so really how does it work?

[Guest guest]

Hi Pat et al.,

I was wondering if you could offer a clarification of

the mechanism of action of xolair. Once it forms a

compound with IgE, how is it eliminated or metabolized

for example? Given this compound cannot bind to mast

cells, does you body then produce way more in the form

of a positive feedback mechanism in order to

compensate???

Can you discuss briefly the reasoning behind why we

cannot re-measure IgE after you begin dosing?

Apparently, there is some confusion in the Canadian

neck of the wood about this.....

__________________________________________________________

Find your next car at http://autos..ca

[Guest guest]

Hi, ,

My pulmo told me that current tests for IgE cannot distinguish

between Xolair-bound-IgE and free IgE. (He said Genentech has been

able to do it at their lab, but they can't yet produce a test that

could be replicated outside of really expensive lab conditions....)

As to your other questions, I hadn't even thought about those....

Addy

>

> Hi Pat et al.,

>

> I was wondering if you could offer a clarification of

> the mechanism of action of xolair. Once it forms a

> compound with IgE, how is it eliminated or metabolized

> for example? Given this compound cannot bind to mast

> cells, does you body then produce way more in the form

> of a positive feedback mechanism in order to

> compensate???

>

> Can you discuss briefly the reasoning behind why we

> cannot re-measure IgE after you begin dosing?

>

> Apparently, there is some confusion in the Canadian

> neck of the wood about this.....

>

>

>

>

>

>

>

>

> __________________________________________________________

> Find your next car at http://autos..ca

>

[Guest guest]

When IgE is bound it is ineffective. No matter how many allergens invade the

body that particular IgE can not cause a problem. We have many (hundreds,

thousands) of IgE. IgE keep being manufactured by the body. When an IgE is

bound it can live for up to a year until it gets routed thru the liver, broken

down & excreted. The commercial tests for IgE only count IgE, whether they are

bound with Xolair or free floating. Genentech & Novartis came up with a test

that can measure bound IgE. It is VERY expensive and not available

commercially. SO, the physician can order another IgE level but it will not be

a true accounting of how many free floating IgE are still in the system. If he

is silly enough to order the test, he may be silly enough to change therapy

because of the result. If any of your physicians want to change your Xolair

therapy because of a re-evaluation of the IgE, PLEASE tell them to call

Genentech and speak to one of the researchers. Don't call them stupid to

their face as this might ruin your Dr, Patient relationship, gently redirect

them. I have had several physicians call & say " I'm taking my pt. off Xolair

because their IgE keeps rising " . After I educate them, they agree to let their

patients to keep using Xolair.

Pat

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