Re: Will Xolair (or others) ever help allergy sufferers?

[Guest guest]

Jeff,

I don't know about any studies for Xolair in pill form, but I do know that

it's currently being tested for food allergies. I'd imagine that seasonal

allergies will also be tested, although it would be a big insurance company

challenge unless they can find a way to bring the price way down (which is

probably

why you mentioned pill form).

Meryl

Does anyone know if the science behind Xolair will ever be in pill form to

help

the millions of us who don't have asthma, but do have terrible allergies?

Thanks.

[Guest guest]

Given my understanding of the pharmacodynamics of the

med, I would be very surprised if they could find a

way for xolair to be absorbed in a pill

format...xolair is made with recombinant DNA

technology and derived at one point in time from

chinese hampster. (I joked with my pulmo that one side

effect would be that I grew a tail!) The protein

structure would likely be destroyed by stomach acid

and the digestive process.

However I know that xolair has been tested for

pernennial allergy without asthma and is in clinical

trials for peanut allergy.

ps the website has lots of info about it www.xolair.com

__________________________________________________

[Guest guest]

Xolair is a protein, so in pill form it would get 'chewed up' in the stomach and

inactivated. Maybe they'll find a way to keep it from degrading in the

hydrochloric acid in our stomachs. That would be great!

__________________________________________________

[Guest guest]

> Does anyone know if the science behind Xolair will ever be in pill

form to help

> the millions of us who don't have asthma, but do have terrible

allergies?

>

> Thanks.

Xolair in its current form has been in clinical trials for allergic

rhinitis and peanut allergy.

Xolair has improved my allergic rhinitis and skin allergy symptoms

IMMENSELY. I have severe allergic rhinitis with inflammation and

recurring sinus infections and Xolair has pretty much put a stop to it.

I know that they continue to research how they could offer Xolair in

an easier form, but so far I have only heard of progress in putting it

in premade vials and/or an epi-pen type of mechanism.

Addy

[Guest guest]

> Does anyone know if the science behind Xolair will ever be in pill

form to help

> the millions of us who don't have asthma, but do have terrible

allergies?

>

> Thanks.

There are some doctors out there talking about 1/2 dosages trial (ie.

half a vial) to those people who have severe allergies without

ashthma. This would be off label at the moment. You would still need

to get injected but the cost would be about $250 a month, which would

bring it more in line with the cost of the current medications and may

make it easier for insurance companies to cover it. You can talk to

your doctor about this. Look at Dr. Bob Lanier's web site.

Homer

[Guest guest]

Dear :

I don't know about pill form but,Xolair is helping me with my other allergies

(sinus) I am much better since being on Xolair. I take four medicines for sinus

allergies alone. All my doctors say the improvement is due to the Xolair,

except my otolaringologist (I think that's how it's spelt)

Kathy.

<carrie72583@...> wrote:

Given my understanding of the pharmacodynamics of the

med, I would be very surprised if they could find a

way for xolair to be absorbed in a pill

format...xolair is made with recombinant DNA

technology and derived at one point in time from

chinese hampster. (I joked with my pulmo that one side

effect would be that I grew a tail!) The protein

structure would likely be destroyed by stomach acid

and the digestive process.

However I know that xolair has been tested for

pernennial allergy without asthma and is in clinical

trials for peanut allergy.

ps the website has lots of info about it www.xolair.com

__________________________________________________

[Guest guest]

> Does anyone know if the science behind Xolair will ever be in pill

form to help

> the millions of us who don't have asthma, but do have terrible

allergies?

>

> Thanks.

Probably never in pill form...because of the fact that Xolair is

essentially a synthetic antibody (a protein molecule), if it were

taken in a pill form these antibody molecules would be chewed up by

the same digestive processes in your stomach which cause any other

dietary proteins to be digested. In short--it's pretty much

injections or nothing at all...you might check to see if the FDA is

considering approving Xolair for allergy sufferers anytime

soon...the long term goal (5-10 years out) would be to block certain

cytokine pathways (which happens before IgE is

produced)...lookup " small molecular weight cytokine inhibitors " I

think there might be some promising developments in this field

Nick