Re: If Xolair is good for allergic inflammation is it good for other inflammation?

[Guest guest]

Hi,

I'm the only one with allergic asthma but other women in my family

have arthritis. They are all inflammatory diseases, so there is

probably a gene that makes one more susceptible to inflammatory

issues than others.

Xolair should reduce inflammation due to allergic processes ONLY

because it acts to prevent the IgE cell from binding to the mast cell

and starting the allergic cascade.

I do not know the scientific answer to your question, but I doubt it

has anti-inflammatory benefits generally because my early onset

arthritis has started rearing its ugly head now that I know longer

need prednisone on a regular basis for my asthma. Previously the

pred was masking the onset of the arthritis. Yep, I'm bummed.

Take care, and let us know how you're doing with your treatment.

Addy

Group co-owner

These experiences are mine only. See your doctor for questions about

your own care.

--- In , " instdesgn1 " <instdesgn1@...>

wrote:

>

> I noticed others were wondering if severe allergies were in any way

> related to autoimmune disorders such as hashimotos.

>

> Various doctors have told me that the three " A's " - asthma,

allergies,

> arthritis - and I have them all - are all interrelated although

they

> didn't tell me how. There seemed to be some self righteousness in

> their delivery of the statement. There seemed to be implication

that

> it was a psychological problem. I strongly disagree.

>

> I will be talking to a doctor about starting xolair in a few days.

I

> know it's used to lower IgE and wonder if anyone has noticed any

other

> benefit - like lowering C-reactive protein (mine is high but it's

> supposed to be influenced by allergies) or arthritis or anything

else?

> Perhaps just having asthma under control could make other

conditions

> seem milder. Just a guess.

>

[Guest guest]

Hi there!

Just wanted to make a quick point. Since you're going to be taking Xolair,

you should better understand the way it works.

Xolair doesn't " lower " IgE at all. It binds with IgE, preventing the IgE

from binding with mast cells. When IgE binds with mast cells, it releases

histimine, which, as you know, is what triggers our allergies and asthma

attacks.

Our bodies are constantly producing new IgE, which is why we need to keep

taking Xolair. The new IgE must be sought out and bound before it has a

chance to bind with the mast cells. My doctor said that we will never be

able to have ALL of our IgE bound with Xolair, which is why most of us will

never be 100% symptom free. The Xolair just keeps us from producing so much

histamine that our bodies push past our envelope of natural tolerance, which

keeps us healthier and out of flare ups as often.

I don't know much about C-reactive protein, that is something you should ask

your Xolair prescribing doctor about.

As far as allergies, asthma and arthritis... I've never heard of all three

being lumped together before, maybe someone else has.

Allergies and Arthritis being psychological, I would tend to disagree as

well, it would seem to me that you either have those or you don't.

I would keep an open mind about asthma having a psychological connection.

Keep an open mind on this one, to a degree. Do I think all asthma is

psychological? Surely not, no one who has been through what I have could

say that with a straight face!!! However, I do know that for myself and

many others, stress, and other high emotions absolutely play a role in

asthma! For quite a while I took klonopin twice daily to keep my anxiety

and stress in check as they were definitely contributing to the number of

attacks I had.

I don't believe that all asthma is psychological, nor to I believe that all

asthma can be treated by telling a patient that it's all in their head. I

do believe that for many of us that have lived with such severe asthma...

you can get to a point that you're living with anxiety simply because you're

constantly worrying when the next major attack is going to be. If you live

day to day on oral steroids and still wheeze, you're going to live with

stress and anxiety, and for many people, that can contribute to more attacks

I'd be interested to know more about the c-reactive protein and arthritis.

But my understanding from my doctor is that Xolair is an incredibly specific

medication. Perhaps there is something to be gained from having asthma

under better control in general... I no longer need the klonopin.

~

-------Original Message-------

From: instdesgn1

Date: 01/12/07 06:26:14

Subject: [ ] If Xolair is good for allergic inflammation is it

good for other inflammation?

I noticed others were wondering if severe allergies were in any way

related to autoimmune disorders such as hashimotos.

Various doctors have told me that the three " A's " - asthma, allergies,

arthritis - and I have them all - are all interrelated although they

didn't tell me how. There seemed to be some self righteousness in

their delivery of the statement. There seemed to be implication that

it was a psychological problem. I strongly disagree.

I will be talking to a doctor about starting xolair in a few days. I

know it's used to lower IgE and wonder if anyone has noticed any other

benefit - like lowering C-reactive protein (mine is high but it's

supposed to be influenced by allergies) or arthritis or anything else?

Perhaps just having asthma under control could make other conditions

seem milder. Just a guess.

[Guest guest]

Stress, anxiety, depression and other negative emotions do have an effect on

allergies and asthma. A recent study has shown that people with lots of anxiety

are more prone to immune dysfunction. However, I personally think that when you

go through life having to carry epi pens and albuterol and benadryl elixir

everywhere combined with the negative effect histamine itself has on emotions,

that that the underlying cause is the allergic mechanism itself. Of note, many

anti-depressants lower histamine.

If you google xolair and off label uses, you may find that some people are

using it for chronic allergic dermatitis and also insect sting allergies. The

food allergy study was stopped. I think this is because most food allergy is

igg mediated and not ige mediated which xolair works with. This causal

relationship can also be googled by entering " igg mediated food allergy. "

Currier <redsoxkitten@...> wrote:

Hi there!

Just wanted to make a quick point. Since you're going to be taking Xolair,

you should better understand the way it works.

Xolair doesn't " lower " IgE at all. It binds with IgE, preventing the IgE

from binding with mast cells. When IgE binds with mast cells, it releases

histimine, which, as you know, is what triggers our allergies and asthma

attacks.

Our bodies are constantly producing new IgE, which is why we need to keep

taking Xolair. The new IgE must be sought out and bound before it has a

chance to bind with the mast cells. My doctor said that we will never be

able to have ALL of our IgE bound with Xolair, which is why most of us will

never be 100% symptom free. The Xolair just keeps us from producing so much

histamine that our bodies push past our envelope of natural tolerance, which

keeps us healthier and out of flare ups as often.

I don't know much about C-reactive protein, that is something you should ask

your Xolair prescribing doctor about.

As far as allergies, asthma and arthritis... I've never heard of all three

being lumped together before, maybe someone else has.

Allergies and Arthritis being psychological, I would tend to disagree as

well, it would seem to me that you either have those or you don't.

I would keep an open mind about asthma having a psychological connection.

Keep an open mind on this one, to a degree. Do I think all asthma is

psychological? Surely not, no one who has been through what I have could

say that with a straight face!!! However, I do know that for myself and

many others, stress, and other high emotions absolutely play a role in

asthma! For quite a while I took klonopin twice daily to keep my anxiety

and stress in check as they were definitely contributing to the number of

attacks I had.

I don't believe that all asthma is psychological, nor to I believe that all

asthma can be treated by telling a patient that it's all in their head. I

do believe that for many of us that have lived with such severe asthma...

you can get to a point that you're living with anxiety simply because you're

constantly worrying when the next major attack is going to be. If you live

day to day on oral steroids and still wheeze, you're going to live with

stress and anxiety, and for many people, that can contribute to more attacks

I'd be interested to know more about the c-reactive protein and arthritis.

But my understanding from my doctor is that Xolair is an incredibly specific

medication. Perhaps there is something to be gained from having asthma

under better control in general... I no longer need the klonopin.

~

-------Original Message-------

From: instdesgn1

Date: 01/12/07 06:26:14

Subject: [ ] If Xolair is good for allergic inflammation is it

good for other inflammation?

I noticed others were wondering if severe allergies were in any way

related to autoimmune disorders such as hashimotos.

Various doctors have told me that the three " A's " - asthma, allergies,

arthritis - and I have them all - are all interrelated although they

didn't tell me how. There seemed to be some self righteousness in

their delivery of the statement. There seemed to be implication that

it was a psychological problem. I strongly disagree.

I will be talking to a doctor about starting xolair in a few days. I

know it's used to lower IgE and wonder if anyone has noticed any other

benefit - like lowering C-reactive protein (mine is high but it's

supposed to be influenced by allergies) or arthritis or anything else?

Perhaps just having asthma under control could make other conditions

seem milder. Just a guess.