Re: Lowdown on Black box warning

[Guest guest]

Barbara,

Thanks for that information. I think that the reason that the

percentage of folks experiencing reactions is so low is b/c we're not

all allergic to the same things. I " d be interested to hear what Pat

or Fran have to say about this. I've been on Xolair for three years

without any trouble. It's saving my life.

Addy

Group co-owner

>

> Hi Everyone:

>

> I went to an immunologist here in New Mexico where I am relocating

to

> just to touch base and establish myself as a new patient.

>

> I had a long and very interesting conversation with him with

regards

> to Xolair.

>

> The reason for the black box warning is this: People who have

> allergic asthma do very well on Xolair. Xolair tames the IgE in

> blood and lowers the allergic response to triggers. Some people,

who

> have been on the Xolair for extended periods (1 yr. or more, who

have

> never reacted to the Xolair) are now having an allergic response to

> the actual Xolair that is being injected. This is due from the

fact

> that Xolair is a foreign substance going into the bloodstream and

> with that being the case, the IgE is now identifying it as a

foreign

> substance and reacting to the actual Xolair.

>

> This is the very first time that ANYONE has explained this to me in

> terms that I understood.

>

> He is still requesting that I stay 2 hours for the first 2 times I

> see him and then if no reactions, I can leave after 30 minutes,

with

> an Epi-pen in hand.

>

> I still am not happy discontinuing the home injections, but I can

> live with the 30 min. waiting room protocol.

>

> Each doctor will have their own protocol, this just happens to be

his

> for his office.

>

> Barbara

>

[Guest guest]

Right, Addy, each allergic individual has her/his own range of

sensitivities related to the individual genetic makeup of the immune

system. Luckily, most people tolerate Xolair without allergic

reactions.

Fran

> >

> > Hi Everyone:

> >

> > I went to an immunologist here in New Mexico where I am

relocating

> to

> > just to touch base and establish myself as a new patient.

> >

> > I had a long and very interesting conversation with him with

> regards

> > to Xolair.

> >

> > The reason for the black box warning is this: People who have

> > allergic asthma do very well on Xolair. Xolair tames the IgE in

> > blood and lowers the allergic response to triggers. Some people,

> who

> > have been on the Xolair for extended periods (1 yr. or more, who

> have

> > never reacted to the Xolair) are now having an allergic response

to

> > the actual Xolair that is being injected. This is due from the

> fact

> > that Xolair is a foreign substance going into the bloodstream and

> > with that being the case, the IgE is now identifying it as a

> foreign

> > substance and reacting to the actual Xolair.

> >

> > This is the very first time that ANYONE has explained this to me

in

> > terms that I understood.

> >

> > He is still requesting that I stay 2 hours for the first 2 times

I

> > see him and then if no reactions, I can leave after 30 minutes,

> with

> > an Epi-pen in hand.

> >

> > I still am not happy discontinuing the home injections, but I can

> > live with the 30 min. waiting room protocol.

> >

> > Each doctor will have their own protocol, this just happens to be

> his

> > for his office.

> >

> > Barbara

> >

>