Ovarian Cancer+saturated fat

[Guest guest]

Dietary fat and ovarian cancer - adapted from the Journal of the National Cancer

Institute, September 21, 1994

Nutrition Research Newsletter, Nov-Dec, 1994

Cancer of the ovary is a hormone-related disease, and risk is known to be

influenced by factors that affect hormonal status, including number of

pregnancies and use of oral contraceptives. Since dietary factors may influence

circulating hormone levels, it is suspected that they may play a role in the

development of ovarian cancer. In particular, high intakes of total fat and

saturated fat have been hypothesized to increase ovarian cancer risk.

Saturated fat consumption was positively associated with ovarian cancer risk

(odds ratio 1.20 for each 10 g/day of intake; 95% confidence interval

1.03-1.40). Unsaturated fat showed no association. Egg consumption was

associated with increased risk, but this may have resulted from disease-related

changes in the eating habits of the case subjects. Carotenes and vegetable fiber

were associated with decreased risk (odds ratio 0.63 for each 10 g/day of

vegetable fiber; 95% confidence interval 0.49-0.80). Fruit and cereal fibers

showed no effect.

These findings indicate that diet may contribute to the risk of ovarian cancer

development. If confirmed, these results suggest that ovarian cancer risk may be

reduced by dietary changes, including decreases in the intake of saturated fat

(and perhaps eggs) and increases in vegetable consumption.

Harvey A Risch, Meera Jain, Loraine D Marrett, and Geoffrey R Howe, Dietary Fat

Intake and Risk of Epithelial Ovarian Cancer, J National Cancer Institute

86(18):1409-1415 (21 Sept 1994) [Correspondence: Harvey A Risch, MD, Phd,

Department of Epidemiology and Public Health, Yale University School of

Medicine, 60 College Street, PO Box 3333, New Haven CT 06510!

COPYRIGHT 1994 Frost & Sullivan

COPYRIGHT 2004 Gale Group

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Harvey A Risch, Meera Jain, Loraine D Marrett, and Geoffrey R Howe, Dietary Fat

Intake and Risk of Epithelial Ovarian Cancer, J National Cancer Institute

86(18):1409-1415 (21 Sept 1994) [Correspondence: Harvey A Risch, MD, Phd,

Department of Epidemiology and Public Health, Yale University School of

Medicine, 60 College Street, PO Box 3333, New Haven CT 06510!