Guest guest Posted August 25, 2008 Report Share Posted August 25, 2008 _tpowell1977@..._ (mailto:tpowell1977@...) writes: << Seretonin syndrome is directly related to the release of seretonin in your brain, something that narcotics and antidepressants do. It has nothing to do with relaxation. Narcotics and antidepressants also do not have a " relaxant " effect. I am also pretty certain that muscle relaxers do NOT cause seretonin syandome, as I am very familiar with this effect....>> _http://www.medscape.com/druginfo/druginteractions?drug_4398=Tramadol%20Oral & d rug_11372=Flexeril%20Oral & drug_32971=Avinza%20Oral_ (http://www.medscape.com/druginfo/druginteractions?drug_4398=Tramadol%20Oral & dru\ g_11372=Flexeril%20Oral & drug_32971=Avinza%20Oral) & Interactions Severe Interaction _TRAMADOL/TRICYCLIC COMPOUNDS; CARBAMAZEPINE_ (http://www.medscape.com/druginfo/druginteractions?drug_4398=Tramadol%20Oral & dru\ g_11372=Flexeril%20Oral & drug_3 2971=Avinza%20Oral & #inter_1205) Tramadol Oral and Flexeril Oral may interact based on the potential interaction between TRAMADOL and TRICYCLIC COMPOUNDS; CARBAMAZEPINE. Tramadol/Tricyclic Compounds; Carbamazepine This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. MONOGRAPH TITLE: Tramadol/Tricyclic Compounds; Carbamazepine SEVERITY LEVEL: 2-Severe Interaction: Action is required to reduce the risk of severe adverse interaction. MECHANISM OF ACTION: Tramadol and tricyclic compounds, including carbamazepine, may lower the seizure threshold.(1) Carbamazepine may also induce the metabolism of tramadol.(1) CLINICAL EFFECTS: Concurrent use of tramadol and a tricyclic compound may result in seizures(1) or serotonin syndrome.(2) Concurrent use of tramadol and carbamazepine may result in seizures and decreased efficacy of tramadol. (1) PREDISPOSING FACTORS: Risk of seizures may be increased in patients with epilepsy, a history of seizures, head trauma, metabolic disorders, alcohol or drug withdrawal, or infections of the central nervous system.(1) PATIENT MANAGEMENT: Tramadol should be used with caution in patients taking tricyclic compounds.(1) The use of tramadol and carbamazepine is not recommended.(1) DISCUSSION: The use of tramadol in patients treated with tricyclic compounds may increase the risk of seizures.(1) A review of 124 reports of seizures following tramadol therapy received by the FDA through July 31, 1996 revealed that 23% of the patients were also taking tricyclic antidepressants.(3) Therefore, the manufacturer of tramadol states that tramadol should be used with caution in patients treated with tricyclic compounds.(1) The manufacturer of tramadol also states that the use of tramadol with carbamazepine is not recommended.(1) In a case report, a 79 year-old female developed serotonin syndrome three days after the addition of tramadol to amitriptyline therapy. Over the next four days, her condition deteriorated and she died.(2) REFERENCES: 1.Ultram (tramadol) US prescribing information. Ortho-McNeil Pharmaceutical, Inc. May, 2004. 2.Kitson R, Carr B. Tramadol and severe serotonin syndrome. Anaesthesia 2005 Sep;60(9):934-5. 3.Kahn LH, Alderfer RJ, Graham DJ. Seizures reported with tramadol. JAMA 1997 Nov 26;278(20):1661. Best regards, Patty A **************It's only a deal if it's where you want to go. Find your travel deal here. (http://information.travel.aol.com/deals?ncid=aoltrv00050000000047) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 25, 2008 Report Share Posted August 25, 2008 _tpowell1977@..._ (mailto:tpowell1977@...) writes: << I couldn't open the first few links you sent as I'm not a medscape member, what did they say about Flexeril and seretonin syndrome? ...I guess the lesson with any and all of these drugs is, use the same pharmacy for all your meds for one, this will help the pharmacist keep an eye on what meds you are mixing. Secondly, take care when starting any new meds and report any strange or abnormal side effects to your doctor....>> Oh, sorry, I always include links if I copy & paste the actual article in case someone wishes to peruse the site in more detail. I actually pasted the body of the article in my post, so you're not missing anything. But I just found this too because I wanted to make sure they were referring to Cyclobenzaprine. I don't have time to read the entire thing now but it looks like case #2 might be of some interest...? _http://www.anesthesia-analgesia.org/cgi/content/full/103/6/1466_ (http://www.anesthesia-analgesia.org/cgi/content/full/103/6/1466) Not only do I try to stick with one pharmacy but I try very hard to pick out the most knowledgeable pharmacist there and if they don't know anything about WLS (weight loss surgery) and our *special* needs, I'm outta there! We're an entirely different breed that very few medical professionals are trained in. 'til tomorrow! Best regards, Patty A **************It's only a deal if it's where you want to go. Find your travel deal here. (http://information.travel.aol.com/deals?ncid=aoltrv00050000000047) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 25, 2008 Report Share Posted August 25, 2008 I couldn't open the first few links you sent as I'm not a medscape member, what did they say about Flexeril and seretonin syndrome? I am reminded of the potential for seizure risk increase with the tricyclics and tramadol as well as flexeril. I was told that unless you have a history of seizures the risk is nominal. I guess the lesson with any and all of these drugs is, use the same pharmacy for all your meds for one, this will help the pharmacist keep an eye on what meds you are mixing. Secondly, take care when starting any new meds and report any strange or abnormal side effects to your doctor. With us chronic pain patients, we need all the help we can get. I feel that as long as we are monitored, we should try meds that are known to work well. I'd personally rather take a combo of meds that are well known and keep an eye out for a reaction, than to take a new med on the market. That just me! Thanks for the info! --- --- NCGorgeous1963@... wrote: > > > _tpowell1977@..._ > (mailto:tpowell1977@...) writes: << > Seretonin > syndrome is directly related to the release of > seretonin in your brain, > something that narcotics and antidepressants do. It > has nothing to do with > relaxation. Narcotics and antidepressants also do > not have a " relaxant " effect. I > am also pretty certain that muscle relaxers do NOT > cause seretonin syandome, > as I am very familiar with this effect....>> > > _http://www.medscape.com/druginfo/druginteractions?drug_4398=Tramadol%20Oral & d > rug_11372=Flexeril%20Oral & drug_32971=Avinza%20Oral_ > (http://www.medscape.com/druginfo/druginteractions?drug_4398=Tramadol%20Oral & dru\ g_11372=Flexeril%20Oral & > drug_32971=Avinza%20Oral) & > > Interactions > > Severe Interaction > _TRAMADOL/TRICYCLIC COMPOUNDS; CARBAMAZEPINE_ > (http://www.medscape.com/druginfo/druginteractions?drug_4398=Tramadol%20Oral & dru\ g_11372=Flexeril%20Oral & drug_3 > 2971=Avinza%20Oral & #inter_1205) > Tramadol Oral and Flexeril Oral may interact based > on the potential > interaction between TRAMADOL and TRICYCLIC > COMPOUNDS; CARBAMAZEPINE. > > > > Tramadol/Tricyclic Compounds; Carbamazepine > > This information is generalized and not intended as > specific medical advice. > Consult your healthcare professional before taking > or discontinuing any drug > or commencing any course of treatment. > MONOGRAPH TITLE: Tramadol/Tricyclic Compounds; > Carbamazepine > SEVERITY LEVEL: 2-Severe Interaction: Action is > required to reduce the risk > of severe adverse interaction. > MECHANISM OF ACTION: Tramadol and tricyclic > compounds, including > carbamazepine, may lower the seizure threshold.(1) > Carbamazepine may also induce the > metabolism of tramadol.(1) > CLINICAL EFFECTS: Concurrent use of tramadol and a > tricyclic compound may > result in seizures(1) or serotonin syndrome.(2) > Concurrent use of tramadol and > carbamazepine may result in seizures and decreased > efficacy of tramadol. (1) > PREDISPOSING FACTORS: Risk of seizures may be > increased in patients with > epilepsy, a history of seizures, head trauma, > metabolic disorders, alcohol or > drug withdrawal, or infections of the central > nervous system.(1) > PATIENT MANAGEMENT: Tramadol should be used with > caution in patients taking > tricyclic compounds.(1) The use of tramadol and > carbamazepine is not > recommended.(1) > DISCUSSION: The use of tramadol in patients treated > with tricyclic compounds > may increase the risk of seizures.(1) A review of > 124 reports of seizures > following tramadol therapy received by the FDA > through July 31, 1996 revealed > that 23% of the patients were also taking tricyclic > antidepressants.(3) > Therefore, the manufacturer of tramadol states that > tramadol should be used with > caution in patients treated with tricyclic > compounds.(1) The manufacturer of > tramadol also states that the use of tramadol with > carbamazepine is not > recommended.(1) > In a case report, a 79 year-old female developed > serotonin syndrome three > days after the addition of tramadol to amitriptyline > therapy. Over the next four > days, her condition deteriorated and she died.(2) > REFERENCES: > 1.Ultram (tramadol) US prescribing information. > Ortho-McNeil Pharmaceutical, > Inc. May, 2004. > 2.Kitson R, Carr B. Tramadol and severe serotonin > syndrome. Anaesthesia 2005 > Sep;60(9):934-5. > 3.Kahn LH, Alderfer RJ, Graham DJ. Seizures reported > with tramadol. JAMA 1997 > Nov 26;278(20):1661. > Best regards, > Patty A > > > > > > **************It's only a deal if it's where you > want to go. Find your travel > deal here. > (http://information.travel.aol.com/deals?ncid=aoltrv00050000000047) > > > [Non-text portions of this message have been > removed] > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 25, 2008 Report Share Posted August 25, 2008 I believe Carbamazepine is a seizure/ bipolar drug. I think it's an anticonvulsant. It's not the same as Flexeril. --- --- NCGorgeous1963@... wrote: > > > _tpowell1977@..._ > (mailto:tpowell1977@...) writes: << I > couldn't open the first few links you sent as I'm > not a medscape member, what did > they say about Flexeril and seretonin syndrome? ...I > guess the lesson with any > and all of these drugs is, use the same pharmacy for > all your meds for one, > this will help the pharmacist keep an eye on what > meds you are mixing. > Secondly, take care when starting any new meds and > report any strange or abnormal side effects to your > doctor....>> > > > > Oh, sorry, I always include links if I copy & paste > the actual article in > case someone wishes to peruse the site in more > detail. I actually pasted the > body of the article in my post, so you're not > missing anything. > > But I just found this too because I wanted to make > sure they were referring > to Cyclobenzaprine. I don't have time to read the > entire thing now but it > looks like case #2 might be of some interest...? > _http://www.anesthesia-analgesia.org/cgi/content/full/103/6/1466_ > > (http://www.anesthesia-analgesia.org/cgi/content/full/103/6/1466) > > > Not only do I try to stick with one pharmacy but I > try very hard to pick out > the most knowledgeable pharmacist there and if they > don't know anything > about WLS (weight loss surgery) and our *special* > needs, I'm outta there! We're > an entirely different breed that very few medical > professionals are trained in. > > 'til tomorrow! > Best regards, > Patty A > > > > **************It's only a deal if it's where you > want to go. Find your travel > deal here. > (http://information.travel.aol.com/deals?ncid=aoltrv00050000000047) > > > [Non-text portions of this message have been > removed] > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 3, 2008 Report Share Posted September 3, 2008 Hi havent heard back from you, did you get my email? I was just wondering how you were progressing. Re: seretonin syndrome I couldn't open the first few links you sent as I'm not a medscape member, what did they say about Flexeril and seretonin syndrome? I am reminded of the potential for seizure risk increase with the tricyclics and tramadol as well as flexeril. I was told that unless you have a history of seizures the risk is nominal. I guess the lesson with any and all of these drugs is, use the same pharmacy for all your meds for one, this will help the pharmacist keep an eye on what meds you are mixing. Secondly, take care when starting any new meds and report any strange or abnormal side effects to your doctor. With us chronic pain patients, we need all the help we can get. I feel that as long as we are monitored, we should try meds that are known to work well. I'd personally rather take a combo of meds that are well known and keep an eye out for a reaction, than to take a new med on the market. That just me! Thanks for the info! --- --- NCGorgeous1963@... wrote: > > > _tpowell1977@..._ > (mailto:tpowell1977@...) writes: << > Seretonin > syndrome is directly related to the release of > seretonin in your brain, > something that narcotics and antidepressants do. It > has nothing to do with > relaxation. Narcotics and antidepressants also do > not have a " relaxant " effect. I > am also pretty certain that muscle relaxers do NOT > cause seretonin syandome, > as I am very familiar with this effect....>> > > _http://www.medscape.com/druginfo/druginteractions?drug_4398=Tramadol%20Oral & d > rug_11372=Flexeril%20Oral & drug_32971=Avinza%20Oral_ > (http://www.medscape.com/druginfo/druginteractions?drug_4398=Tramadol%20Oral & dru\ g_11372=Flexeril%20Oral & > drug_32971=Avinza%20Oral) & > > Interactions > > Severe Interaction > _TRAMADOL/TRICYCLIC COMPOUNDS; CARBAMAZEPINE_ > (http://www.medscape.com/druginfo/druginteractions?drug_4398=Tramadol%20Oral & dru\ g_11372=Flexeril%20Oral & drug_3 > 2971=Avinza%20Oral & #inter_1205) > Tramadol Oral and Flexeril Oral may interact based > on the potential > interaction between TRAMADOL and TRICYCLIC > COMPOUNDS; CARBAMAZEPINE. > > > > Tramadol/Tricyclic Compounds; Carbamazepine > > This information is generalized and not intended as > specific medical advice. > Consult your healthcare professional before taking > or discontinuing any drug > or commencing any course of treatment. > MONOGRAPH TITLE: Tramadol/Tricyclic Compounds; > Carbamazepine > SEVERITY LEVEL: 2-Severe Interaction: Action is > required to reduce the risk > of severe adverse interaction. > MECHANISM OF ACTION: Tramadol and tricyclic > compounds, including > carbamazepine, may lower the seizure threshold.(1) > Carbamazepine may also induce the > metabolism of tramadol.(1) > CLINICAL EFFECTS: Concurrent use of tramadol and a > tricyclic compound may > result in seizures(1) or serotonin syndrome.(2) > Concurrent use of tramadol and > carbamazepine may result in seizures and decreased > efficacy of tramadol. (1) > PREDISPOSING FACTORS: Risk of seizures may be > increased in patients with > epilepsy, a history of seizures, head trauma, > metabolic disorders, alcohol or > drug withdrawal, or infections of the central > nervous system.(1) > PATIENT MANAGEMENT: Tramadol should be used with > caution in patients taking > tricyclic compounds.(1) The use of tramadol and > carbamazepine is not > recommended.(1) > DISCUSSION: The use of tramadol in patients treated > with tricyclic compounds > may increase the risk of seizures.(1) A review of > 124 reports of seizures > following tramadol therapy received by the FDA > through July 31, 1996 revealed > that 23% of the patients were also taking tricyclic > antidepressants.(3) > Therefore, the manufacturer of tramadol states that > tramadol should be used with > caution in patients treated with tricyclic > compounds.(1) The manufacturer of > tramadol also states that the use of tramadol with > carbamazepine is not > recommended.(1) > In a case report, a 79 year-old female developed > serotonin syndrome three > days after the addition of tramadol to amitriptyline > therapy. Over the next four > days, her condition deteriorated and she died.(2) > REFERENCES: > 1.Ultram (tramadol) US prescribing information. > Ortho-McNeil Pharmaceutical, > Inc. May, 2004. > 2.Kitson R, Carr B. Tramadol and severe serotonin > syndrome. Anaesthesia 2005 > Sep;60(9):934-5. > 3.Kahn LH, Alderfer RJ, Graham DJ. Seizures reported > with tramadol. JAMA 1997 > Nov 26;278(20):1661. > Best regards, > Patty A > > > > > > **************It's only a deal if it's where you > want to go. Find your travel > deal here. > (http://information.travel.aol.com/deals?ncid=aoltrv00050000000047) > > > [Non-text portions of this message have been > removed] > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 3, 2008 Report Share Posted September 3, 2008 Hi , Â I'm doing great so far! I had about a 50-60% reduction in pain within days of my surgery. Of course I was sore in the beginning from the surgery itself, but very quickly I could tell that the old pains were gone! I just have to highly recommend this surgery to anyone who's had a fusion with instrumentation and still has pain. The fact is it's a foreign body and just doesn't belong there. Our bodies are designed to respond unfavorably when there's a foreign body present. My surgeon was so pleased with my quick pain relief, he said it really made him question wether or not he should be removing hardware on a regular basis! Â So, that's how I'm doing...how are you ? Â --- Re: seretonin syndrome I couldn't open the first few links you sent as I'm not a medscape member, what did they say about Flexeril and seretonin syndrome? I am reminded of the potential for seizure risk increase with the tricyclics and tramadol as well as flexeril. I was told that unless you have a history of seizures the risk is nominal. I guess the lesson with any and all of these drugs is, use the same pharmacy for all your meds for one, this will help the pharmacist keep an eye on what meds you are mixing. Secondly, take care when starting any new meds and report any strange or abnormal side effects to your doctor. With us chronic pain patients, we need all the help we can get. I feel that as long as we are monitored, we should try meds that are known to work well. I'd personally rather take a combo of meds that are well known and keep an eye out for a reaction, than to take a new med on the market. That just me! Thanks for the info! --- --- NCGorgeous1963@ aol.com wrote: > > > _tpowell1977_ > (mailto:tpowell1977) writes: << > Seretonin > syndrome is directly related to the release of > seretonin in your brain, > something that narcotics and antidepressants do. It > has nothing to do with > relaxation. Narcotics and antidepressants also do > not have a " relaxant " effect. I > am also pretty certain that muscle relaxers do NOT > cause seretonin syandome, > as I am very familiar with this effect....>> > > _http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & d > rug_11372=Flexeril% 20Oral & drug_ 32971=Avinza% 20Oral_ > (http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & drug_ 11372=Flexeril% 20Oral & > drug_32971=Avinza% 20Oral) & > > Interactions > > Severe Interaction > _TRAMADOL/TRICYCLIC COMPOUNDS; CARBAMAZEPINE_ > (http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & drug_ 11372=Flexeril% 20Oral & drug_ 3 > 2971=Avinza% 20Oral & #inter_ 1205) > Tramadol Oral and Flexeril Oral may interact based > on the potential > interaction between TRAMADOL and TRICYCLIC > COMPOUNDS; CARBAMAZEPINE. > > > > Tramadol/Tricyclic Compounds; Carbamazepine > > This information is generalized and not intended as > specific medical advice. > Consult your healthcare professional before taking > or discontinuing any drug > or commencing any course of treatment. > MONOGRAPH TITLE: Tramadol/Tricyclic Compounds; > Carbamazepine > SEVERITY LEVEL: 2-Severe Interaction: Action is > required to reduce the risk > of severe adverse interaction. > MECHANISM OF ACTION: Tramadol and tricyclic > compounds, including > carbamazepine, may lower the seizure threshold.(1) > Carbamazepine may also induce the > metabolism of tramadol.(1) > CLINICAL EFFECTS: Concurrent use of tramadol and a > tricyclic compound may > result in seizures(1) or serotonin syndrome.(2) > Concurrent use of tramadol and > carbamazepine may result in seizures and decreased > efficacy of tramadol. (1) > PREDISPOSING FACTORS: Risk of seizures may be > increased in patients with > epilepsy, a history of seizures, head trauma, > metabolic disorders, alcohol or > drug withdrawal, or infections of the central > nervous system.(1) > PATIENT MANAGEMENT: Tramadol should be used with > caution in patients taking > tricyclic compounds.(1) The use of tramadol and > carbamazepine is not > recommended. (1) > DISCUSSION: The use of tramadol in patients treated > with tricyclic compounds > may increase the risk of seizures.(1) A review of > 124 reports of seizures > following tramadol therapy received by the FDA > through July 31, 1996 revealed > that 23% of the patients were also taking tricyclic > antidepressants. (3) > Therefore, the manufacturer of tramadol states that > tramadol should be used with > caution in patients treated with tricyclic > compounds.(1) The manufacturer of > tramadol also states that the use of tramadol with > carbamazepine is not > recommended. (1) > In a case report, a 79 year-old female developed > serotonin syndrome three > days after the addition of tramadol to amitriptyline > therapy. Over the next four > days, her condition deteriorated and she died.(2) > REFERENCES: > 1.Ultram (tramadol) US prescribing information. > Ortho-McNeil Pharmaceutical, > Inc. May, 2004. > 2.Kitson R, Carr B. Tramadol and severe serotonin > syndrome. Anaesthesia 2005 > Sep;60(9):934- 5. > 3.Kahn LH, Alderfer RJ, Graham DJ. Seizures reported > with tramadol. JAMA 1997 > Nov 26;278(20):1661. > Best regards, > Patty A > > > > > > ************ **It's only a deal if it's where you > want to go. Find your travel > deal here. > (http://information. travel.aol. com/deals? ncid=aoltrv00050 000000047) > > > [Non-text portions of this message have been > removed] > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 3, 2008 Report Share Posted September 3, 2008 Im glad you are improving, you have suffered a long time. I have had a series of 3 SI joint injections that really helped with the inflammation and have allowed me to do better in PT. The problems I am still dealing with are sciatic nerve irritation causing my right 2,3 toes to curl under off and on on a daily basis. Also no matter how much I continue to work and strenghten my right hip, gluteal muscles, if I dont do it like every other day they get weak again. I went to a Podiatrist a few weeks ago and he is making me orthotics, to help that right foot. I told him I had issues of sciatica almost daily or every other day. Its not as painful as it was, but my right 2,3,4 toes are numb most of the time, and look slighty flacid compared to the left. I guess I worry about that and wonder if that alone is enough of a reason to have a discectomy. Again, I still havent had a Discogram- kinda scarred really since I had such a terrible reaction to the Prolotherapy that my Physiatrist did to my right SI joint in April. I just worry about those toes and if they will reach a point of no return. FYI- I am not a diabetic, so that isnt an issue and have no other medical conditions beside the back! God thats enough isnt it.... Im curious what your surgeons would think about the toes and sciatica? I know the neurosurgeons I have seen say I should live with it. I really dont want to take Lyrica or Neurontin because I just dont do well with meds that make me dizzy , woozy , sleepy or out of it, ya know? thanks, Re: seretonin syndrome I couldn't open the first few links you sent as I'm not a medscape member, what did they say about Flexeril and seretonin syndrome? I am reminded of the potential for seizure risk increase with the tricyclics and tramadol as well as flexeril. I was told that unless you have a history of seizures the risk is nominal. I guess the lesson with any and all of these drugs is, use the same pharmacy for all your meds for one, this will help the pharmacist keep an eye on what meds you are mixing. Secondly, take care when starting any new meds and report any strange or abnormal side effects to your doctor. With us chronic pain patients, we need all the help we can get. I feel that as long as we are monitored, we should try meds that are known to work well. I'd personally rather take a combo of meds that are well known and keep an eye out for a reaction, than to take a new med on the market. That just me! Thanks for the info! --- --- NCGorgeous1963@ aol.com wrote: > > > _tpowell1977_ > (mailto:tpowell1977) writes: << > Seretonin > syndrome is directly related to the release of > seretonin in your brain, > something that narcotics and antidepressants do. It > has nothing to do with > relaxation. Narcotics and antidepressants also do > not have a " relaxant " effect. I > am also pretty certain that muscle relaxers do NOT > cause seretonin syandome, > as I am very familiar with this effect....>> > > _http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & d > rug_11372=Flexeril% 20Oral & drug_ 32971=Avinza% 20Oral_ > (http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & drug_ 11372=Flexeril% 20Oral & > drug_32971=Avinza% 20Oral) & > > Interactions > > Severe Interaction > _TRAMADOL/TRICYCLIC COMPOUNDS; CARBAMAZEPINE_ > (http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & drug_ 11372=Flexeril% 20Oral & drug_ 3 > 2971=Avinza% 20Oral & #inter_ 1205) > Tramadol Oral and Flexeril Oral may interact based > on the potential > interaction between TRAMADOL and TRICYCLIC > COMPOUNDS; CARBAMAZEPINE. > > > > Tramadol/Tricyclic Compounds; Carbamazepine > > This information is generalized and not intended as > specific medical advice. > Consult your healthcare professional before taking > or discontinuing any drug > or commencing any course of treatment. > MONOGRAPH TITLE: Tramadol/Tricyclic Compounds; > Carbamazepine > SEVERITY LEVEL: 2-Severe Interaction: Action is > required to reduce the risk > of severe adverse interaction. > MECHANISM OF ACTION: Tramadol and tricyclic > compounds, including > carbamazepine, may lower the seizure threshold.(1) > Carbamazepine may also induce the > metabolism of tramadol.(1) > CLINICAL EFFECTS: Concurrent use of tramadol and a > tricyclic compound may > result in seizures(1) or serotonin syndrome.(2) > Concurrent use of tramadol and > carbamazepine may result in seizures and decreased > efficacy of tramadol. (1) > PREDISPOSING FACTORS: Risk of seizures may be > increased in patients with > epilepsy, a history of seizures, head trauma, > metabolic disorders, alcohol or > drug withdrawal, or infections of the central > nervous system.(1) > PATIENT MANAGEMENT: Tramadol should be used with > caution in patients taking > tricyclic compounds.(1) The use of tramadol and > carbamazepine is not > recommended. (1) > DISCUSSION: The use of tramadol in patients treated > with tricyclic compounds > may increase the risk of seizures.(1) A review of > 124 reports of seizures > following tramadol therapy received by the FDA > through July 31, 1996 revealed > that 23% of the patients were also taking tricyclic > antidepressants. (3) > Therefore, the manufacturer of tramadol states that > tramadol should be used with > caution in patients treated with tricyclic > compounds.(1) The manufacturer of > tramadol also states that the use of tramadol with > carbamazepine is not > recommended. (1) > In a case report, a 79 year-old female developed > serotonin syndrome three > days after the addition of tramadol to amitriptyline > therapy. Over the next four > days, her condition deteriorated and she died.(2) > REFERENCES: > 1.Ultram (tramadol) US prescribing information. > Ortho-McNeil Pharmaceutical, > Inc. May, 2004. > 2.Kitson R, Carr B. Tramadol and severe serotonin > syndrome. Anaesthesia 2005 > Sep;60(9):934- 5. > 3.Kahn LH, Alderfer RJ, Graham DJ. Seizures reported > with tramadol. JAMA 1997 > Nov 26;278(20):1661. > Best regards, > Patty A > > > > > > ************ **It's only a deal if it's where you > want to go. Find your travel > deal here. > (http://information. travel.aol. com/deals? ncid=aoltrv00050 000000047) > > > [Non-text portions of this message have been > removed] > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 3, 2008 Report Share Posted September 3, 2008 , I am worried about you. If there is nerve involvement, which from your post it sound like there is some, you should consider the surgery. If left untreated, or unrepaired you can have permanent nerve damage. Also, from what you are saying, the surgery would be considered relatively simple compared to what some of the others on here have had to endure. I had laminectomy, laminotomy and foraminotomy on both the lumbar and cervical spine. Right now, I am still in recovery stage. It is taking a long time, but I have extinuating circumstances. If you are active and in good health otherwise, the surgery might be the right way to go. Most neurosurgeons will want you to do every conservative treatment under the sun, before they will consider doing the surgery. Have they tried injections on you yet? Physical therapy? What all have they done for you at this point?  Shayna  It is better to be hated for who you are than liked for who you aren't. > > > _tpowell1977_ > (mailto:tpowell1977 ) writes: << > Seretonin > syndrome is directly related to the release of > seretonin in your brain, > something that narcotics and antidepressants do. It > has nothing to do with > relaxation. Narcotics and antidepressants also do > not have a " relaxant " effect. I > am also pretty certain that muscle relaxers do NOT > cause seretonin syandome, > as I am very familiar with this effect....>> > > _http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & d > rug_11372=Flexeril% 20Oral & drug_ 32971=Avinza% 20Oral_ > (http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & drug_ 11372=Flexeril% 20Oral & > drug_32971=Avinza% 20Oral) & > > Interactions > > Severe Interaction > _TRAMADOL/TRICYCLIC COMPOUNDS; CARBAMAZEPINE_ > (http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & drug_ 11372=Flexeril% 20Oral & drug_ 3 > 2971=Avinza% 20Oral & #inter_ 1205) > Tramadol Oral and Flexeril Oral may interact based > on the potential > interaction between TRAMADOL and TRICYCLIC > COMPOUNDS; CARBAMAZEPINE. > > > > Tramadol/Tricyclic Compounds; Carbamazepine > > This information is generalized and not intended as > specific medical advice. > Consult your healthcare professional before taking > or discontinuing any drug > or commencing any course of treatment. > MONOGRAPH TITLE: Tramadol/Tricyclic Compounds; > Carbamazepine > SEVERITY LEVEL: 2-Severe Interaction: Action is > required to reduce the risk > of severe adverse interaction. > MECHANISM OF ACTION: Tramadol and tricyclic > compounds, including > carbamazepine, may lower the seizure threshold.(1) > Carbamazepine may also induce the > metabolism of tramadol.(1) > CLINICAL EFFECTS: Concurrent use of tramadol and a > tricyclic compound may > result in seizures(1) or serotonin syndrome.(2) > Concurrent use of tramadol and > carbamazepine may result in seizures and decreased > efficacy of tramadol. (1) > PREDISPOSING FACTORS: Risk of seizures may be > increased in patients with > epilepsy, a history of seizures, head trauma, > metabolic disorders, alcohol or > drug withdrawal, or infections of the central > nervous system.(1) > PATIENT MANAGEMENT: Tramadol should be used with > caution in patients taking > tricyclic compounds.(1) The use of tramadol and > carbamazepine is not > recommended. (1) > DISCUSSION: The use of tramadol in patients treated > with tricyclic compounds > may increase the risk of seizures.(1) A review of > 124 reports of seizures > following tramadol therapy received by the FDA > through July 31, 1996 revealed > that 23% of the patients were also taking tricyclic > antidepressants. (3) > Therefore, the manufacturer of tramadol states that > tramadol should be used with > caution in patients treated with tricyclic > compounds.(1) The manufacturer of > tramadol also states that the use of tramadol with > carbamazepine is not > recommended. (1) > In a case report, a 79 year-old female developed > serotonin syndrome three > days after the addition of tramadol to amitriptyline > therapy. Over the next four > days, her condition deteriorated and she died.(2) > REFERENCES: > 1.Ultram (tramadol) US prescribing information. > Ortho-McNeil Pharmaceutical, > Inc. May, 2004. > 2.Kitson R, Carr B. Tramadol and severe serotonin > syndrome. Anaesthesia 2005 > Sep;60(9):934- 5. > 3.Kahn LH, Alderfer RJ, Graham DJ. Seizures reported > with tramadol. JAMA 1997 > Nov 26;278(20):1661. > Best regards, > Patty A > > > > > > ************ **It's only a deal if it's where you > want to go. Find your travel > deal here. > (http://information. travel.aol. com/deals? ncid=aoltrv00050 000000047) > > > [Non-text portions of this message have been > removed] > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 3, 2008 Report Share Posted September 3, 2008 I have had numerous injections and going on two years of physical therapy. See my MRI shows only a " small central disc protusion at L5 (aka small herniation ) as well as a tear at L4. Re: seretonin syndrome , I am worried about you. If there is nerve involvement, which from your post it sound like there is some, you should consider the surgery. If left untreated, or unrepaired you can have permanent nerve damage. Also, from what you are saying, the surgery would be considered relatively simple compared to what some of the others on here have had to endure. I had laminectomy, laminotomy and foraminotomy on both the lumbar and cervical spine. Right now, I am still in recovery stage. It is taking a long time, but I have extinuating circumstances. If you are active and in good health otherwise, the surgery might be the right way to go. Most neurosurgeons will want you to do every conservative treatment under the sun, before they will consider doing the surgery. Have they tried injections on you yet? Physical therapy? What all have they done for you at this point? Shayna It is better to be hated for who you are than liked for who you aren't. > > > _tpowell1977_ > (mailto:tpowell1977 ) writes: << > Seretonin > syndrome is directly related to the release of > seretonin in your brain, > something that narcotics and antidepressants do. It > has nothing to do with > relaxation. Narcotics and antidepressants also do > not have a " relaxant " effect. I > am also pretty certain that muscle relaxers do NOT > cause seretonin syandome, > as I am very familiar with this effect....>> > > _http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & d > rug_11372=Flexeril% 20Oral & drug_ 32971=Avinza% 20Oral_ > (http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & drug_ 11372=Flexeril% 20Oral & > drug_32971=Avinza% 20Oral) & > > Interactions > > Severe Interaction > _TRAMADOL/TRICYCLIC COMPOUNDS; CARBAMAZEPINE_ > (http://www.medscape .com/druginfo/ druginteractions ?drug_4398= Tramadol% 20Oral & drug_ 11372=Flexeril% 20Oral & drug_ 3 > 2971=Avinza% 20Oral & #inter_ 1205) > Tramadol Oral and Flexeril Oral may interact based > on the potential > interaction between TRAMADOL and TRICYCLIC > COMPOUNDS; CARBAMAZEPINE. > > > > Tramadol/Tricyclic Compounds; Carbamazepine > > This information is generalized and not intended as > specific medical advice. > Consult your healthcare professional before taking > or discontinuing any drug > or commencing any course of treatment. > MONOGRAPH TITLE: Tramadol/Tricyclic Compounds; > Carbamazepine > SEVERITY LEVEL: 2-Severe Interaction: Action is > required to reduce the risk > of severe adverse interaction. > MECHANISM OF ACTION: Tramadol and tricyclic > compounds, including > carbamazepine, may lower the seizure threshold.(1) > Carbamazepine may also induce the > metabolism of tramadol.(1) > CLINICAL EFFECTS: Concurrent use of tramadol and a > tricyclic compound may > result in seizures(1) or serotonin syndrome.(2) > Concurrent use of tramadol and > carbamazepine may result in seizures and decreased > efficacy of tramadol. (1) > PREDISPOSING FACTORS: Risk of seizures may be > increased in patients with > epilepsy, a history of seizures, head trauma, > metabolic disorders, alcohol or > drug withdrawal, or infections of the central > nervous system.(1) > PATIENT MANAGEMENT: Tramadol should be used with > caution in patients taking > tricyclic compounds.(1) The use of tramadol and > carbamazepine is not > recommended. (1) > DISCUSSION: The use of tramadol in patients treated > with tricyclic compounds > may increase the risk of seizures.(1) A review of > 124 reports of seizures > following tramadol therapy received by the FDA > through July 31, 1996 revealed > that 23% of the patients were also taking tricyclic > antidepressants. (3) > Therefore, the manufacturer of tramadol states that > tramadol should be used with > caution in patients treated with tricyclic > compounds.(1) The manufacturer of > tramadol also states that the use of tramadol with > carbamazepine is not > recommended. (1) > In a case report, a 79 year-old female developed > serotonin syndrome three > days after the addition of tramadol to amitriptyline > therapy. Over the next four > days, her condition deteriorated and she died.(2) > REFERENCES: > 1.Ultram (tramadol) US prescribing information. > Ortho-McNeil Pharmaceutical, > Inc. May, 2004. > 2.Kitson R, Carr B. Tramadol and severe serotonin > syndrome. Anaesthesia 2005 > Sep;60(9):934- 5. > 3.Kahn LH, Alderfer RJ, Graham DJ. Seizures reported > with tramadol. JAMA 1997 > Nov 26;278(20):1661. > Best regards, > Patty A > > > > > > ************ **It's only a deal if it's where you > want to go. Find your travel > deal here. > (http://information. travel.aol. com/deals? ncid=aoltrv00050 000000047) > > > [Non-text portions of this message have been > removed] > > Quote Link to comment Share on other sites More sharing options...
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