dosing explained - sort of

February 11, 2007

It sounds like your usual dose is 375mg, or 2 and a half vials of

Xolair. This is normally given in three shots, usually every two

weeks and is the generally accepted highest dose. Jo Ann, one of the

Xolair nurses who posts here, has previously described how they

calculate higher dosing for folks with excessive IgE and/or weight.

Dosing is based on IgE levels and weight. Really high IgE scorers

who weigh 130lbs or more normally qualify for 375mg every two weeks.

You can go to www.xolair.com and look at the full prescribing

information to see the dosing charge. It is a little bit misleading -

Doug and I have IgE scores above the highest score on the chart and

we get 375mg every two weeks. We have a few folks here on the low

end of the chart who are getting a slightly higher dose than

recommended normally b/c they didn't respond to the original dose.

Like you, I have huge sinus inflammatory issues. I call it " severe

persistent allergic sinus disease " because I keep showing negative on

all tests/scans/xrays to prove that it's anything else. Xolair has

helped ENORMOUSLY with this, but it has not cured it.

Welcome to the group

Addy

Co-owner and definitely not a " feller "

> >

> > I cannot remember that we've had more than a handful of posts

where

> > someone became ill following their first treatment. I can't

remember

> > anyone discontinuing it. You might look through past posts

> > under " first shot " or " first treatment. " This is a high risk

group for

> > upper respiratory stuff as it is.

> >

> > Addy

> > Group co-owner

> >

> > --- In , " Terry " <onabeach@>

wrote:

> > >

> > > Has anyone had relatively upleasant reaction to first

treatment (2-

> > 1/2

> > > doses)of Xolair? The morning after my first treatment, I had

total

> > > blocking of my nasal passages, tremendous pressure all around

that

> > > area, wheezing, sore and swollen throat, difficulty

swallowing and

> > > labored breathing. Was sent to emergency at hosp. where I

received

> > > injection of 120 mg of prednisone and 50mg of benadryl.

Prednisone

> > > injection felt like someone shot me in the arm with a gun and

is

> > still

> > > sore 12 hrs.later but it seems to be doing the job.

> > >

> > > Has anyone else had a reaction like this, and if so, was it

just a

> > > first-time anomaly, or did it cause discontinuance of the

program?

> > >

> > > I'm currently waiting for doc to get back to me re the

reaction.

> > >

> >

>

February 12, 2007

Hi not-a-feller Addy There may be a common thread here. The ENT doc has gone

out on a limb and said he feels my problems are the result of long- term

sinusitis causing the allergy-like symptoms and the asthma. This kind of falls

in place to me because my allergy tests don't really show anything that I'm all

that allergic to, but yet I have all this bloody IgE running about in my cute

little bod. The pulmonary doc isn't ready to sign off on that yet because my

sinuses won't clear up completely, even after extensive prednisone. At Duke,

they told me one of the most important things I could do is flush those rascals

regularly, which I do, sometimes shooting more than a quart of water up there.

It really helps. It will be interesting to see how this all works out. I

wonder if there is any kind of a gender factor involved in this kind of a

problem.

Terry a.k.a. Ohldepharte

----- Original Message -----

From: pyle456

Sent: Sunday, February 11, 2007 6:26 PM

Subject: [ ] dosing explained - sort of