Guest guest Posted March 22, 2007 Report Share Posted March 22, 2007 Mark, Great to have another North Carolinian in the group. I am not sure I understand your question. I did read a year back that they think Xolair MAY have some anti-inflammatory effect itself, but I don't know if the jury's still out on that or not. I do know that by preventing our IgE from binding to the mast cell and thus starting the allergic cascade (OK - it took me a year to figure out what all that meant, I admit), theoretically we should all have less inflammation in our sinuses and lungs because our allergies aren't irritating the soft tissue and triggering inflammation. (If I didn't say that right, Pat, Fran or Joanne will straighten me out, thank goodness.) I know that Xolair has helped my sinus inflammation a lot by greatly decreasing my allergic rhinitis symptoms. Addy Group co-owner > > Okay I'm a believer and on Xolair now. Thanks for what you all have said to contribute to my belief in the drug--I've been reading a while! I waited 1 hr post shots today and want to think that my nose cleared up before I left the office and since then. Hmmmm, interesting. Question for those who know about inflamatory response. I understand this drug will " prevent " inflammation from starting. If I understand that correctly, then are there any times we NEED this response for proper health? Would Xolair prohibit this? Keeping up hope, > Mark > Greensboro, NC > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 22, 2007 Report Share Posted March 22, 2007 Addy: I think you have just adequately explained to me why I have made it through two seasons without a sinus infection which usually leads to a respiratory infection which leads to an unpleasant asthma event. I have not had any sinus trouble since beginning xolair--now I am beginning to understand why! Thanks. At least it helped me understand. Adah pyle456 <coachmac@...> wrote: Mark, Great to have another North Carolinian in the group. I am not sure I understand your question. I did read a year back that they think Xolair MAY have some anti-inflammatory effect itself, but I don't know if the jury's still out on that or not. I do know that by preventing our IgE from binding to the mast cell and thus starting the allergic cascade (OK - it took me a year to figure out what all that meant, I admit), theoretically we should all have less inflammation in our sinuses and lungs because our allergies aren't irritating the soft tissue and triggering inflammation. (If I didn't say that right, Pat, Fran or Joanne will straighten me out, thank goodness.) I know that Xolair has helped my sinus inflammation a lot by greatly decreasing my allergic rhinitis symptoms. Addy Group co-owner > > Okay I'm a believer and on Xolair now. Thanks for what you all have said to contribute to my belief in the drug--I've been reading a while! I waited 1 hr post shots today and want to think that my nose cleared up before I left the office and since then. Hmmmm, interesting. Question for those who know about inflamatory response. I understand this drug will " prevent " inflammation from starting. If I understand that correctly, then are there any times we NEED this response for proper health? Would Xolair prohibit this? Keeping up hope, > Mark > Greensboro, NC > --------------------------------- Bored stiff? Loosen up... Download and play hundreds of games for free on Games. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 26, 2007 Report Share Posted March 26, 2007 Hi Mark - welcome to the group! You're right that during infections inflammation may play a useful role in clearing the body of the infecting organism. But in allergic reactions, the immune system is reacting to a noninfective foreign substance. The resulting inflammation in allergy can, as we've all experienced, be severe enough to at least be miserable and at most make us seriously ill. This type of inflammation is triggered by the allergic cascade, beginning with the binding of IgE to the offending allergen. Xolair blocks this pathway to non-productive inflammation by removing IgE before it binds to mast cells so that the inflammatory process never takes place. Besides blocking all that inflammation, it is believed that we all benefit further by being less susceptible to infections because the linings of our noses/sinuses/lungs are more intact barriers to infection in the absence of allergic inflammation. Xolair wouldn't be expected to interfere with useful inflammatory processes mounted in defense against bacterial or viral infections because these processes utilize different classes of antibodies (IgM and IgG primarily) than the IgE that is involved in allergic inflammation. I do wonder about parasitic infection though, since IgE is involved in defending the body against parasites. I haven't yet found any information about whether that's been researched at all yet but it's been on my mind and I'll do a better literature search over time to see if that's being addressed. But for now, most of us would not be willing to give up our Xolair for a concern that is only theoretical. Fran > > > > Okay I'm a believer and on Xolair now. Thanks for what you all > have said to contribute to my belief in the drug--I've been reading a > while! I waited 1 hr post shots today and want to think that my nose > cleared up before I left the office and since then. Hmmmm, > interesting. Question for those who know about inflamatory > response. I understand this drug will " prevent " inflammation from > starting. If I understand that correctly, then are there any times > we NEED this response for proper health? Would Xolair prohibit > this? Keeping up hope, > > Mark > > Greensboro, NC > > > Quote Link to comment Share on other sites More sharing options...
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