Turmeric and Curcumin

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Home <http://www.curcuminhealth.info> | Thursday 18th August 2005

'Curcumin Can Work On At Least

One Dozen Cancers'

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Dear Friend of Truth in Health,

My name is Redfern, and I make it my job to publicize studies

that prove poisonous drugs are not the best way to health, and there are

many natural health remedies that can resolve the problem, without any

side effects. One such remedy is Curcumin. This is the first of a series

of newsletters that will explore the many uses of this amazing solution

to a wide range of health problems.

Today's News Story:

'Curcumin Can Work On At Least One Dozen Cancers'

Says Dr. Bharat Aggarwal.

Dr. Bharat Aggarwal, who headed the 12-member team of

researchers at University of Texas (U.T.) M.D. Cancer Center,

said earlier this week that his clinical research has made available not

only "the master switch to turn off cancer, but also a cure for it."

"It was already known that Curcumin can prevent cancer,"

Aggarwal said. "Now it can also be used to cure cancer." And, he added:

"We are providing evidence that Curcumin can work on at least one dozen

cancers."

"In fact, let's put it this way: we have not found a single

cancer on which Curcumin doesn't work," Aggarwal asserted.

Turmeric, whose vernacular name is haldi, is a rhizome of the

plant Curcuma longa. The medicinal use of this plant has been documented

in Ayurveda, a 5,000-year-old system of medicine that has its origins in

India.

Turmeric has long been used as a food preservative, a coloring

agent, a spice to flavor food, and as a folk medicine to cleanse the

body.

"Because of turmeric's extensive use in foods in India and

Pakistan, the incidence of cancer, especially breast, colon, prostate

and lung, is a lot less in those countries", Aggarwal said. "And because

South Indians use turmeric more widely than North Indians, the

prevalence of cancer is less among them than among North Indians," he

said.

"The spice has been shown to relieve arthritis as well", he

added. The U.T. team's research focused on how Curcumin stops laboratory

strains of melanoma from proliferating, and pushes the cancer cells to

commit suicide.

The team homed in on a molecule called NF-kappa B, a powerful

protein known to promote an abnormal inflammatory response that leads to

cancer in some people, arthritis in others, and a wide range of other

diseases in other people.

Aggarwal said, "Nearly 98 percent of all diseases are controlled

by this molecule. The humble yellow dye can subdue this potent molecule.

"

Two to five percent of turmeric is Curcumin and researchers have

now found that Curcumin at 95% concentration is far more potent than

plain old Turmeric. When combined with Piperine (a black pepper extract)

supplements become up to 20 times more potent, a fact that has resulted

in the manufacture in the U.S. of a formulation containing 200 capsules

each containing 500mg of 95% Curcumin and 3mg of Piperine and sold as a

dietary supplement.

Aggarwal said that Indians have known all along about the

anti-inflammatory benefits of turmeric, but "there was no documented

proof" up until now.

Dozens of clinical trials have already begun in the U.S., India,

Israel and the U.K., to see if Curcumin also has the same effect on

people as it has in the laboratory experiences.

The UT findings will be published in the Aug. 15 issue of the

journal, Cancer.

What is Curcumin?

Curcumin is a standardized extract of Curcuma Longa root. The

active ingredients in Curcuma Longa are a group of plant substances

called curcuminoids. Known collectively as "Curcumin," curcuminoids have

demonstrated potent antioxidant properties in scientific studies. In the

better formulas, there are 200 capsules of 500 mg Curcumin + 3mg

Piperine in each bottle.

Curcuminoids are responsible for turmeric's distinctive yellow

color, but there can be less than 4% content in turmeric. Advanced

Curcumin complexes usually supply 95% total curcuminoids, and Piperine

is added as a natural bio-enhancer, to promote absorption of the

Curcumin.

Where does it come from? Turmeric Plant

Native to Southeast Asia, Curcuma longa is a tall tropical

shrub. The genus "Curcuma" belongs to the Zingiberaceae family, which

includes ginger. The plant possesses a large root structure with fleshy,

bulbous underground parts called "rhizomes." These rhizomes, known as

turmeric root, are harvested at maturity, dried and cured for commercial

use.

Turmeric is named in ancient Ayurvedic and Chinese herbal texts

as a traditional folk remedy. Historically, turmeric was used externally

for wounds, and sprains, and internally for digestive complaints,

rheumatism, liver disorders, coughs and colds.

Nature's Absorption Enhancer Boosts Curcumin Power

Traditional Ayurvedic herbal formulas often include black pepper

and long pepper as synergistic herbs. The active ingredient in both

black pepper and long pepper is the alkaloid Piperine. Experiments

carried out to evaluate the scientific basis for the use of peppers have

shown that Piperine significantly enhances bio-availability when

consumed with other substances. Several, double blind, clinical studies,

have confirmed that Piperine increases absorption of nutrients.

All Around Herb for General Wellbeing.

Curcumin is the main biologically active part of Turmeric. Over

500 references to articles on Turmeric and Curcumin have been published

in peer reviewed professional journals.

It has been identified in pharmacology as:

v Anti-bacterial v Anti-inflammatory

v Anti-viral v Anti-oxidant

v Anti-fungal v Anti-spasmodic

v Anti-yeast v Carminative

v Anti-allergenic v Diuretic and anti-tumour

Turmeric and Curcumin have traditionally also been used to

support those suffering from pain and inflammatory conditions:

v Acne, allergies v Chicken pox

v Ascites v Diabetes

v Auto- immune disorders v Digestive disorders

v Burns v Gallbladder problems

v Liver damage v Liver disorders

v Skin rashes v Ulcers

v Tumours v Eye problems such as cataracts

If that is not enough, Turmeric has been used for thousands of

years by Indian women to make their skin beautiful and blemish free.

There are plenty of New Studies that show potential benefits

with:

v Alzheimer's v Kidney-Disease

v Liver Disease v Anti-Arthritic

v Anti-Coagulant v Anti-Carcinogenic and Anti-Cancer

v Lowering-LDL v Raising HDL-Cholesterols

The Science

The numerous beneficial effects attributed to Turmeric are

probably due to the antioxidant properties of Curcumin.

Antioxidants neutralize free radicals, which are highly unstable

molecules that can damage cellular structures through abnormal oxidative

reactions. Curcumin is a potent "scavenger" of the superoxide radical, a

free radical that initiates potentially harmful oxidative processes,

such as lipid peroxidation. Through this activity, Curcumin has been

shown to protect skin cells from the injurious effect of nitro blue

tetrazolium, a toxin that generates superoxide radicals.

Curcumin also increases survival of cells exposed in vitro to

the enzyme hypoxanthine/xanthine oxidase, which stimulates superoxide

and hydrogen peroxide production, possibly by stimulating the enzyme

catalyse.

Curcumin itself is not toxic to cells, even at high

concentrations. Because free radicals are involved in aging and exert

harmful effects on skin, these results suggest Curcumin may help to slow

skin aging.

Curcumin demonstrates several other in vitro effects linked to free

radical scavenging.

Curcumin scavenges nitric oxide, a compound that when in excess

is associated with the body's inflammatory response.

Pure curcumin and turmeric extracts protect red blood cells from

lipid peroxidation induced by hydrogen peroxide.

Curcumin has been shown to protect DNA from oxidative damage,

inhibit binding of toxic metabolites to DNA, and reduce DNA mutations in

the Ames test.

Curcumin also demonstrates in vitro inhibition of COX-I and

COX-II enzymes, which are involved in the inflammatory reaction.

Together, these results strongly suggest that curcumin has a

potent bio-protective effect, with a potentially wide range of

therapeutic applications.

Curcumin is poorly absorbed in the intestinal tract, limiting its

therapeutic effectiveness. Oral doses are largely excreted in faeces,

and only trace amounts appear in the blood. Administration of 3 mg of

Piperine with 500mg of Curcumin (1 capsule) can, in exceptional

circumstances increase the bio availability of curcumin by 2000%.

We state 100% increase from 500mg to the equivalent to 1000mg is about

right. Be aware that the bioavailability of all other nutrients taken

around the same time (and DRUGS) may also be increased by the same

proportion.

Side Effects

No side effects have been found when taking high doses of

Curcumin. Rare cases of stomach upset or diarrhoea may be resolved by

temporarily reducing the dosage and taking with food.

With kindest and healthiest regards

Redfern

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