Re:off Xolair! --- bummer.....

[Guest guest]

This is interesting ... I'd really like to hear more. I'm still waiting to

start xolair and my eos is ALWAYS high - sometimes sky-high. I saw another doc

last night (a specialist totally unrelated to asthma & allergies) who brushed it

aside saying it was just typical of allergies. Ok, so is there anything

dangerous about high EOS? I have rashes all the time - just wearing clothes

gives me a rash - so does not wearing clothes! Just the curse of allergies, I

assume! Is EOS expected to go up or down on treatment?

_______________________________________________ Posted by: " wikkenkaren "

wikkenkaren@... wikkenkaren Mon Mar 5, 2007 1:12 pm (PST) So, two

shots down and looking forward to my third -- my cough was

finally going away... BUT, because of the rash that I aquired (weather

from Xolair or not) and my high EOS number the doctor has decided to

take me off Xolair till we can get everything straightened out.

I'm bummed out, to put it mildly -- I liked the idea of not coughing

anymore. Hopefully in a few months when we get everything else

straightened out I can attempt Xolair again.

karen

---------------------------------

8:00? 8:25? 8:40? Find a flick in no time

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[Guest guest]

what laundry detergent are you using?

SD Designer <instdesgn1@...> wrote: This

is interesting ... I'd really like to hear more. I'm still waiting to start

xolair and my eos is ALWAYS high - sometimes sky-high. I saw another doc last

night (a specialist totally unrelated to asthma & allergies) who brushed it

aside saying it was just typical of allergies. Ok, so is there anything

dangerous about high EOS? I have rashes all the time - just wearing clothes

gives me a rash - so does not wearing clothes! Just the curse of allergies, I

assume! Is EOS expected to go up or down on treatment?

_______________________________________________ Posted by: " wikkenkaren "

wikkenkaren@... wikkenkaren Mon Mar 5, 2007 1:12 pm (PST) So, two

shots down and looking forward to my third -- my cough was

finally going away... BUT, because of the rash that I aquired (weather

from Xolair or not) and my high EOS number the doctor has decided to

take me off Xolair till we can get everything straightened out.

I'm bummed out, to put it mildly -- I liked the idea of not coughing

anymore. Hopefully in a few months when we get everything else

straightened out I can attempt Xolair again.

karen

---------------------------------

8:00? 8:25? 8:40? Find a flick in no time

with the Search movie showtime shortcut.

[Guest guest]

No, there is nothing dangerous about a high eosiniphil count due to

allergies. Eosinophils are present in many allergic rashes, e.g.

eczema, but as far as I know, it is not yet clear whether the

eosinophils actually cause the rashes or are just innocent bystanders

in the allergic responses that produce rashes.

Novartis showed in its European premarketing studies that eosinophils

drop dramatically during Xolair treatment. Novartis didn't address

this point in its premarketing studies in the U.S.

Eosiniphils can also be elevated when there is a parasitic infection

like intestinal worms - if you have any significant chronic

intestinal symptoms, see your primary about having your stools tested

for parasites. Parasites as a sole or contributing cause of high eos

can easiy be overlooked in an allergic patient, in whom high eos are

assumed to be due to allergies.

Good luck with your Xolair treatment - it seems your eos count should

drop after you start and hopefully your rashes will go away as well.

Fran (retired pediatrician)

--- In , SD Designer <instdesgn1@...>

wrote:

>

> This is interesting ... I'd really like to hear more. I'm still

waiting to start xolair and my eos is ALWAYS high - sometimes sky-

high. I saw another doc last night (a specialist totally unrelated

to asthma & allergies) who brushed it aside saying it was just

typical of allergies. Ok, so is there anything dangerous about

high EOS? I have rashes all the time - just wearing clothes gives

me a rash - so does not wearing clothes! Just the curse of

allergies, I assume! Is EOS expected to go up or down on

treatment?

>

> _______________________________________________ Posted

by: " wikkenkaren " wikkenkaren@... wikkenkaren Mon Mar 5, 2007

1:12 pm (PST) So, two shots down and looking forward to my third --

my cough was

> finally going away... BUT, because of the rash that I aquired

(weather

> from Xolair or not) and my high EOS number the doctor has decided to

> take me off Xolair till we can get everything straightened out.

>

> I'm bummed out, to put it mildly -- I liked the idea of not coughing

> anymore. Hopefully in a few months when we get everything else

> straightened out I can attempt Xolair again.

>

> karen

>

>

>

> ---------------------------------

> 8:00? 8:25? 8:40? Find a flick in no time

> with the Search movie showtime shortcut.

>

>

[Guest guest]

--- In , " tiredofsteroids " <sitesee@...>

wrote:

>

> No, there is nothing dangerous about a high eosiniphil count due to

> allergies. Eosinophils are present in many allergic rashes,

Problems arise if the high eosiniphil count is because of something

else. And in my rare case (and because of other symptoms) we don't

think it is because of an allergy -- So we have to look into other

causes because we don't want to overlook any underlying conditions.

Everyone's situation is different. My sudden onset of asthma and

allergies just 7 short months ago (never had any allergy or respitory

problems before this) and my symptoms have been on fast forward ever

since. So symptoms we have to rule out as being medicine induced or

something else.

I went on Xolair as a hope to stop the cough that was interrupting my

life. I qualified on IGE and allergy testing and the fact that my

asthma was very hard to control. My IGE was never 'that' high... but

high enough to qualify and the sudden allergies were just odd...

Now we have to look into other high EOS disorders.

karen

ps -- and as of last night my cough came back!

[Guest guest]

, I'm sorry to hear about your sudden onset. It sounds

remarkably similar to my situation - only mine started five years

ago now which is still hard for me to believe. I have been

diagnosed with idiopathic hypereosinophilia. I believe there is at

least one other person on this board with that diagnosis as well. I

was started on Xolair as sort of a last ditch attempt to control my

eosinophil count without steroids. Of all the things I've tried,

it's probably worked the best - but not 100%. I still take daily

steroids after 2.5 years but the dose is lower than what I had been

taking. Over the last four months, however, my steroids have

actually not been working as well for me... but that's a short time

relatively speaking and I can't say if it's a trend yet or not.

Anyway, if you have any questions about my experiences coming to

that diagnosis just email me - I'd be happy to answer your

questions. Good luck.

Peggy

> >

> > No, there is nothing dangerous about a high eosiniphil count due

to

> > allergies. Eosinophils are present in many allergic rashes,

>

> Problems arise if the high eosiniphil count is because of something

> else. And in my rare case (and because of other symptoms) we don't

> think it is because of an allergy -- So we have to look into other

> causes because we don't want to overlook any underlying conditions.

> Everyone's situation is different. My sudden onset of asthma and

> allergies just 7 short months ago (never had any allergy or

respitory

> problems before this) and my symptoms have been on fast forward

ever

> since. So symptoms we have to rule out as being medicine induced

or

> something else.

>

> I went on Xolair as a hope to stop the cough that was interrupting

my

> life. I qualified on IGE and allergy testing and the fact that my

> asthma was very hard to control. My IGE was never 'that' high...

but

> high enough to qualify and the sudden allergies were just odd...

>

> Now we have to look into other high EOS disorders.

>

> karen

>

> ps -- and as of last night my cough came back!

>