Axons can be remyelinated

[Guest guest]

CNS axons retain their competence for myelination throughout life.

Setzu A, Ffrench-Constant C, lin RJ.

Cambridge Centre for Brain Repair and Department of Clinical

Veterinary Medicine, University of Cambridge, Cambridge, United

Kingdom.

An important question relevant to developing remyelination therapies

is whether axons that remain without myelin sheaths after an episode

of demyelination retain myelination competence. To resolve this, we

have developed a model of transplantation into the nerve fibre layer

of the adult rat retina, where the axons are unmyelinated. In the

adult, these axons can be myelinated by transplantation of both the

oligodendrocyte progenitor cells (OPCs) and an OPC line (CG4). The

extent of myelination achieved following transplantation of OPCs is

the same in young adult recipients (2 months old) as that which

occurs in old adult recipients (12-18 months old), indicating that

there are no changes in axons remaining unmyelinated for many months

that would prevent effective remyelination. This finding suggests

that chronically demyelinated regions of axons such as those in seen

in multiple sclerosis are likely to remain competent to be

remyelinated. Copyright 2003 Wiley-Liss, Inc.

[Guest guest]

Im all for remyelination!!! That's the aim and result we all want to

achieve at the end of it all isnt it. I believe LDN is creating the

environment in our bodies for that repair to happen - slowly but

surely.

Friday

>

>

> CNS axons retain their competence for myelination throughout life.

>

> Setzu A, Ffrench-Constant C, lin RJ.

>

> Cambridge Centre for Brain Repair and Department of Clinical

> Veterinary Medicine, University of Cambridge, Cambridge, United

> Kingdom.

>

> An important question relevant to developing remyelination

therapies

> is whether axons that remain without myelin sheaths after an

episode

> of demyelination retain myelination competence. To resolve this, we

> have developed a model of transplantation into the nerve fibre

layer

> of the adult rat retina, where the axons are unmyelinated. In the

> adult, these axons can be myelinated by transplantation of both the

> oligodendrocyte progenitor cells (OPCs) and an OPC line (CG4). The

> extent of myelination achieved following transplantation of OPCs is

> the same in young adult recipients (2 months old) as that which

> occurs in old adult recipients (12-18 months old), indicating that

> there are no changes in axons remaining unmyelinated for many

months

> that would prevent effective remyelination. This finding suggests

> that chronically demyelinated regions of axons such as those in

seen

> in multiple sclerosis are likely to remain competent to be

> remyelinated. Copyright 2003 Wiley-Liss, Inc.