x 10(-7)-10(-4)M)

were performed by labeling opiate receptors with [3H]diprenorphine

(0.3-0.4 nM). 3. Only 7 drugs (alpha,5beta-

tetrahydrodeoxycorticosterone, megestrol acetate, mifepristone,

17alpha-ethynylestradiol, diethylstilbestrol, clomiphene citrate and

tamoxifen citrate) inhibited [3H]diprenorphine binding more than 50%

at the highest concentration assayed (10(-4) M). The IC50 values

ranged between 6x10(-5) M. 4. Thus, the present results show that

only a limited number of steroids, from diverse classes, bind to

opiate receptors.

--- In low dose naltrexone , " janebee " <bee3@c...>

wrote:

> I'm 65 and have had MS for 32 years. I have been SPMS for the last

12

> years, slowly getting worse. I've done Solu-Medrol about 8 times

since

> 1992, with varying results.

>

> I use a Rollator (wheeled walker), but in the last month my back

> became so weak I can barely hold myself up. My legs are numb, I

cannot

> tell where my left foot is or even if it is flat on the floor. I

> have developed scoliosis over the past 5 years and with that, the

back

> muscles on one side have atrophied and on the other side they are

over

> developed. On the atrophied side it feels like there is an Ace

> bandage wrapped tightly around my ribs, sometimes so tightly I

can't

> get by breath

>

> I started LDN 23 days ago and have noticed almost nothing.

Previously

> I have had no trouble sleeping, and did not have to get up during

the

> night--so there has been no change there. The only thing it may

have

> helped is incontinence. I think I don't have to go as often and

can

> usually make it in time.

>

> Anyhow, my question is... I have to stop LDN until the treatment is

> over and I have done the 1 week Prednisone taper off. How much

time

> must then pass before I can begin LDN again?

>

> Janbee

[Guest guest]

Hi .. Many have taken LDN with solumedrol or prednisone .. again

these are not narcotics ... it is debated as to how they effect the

benefits of LDN but there is no medical problem there with 4.5mg or

less .. you can start the LDN again whenever suits you.

> I'm 65 and have had MS for 32 years. I have been SPMS for the last

12

> years, slowly getting worse. I've done Solu-Medrol about 8 times

since

> 1992, with varying results.

>

> I use a Rollator (wheeled walker), but in the last month my back

> became so weak I can barely hold myself up. My legs are numb, I

cannot

> tell where my left foot is or even if it is flat on the floor. I

> have developed scoliosis over the past 5 years and with that, the

back

> muscles on one side have atrophied and on the other side they are

over

> developed. On the atrophied side it feels like there is an Ace

> bandage wrapped tightly around my ribs, sometimes so tightly I can't

> get by breath

>

> I started LDN 23 days ago and have noticed almost nothing.

Previously

> I have had no trouble sleeping, and did not have to get up during

the

> night--so there has been no change there. The only thing it may

have

> helped is incontinence. I think I don't have to go as often and can

> usually make it in time.

>

> Anyhow, my question is... I have to stop LDN until the treatment is

> over and I have done the 1 week Prednisone taper off. How much time

> must then pass before I can begin LDN again?

>

> Janbee

[Guest guest]

I just finished the 3 days of 1000mg Solu-Medrol yesterday.

I didn't stop LDN 4.5. My neuro used to give me a 16 day taper off

with Prednisone. The last time he said it was not necessary at all.

Now I have a new Neuro and she gave me a 5 day taper off; 6, then 5,

4, 3, 2, 1, Go figure. I did not experience any side effects from the

Solu-Medrol this time--no swelling, red-face, sleeplessless,

irritablility.

Of course S-M " cures " all arthritic pain--temporairly. I can stand up

straighter, and hope it lasts. I hope the LDN will help stabilize me

now. My neuro doesn't even know I am doing LDN since she wouldn't

prescribe it.

Good Luck with your infusion.

Janebee

> I'm doing a solumedrol run for 4 days at 1000 mg a day then doing an

oral

> pred taper beginning at 60 for three days then down. I decided to

lay off

> the LDN 2 days before starting and I will prob go right back on

after the

> taper ends. I want to get the benefit of the steroids but don't

believe that

> after that benefit has occurred taking the LDN will effect my health

I may

> be wrong and someone can let me know. As far as my neuro knows he

thinks I

> am doing these together.

>

>

>

> _____

>

> From: mboylebradley [mailto:mboylebradley@v...]

> Sent: Tuesday, April 13, 2004 10:30 PM

> low dose naltrexone

> Subject: [low dose naltrexone] Re: Going for 3 days of IV Solumedrol

tomorrow

> - have to stop LDN for how long?

>

>

>

> Hi .. Many have taken LDN with solumedrol or prednisone .. again

> these are not narcotics ... it is debated as to how they effect the

> benefits of LDN but there is no medical problem there with 4.5mg or

> less .. you can start the LDN again whenever suits you.

>

>

>

>

> --- In low dose naltrexone , " janebee " <bee3@c...>

wrote:

> > I'm 65 and have had MS for 32 years. I have been SPMS for the

last

> 12

> > years, slowly getting worse. I've done Solu-Medrol about 8 times

> since

> > 1992, with varying results.

> >

> > I use a Rollator (wheeled walker), but in the last month my back

> > became so weak I can barely hold myself up. My legs are numb, I

> cannot

> > tell where my left foot is or even if it is flat on the floor. I

> > have developed scoliosis over the past 5 years and with that, the

> back

> > muscles on one side have atrophied and on the other side they are

> over

> > developed. On the atrophied side it feels like there is an Ace

> > bandage wrapped tightly around my ribs, sometimes so tightly I

can't

> > get by breath

> >

> > I started LDN 23 days ago and have noticed almost nothing.

> Previously

> > I have had no trouble sleeping, and did not have to get up during

> the

> > night--so there has been no change there. The only thing it may

> have

> > helped is incontinence. I think I don't have to go as often and

can

> > usually make it in time.

> >

> > Anyhow, my question is... I have to stop LDN until the treatment

is

> > over and I have done the 1 week Prednisone taper off. How much

time

> > must then pass before I can begin LDN again?

> >

> > Janbee

>

>

>

>

> _____

>

>