Re: how long does each dose last?

[Guest guest]

--- In , " heather " <heaven1975@y...>

wrote:

> does xolair wear off? am i imagining this? is it just coincidence

> with the weather??? am i crazy???

Hi, -

I was thinking the same sort of thing after my second shot. For two

weeks after the shot (I only get them once a month), my breathing and

allergy symptoms were less, even though the pollen was really awful.

Then as the pollen lessened, my symptoms worsened, and I thought

maybe it was the xolair " wearing off. "

So I've paid extra close attention since this shot, my third. The

good news (for those who have followed my headache saga) is that this

time the headache has been more intermittent, and I haven't taken any

darvocet for it (going with the pattern of the other shots, today

should be my worst day - and I do feel pretty crummy). And my peak

flow seems better - although I'm having major issues with my new peak

flow meter. I bought it about two months ago, and it gives very

different readings from my old one, which has a crack in the

mouthpiece. This one is consistently about 50 units lower than my

old one - kind of depressing.

I was in Montreal for a conference part of last week. My peak flow

was great, the headache was gone. Then I came home, stepped out of

the Richmond airport, and my peak flow took a nosedive, the headache

was back within hours (in fact, it was really bad when I went for my

shot - the nurse wondered how I'd know if the shot gave me a headache

when it was already so bad? - but it actually lessened after the

shot). I want to move so desperately, and it's on the roadmap - but

not for at least another five years. Our air quality here is so poor

and it's obvious to me that that's a major part of my headache issues.

Joyce

[Guest guest]

thanks for the advice/info. i'm already on the max dose (3 shots

every two weeks) but i'll mention it to my dr...see what she has to

say about it. its not that i got from great to horrible in a matter

of a few days, but i do notice a slight (10% of so on the PF)

decline.

thanks

heather

> yes; it wears off, as the antibody is depleted by binding to IgE

(doing its designated function) and also perhaps by your immune

system seeking to clear it. You should see if they'll approve more

frequent or larger dosages for you.

>

[Guest guest]

Hi ,

Just to let you know, that you are not alone in how you are feeling.

I feel the same way also. I have been taking Xolair since last year,

and in the first week I feel great and then I feel it seems to wear

off in the second week.

Ash

> > yes; it wears off, as the antibody is depleted by binding to IgE

> (doing its designated function) and also perhaps by your immune

> system seeking to clear it. You should see if they'll approve

more

> frequent or larger dosages for you.

> >