Re: Mild and rare Xolair side effects

March 31, 2007

I had my second shot last week. Both times, I have slept like the

dead for most of 48 hours after. It is bad enough that I am moving my

shots so that I have child care and things arranged for me to be out

of it. Anyone else sleeping?

March 31, 2007

>

> I had my second shot last week. Both times, I have slept like the

> dead for most of 48 hours after. It is bad enough that I am moving my

> shots so that I have child care and things arranged for me to be out

> of it. Anyone else sleeping?

>

I have never heard of sleeping being a side effect. I believe that you

are the first to ask this question on this board. Do ask your doctor

what he/she thinks. Thanks for your post

Doug

Group founder/co-owner/moderator

On Xolair for 3 1/2 years

April 1, 2007

Well I would like to be! Unfortunately I work two jobs

so I feel like I am on autopilot for nearly a week

afterwards. I just want to sleep!

Jeannie

--- schoolontherock <fromthebirdhouse@...>

wrote:

> I had my second shot last week. Both times, I have

> slept like the

> dead for most of 48 hours after. It is bad enough

> that I am moving my

> shots so that I have child care and things arranged

> for me to be out

> of it. Anyone else sleeping?

>

________________________________________________________________________________\

____

Need Mail bonding?

Go to the Q & A for great tips from Answers users.

http://answers./dir/?link=list & sid=396546091

April 2, 2007

I had terrible fatigue when starting Xolair, but it coincided with not

needing pred any more and we determined that I had adrenal fatigue.

Even tho I had always tapered my pred doses, apparently taking one

taper per month for about 3 years wore my adrenals down. So when

Xolair kicked in and I didn't need another taper, my adrenals had a fit.

Generally, I have slept better since starting Xolair. I used to wake

up with the sweats at least once a night, and that stopped once I

stopped using pred. It was terrible. I would go to sleep with a towel

between me and the sheets so that I could wake up with the towel wet,

and not the sheets, and then ditch the towel and go back to sleep on

dry sheets. TMI?

Addy

Group co-owner

>

> I had my second shot last week. Both times, I have slept like the

> dead for most of 48 hours after. It is bad enough that I am moving

my

> shots so that I have child care and things arranged for me to be out

> of it. Anyone else sleeping?

>

April 2, 2007

Well, yes, I also slept a good deal after the first shot(s) (I get two

at a time). It seemed possible that it was from sinusitis and allergy

attacks from being outside 2 days but, as I believe I said in previous

posts, I could sleep for 12, 13, even 15 hours!!!! This has gone on for

a week. Maybe weather had something to do with it too. Dunno. My hubby

was obviously shocked when I was still groggy in bed at 12:30 pm.

If I was working right now it would be tough. Even if I had dragged

myself out last week my mind was not all there. Actually, I've read

that one of the side effects can be fatigue as well as dizziness. I

wonder why? There is an increase in IgE in the blood following the

doses but don't know if that relates to fatigue. If there was suddenly

a lot of relief from allergies I could understand the " relaxing " effect

on the body. But that wasn't really the case for me. I'm not sure why

it happened but am currently chalking it up to environmental allergies.

This coming Friday, April 6th, I'm supposed to have my second shot

(again two at a time - total of 300 mgs). If the extreme

sleepiness/fatigue happens again and there's no particularly active

sinusitis then I'll be suspicious it's the Xolair. Maybe it just takes

getting used to? I'm still in the learning phase!

Here are some places where it mentions tiredness as a side effects of

Xolair: http://www.xolair.com/patient/important_information.jsp

<http://www.xolair.com/patient/important_information.jsp>

http://www.webmd.com/content/pages/20/105743.htm?z=1660_05741_4012_rc_03\

#a5

<http://www.webmd.com/content/pages/20/105743.htm?z=1660_05741_4012_rc_0\

3#a5>

On Wikipedia they mention, at the bottom: " Concerns have also been

raised about possible induction of Churg-Strauss syndrome, nasal polyps,

and adrenal insufficiency.[2] " Adrenal insufficiency could certainly

cause fatigue but that can be checked out.

http://en.wikipedia.org/wiki/Omalizumab

<http://en.wikipedia.org/wiki/Omalizumab>

http://www.gene.com/gene/common/inc/pi/xolair.jsp#reactions

<http://www.gene.com/gene/common/inc/pi/xolair.jsp#reactions>

It's important to remember that patients were only followed for a year

during the trials so no one really knows what all side effects there

are, especially since it's been tried on a relatively small number of

patients.

I'll bet someone else out there has had sleepiness as a side effect too.

How long did it last?

Best of luck!

>

I had my second shot last week. Both times, I have slept like the

dead for most of 48 hours after. It is bad enough that I am moving my

shots so that I have child care and things arranged for me to be out of

it. Anyone else sleeping?

>

April 2, 2007

That's interesting--about the pred and adrenal fatigue. I have not taken pred

on a regular basis for about 15 years--only bursts two or three times a years

when I had sinusitis which led to respiratory infections which led to asthma

attacks. But I have felt a little fatigue the day I've gotten my shot and some

fatigue the next day. This last shot, however, I really felt the fatigue the

next day. I had agreed to substitute at a school and went, but was very tired

all day, and could hardly wait to get home a take a nap. I don't sleep straight

through--but I have noticed the fatigue. Don't think mine is adrenal fatigue,

though. I made sure I got to bed early enough the night before, so it wasn't

from lack of sleep. It really felt more like the time I was extremely anemic--I

made myself keep going but my body really objected--my tail was dragging!

Adah

pyle456 <coachmac@...> wrote: