[Fwd: Re: [PLS-FRIENDS] LDN]

[Guest guest]

Hi .... I should have added that Naltrexone, a derivative of

naloxone is an orally active and long acting pure narcotic

antagonist. Clinical pharmacology studies demonstrated that oral

naltrexone at 50, 100 and 150mg effectively blocks the physiological

and subjective effects of heroin, hydromorphone or morphine for 24,

48 and 72 hours respectively. That is probably why Suboxone was

linked to Naltrexone .. they are both used for drug addiction ... but

Suboxone 4.5mg would not work as Naltrexone 4.5mg (LDN) .. I hope

that makes sense ...

All the Best

> This was posted on PLS-FRIENDS by one of the members - does anybody

here

> have any info on this?

>

>

>

> -------- Original Message --------

> According to BlueCross BlueShield there is a compound called

Suboxone

> (buprenurphine hcl/naloxone hcl) in .5 mg to 8mg dosages. Does

> anyone know if this item will serve as LDN?

>

> Don

>

> --

> .

> ,-._|\ Covington

> / Oz \

> \_,--.x/

> v

[Guest guest]

Thanks . :-)

I figured it wouldn't or Dr Bihari and others would be using it already

but I wanted a definitive answer for my fellow PLS-FRIEND.

Thanks,

mboylebradley wrote:

> Hi .. It will not serve as LDN at all ... Suboxone is FDA

> approved to treat drug addicts. Suboxone offers a combination of a

> weak narcotic (buprenorphine) and a narcotic antagonist (naloxone).

> The latter is added to prevent addicts from injecting the tablets

> intravenously, as has happened with tablets only containing

> buprenorphine; because it contains naloxone, Suboxone is highly

> likely to produce intense withdrawal symptoms if misused

> intravenously by opioid-addicted individuals.

> Buprenorphine is a partial agonist at the mu-opioid receptor and an

> antagonist at the kappaopioid receptor. Naloxone is an antagonist at

> the mu-opioid receptor.

> All the Best

>

[Guest guest]

Thanks again . :-)

mboylebradley wrote:

> Hi .... I should have added that Naltrexone, a derivative of

> naloxone is an orally active and long acting pure narcotic

> antagonist. Clinical pharmacology studies demonstrated that oral

> naltrexone at 50, 100 and 150mg effectively blocks the physiological

> and subjective effects of heroin, hydromorphone or morphine for 24,

> 48 and 72 hours respectively. That is probably why Suboxone was

> linked to Naltrexone .. they are both used for drug addiction ... but

> Suboxone 4.5mg would not work as Naltrexone 4.5mg (LDN) .. I hope

> that makes sense ...

>

> All the Best

>

--

.

,-._|\ Covington

/ Oz \

\_,--.x/

v