IgE UP to 1,370 on Xolair from original of 350

[Guest guest]

Just got my first labs back after first 3 injections of Xolair. Everything was

" normal " (despite feeling terrible, having chills, fatigue, headache, sneezing)

except that my IgE jumped from 350 pre Xolair to 1,370 on Xolair.

I've read, on this board, I believe, that IgE will jump up on Xolair but that

it is not " available " - i.e., somehow is allegedly not affecting the body.

Could someone explain this to me again? I'm beginning to have doubt about

Xolair. Thanks so much.

---------------------------------

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Check outnew cars at Autos.

[Guest guest]

Dear SD,

It took me 1.5 YEARS to feel better on xolair. IgE values measured post xolair

are meaningless. We cannot interpret the usual tests in the same way as the test

cannot differentiate between bound and un-bound IgE. Personally, I think its a

waste of resources to run IgEs post xolair but that is just IMHO.

Recall that xolair is not a miracle treatment despite all the positive reports

you may get here. In many people it has helped tremendously, in others it has

helped some and in a smaller group, it has made no difference. It has helped me

some but I ain't cured yet....

Who will be off pred when cows begin to fly.....

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[Guest guest]

Hope this helps!

Serum total IgE levels increase following

administration of XOLAIR due to formation of

XOLAIR:IgE complexes. Elevated serum total IgE levels

may persist for up to 1 year following discontinuation

of XOLAIR. Serum total IgE levels obtained less than 1

year following discontinuation may not reflect

steady-state free IgE levels and should not be used to

reassess the dosing regimen.

--- SD Designer <instdesgn1@...> wrote:

> Just got my first labs back after first 3 injections

> of Xolair. Everything was " normal " (despite feeling

> terrible, having chills, fatigue, headache,

> sneezing) except that my IgE jumped from 350 pre

> Xolair to 1,370 on Xolair.

>

> I've read, on this board, I believe, that IgE will

> jump up on Xolair but that it is not " available " -

> i.e., somehow is allegedly not affecting the body.

>

> Could someone explain this to me again? I'm

> beginning to have doubt about Xolair. Thanks so

> much.

>

>

>

> ---------------------------------

> Ahhh...imagining that irresistible " new car " smell?

> Check outnew cars at Autos.

>

> [Non-text portions of this message have been

> removed]

>

>

__________________________________________________

[Guest guest]

Just to expand a bit more - The tests currently available to measure

IgE cannot tell the difference between plain old IgE and IgE that is

bound to Xolair and the Xolair-IgE complexes can accumulate and hang

around for a while in the blood. That's why the IgE levels increase

over time while you're receiving Xolair. However, the IgE that is

bound to Xolair cannot trigger allergic responses by binding to mast

cells. That is way the IgE levels measure while on Xolair and for up

to a year afterward are not clinically useful, including as a basis

for recalculating Xolair dosing.

There are ways to measure free IgE without including Xolair-bound IgE

but they are not available commercially. I agree completely with

that testing for IgE under these conditions is a waste of

resources. Do you know why your doctor tested for IgE after you were

already on Xolair? I can't think of a reasonable reason to do so but

perhaps we're all overlooking something.

Fran

>

> > Just got my first labs back after first 3 injections

> > of Xolair. Everything was " normal " (despite feeling

> > terrible, having chills, fatigue, headache,

> > sneezing) except that my IgE jumped from 350 pre

> > Xolair to 1,370 on Xolair.

> >

> > I've read, on this board, I believe, that IgE will

> > jump up on Xolair but that it is not " available " -

> > i.e., somehow is allegedly not affecting the body.

> >

> > Could someone explain this to me again? I'm

> > beginning to have doubt about Xolair. Thanks so

> > much.

> >

> >

> >

> > ---------------------------------

> > Ahhh...imagining that irresistible " new car " smell?

> > Check outnew cars at Autos.

> >

> > [Non-text portions of this message have been

> > removed]

> >

> >

>

>

> __________________________________________________

>

[Guest guest]

Hi,

I'm confused by the doctor choosing to do labs, too.

I've had four treatments, and all my doc does is check

my breathing beforehand. It improved the first couple

of times, but then I had to wait an extra week for a

shot, and so my exhales weren't quite as strong this

last time. Still, my peak flows are MUCH better than

the past few Springs. BTW, the woman who gave me the

shots explained that it takes up to a year for the

Xolair to build up in your system enough so that you

don't feel worse in the days right before your next

shot is due.

Are you keeping track of your peak flows? Don't give

up. The Xolair really might help!

Best of luck.

__________________________________________________

[Guest guest]

Hi all ~~~~

I don't know why the doc ordered the IgE test either but it was

perfectly ok w/me. I have a lot of confidence in this doc - in a

major med center.

What I don't understand is: It seems like Xolair is sort've the

garbage collector running around nabbing all those nasty excessive

IgEs in the blood and disarming them someplace with a high wall so

that they cannot get out and bind to mast cells and get the allergic

cascade of events going. (Obviously these are my words!) So, after

3 series of shots there's a whale of a lot of IgE in me. So, either

the Xolair is holding up a lot of IgE or there's an awful lot running

around free causing trouble. I can't help but wonder if there's some

sort of feedback mechanism going on that's saying " whoa, we don't

have all the IgE we used to have so let's make more. " ???? I just

don't think the whole story is out there yet.

It seems that Xolair should be reducing the amount of IgE and

there should be some sort of improvement. I'm not any worse and not

any better in my opinion re asthma. BUT, I've had a long term cold

and horrible sinusitis for 2-1/2 weeks. I have a slightly

uncomfortable feeling that Xolair is contributing to it as Xolair is

associated with upper respiratory infections and sinusitis. (I've

got a history of sinusitis.) I feel ever so slightly strange.

My doc's office said 6 months to see if it's doing any good.

But, they also seemed concerned that my IgE went up this high this

fast. They're contacting Genentech. My suspicion is that MOST INFO

FLOATING AROUND ABOUT XOLAIR IS OUT OF DATE since it's mostly based

on the trials. For instance, I now know that my weight is not an

issue in determining dosage now - it's the IgE. I had another IgE

test today and I know that this level of docs I'm dealing with would

not do it w/o a really good reason.

My injections are all at home - I mixed and inject myself

w/absolutely no problems. I guess I'll know more about this in a few

days.

Here's to a nice deep breath with a clear head!

>

> > Just got my first labs back after first 3 injections

> > of Xolair. Everything was " normal " (despite feeling

> > terrible, having chills, fatigue, headache,

> > sneezing) except that my IgE jumped from 350 pre

> > Xolair to 1,370 on Xolair.

> >

> > I've read, on this board, I believe, that IgE will

> > jump up on Xolair but that it is not " available " -

> > i.e., somehow is allegedly not affecting the body.

> >

> > Could someone explain this to me again? I'm

> > beginning to have doubt about Xolair. Thanks so

> > much.

>> __________________________________________________

>