Re: Delayed Reactions - Average Time To Obtain Relief - Xolair

[Guest guest]

I can attest to the sleepiness! When I get my shots I

feel on verge of exhaustion for about a week! It took

me a while to figure out what was going on. I work two

jobs so ,at first, I thought it was that was the

problem.

I don't know about anybody else but it took several

months before I noticed a difference in my asthma

after starting treatment with Xolair. I have been

doing great but this spring has been a little tough

with all the pollen. I am not having the sneezing and

watering eyes but I am wheezing a bit more than I had

been since I started Xolair. But this is a tough time

with everything colored with the yellow/green pollen

here in the south!

I have not always been exactly 4 weeks between my

shots. I have been off by a few days to 2 weeks when

my company switched insurance. It didn't seem to be a

big deal.

Good luck!

Jeannie

>

> Now that I'm finally on Xolair a couple thoughts

> have come to mind and I

> would like to hear what others have experienced.

>

> 1. I've read that anaphylaxsis is much more likely

> to occur in repeat

> injections of Xolair (something like 60% ?) as

> compared to the first

> injection (something like 40%). These percents of

> course are of those

> who had a significant reaction to Xolair (.1%) - not

> just of those who

> received Xolair. How many people have had a delayed

> reaction - i.e.,

> later than 2 hours after injection? I didn't feel

> there was any

> reaction at all but I guess I'm a tad bit nervous

> now about future

> injections.

>

> 2. I tend to have delayed reactions to allergy

> triggers. For instance,

> this past Fri. I had my first Xolair injections and

> thought I actually

> felt a tad bit less allergic (?!?!) so " tempted

> fate " by going for a

> hike in the country and woods 2 days in a row. The

> next day I woke up

> w/a sinus headache. Really, it could have been much

> worse overall so

> I'm still thinking Xolair helped.

>

> 3. How fast does it take (on average) to get relief

> using Xolair? What

> influences the length of time and amount of relief?

> I've read that I

> should expect at least several weeks. What is it

> based on? How bad the

> allergy was to begin with? Amount of allergens

> exposed to?

>

> 4. Why was I told that if I missed my shot by more

> than 3 days I should

> call my doctor first? (I think this came up in a

> previous post) My

> understanding is that it's the same drug prepared in

> the same way and

> given at the same dose so why is there a big deal

> about being late other

> than having a return of symptoms?

>

> 5. Does Xolair cause sleepiness? Probably it was

> just the hike in the

> country (more exercise than what I'm accustomed to)

> and allergy attack

> but I felt like I could have slept 15 hours today!

>

> Thanx, and good health!

>

>

>

>

>

> [Non-text portions of this message have been

> removed]

>

>

________________________________________________________________________________\

____

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(and love to hate): TV's Guilty Pleasures list.

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[Guest guest]

I can attest to the sleepiness! When I get my shots I

feel on verge of exhaustion for about a week! It took

me a while to figure out what was going on. I work two

jobs so ,at first, I thought it was that was the

problem.

I don't know about anybody else but it took several

months before I noticed a difference in my asthma

after starting treatment with Xolair. I have been

doing great but this spring has been a little tough

with all the pollen. I am not having the sneezing and

watering eyes but I am wheezing a bit more than I had

been since I started Xolair. But this is a tough time

with everything colored with the yellow/green pollen

here in the south!

I have not always been exactly 4 weeks between my

shots. I have been off by a few days to 2 weeks when

my company switched insurance. It didn't seem to be a

big deal.

Good luck!

Jeannie

>

> Now that I'm finally on Xolair a couple thoughts

> have come to mind and I

> would like to hear what others have experienced.

>

> 1. I've read that anaphylaxsis is much more likely

> to occur in repeat

> injections of Xolair (something like 60% ?) as

> compared to the first

> injection (something like 40%). These percents of

> course are of those

> who had a significant reaction to Xolair (.1%) - not

> just of those who

> received Xolair. How many people have had a delayed

> reaction - i.e.,

> later than 2 hours after injection? I didn't feel

> there was any

> reaction at all but I guess I'm a tad bit nervous

> now about future

> injections.

>

> 2. I tend to have delayed reactions to allergy

> triggers. For instance,

> this past Fri. I had my first Xolair injections and

> thought I actually

> felt a tad bit less allergic (?!?!) so " tempted

> fate " by going for a

> hike in the country and woods 2 days in a row. The

> next day I woke up

> w/a sinus headache. Really, it could have been much

> worse overall so

> I'm still thinking Xolair helped.

>

> 3. How fast does it take (on average) to get relief

> using Xolair? What

> influences the length of time and amount of relief?

> I've read that I

> should expect at least several weeks. What is it

> based on? How bad the

> allergy was to begin with? Amount of allergens

> exposed to?

>

> 4. Why was I told that if I missed my shot by more

> than 3 days I should

> call my doctor first? (I think this came up in a

> previous post) My

> understanding is that it's the same drug prepared in

> the same way and

> given at the same dose so why is there a big deal

> about being late other

> than having a return of symptoms?

>

> 5. Does Xolair cause sleepiness? Probably it was

> just the hike in the

> country (more exercise than what I'm accustomed to)

> and allergy attack

> but I felt like I could have slept 15 hours today!

>

> Thanx, and good health!

>

>

>

>

>

> [Non-text portions of this message have been

> removed]

>

>

________________________________________________________________________________\

____

We won't tell. Get more on shows you hate to love

(and love to hate): TV's Guilty Pleasures list.

http://tv./collections/265

[Guest guest]

I've been on Xolair since September of '05. Here's what I have to say:

I personally have not had any issues with anaphylaxis. I have always

had very sensitive allergies to many things, and *have* had

anaphylactic reactions before to various combinations of things.

I also tend to have delayed reactions (about 2-4 hours in some

instances).

I noticed a significant change in how I was feeling within about a

week (peak serum levels are 7-8 days post-injection). After about 3

months, and every three months subsequent, my pulmonologist has

reduced the amount of other medication I have to take to manage my

asthma. I went from being a persistent severe asthmatic constantly on

prednisone (60+ mg) and antibiotics (on top of the albuterol MDI and

nebs, Advair 500/50, singulair, claritin every day, the list goes on

and on...) to taking a puff from a 220 mg Asmanex inhaler every night.

That's it. The neb has been sitting in the closet collecting dust

for over a year now, even when I get colds. What they report is an

average based on several studies (from what I understand), but it's

different for everyone.

Never heard about the 3 day thing...my doc will let me go up to a week

if I have to (vacation, etc), but now that I'm giving the injections

myself, that shouldn't happen as much. Have noticed a return of

symptoms after more than 3 weeks have gone by (don't ask...insurance

fubar...BAD).

Haven't had any issues with sleepiness. drugs affect people in

different ways though, so it doesn't surprise me! I fall asleep after

an albuterol neb when I'm sick!!